CN110612300B - 制备乙型肝炎核心蛋白调节剂的方法 - Google Patents

制备乙型肝炎核心蛋白调节剂的方法 Download PDF

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Publication number
CN110612300B
CN110612300B CN201880030078.4A CN201880030078A CN110612300B CN 110612300 B CN110612300 B CN 110612300B CN 201880030078 A CN201880030078 A CN 201880030078A CN 110612300 B CN110612300 B CN 110612300B
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compound
formula
hours
mmol
reaction
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Chinese (zh)
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CN110612300A (zh
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L.李
L.D.阿诺德
S.雷迪
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Assembly Biosciences Inc
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Assembly Biosciences Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN201880030078.4A 2017-03-13 2018-03-13 制备乙型肝炎核心蛋白调节剂的方法 Expired - Fee Related CN110612300B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762470560P 2017-03-13 2017-03-13
US62/470,560 2017-03-13
PCT/US2018/022100 WO2018169907A1 (en) 2017-03-13 2018-03-13 Process for making hepatitis b core protein modulators

Publications (2)

Publication Number Publication Date
CN110612300A CN110612300A (zh) 2019-12-24
CN110612300B true CN110612300B (zh) 2023-10-20

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US (2) US11040965B2 (https=)
EP (1) EP3596070A1 (https=)
JP (1) JP7179751B2 (https=)
KR (1) KR102575605B1 (https=)
CN (1) CN110612300B (https=)
AU (1) AU2018236188B2 (https=)
CA (1) CA3056696A1 (https=)
SG (1) SG11201908475RA (https=)
WO (1) WO2018169907A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017326356A1 (en) 2016-09-15 2019-04-11 Assembly Biosciences, Inc. Hepatitis B core protein modulators
SG11201908012SA (en) 2017-03-02 2019-09-27 Assembly Biosciences Inc Cyclic sulfamide compounds and methods of using same
SG11202112590WA (en) * 2019-05-24 2021-12-30 Assembly Biosciences Inc Pharmaceutical compositions for the treatment of hbv
CN111333513B (zh) * 2020-04-17 2021-08-27 江苏恒沛药物科技有限公司 一种2,4-二氟-3-硝基苯甲酸的制备方法

Citations (2)

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CN106413402A (zh) * 2014-03-13 2017-02-15 美国印第安纳大学研究和技术公司 乙型肝炎核心蛋白变构调节剂

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JPS58225074A (ja) 1982-06-25 1983-12-27 Chugai Pharmaceut Co Ltd ジベンゾオキサゼピン誘導体
GB9109557D0 (en) 1991-05-02 1991-06-26 Wellcome Found Chemical compounds
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US20070105835A1 (en) 2005-11-07 2007-05-10 Kazantsev Aleksey G Compositions and methods for modulating poly(ADP-ribose) polymerase activity
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WO2008036139A2 (en) 2006-06-07 2008-03-27 The Regents Of The University Of California Inhibitors of mshc and homologs thereof, and methods of identifying same
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CN102164605A (zh) 2008-07-23 2011-08-24 美国卫生和人力服务部 用作抗疟药的疟原虫表面阴离子通道抑制剂
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CN106413402A (zh) * 2014-03-13 2017-02-15 美国印第安纳大学研究和技术公司 乙型肝炎核心蛋白变构调节剂

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Also Published As

Publication number Publication date
US11040965B2 (en) 2021-06-22
AU2018236188B2 (en) 2022-01-27
CN110612300A (zh) 2019-12-24
CA3056696A1 (en) 2019-09-20
WO2018169907A1 (en) 2018-09-20
AU2018236188A1 (en) 2019-10-17
US20210380577A1 (en) 2021-12-09
KR20190128675A (ko) 2019-11-18
SG11201908475RA (en) 2019-10-30
JP7179751B2 (ja) 2022-11-29
JP2020510059A (ja) 2020-04-02
EP3596070A1 (en) 2020-01-22
KR102575605B1 (ko) 2023-09-05
US20200002325A1 (en) 2020-01-02

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Granted publication date: 20231020