CN110621652A - 二氨基苯化合物的制造方法 - Google Patents

二氨基苯化合物的制造方法 Download PDF

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Publication number
CN110621652A
CN110621652A CN201880031471.5A CN201880031471A CN110621652A CN 110621652 A CN110621652 A CN 110621652A CN 201880031471 A CN201880031471 A CN 201880031471A CN 110621652 A CN110621652 A CN 110621652A
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CN
China
Prior art keywords
compound
formula
alkali metal
protected
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201880031471.5A
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English (en)
Chinese (zh)
Inventor
关雅彦
田中健次
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokuyama Corp
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Tokuyama Corp
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Publication date
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Publication of CN110621652A publication Critical patent/CN110621652A/zh
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201880031471.5A 2017-05-17 2018-05-15 二氨基苯化合物的制造方法 Withdrawn CN110621652A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017098083 2017-05-17
JP2017-098083 2017-05-17
PCT/JP2018/018703 WO2018212162A1 (fr) 2017-05-17 2018-05-15 Procédé de production de composé diaminobenzène

Publications (1)

Publication Number Publication Date
CN110621652A true CN110621652A (zh) 2019-12-27

Family

ID=64273778

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880031471.5A Withdrawn CN110621652A (zh) 2017-05-17 2018-05-15 二氨基苯化合物的制造方法

Country Status (4)

Country Link
JP (1) JPWO2018212162A1 (fr)
KR (1) KR20200009001A (fr)
CN (1) CN110621652A (fr)
WO (1) WO2018212162A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006015134A1 (fr) * 2004-07-28 2006-02-09 Dr. Reddy's Laboratories Ltd. Processus de fabrication de candésartan cilexétil
CN101595110A (zh) * 2006-11-16 2009-12-02 法马科皮亚有限公司 用于免疫抑制的7-取代嘌呤衍生物
WO2011112731A2 (fr) * 2010-03-10 2011-09-15 Kalypsys, Inc. Inhibiteurs hétérocycliques de récepteurs de l'histamine destinés au traitement de maladie
US20120225900A1 (en) * 2009-11-10 2012-09-06 Pfizer Inc. N2-pyrazolospiroketone acetyl-coa carboxylase inhibitors
US20130274243A1 (en) * 2012-02-03 2013-10-17 Pfizer Limited Chemical Compounds
CN103539659A (zh) * 2013-10-23 2014-01-29 东南大学 2，4-二苄氧基苯甲酸衍生物及其制备方法与应用
CN103724276A (zh) * 2013-12-13 2014-04-16 成都丽璟科技有限公司 一种由硝基苯胺制备苯并咪唑类化合物的新方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA022127B1 (ru) 2010-08-04 2015-11-30 Бристол-Майерс Сквибб Компани Ингибиторы вируса гепатита с
WO2015173970A1 (fr) 2014-05-15 2015-11-19 ジェイファーマ株式会社 Composition d'agent anti-tumeur maligne

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006015134A1 (fr) * 2004-07-28 2006-02-09 Dr. Reddy's Laboratories Ltd. Processus de fabrication de candésartan cilexétil
CN101595110A (zh) * 2006-11-16 2009-12-02 法马科皮亚有限公司 用于免疫抑制的7-取代嘌呤衍生物
US20120225900A1 (en) * 2009-11-10 2012-09-06 Pfizer Inc. N2-pyrazolospiroketone acetyl-coa carboxylase inhibitors
WO2011112731A2 (fr) * 2010-03-10 2011-09-15 Kalypsys, Inc. Inhibiteurs hétérocycliques de récepteurs de l'histamine destinés au traitement de maladie
US20130274243A1 (en) * 2012-02-03 2013-10-17 Pfizer Limited Chemical Compounds
CN103539659A (zh) * 2013-10-23 2014-01-29 东南大学 2，4-二苄氧基苯甲酸衍生物及其制备方法与应用
CN103724276A (zh) * 2013-12-13 2014-04-16 成都丽璟科技有限公司 一种由硝基苯胺制备苯并咪唑类化合物的新方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
M. JONATHAN FRAY等: "Structure-Activity Relationships of 1,4-Dihydro-(1H,4H)-quinoxaline- 2,3-diones as N-Methyl-D-aspartate (Glycine Site) Receptor Antagonists. 1. Heterocyclic Substitude 5-Alkyl Derivatives", 《J. MED. CHEM.》 *
MASAHIRO FUKUZUMI等: "Synthesis of ortho-Phenylenebis(guanidine) Derivatives with Potential Chirality", 《HELVETICA CHIMICA ACTA》 *
N. I. AVDYUNINA等: "evelopment of synthesis technology for the selective anxiolytic drug afobazole", 《PHARMACEUTICAL CHEMISTRY JOURNAL》 *
高勇等: "3,4-二氨基苯乙酸的合成", 《化学试剂》 *

Also Published As

Publication number Publication date
WO2018212162A1 (fr) 2018-11-22
JPWO2018212162A1 (ja) 2020-03-19
KR20200009001A (ko) 2020-01-29

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Application publication date: 20191227