CN110621350A - 病毒 - Google Patents

病毒 Download PDF

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Publication number
CN110621350A
CN110621350A CN201880006090.1A CN201880006090A CN110621350A CN 110621350 A CN110621350 A CN 110621350A CN 201880006090 A CN201880006090 A CN 201880006090A CN 110621350 A CN110621350 A CN 110621350A
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CN
China
Prior art keywords
formula
compound
physiologically acceptable
acceptable salt
capsule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880006090.1A
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English (en)
Chinese (zh)
Inventor
杰弗里·德鲁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stable Technology Biopharmaceutical Co Ltd
Original Assignee
Stable Technology Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1700259.3A external-priority patent/GB201700259D0/en
Priority claimed from GBGB1716047.4A external-priority patent/GB201716047D0/en
Application filed by Stable Technology Biopharmaceutical Co Ltd filed Critical Stable Technology Biopharmaceutical Co Ltd
Publication of CN110621350A publication Critical patent/CN110621350A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
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    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
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    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/01Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01008Cholinesterase (3.1.1.8), i.e. butyrylcholine-esterase
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201880006090.1A 2017-01-06 2018-01-05 病毒 Pending CN110621350A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1700259.3A GB201700259D0 (en) 2017-01-06 2017-01-06 Virus
GB1700259.3 2017-01-06
GB1716047.4 2017-10-02
GBGB1716047.4A GB201716047D0 (en) 2017-10-02 2017-10-02 Virus
PCT/GB2018/050021 WO2018127702A1 (en) 2017-01-06 2018-01-05 Virus

Publications (1)

Publication Number Publication Date
CN110621350A true CN110621350A (zh) 2019-12-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880006090.1A Pending CN110621350A (zh) 2017-01-06 2018-01-05 病毒

Country Status (11)

Country Link
US (2) US12016949B2 (enExample)
EP (1) EP3565591A1 (enExample)
JP (2) JP7728634B2 (enExample)
KR (1) KR20190104051A (enExample)
CN (1) CN110621350A (enExample)
AU (1) AU2018206304A1 (enExample)
BR (1) BR112019014004A2 (enExample)
CA (1) CA3048313A1 (enExample)
IL (1) IL267785A (enExample)
MX (1) MX2019008105A (enExample)
WO (1) WO2018127702A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113880723A (zh) * 2021-11-15 2022-01-04 河南海尔希生物科技有限公司 一种盐酸甜菜碱的制备方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE033656T2 (en) 2010-03-31 2017-12-28 Stabilitech Ltd Binders for stabilizing virus particles
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions
US20200061210A1 (en) * 2018-08-27 2020-02-27 BioViva USA, Inc. Novel method for gene therapy using intranasal administration of genetically modified viral vectors
JP7436274B2 (ja) * 2020-04-16 2024-02-21 デンカ株式会社 アデノウイルスの免疫測定方法及び免疫測定器具
GB202104320D0 (en) 2021-03-26 2021-05-12 Iosbio Ltd Enhancement of viral titres

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003039593A1 (en) * 2001-11-08 2003-05-15 Akzo Nobel N.V. Fowl adenovirus vaccine
US20050163756A1 (en) * 1995-06-07 2005-07-28 Yale University Oral delivery of adeno-associated viral vectors
US20060140908A1 (en) * 2003-06-18 2006-06-29 Ertl Hildegund C J Methods for inducing an immune response via oral administration of an adenovirus
CN102264760A (zh) * 2008-12-22 2011-11-30 昂克斯治疗有限公司 溶瘤性腺病毒载体及与其相关的方法和用途
US20130129685A1 (en) * 2010-03-31 2013-05-23 Stabilitech Ltd. Stabilisation of Viral Particles
CN103221423A (zh) * 2010-09-24 2013-07-24 昂克斯治疗有限公司 溶瘤腺病毒载体及与其相关的方法和用途
CN107096041A (zh) * 2012-10-17 2017-08-29 脉管生物生长有限公司 使用腺病毒的治疗方法
CN108795984A (zh) * 2018-07-05 2018-11-13 天津医科大学 一种利用腺病毒载体构建小肠降表达胰岛素大鼠模型的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296130A (en) 1979-08-30 1981-10-20 Herschler R J Methylsulfonylmethane and methods of use
US6616931B1 (en) 1996-09-26 2003-09-09 Merck & Co., Inc. Rotavirus vaccine formulations
JP2002540175A (ja) 1999-02-19 2002-11-26 ドウアリング,マシユー・ジエイ 糖尿病及び肥満症の経口遺伝子治療
CA2403205A1 (en) 2000-03-13 2001-09-20 Engene, Inc. Compositions and methods of regulated protein expression in gut endocrine k cells
US7226779B2 (en) 2001-01-30 2007-06-05 The United States Of America As Represented By The Department Of Health And Human Services Hybrid adenoviral vector
US20030003583A1 (en) 2001-06-08 2003-01-02 Raphael Hirsch Regulation of transgene expression following AAV transduction
JP4888876B2 (ja) 2003-06-13 2012-02-29 田平 武 アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
CA2609142C (en) 2005-05-27 2016-02-09 Fondazione Centro San Raffaele Del Monte Tabor Therapeutic gene vectors comprising mirna target sequences
US20090155351A1 (en) 2005-10-04 2009-06-18 Alk-Abello A/S Solid Vaccine Formulation
EP1996238B1 (en) * 2006-02-28 2016-04-06 Vaxart, Inc. Chimeric Adenoviral Vectors and dsRNA as TLR3 Agonist
WO2010146598A2 (en) 2008-11-07 2010-12-23 Serum Institute Of India Ltd. Stable, dried rotavirus vaccine, compositions and process for preparation thereof
WO2011034950A1 (en) 2009-09-16 2011-03-24 Vaxart, Inc. Immunization strategy to prevent h1n1 infection
HUE033656T2 (en) * 2010-03-31 2017-12-28 Stabilitech Ltd Binders for stabilizing virus particles
US20120219590A1 (en) * 2011-02-24 2012-08-30 Paxvax, Inc. Formulations useful for spray drying vaccines
GB201117233D0 (en) * 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
JP6797692B2 (ja) * 2014-02-20 2020-12-09 バクサート インコーポレイテッド 小腸送達のための製剤
US9750801B2 (en) * 2014-02-28 2017-09-05 Janssen Vaccines & Prevention B.V. Replicating recombinant adenovirus vectors, compositions, and methods of use thereof
GB201406569D0 (en) * 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
CA2988761A1 (en) * 2015-06-12 2016-12-15 Vaxart, Inc. Formulations for small intestinal delivery of rsv and norovirus antigens
GB2562241B (en) * 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050163756A1 (en) * 1995-06-07 2005-07-28 Yale University Oral delivery of adeno-associated viral vectors
WO2003039593A1 (en) * 2001-11-08 2003-05-15 Akzo Nobel N.V. Fowl adenovirus vaccine
US20060140908A1 (en) * 2003-06-18 2006-06-29 Ertl Hildegund C J Methods for inducing an immune response via oral administration of an adenovirus
CN102264760A (zh) * 2008-12-22 2011-11-30 昂克斯治疗有限公司 溶瘤性腺病毒载体及与其相关的方法和用途
US20130129685A1 (en) * 2010-03-31 2013-05-23 Stabilitech Ltd. Stabilisation of Viral Particles
CN103221423A (zh) * 2010-09-24 2013-07-24 昂克斯治疗有限公司 溶瘤腺病毒载体及与其相关的方法和用途
CN107096041A (zh) * 2012-10-17 2017-08-29 脉管生物生长有限公司 使用腺病毒的治疗方法
CN108795984A (zh) * 2018-07-05 2018-11-13 天津医科大学 一种利用腺病毒载体构建小肠降表达胰岛素大鼠模型的方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHARLES H. HOKE JR等: "History of the restoration of adenovirus type 4 and type 7 vaccine, live oral (Adenovirus Vaccine) in the context of the Department of Defense acquisition system", 《VACCINE》 *
GEORGE T. MERCIER等: "Oral immunization of rhesus macaques with adenoviral HIV vaccines using enteric-coated capsules", 《VACCINE》 *
张德礼等: "腺病毒载体活疫苗─—口服免疫的新时代", 《生命科学》 *
钟辉: "壳聚糖增强重组腺病毒转导效率及口服免疫效果初步研究", 《中国博士学位论文全文数据库医药卫生科技辑》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113880723A (zh) * 2021-11-15 2022-01-04 河南海尔希生物科技有限公司 一种盐酸甜菜碱的制备方法

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