CN110604766A

CN110604766A - Traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson's disease and preparation method thereof

Info

Publication number: CN110604766A
Application number: CN201910940434.2A
Authority: CN
Inventors: 沈晓明; 边颂博; 苏朝阳; 王佳彬; 黄艳丽; 马云枝; 贾晓倩; 左俊岭; 张�杰; 兰瑞; 许玉珉
Original assignee: Henan University of Traditional Chinese Medicine HUTCM
Current assignee: Henan University of Traditional Chinese Medicine HUTCM
Priority date: 2019-09-30
Filing date: 2019-09-30
Publication date: 2019-12-24

Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson disease and a preparation method thereof, wherein red ginseng, hispid fig, pubescent holly root, philippine flemingia root, fried immature bitter orange, tinospora sinensis, medicinal cyathula root, cassia bark and Chinese thorowax root are adopted, respectively crushed by a crusher, sieved and uniformly mixed to obtain mixed medicinal powder, and the mixed medicinal powder is prepared into granules, capsules, tablets or pills according to the conventional process, or water is added into the medicinal materials for soaking and decocting, the first medicinal liquid is obtained by filtering, the second medicinal liquid is obtained by filtering after the medicinal residues are decocted by adding water, the first medicinal liquid and the second medicinal liquid are combined, filtered, sterilized and subpackaged to obtain a decoction; the traditional Chinese medicine composition is obtained by combining deficiency and excess, treating both principal and secondary aspects, relieving urgency and reducing contraction, regulating the internal and external, and screening natural botanical drugs with the efficacies of tonifying liver and kidney, calming wind, reducing phlegm and stopping tremor.

Description

Traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson's disease and preparation method thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson's disease and a preparation method thereof, wherein the traditional Chinese medicine composition has the advantages of obvious curative effect, high safety and no toxic or side effect.

Background

Parkinson's disease, also known as paralysis agitans, is one of three diseases causing disability of middle-aged and elderly people, is a common nervous system degenerative disease of middle-aged and elderly people, and has clinical symptoms mainly including resting tremor, muscular rigidity, bradykinesia, postural dysreflexia and the like. The prevalence rate is about one percent of the population above 55 years old, and increases with age, with slightly more men than women. With the aging population proportion in China, the incidence of the Parkinson disease is continuously increased.

The main pathological feature of parkinsonism is the accumulation of alpha-synuclein in brain tissue to form lewy bodies and the selective absence of dopaminergic neurons in the midbrain's black nucleus. The Parkinson's disease is difficult to cure, an effective treatment method is not available at present, most western medicines are selected for treatment, for example, Meiduoba is a ' golden medicine ' for clinically treating PD at present, but most patients can have complications of different degrees such as movement disorder, symptom fluctuation and psychological disorder induced by medicines after 5-10 years of administration, and adverse drug reactions of different degrees such as nausea, vomiting and abdominal pain, but cannot prevent the natural development process of PD, so that many patients are forced to stop taking the medicines due to intolerance. With the development of the disease condition, the patient can not take care of the disease even in life, which not only brings serious harm to the patient, but also brings influence to the family.

After the inventor consults the literature, the inventor finds that the existing related patent traditional Chinese medicines for treating the Parkinson disease mostly adopt medicines for removing wind and dredging collaterals, calming wind and reducing phlegm, or medicines for tonifying kidney, replenishing essence and benefiting marrow to treat or relieve the symptoms of the Parkinson disease. However, the Parkinson's disease is one of three major diseases causing disability of the middle-aged and the elderly, the pathogenesis of the Parkinson's disease is complex and changeable, the treatment difficulty is high, and the Parkinson's disease can be solved by a single method of calming endogenous wind, reducing phlegm or tonifying. The Parkinson's disease is a disease which harms the middle-aged and the elderly, and the disease is mainly deficiency and excess, and the deficiency and excess are mixed according to the characteristics of the middle-aged and the elderly, and the deficiency and excess should be combined in treatment, the symptoms and the root causes should be considered, the patient is relieved and cured, and the treatment is performed according to the differentiation of symptoms and signs. According to the characteristics of the physique of middle-aged and old people and the disease course of the Parkinson's disease, the disease development finally tends to liver and kidney deficiency, the inventor selects natural botanical drugs with the effects of tonifying liver and kidney, calming endogenous wind, eliminating phlegm and stopping tremor by taking the natural botanical drugs as the entry points, and the traditional Chinese medicine composition prepared according to a certain weight ratio according to the theoretical formula of traditional Chinese medicine obtains better curative effect for treating the liver and kidney deficiency type Parkinson's disease through clinical verification, thereby not only making up the weak point of the current treatment of the Parkinson's disease, but also providing a better choice for patients.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provides the traditional Chinese medicine composition for treating the liver and kidney deficiency type Parkinson disease and the preparation method thereof, wherein the traditional Chinese medicine composition has the advantages of obvious curative effect, high safety and no toxic or side effect.

The technical scheme of the invention is realized as follows:

a traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson disease comprises the following traditional Chinese medicinal materials in parts by weight:

6-12 parts of red ginseng, 6-24 parts of hispid fig, 6-12 parts of pubescent holly root, 6-36 parts of philippine flemingia root, 6-12 parts of fried immature bitter orange, 6-18 parts of tinospora sinensis, 6-12 parts of medicinal cyathula root, 6-12 parts of cinnamon and 6-12 parts of radix bupleuri.

Further, the traditional Chinese medicine composition comprises the following traditional Chinese medicinal materials in parts by weight:

9 parts of red ginseng, 15 parts of radix fici simplicissimae, 9 parts of pubescent holly root, 21 parts of philippine flemingia root, 9 parts of fried immature bitter orange, 12 parts of tinospora sinensis, 9 parts of medicinal cyathula root, 9 parts of cinnamon and 9 parts of radix bupleuri.

The traditional Chinese medicine composition is prepared into any clinically acceptable preparation by a conventional method.

A preparation method of a traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson disease comprises the following steps:

step 1), weighing red ginseng, hispid fig, pubescent holly root, philippine flemingia root, fried immature bitter orange, tinospora sinensis, medicinal cyathula root, cassia bark and radix bupleuri according to weight, respectively crushing by using a crusher, sieving by a 600-plus-1500-mesh sieve, mixing and uniformly stirring to obtain mixed medicinal powder;

step 2), mixing the mixed medicinal powder and lactose according to the proportion of 1: 1 weight ratio, and preparing into granules by dry granulation according to the prior art; ② preparing pills by ethanol, or coating, drying, filling into hollow capsules, and preparing into capsules, wherein the medicine content of each capsule is 0.4 g; thirdly, mixing the mixed medicinal powder and starch according to the proportion of 1: 1 weight ratio, and preparing tablets according to the existing tabletting process, wherein the medicine content of each tablet is 0.5 g; fourthly, mixing the mixed medicinal powder and honey according to the proportion of 1: 1.5 weight ratio, adding water to make pills, drying, and preparing pills according to the prior art, wherein each 10 pills are equivalent to 6g of the original medicine.

step 1), weighing red ginseng, hispid fig, pubescent holly root, philippine flemingia root, fried immature bitter orange, tinospora sinensis, medicinal cyathula root, cinnamon and radix bupleuri according to the weight, and uniformly mixing to obtain a mixed medicinal material;

step 2), adding water into the mixed medicinal materials obtained in the step 1), wherein the weight of the water is 8 times of that of the mixed medicinal materials, soaking for 30-60min, boiling with strong fire, then decocting with slow fire for 60min, and filtering to obtain a first liquid medicine, wherein the dregs are reserved;

step 3), adding water into the medicine residues remained in the step 2), wherein the weight of the water is 6 times of that of the mixed medicinal materials in the step 1), boiling with strong fire, then decocting with slow fire for 40min, and filtering to obtain a second liquid medicine;

and 4) combining the first liquid medicine and the second liquid medicine, filtering, sterilizing and subpackaging to obtain the decoction.

The sterilization in the step 4) adopts a radiation sterilization method.

The clinical curative effect is summarized as follows:

1. case selection

150 patients who receive treatment in the first subsidiary hospital of medical university in 8-month south China are selected as study objects, and all the patients are clinically diagnosed as the liver and kidney deficiency type Parkinson disease. The data of all patients were analyzed, wherein 89 cases were male and 83 cases were female; the age range is 55-78 years, with the mean age (64.6 ± 5.8) years; the course of disease is 1-12 years, and the average course of disease (5.3 +/-3.2) years. Meanwhile, dividing the disease condition of the patient into 5 stages according to an H-Y stage scale, wherein the 1-2 stages represent mild conditions, the 2.5-3 stages represent moderate conditions, and the 3-5 stages represent severe conditions. Of all patients, there were 51 mild, 98 moderate and 1 severe. All patients are randomly divided into a full prescription group, a control group, a qi-moving group, a liver-tonifying group and a collateral-activating group, wherein each group comprises 30 cases, the full prescription group, the qi-moving group, the liver-tonifying group and the collateral-activating group are all test groups, the whole prescription is the traditional Chinese medicine composition of the invention, the qi-moving prescription is a traditional Chinese medicine preparation prepared by compatibility of pubescent holly root and fried immature bitter orange, the liver-tonifying prescription is a traditional Chinese medicine preparation prepared by compatibility of red ginseng and cinnamon, the collateral-activating prescription is a traditional Chinese medicine preparation prepared by compatibility of philippine flemingia root, caulis tinosporae, radix cyathulae, radix bupleuri and radix fici simplicissimae, and the preparation methods of the traditional Chinese medicine. The comparison of the basic data of sex, age, disease course and disease condition of five groups of patients has no statistical significance (P >0.05) and is comparable. The enrolled patients were all definitive of the content and purpose of the study, voluntarily participated in the study, and signed an informed consent.

2. Method of treatment

The application method of the traditional Chinese medicine composition orally taken by the whole formula group comprises the following steps:

1) decocting: 200 ml each time, 2 times daily, warm taking. 2) And (3) capsule preparation: the medicine is taken 2-5 granules each time, 3 times a day, and each granule contains 0.4 g of medicine and is taken with warm water. 3) And (3) tablet preparation: 2-4 tablets each time, 3 times a day, each tablet contains 0.5 g of medicine, and is taken with warm water. 4) And (3) pill preparation: 6g each time, 3 times a day, and is taken with warm water. 5) Granules: 6g each time, 3 times daily. It is administered with warm water. The continuous taking for 1 month is 1 course of treatment.

Control group: the traditional Chinese medicine decoction of the comparative example 1 is orally taken, and the using method is the same as that of the whole formula.

Qi circulation promoting group: the traditional Chinese medicine preparation with the same dosage of the qi-moving prescription as the comparative example 1 is orally taken, and the using method is the same as that of the whole prescription.

Liver tonifying group: the liver tonifying traditional Chinese medicine preparation with the same dosage as the comparative example 1 is orally taken, and the using method is the same as that of the whole formula.

Collaterals activating group: the Chinese medicinal preparation of the collateral activating formula is orally taken, and the using method is the same as that of the whole formula group, wherein the dosage of the Chinese medicinal preparation is the same as that of the comparative example 1.

3. Criteria for therapeutic effect

The treatment process of the patients in the test group and the patients in the control group are monitored, the observation standard is recovery, effect, progress and ineffectiveness, the UPDRS scale score is used as the judgment index of the treatment effect of the patients, the recovery is realized when the UPDRS scale score of the patients is reduced by 100%, the effect is realized when the UPDRS scale score is reduced by 50-99%, the progress is realized when the UPDRS scale score is reduced by 20-49%, and the ineffectiveness is realized when the UPDRS scale score is reduced by less than 20%.

4. Results

After 3-6 treatment courses, the results of clinical treatment effect comparison are shown in table 1.

TABLE 1 clinical therapeutic Effect

Group of	Recovery method	Show effect	Progress of the technology	Invalidation	Total effective rate
						Complete set	1	14	11	4	86.67％
Control group	0	8	13	9	70.00％
						Group for promoting the circulation of qi	0	13	10	7	76.67％
Liver tonifying set	1	10	14	6	80.00％
						Collaterals activating group	0	11	13	6	80.00％

A comparison of UPDRS total scores before and after treatment is shown in table 2 below.

TABLE 2 UPDRS Total score comparison before and after treatment

The results show that: through the treatment, 1 patient is cured, 14 patients are obviously effective, 11 patients are improved, 4 patients are ineffective, and the total effective rate is 86.67% in 30 patients of the whole formula group for treating the Parkinson disease by using the traditional Chinese medicine composition provided by the embodiment of the invention. In 30 patients of the control group using the traditional Chinese medicine composition of the comparative example 1, 0 patient is cured, 8 patients with obvious effect, 13 patients are advanced, 9 patients are not effective, and the total effective rate is 70.00%. It can be seen that the total effective rate of the whole formula group is obviously higher than that of the control group, and the difference has statistical significance (P < 0.05). The comparison of the UPDRS total points shows that the UPDRS total points after the treatment of the whole formula group are obviously lower than those of the control group, the drop value of the UPDRS total points is obviously higher than that of the control group, and the difference has statistical significance (P is less than 0.05). The treatment effect of the whole formula group is obviously better than that of a control group, and is better than that of a prescription removing group, a qi promoting group, a liver tonifying group and a collateral activating group.

The invention has the positive effects that:

the traditional Chinese medicine provided by the invention has the advantages of easily available raw materials, low cost, good curative effect on treating the liver-kidney yin deficiency type Parkinson disease and no toxic or side effect. In the formula, the radix fici simplicissimae enters spleen, lung and liver channels, strengthens spleen and tonifies lung, promotes qi circulation and removes dampness, and relaxes tendons and activates collaterals. Modern pharmacological research shows that the compound preparation contains amino acids, saccharides, steroids and coumarins, and has a good antibacterial effect on staphylococcus aureus and streptococcus A. Meanwhile, the health-care tea also has the effects of improving immunity, eliminating phlegm, resisting anoxia and ischemia, resisting oxidation and protecting liver injury. Can be used for relieving inflammation, relieving pain, and relieving smooth muscle. Qianjin, sweet in flavor, astringent and neutral in nature, enters lung, kidney and bladder meridians. Has effects in expelling pathogenic wind, removing dampness, relaxing muscles and tendons, activating collateral flow, strengthening muscle and bone, relieving inflammation, and alleviating pain. Modern pharmacology indicates that philippine flemingia root contains various flavonoid compounds, and has good effects of regulating cardiovascular systems, resisting bacteria and viruses, resisting inflammation, regulating immunity, resisting cancer and resisting tumors. The two medicines are used together, so that the medicine can tonify the innate property, benefit the liver and kidney, strengthen tendons and bones, relax tendons and activate collaterals, and play the effects of tonifying yin and calming yang, calming endogenous wind and stopping tremor, and are monarch medicines of the formula. In the formula, the red ginseng has the effects of greatly invigorating primordial qi, recovering pulse, relieving depletion, benefiting qi and controlling blood, and modern pharmacology shows that the qi is slightly fragrant and specific, and the taste is sweet and slightly bitter; red ginseng has an excitatory effect on the central nervous system, whereas it has an inhibitory effect in large amounts. Can enhance the excitation and inhibition process of the higher nerve activity of animals. The adaptability of the body to all non-specific stimuli can be enhanced, and the fatigue feeling can be reduced (the root, stem and leaf of red ginseng can prolong the swimming duration of mice); red ginseng has direct effects on cardiac muscle and blood vessels, and is generally excitatory at low doses and inhibitory at high doses. The 10% red ginseng extract is used for gastric lavage of cats (or rabbits) at a concentration of 1 ml/kg, and has certain effect of improving myocardial weakness. There was a considerable recovery during the rewarming period. It also has antiallergic shock resisting and heart tonifying effects. Ginseng radix Rubri has effect in inhibiting ATPase activity of rat myocardial cell membrane. Radix fici simplicissimae, pungent and sweet in flavor, mild in nature and slightly warm in nature; psoralen is one of the main active components of Ficus Simplicissima lour, and has antibacterial, antiviral, anticoagulant, antitumor, and immunoregulatory effects. The pubescent holly root is slightly bitter and sweet in taste, mild in nature and non-toxic; clear away heat and toxic material, activate blood and dredge vessels. It can be used for treating wind-heat type common cold, lung heat cough and asthma, larynx edema, tonsillitis, dysentery, coronary atherosclerotic heart disease, hemiplegia due to cerebrovascular accident, thromboangiitis obliterans, erysipelas, scald, central retinitis, uveitis, and acute suppurative inflammation of skin. Can be used for treating coronary atherosclerotic heart disease, acute myocardial infarction, and thromboangiitis obliterans; it is externally used for treating burn, scald and chilblain. Qianjin, root for medicine, has effects of dispelling pathogenic wind, removing dampness, relieving rigidity of muscles, activating collaterals, strengthening tendons and bones, diminishing inflammation, and relieving pain. Stir-frying fructus Aurantii Immaturus, bitter, pungent, slightly sour, and slightly warm; spleen and stomach meridians entered; stagnation is caused internally; fullness and distending pain; constipation; severe diarrhea and dysentery; forming a breast; gastroptosis; uterine prolapse; rectocele. Cyathula root, sweet in nature and slightly bitter and flat; it enters liver and kidney meridians. Dispel wind, promote diuresis, dredge meridians, activate blood. It is indicated for wind-damp, lumbar and knee pain, atrophy and contracture of the feet, stranguria with blood, hematuria, amenorrhea and abdominal mass. Can be used for treating amenorrhea, abdominal mass, retention of exocytosis, arthralgia, flaccidity of feet, spasm of tendons, stranguria with hematuria and blood, and traumatic injury. Cinnamon bark, cortex Cinnamomi, acts to tonify yang, warm the spleen and stomach, remove cold accumulation, and promote blood circulation. It is indicated for decline of vital gate fire, cold limbs and pulse, yang exhaustion and collapse, abdominal pain and diarrhea, cold hernia and dolphin, cold pain in waist and knee, amenorrhea, deep rooted carbuncle, abscess, and floating yang, upper heat and lower cold. Bupleurum root, radix bupleuri, bitter in nature and slightly cold in nature, enters liver and gallbladder meridians. Has the functions of harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia.

The medicine can be used for reinforcing primordial qi, consolidating constitution, invigorating qi, promoting production of blood, moistening blood, relieving dizziness, and relieving tremor. Cinnamon bark, cortex Cinnamomi enters kidney, spleen, heart and liver meridians and has the effects of tonifying fire, supporting yang, warming and activating meridians, and guiding fire to origin. The medicine is pungent and strong in heat, can tonify deficiency of liver and kidney, can return yang and dredge vessels, relax tendons and activate collaterals, and has the effects of assisting monarch drugs in calming endogenous wind and determining tremor when being used together with red ginseng, and is a ministerial drug. Radix Cyathulae enters liver and kidney meridians, and has the functions of removing blood stasis, dredging channels and smoothing joints. Modern pharmacology indicates that radix cyathulae contains ecdysterone and trace element titanium, and has the effects of resisting coagulation, reducing fat, protecting liver, benefiting gallbladder, enhancing glycometabolism and improving immunity. Zhi Shi has the function of resolving phlegm, relieving stuffiness, breaking qi and dissipating nodulation in the recipe. Modern pharmacological studies show that the immature bitter orange injection can increase the blood flow of coronary artery, brain and kidney and reduce the resistance of blood vessels of brain and kidney by intravenous injection. Immature bitter orange is the organ of the recipe for moving qi and resolving phlegm, and is combined with Chuan Xiu Yu to make qi the commander of blood and make blood the chief of qi, so they are combined to promote blood circulation and move qi. Can better exert the treatment effect of the prescription. Bupleurum root, radix bupleuri enters liver, gallbladder and lung meridians, and has the actions of dispelling wind and relieving fever, soothing liver and relieving depression, and lifting yang qi. Modern pharmacology indicates that bupleurum and the saikoside which is the active ingredient of the bupleurum have anti-inflammatory effect, and the anti-inflammatory effect is related to the function of promoting the adrenal cortex system and the like. Saikosaponin also has effect of reducing blood plasma cholesterol. In addition, bupleuri radix has good effects of resisting fatty liver, resisting liver injury, promoting bile flow, reducing transaminase, exciting smooth muscle of intestine, inhibiting gastric acid secretion, resisting ulcer, and inhibiting trypsin. The medicine has effects of dispersing stagnated liver qi, dispelling heat, relieving liver meridian heat, calming endogenous wind, relieving spasm, and lifting yang qi to benefit liver and kidney deficiency. The pubescent holly root enters heart, lung and bladder channels and has the effects of clearing away heat and toxic materials, promoting blood circulation and dredging collaterals. Modern pharmacology indicates that ilex pubescens contains ilex pubescens flavonoid glycoside, which has strong and lasting effect on increasing coronary blood flow and can enhance cardiac contractility. The tinospora sinensis enters liver and spleen channels, and can dispel wind, remove dampness, relax tendons, activate collaterals, dispel wind and relieve pain. The composition can be used together with radix Ilicis Pubescentis for promoting blood circulation, dispelling pathogenic wind, relaxing muscles and tendons, and expelling collateral obstruction. Pharmacological research finds that the compound has the effects of inhibiting nerve cell apoptosis, improving the immunity of the organism, delaying aging and the like, and achieves the aim and the application of the traditional Chinese medicine preparation which can replace western medicine levodopa to treat the Parkinson disease. The formula is a specific prescription for treating the liver and kidney deficiency type Parkinson disease summarized on the basis of years of clinical experience, and compared with the existing similar medicines, the prescription has the advantages that the prescription does not contain any western medicine component, especially does not contain levodopa, and can avoid the side effect caused by the western medicine. Compared with western medicine for prevention and treatment, the traditional Chinese medicine composition has the advantages of obvious curative effects of quick symptom control, good long-term curative effect, few complications, no obvious toxic or side effect and the like for treating patients with the Parkinson's disease caused by deficiency of liver and kidney.

The traditional Chinese medicine has the advantages of treating the Parkinson's disease different from western medicine. The traditional Chinese medicine composition is prepared according to a formula of a theory of traditional Chinese medicine and a certain weight ratio, and has a good curative effect on the liver and kidney deficiency type Parkinson disease through clinical verification.

Detailed Description

Example 1

A traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson disease comprises the following traditional Chinese medicinal materials by weight:

6g of red ginseng, 6g of hispid fig root, 6g of pubescent holly root, 6g of philippine flemingia root, 6g of fried immature bitter orange, 6g of tinospora sinensis, 6g of medicinal cyathula root, 6g of cinnamon and 6g of Chinese thorowax root.

The preparation method of the decoction of the traditional Chinese medicine composition comprises the following steps:

The sterilization in the step 4) adopts a radiation sterilization method.

The decoction prepared by the preparation method is taken in the acute stage of diseases.

The preparation method of the traditional Chinese medicine composition into granules, capsules, tablets and pills comprises the following steps:

The granule, capsule, tablet, and pill prepared by the above preparation method are administered in stable stage of disease.

The dosage form is used as follows:

1) decocting: 200 ml each time, 2 times daily, warm taking. 2) And (3) capsule preparation: the medicine is taken 2-5 granules each time, 3 times a day, and each granule contains 0.4 g of medicine and is taken with warm water. 3) And (3) tablet preparation: 2-4 tablets each time, 3 times a day, each tablet contains 0.5 g of medicine, and is taken with warm water. 4) And (3) pill preparation: 6g each time, 3 times a day, and is taken with warm water. 5) Granules: 6g each time, 3 times daily. It is administered with warm water.

Example 2

red ginseng 12 g, five-finger wild peach 24 g, pubescent holly root 12 g, Qianjin 36 g, fried immature bitter orange 12 g, tinospora sinensis 18 g, cyathula root 12 g, cinnamon 12 g and bupleurum root 12 g.

The preparation method and the use method are the same as the example 1.

Example 3

9 g of red ginseng, 15 g of hispid fig root, 9 g of pubescent holly root, 21 g of philippine flemingia root, 9 g of fried immature bitter orange, 12 g of tinospora sinensis, 9 g of medicinal cyathula root, 9 g of cinnamon and 9 g of Chinese thorowax root.

The preparation method and the use method are the same as the example 1.

Example 4

7 g of red ginseng, 7 g of radix fici simplicissimae, 7 g of pubescent holly root, 7 g of philippine flemingia root, 7 g of fried immature bitter orange, 7 g of tinospora sinensis, 7 g of medicinal cyathula root, 7 g of cinnamon and 7 g of Chinese thorowax root.

The preparation method and the use method are the same as the example 1.

Example 5

11 g of red ginseng, 23 g of hispid fig root, 11 g of pubescent holly root, 35 g of philippine flemingia root, 11 g of fried immature bitter orange, 17 g of tinospora sinensis, 11 g of medicinal cyathula root, 11 g of cinnamon and 11 g of Chinese thorowax root.

The preparation method and the use method are the same as the example 1.

Example 6

8 g of red ginseng, 8 g of hispid fig root, 8 g of pubescent holly root, 8 g of philippine flemingia root, 8 g of fried immature bitter orange, 8 g of tinospora sinensis, 8 g of medicinal cyathula root, 8 g of cinnamon and 8 g of Chinese thorowax root.

The preparation method and the use method are the same as the example 1.

Example 7

red ginseng 10 g, five-finger wild peach 22 g, pubescent holly root 10 g, Qianjin 34 g, fried immature bitter orange 10 g, tinospora sinensis 16 g, cyathula root 10 g, cinnamon 10 g and bupleurum root 10 g.

The preparation method and the use method are the same as the example 1.

Example 8

red ginseng 10 g, five-finger wild peach 12 g, pubescent holly root 10 g, Qianjin 12 g, fried immature bitter orange 10 g, tinospora sinensis 12 g, cyathula root 10 g, cinnamon 10 g and bupleurum root 10 g.

The preparation method and the use method are the same as the example 1.

Example 9

red ginseng 10 g, five-finger wild peach 19 g, pubescent holly root 10 g, Qianjin Flemingia root 16 g, fried immature bitter orange 10 g, tinospora sinensis 15 g, cyathula root 10 g, Cinnamomum cassia 10 g and Bupleurum root 10 g.

The preparation method and the use method are the same as the example 1.

Example 10

9 g of red ginseng, 19 g of hispid fig root, 9 g of pubescent holly root, 25 g of philippine flemingia root, 9 g of fried immature bitter orange, 12 g of tinospora sinensis, 9 g of medicinal cyathula root, 9 g of cinnamon and 9 g of Chinese thorowax root.

The preparation method and the use method are the same as the example 1.

Example 11

9 g of red ginseng, 17 g of hispid fig root, 10 g of pubescent holly root, 30 g of philippine flemingia root, 10 g of fried immature bitter orange, 13 g of tinospora sinensis, 8 g of medicinal cyathula root, 10 g of cinnamon and 9 g of Chinese thorowax root.

The preparation method and the use method are the same as the example 1.

Comparative example 1

The difference between the traditional Chinese medicine compound for treating the liver and kidney deficiency type Parkinson disease in the comparative example and the traditional Chinese medicine compound in the example 1 is that red ginseng is replaced by the same amount of radix codonopsis; radix Cyathulae is replaced by equal amount of radix Achyranthis bidentatae.

Test example

Pharmacological acute toxicity test

Taking 40 healthy mice (each half of a female mouse and a male mouse, the weight (20-40g) of the mice is 40, randomly dividing the mice into a test group and a control group, wherein each group comprises 20 mice, the test group is fasted for 12 hours before drug administration without water prohibition, the intragastric administration dosage is 50g/kg & bw, and is equal to 500 times of the clinical daily dosage of an adult (the clinical dosage is 60kg of the adult for 2 times a day and 3g each time), carrying out conventional feeding after drug administration, observing the death condition of the mice within 3d, immediately carrying out necropsy within 3d, normally feeding the control group, killing the mice respectively on the 3 rd day and the 7 th day after drug administration, carrying out necropsy, and observing the change condition of the internal organs of the mice.

The results show that: within 7 days after administration, the mice in the test group have no death phenomenon and abnormal reaction. Meanwhile, compared with the control group, the visceral tissues and organs of the mice in the test group are healthy and have no abnormality. The traditional Chinese medicine composition provided by the embodiment of the invention has no obvious toxic or side effect.

Case 1

Madam, male, age 68, two years ago patients were diagnosed with parkinson's syndrome, with symptoms: the head and limbs tremble, the tremble is obvious when the head and the limbs are static, the right half body paralysis cannot take care of oneself in life, people need to be assisted when walking, the reaction is slow, the upper and lower limbs are strong, the western medicine compound levodopa is used for 1 year, and the effect is not obvious. The traditional Chinese medicine decoction is taken 200 ml each time for 2 times a day in the morning and evening. After two treatment courses, the tremor of the head, hands and feet is obviously improved, and the life can be basically self-managed by continuously taking the medicine for two treatment courses. Until now, the medicine is stopped for 1 year, no relapse occurs, and the patients basically recover health.

Case 2

Zhang-Zeng, male, age 76, seven years ago no obvious inducement to dizziness, upper limb tremor, upper body stiffness, difficult normal walking, and diagnosis of Parkinson's syndrome in local hospital. After the medobo is taken all the time, the symptoms of the patient are improved, but the symptoms exist all the time and do not disappear. After the medicine is continuously taken for one year, the drug resistance of patients becomes stronger, and other dopamine medicines are taken along with the medicine, but the effect is not good. When the patient is in a hospital, 2-5 capsules are taken each time for 3 times a day, and the capsule is taken with warm water. After two treatment courses, the symptoms of the patient are basically improved, and the patient can basically take care of himself and walk normally though the patient cannot be cured. After the medicine is continuously taken for two treatment courses, the symptoms of the patient basically disappear, and the patient can take care of himself. The medicine is stopped for 2 years till now, no relapse occurs, and the patients basically recover health.

Case 3

Korean is male, 72 years old, and sudden muscle strength, tremor of limbs, left-half paralysis and incapability of self-care in daily life appear five years ago, and technical treatment is needed. The Parkinson disease is diagnosed in the local hospital, and the patient is treated by western medicines in the local hospital, but the effect is not ideal, and the patient can be seen at our hospital. The patient takes the traditional Chinese medicine tablet 2-4 tablets each time and 3 times a day with warm water. After a course of treatment, all symptoms of the patient are improved, although the patient cannot be cured, the muscle of the patient is strong, and the symptoms of the tremor of the limbs are relieved. After the medicine is continuously taken for two treatment courses, the muscle strength and the muscle tension of the patient are recovered to be normal, the limb tremor condition basically disappears, and the limb tremor condition is occasionally attacked. The medicine is stopped for two months till now, no relapse occurs, and the patients basically recover health.

Case 4

Qian, woman, 62 years old, was diagnosed with parkinson's disease in the local hospital five years ago. Symptoms are: tremor of the head and upper limbs, postural dysreflexia, difficulty in movement and difficulty in walking normally. The patients are always treated by taking western dopamine medicines, but the disease condition is gradually worsened due to the increase of the drug resistance of the patients. When the Chinese medicinal pill is used for treatment in our hospital, the patient takes 6g of the Chinese medicinal pill for each time and 3 times a day with warm water. After two treatment courses, the tremor of the head and the upper limbs of the patient is reduced, and the patient can walk although the movement is slow. After the medicine is continuously taken for two treatment courses, all symptoms of the patient basically disappear. The medicine is stopped for two years till now, no relapse occurs, and the patients basically recover health.

Claims

1. The traditional Chinese medicine composition for treating the liver and kidney deficiency type Parkinson disease is characterized by comprising the following traditional Chinese medicinal materials in parts by weight:

2. The traditional Chinese medicine composition for treating the liver and kidney deficiency type Parkinson disease is characterized by comprising the following traditional Chinese medicinal materials in parts by weight:

3. The traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson's disease according to claim 1 or 2, which is characterized in that: making into any clinically acceptable preparation by conventional method.

4. The traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson's disease according to claim 3, which is characterized in that: the preparation is granules, capsules, tablets, pills or decoction.

5. A preparation method of a traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson disease is characterized by comprising the following steps:

6. A preparation method of a traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson disease is characterized by comprising the following steps:

7. The preparation method of the traditional Chinese medicine composition for treating liver and kidney deficiency type Parkinson's disease according to claim 6, which is characterized by comprising the following steps: the sterilization in the step 4) adopts a radiation sterilization method.