CN110662839A - 用于细胞疗法的基于靶向性配体-有效负载的药物递送 - Google Patents

用于细胞疗法的基于靶向性配体-有效负载的药物递送 Download PDF

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CN110662839A
CN110662839A CN201880024308.6A CN201880024308A CN110662839A CN 110662839 A CN110662839 A CN 110662839A CN 201880024308 A CN201880024308 A CN 201880024308A CN 110662839 A CN110662839 A CN 110662839A
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gly
ser
leu
cells
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P.S.洛
M.斯里尼瓦萨劳
B.张
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Purdue Research Foundation
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Purdue Research Foundation
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CN201880024308.6A 2017-02-17 2018-02-17 用于细胞疗法的基于靶向性配体-有效负载的药物递送 Pending CN110662839A (zh)

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US201762460118P 2017-02-17 2017-02-17
US62/460,118 2017-02-17
PCT/US2018/018557 WO2018152451A1 (en) 2017-02-17 2018-02-17 Targeted ligand-payload based drug delivery for cell therapy

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CN201880024308.6A Pending CN110662839A (zh) 2017-02-17 2018-02-17 用于细胞疗法的基于靶向性配体-有效负载的药物递送

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US (2) US12343403B2 (https=)
EP (2) EP3583218B1 (https=)
JP (2) JP7288402B2 (https=)
KR (1) KR102595249B1 (https=)
CN (2) CN118634339B (https=)
AU (1) AU2018221171B2 (https=)
CA (1) CA3053534A1 (https=)
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CN113462649A (zh) * 2021-05-27 2021-10-01 浙江大学 Mek抑制剂在减少car-t细胞耗竭和终末分化中的应用
CN116041545A (zh) * 2022-12-12 2023-05-02 南方医科大学 一种靶向荧光素或生物素的通用型car及其应用
WO2026012294A1 (zh) * 2024-07-09 2026-01-15 深圳虹信生物科技有限公司 一种治疗b细胞过度增殖产生自身抗体所引起的疾病的药物、方法与应用

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4282419A1 (en) 2012-12-20 2023-11-29 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
JP2019508036A (ja) 2016-02-16 2019-03-28 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド 免疫療法組成物及び方法
EP3439675A4 (en) 2016-04-08 2019-12-18 Purdue Research Foundation METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY
US11649288B2 (en) 2017-02-07 2023-05-16 Seattle Children's Hospital Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
CA3053534A1 (en) * 2017-02-17 2018-08-23 Purdue Research Foundation Targeted ligand-payload based drug delivery for cell therapy
WO2018160622A1 (en) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions and methods for car t cell therapy
US11311576B2 (en) 2018-01-22 2022-04-26 Seattle Children's Hospital Methods of use for CAR T cells
US12312416B2 (en) 2018-02-06 2025-05-27 Seattle Children's Hospital Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors
AU2019225174B2 (en) 2018-02-23 2025-11-20 Endocyte, Inc. Sequencing method for CAR T cell therapy
CA3096458A1 (en) 2018-04-12 2019-10-17 Umoja Biopharma, Inc. Viral vectors and packaging cell lines
JP2021530444A (ja) 2018-06-28 2021-11-11 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド 固形および液体悪性病変における多重ｃａｒ ｔ細胞での複数抗原の標的化
CN112543651B (zh) * 2018-08-07 2023-06-02 普渡研究基金会 使car t细胞恢复活力
MX2021008824A (es) * 2019-01-23 2021-10-13 Univ Johns Hopkins Análogos no inmunosupresores de tacrolimus (fk506) y uso de los mismos.
CN114207135A (zh) 2019-06-11 2022-03-18 夏尔人类遗传性治疗公司 用于治疗由失调的血浆激肽释放酶介导的疾病的抗体的腺相关病毒载体递送
WO2021044373A2 (en) * 2019-09-06 2021-03-11 Avectas Limited Engineering of immune cells for ex vivo cell therapy applications
WO2021081280A1 (en) 2019-10-23 2021-04-29 Shire Human Genetic Therapies, Inc. Adeno-associated virus vectors based gene therapy for hereditary angioedema
CN115210252A (zh) 2020-02-04 2022-10-18 西雅图儿童医院（Dba西雅图儿童研究所） 抗二硝基苯酚的嵌合抗原受体
WO2022044024A1 (en) * 2020-08-31 2022-03-03 Ramot At Tel-Aviv University Ltd. Small molecule modulators of gsk-3 activity
WO2022130014A1 (en) 2020-12-16 2022-06-23 Takeda Pharmaceutical Company Limited Adeno associated viral vector delivery of antibodies for the treatment of disease mediated by dysregulated plasma kallikrein
WO2022140556A1 (en) * 2020-12-22 2022-06-30 Eutropics Pharmaceuticals, Inc. Methods and compositions related to bcl2 and bim heterodimer antibodies
IL310057A (en) * 2021-07-21 2024-03-01 Immunitybio Inc Generation of chimeric antigen receptor mRNA molecules for expression in primary NK cells
WO2024206913A2 (en) * 2023-03-31 2024-10-03 Northwestern University Compositions for antigen-specific immune cell activation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016098078A2 (en) * 2014-12-19 2016-06-23 Novartis Ag Dimerization switches and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9523469D0 (en) * 1995-11-16 1996-01-17 Sandoz Ltd Organic compounds
US6093382A (en) 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
ES2502366T3 (es) * 2001-03-09 2014-10-03 Board Of Regents, The University Of Texas System Inducción de inmunidad tumoral por variantes de proteína de unión a folato
US20080260812A1 (en) * 2004-04-26 2008-10-23 Takami Matsuyama C/O Kagoshima University Therapeutic Medicine Containing Monoclonal Antibody Against Folate Receptor Beta (Fr-Beta)
EP2419120A4 (en) * 2009-04-08 2016-01-06 Univ California HUMAN PROTEIN CONCERNS WITH CONTROLLED SERUM PHARMACOKINETICS
CA2785373A1 (en) * 2009-12-23 2011-06-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
WO2016164745A1 (en) * 2015-04-10 2016-10-13 The Methodist Hospital System Cd117 ligand-drug conjugates for targeted cancer therapy
WO2017027843A1 (en) * 2015-08-12 2017-02-16 Massachusetts Institute Of Technology Cell surface coupling of nanoparticles
EP3402495A4 (en) * 2016-01-15 2019-06-19 Etubics Corporation METHOD AND COMPOSITIONS FOR T-CELL IMMUNOTHERAPY
EP3529268B1 (en) * 2016-10-19 2025-02-26 The Scripps Research Institute Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof
LT3535392T (lt) * 2016-11-02 2024-04-25 Universität Basel Imunologiškai atpažįstami ląstelių paviršiaus variantai, skirti naudoti ląstelių terapijoje
CA3053534A1 (en) 2017-02-17 2018-08-23 Purdue Research Foundation Targeted ligand-payload based drug delivery for cell therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016098078A2 (en) * 2014-12-19 2016-06-23 Novartis Ag Dimerization switches and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOHN R JAMES等: "Biophysical mechanism of T-cell receptor triggering in a reconstituted system", 《NATURE》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113462649A (zh) * 2021-05-27 2021-10-01 浙江大学 Mek抑制剂在减少car-t细胞耗竭和终末分化中的应用
CN116041545A (zh) * 2022-12-12 2023-05-02 南方医科大学 一种靶向荧光素或生物素的通用型car及其应用
WO2026012294A1 (zh) * 2024-07-09 2026-01-15 深圳虹信生物科技有限公司 一种治疗b细胞过度增殖产生自身抗体所引起的疾病的药物、方法与应用

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