CN110652554A - Mixture for tonifying heart, relieving depression and improving sleep and preparation method thereof - Google Patents

Mixture for tonifying heart, relieving depression and improving sleep and preparation method thereof Download PDF

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CN110652554A
CN110652554A CN201911048800.XA CN201911048800A CN110652554A CN 110652554 A CN110652554 A CN 110652554A CN 201911048800 A CN201911048800 A CN 201911048800A CN 110652554 A CN110652554 A CN 110652554A
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mixture
improving sleep
donkey
hostwood
poria
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张谦
张守光
邓华
李含君
郝树立
夏玲霞
齐方
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Abstract

The invention discloses a mixture for tonifying heart, resolving depression and improving sleep and a preparation method thereof, wherein the mixture is prepared from the following raw materials in percentage by mass: 9-11g of bighead atractylodes rhizome, 5-7g of American ginseng, 8-12g of astragalus, 5-76g of donkey-hide gelatin, 11-13g of white paeony root, 9-11g of liquorice, 10-14g of poria with hostwood, 8-12g of polygala tenuifolia, 9-11g of spina date seed, 9-11g of longan pulp, 11-13g of Chinese yam, 11-13g of radix bupleuri, 8-12g of cape jasmine fruit, 8-12g of dandelion, 5-7g of ligusticum wallichii and 11-13g of lotus plumule. The formula of the traditional Chinese medicine composition is scientific and reasonable, poria with hostwood and bighead atractylodes rhizome are used as monarch drugs in the formula, astragalus mongholicus, white paeony root and dried longan pulp are used in a compatibility mode, the efficacy of tonifying qi and soothing nerves is enhanced, poria with hostwood, donkey-hide gelatin and the like have the effects of tranquilizing mind and sleeping, and licorice root is used for harmonizing the drug properties, so that the traditional Chinese medicine composition has the efficacy of tonifying spleen and qi, soothing liver and relieving depression, nourishing heart and soothing nerves, and can.

Description

Mixture for tonifying heart, relieving depression and improving sleep and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a heart-tonifying, depression-resolving and sleep-improving mixture and a preparation method thereof.
Background
Along with the improvement of living standard, people pay more and more attention to their health, and the people look to the aspects of Chinese medicine nourishing preparations besides daily green nutritious diet. The traditional Chinese medicine nourishing preparation comprises traditional Chinese medicine granules, syrup and the like, the traditional Chinese medicine granules can avoid the trouble of decoction, are convenient to carry and use, are easy to take with water, and compared with oral preparations such as tablets, dropping pills and the like, the preparation method is simpler, is a clinically widely used preparation form, and is the first choice for developing most traditional Chinese medicine decoction into modern preparation forms; the syrup is a nearly saturated aqueous solution of sucrose, and microorganisms can not grow in such a hypertonic environment, so that the syrup has larger drug-loading rate than granules and better mouthfeel by adding a small amount of preservative, and is easy to accept by patients. However, the above preparations all use simple and single formula as a premise, and when a compound preparation is selected, the medicine taste is more and the components in each medicine taste are complex, the medicine effect of the preparation can be influenced.
Meanwhile, in the extraction of the traditional Chinese medicine components, a water extraction and alcohol precipitation method is selected in the traditional mode for extraction, a part of redundant polysaccharide which is soluble in water but insoluble in ethanol is discarded, the volatile oil is lost due to the conventional water decoction process, a volatile oil extractor is connected for extracting the volatile oil in the prescription, cyclodextrin (beta-CD) is used for inclusion of the volatile oil, the beta-CD inclusion process is also screened, if the volatile oil is low in amount, the drug effect is possibly damaged, and the difficulty of the preparation process is increased.
Disclosure of Invention
The invention aims to make up the defects of the prior art and provides a mixture for tonifying heart, resolving depression and improving sleep and a preparation method thereof.
In order to achieve the above object, the present invention provides the following technical solutions:
a mixture for tonifying heart, resolving depression and improving sleep is prepared from the following raw materials in percentage by mass: 9-11g of bighead atractylodes rhizome, 5-7g of American ginseng, 8-12g of astragalus, 5-7g of donkey-hide gelatin, 11-13g of white paeony root, 9-11g of liquorice, 10-14g of poria with hostwood, 8-12g of polygala tenuifolia, 9-11g of spina date seed, 9-11g of longan pulp, 11-13g of Chinese yam, 11-13g of radix bupleuri, 8-12g of cape jasmine fruit, 8-12g of dandelion, 5-7g of ligusticum wallichii and 11-13g of lotus plumule.
Preferably, the mixture for tonifying heart, resolving depression and improving sleep is prepared from the following raw materials in percentage by mass: 10g of bighead atractylodes rhizome, 6g of American ginseng, 10g of astragalus membranaceus, 6g of donkey-hide gelatin, 12g of white paeony root, 10g of liquorice, 12g of poria with hostwood, 10g of polygala tenuifolia, 10g of spina date seed, 10g of longan pulp, 12g of Chinese yam, 12g of radix bupleuri, 10g of cape jasmine fruit, 10g of dandelion, 6g of ligusticum wallichii and 12g of lotus plumule.
Because the prescription takes more crude drugs every day, the cream yield is larger, the thick paste obtained by extracting the medicinal materials has large viscosity and cannot be directly dried into dry cream, and then the thick paste is mixed with auxiliary materials and dried, crushed and then granulated, and the required auxiliary materials have larger quantity, the single-day dose of a patient reaches 100g after the granules are prepared, namely the granule has small drug-loading rate, simultaneously, the dissolubility of dextrin and starch is not ideal, and the granule is not the first choice of the preparation of the prescription because of the above reasons.
Meanwhile, considering that the treatment course of the depression is long, the long-term intake of a large amount of cane sugar is not beneficial to health, and patients with hyperglycemia cannot take the medicament, and meanwhile, syrup is thick, the pouring is inconvenient, the dosage is not easy to accurately control, so the syrup is not considered when the dosage form is determined.
Through the above analysis, a mixture is used as the formulation of the present invention.
A preparation method of the mixture for tonifying heart, resolving depression and improving sleep comprises the following steps:
(1) weighing the raw materials except the donkey-hide gelatin according to the mass ratio, adding water for decoction, filtering decoction, combining filtrates, and concentrating to obtain thick paste with the relative density of 1.15 for later use;
(2) adding colla Corii Asini into the above soft extract, melting, stirring, and cooling to obtain medicinal liquid;
(3) dissolving menthol in ethanol, slowly adding the menthol into the liquid medicine, adding sodium benzoate, stirring uniformly, adding water to a constant volume, stirring uniformly, and filtering to obtain the mixture.
Furthermore, the decoction of the raw materials in the step 1 is carried out for 3 times, 8 times of water is added for 3 hours for the first time, and 6 times of water is added for 3 hours for the 2 nd time and the 3 rd time.
The invention has the advantages that:
1. the formula of the invention is scientific and reasonable, poria with hostwood and bighead atractylodes rhizome are used as monarch drugs in the formula, astragalus, white paeony root and dried longan pulp are used in a compatibility manner, so that the efficacy of tonifying qi and soothing nerves is enhanced, poria with hostwood, donkey-hide gelatin and the like have the effects of tranquilizing mind and sleeping, and licorice is used for regulating the drug properties, so that the effects of tonifying spleen and qi, soothing liver-qi stagnation and nourishing heart and soothing nerves are achieved, the sleep dysfunction, depression and climacteric syndrome can be effectively treated, and a proper amount of flavoring components can be added according to the taste, so.
2. Compared with the traditional granules and syrup, the mixture has larger drug-loading rate, can cover the bad taste of the original medicine, is easy to control the dosage, has no addition components such as sucrose and the like, has simpler preparation process flow, and is convenient to carry and easy to take.
3. The optimal water extraction process is screened in the preparation process of the mixture, and the mixture is extracted by different water addition amounts for 3 times, so that the effective components are maximally extracted, and the extraction process is simplified.
Detailed Description
The technical scheme of the invention is further explained by combining the specific examples as follows:
example 1
A mixture for tonifying heart, resolving depression and improving sleep is prepared from the following raw materials in percentage by mass: 10g of bighead atractylodes rhizome, 6g of American ginseng, 10g of astragalus membranaceus, 6g of donkey-hide gelatin, 12g of white paeony root, 10g of liquorice, 12g of poria with hostwood, 10g of polygala tenuifolia, 10g of spina date seed, 10g of longan pulp, 12g of Chinese yam, 12g of radix bupleuri, 10g of cape jasmine fruit, 10g of dandelion, 6g of ligusticum wallichii and 12g of lotus plumule.
A preparation method of the mixture for tonifying heart, resolving depression and improving sleep comprises the following steps:
(1) weighing the raw materials except the donkey-hide gelatin according to the mass ratio, adding water for decoction, decocting for 3 times, adding 8 times of water for decoction for 3 hours for the first time, adding 6 times of water for decoction for 3 hours for the 2 nd time and the 3 rd time, filtering decoction, combining filtrates, and concentrating to obtain thick paste with the relative density of 1.15 for later use;
(2) adding colla Corii Asini into the above soft extract, melting, stirring, and cooling to obtain medicinal liquid;
(3) dissolving menthol in ethanol, slowly adding the menthol into the liquid medicine, adding sodium benzoate, stirring uniformly, adding water to a constant volume, stirring uniformly, and filtering to obtain the mixture.
Example 2
A mixture for tonifying heart, resolving depression and improving sleep is prepared from the following raw materials in percentage by mass: 9g of bighead atractylodes rhizome, 5g of American ginseng, 8g of astragalus, 5g of donkey-hide gelatin, 11g of white peony root, 9g of liquorice, 10g of poria with hostwood, 8g of polygala root, 9g of spina date seed, 9g of longan pulp, 11g of Chinese yam, 11g of radix bupleuri, 8g of gardenia, 8g of dandelion, 5g of ligusticum wallichii and 11g of lotus plumule.
A preparation method of the mixture for tonifying heart, resolving depression and improving sleep comprises the following steps:
(1) weighing the raw materials except the donkey-hide gelatin according to the mass ratio, adding water for decoction, decocting for 3 times, adding 8 times of water for decoction for 3 hours for the first time, adding 6 times of water for decoction for 3 hours for the 2 nd time and the 3 rd time, filtering decoction, combining filtrates, and concentrating to obtain thick paste with the relative density of 1.15 for later use;
(2) adding colla Corii Asini into the above soft extract, melting, stirring, and cooling to obtain medicinal liquid;
(3) dissolving menthol in ethanol, slowly adding the menthol into the liquid medicine, adding sodium benzoate, stirring uniformly, adding water to a constant volume, stirring uniformly, and filtering to obtain the mixture.
Example 3
A mixture for tonifying heart, resolving depression and improving sleep is prepared from the following raw materials in percentage by mass: 11g of bighead atractylodes rhizome, 7g of American ginseng, 12g of astragalus, 7g of donkey-hide gelatin, 13g of white peony root, 11g of liquorice, 14g of poria with hostwood, 12g of polygala root, 11g of spina date seed, 11g of longan pulp, 13g of Chinese yam, 13g of radix bupleuri, 12g of gardenia, 12g of dandelion, 7g of ligusticum wallichii and 13g of lotus plumule.
A preparation method of the mixture for tonifying heart, resolving depression and improving sleep comprises the following steps:
(1) weighing the raw materials except the donkey-hide gelatin according to the mass ratio, adding water for decoction, decocting for 3 times, adding 8 times of water for decoction for 3 hours for the first time, adding 6 times of water for decoction for 3 hours for the 2 nd time and the 3 rd time, filtering decoction, combining filtrates, and concentrating to obtain thick paste with the relative density of 1.15 for later use;
(2) adding colla Corii Asini into the above soft extract, melting, stirring, and cooling to obtain medicinal liquid;
(3) dissolving menthol in ethanol, slowly adding the menthol into the liquid medicine, adding sodium benzoate, stirring uniformly, adding water to a constant volume, stirring uniformly, and filtering to obtain the mixture.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (4)

1. The mixture for tonifying heart, resolving depression and improving sleep is characterized by being prepared from the following raw materials in percentage by mass: 9-11g of bighead atractylodes rhizome, 5-7g of American ginseng, 8-12g of astragalus, 5-7g of donkey-hide gelatin, 11-13g of white paeony root, 9-11g of liquorice, 10-14g of poria with hostwood, 8-12g of polygala tenuifolia, 9-11g of spina date seed, 9-11g of longan pulp, 11-13g of Chinese yam, 11-13g of radix bupleuri, 8-12g of cape jasmine fruit, 8-12g of dandelion, 5-7g of ligusticum wallichii and 11-13g of lotus plumule.
2. The mixture for tonifying heart, resolving depression and improving sleep as claimed in claim 1, which is prepared from the following raw materials in percentage by mass: 10g of bighead atractylodes rhizome, 6g of American ginseng, 10g of astragalus membranaceus, 6g of donkey-hide gelatin, 12g of white paeony root, 10g of liquorice, 12g of poria with hostwood, 10g of polygala tenuifolia, 10g of spina date seed, 10g of longan pulp, 12g of Chinese yam, 12g of radix bupleuri, 10g of cape jasmine fruit, 10g of dandelion, 6g of ligusticum wallichii and 12g of lotus plumule.
3. A method for preparing a mixture for tonifying heart, resolving depression and improving sleep as claimed in claim 1, comprising the steps of:
(1) weighing the raw materials except the donkey-hide gelatin according to the mass ratio, adding water for decoction, filtering decoction, combining filtrates, and concentrating to obtain thick paste with the relative density of 1.15 for later use;
(2) adding colla Corii Asini into the above soft extract, melting, stirring, and cooling to obtain medicinal liquid;
(3) dissolving menthol in ethanol, slowly adding the menthol into the liquid medicine, adding sodium benzoate, stirring uniformly, adding water to a constant volume, stirring uniformly, and filtering to obtain the mixture.
4. The method for preparing mixture for tonifying heart, resolving depression and improving sleep as claimed in claim 3, wherein the raw materials in step 1 are decocted 3 times, 8 times of water is added for 3 hours for the first time, and 6 times of water is added for 3 hours for both the 2 nd and the 3 rd time.
CN201911048800.XA 2019-10-31 2019-10-31 Mixture for tonifying heart, relieving depression and improving sleep and preparation method thereof Pending CN110652554A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101254247A (en) * 2008-03-25 2008-09-03 深圳力瑞医药科技有限公司 Pharmaceutical combination with depression resistance and angst resistance effect and method of preparing the same
CN105796945A (en) * 2016-03-16 2016-07-27 曲思廉 Traditional Chinese medicine for treating depression syndromes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101254247A (en) * 2008-03-25 2008-09-03 深圳力瑞医药科技有限公司 Pharmaceutical combination with depression resistance and angst resistance effect and method of preparing the same
CN105796945A (en) * 2016-03-16 2016-07-27 曲思廉 Traditional Chinese medicine for treating depression syndromes

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屈沂: "归脾汤治疗心脾两虚型郁证 62例", 《中国民间疗法》 *

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Application publication date: 20200107