CN110575472A - Spray with anti-inflammatory, analgesic and blood circulation promoting effects - Google Patents

Spray with anti-inflammatory, analgesic and blood circulation promoting effects Download PDF

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Publication number
CN110575472A
CN110575472A CN201910966358.2A CN201910966358A CN110575472A CN 110575472 A CN110575472 A CN 110575472A CN 201910966358 A CN201910966358 A CN 201910966358A CN 110575472 A CN110575472 A CN 110575472A
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Prior art keywords
parts
spray
blood circulation
root
diminishing inflammation
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Pending
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CN201910966358.2A
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Chinese (zh)
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杨淑明
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Individual
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Individual
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Priority to CN201910966358.2A priority Critical patent/CN110575472A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a spray with the functions of diminishing inflammation, easing pain and promoting blood circulation. The spray with the functions of diminishing inflammation, easing pain and promoting blood circulation comprises the following components in parts by weight: 10-20 parts of lycopodium clavatum root; 15-20 parts of madder; 10-15 parts of radix aconiti; 3-5 parts of safflower; 20-30 parts of borneol. Mixing the raw materials, percolating with ethanol to obtain alcoholic solution, decocting to obtain concentrated mixture, mixing the two solutions, concentrating, adding appropriate amount of solvent, and making into spray. The spray with the functions of diminishing inflammation, easing pain and activating blood circulation provided by the invention can treat related diseases such as indication sprain, contusion, arthralgia and myalgia.

Description

Spray with anti-inflammatory, analgesic and blood circulation promoting effects
Technical Field
The invention relates to the field of medicines, in particular to a spray with the functions of diminishing inflammation, easing pain and promoting blood circulation.
Background
Inflammation is what is commonly called "inflammation" and is a defense response of the body to stimuli, manifested by redness, swelling, heat, pain, and dysfunction. The inflammation may be infectious inflammation caused by infection or non-infectious inflammation not caused by infection. Normally, inflammation is beneficial and an automatic defense response of the human body, but sometimes, inflammation is also harmful, such as attack on the body's own tissues, inflammation occurring in transparent tissues, and the like.
In order to prevent inflammation diffusion, anti-inflammatory and analgesic drugs are often required to be taken, the drugs generally have slow effect, certain side effects exist in human bodies after being taken, certain skin inflammations are often accompanied with bleeding, and the common anti-inflammatory and analgesic drugs do not directly act on inflammation parts and cannot stop bleeding quickly, so that the anti-inflammatory and analgesic effects are poor.
Disclosure of Invention
Aiming at the defects in the prior art, the spray with the effects of diminishing inflammation, easing pain and activating blood provided by the invention solves the technical problems, and provides the spray with the effects of diminishing inflammation, easing pain and activating blood and treating related diseases such as indication sprain, contusion, arthralgia and myalgia and the like.
in order to achieve the purpose, the invention provides the following technical scheme:
A spray with anti-inflammatory, analgesic and blood circulation promoting effects comprises the following components in parts by weight: 10-20 parts of lycopodium clavatum root; 15-20 parts of madder; 10-15 parts of radix aconiti; 3-5 parts of safflower; 20-30 parts of borneol.
The paint comprises the following components in parts by weight: 10 parts of buck grass root; 15 parts of madder; 10 parts of radix aconiti; 3 parts of safflower; 23 parts of borneol.
The paint comprises the following components in parts by weight: 20 parts of buck grass root; 20 parts of madder; 14 parts of radix aconiti; 5 parts of safflower; 30 parts of borneol.
The paint comprises the following components in parts by weight: 15 parts of lycopodium clavatum root; 17 parts of madder; 12 parts of radix aconiti; 4 parts of safflower; 24 parts of borneol.
A preparation method of a spray with the functions of diminishing inflammation, easing pain and promoting blood circulation comprises the following steps:
A. mixing the raw materials of the root of common clubmoss herb, the India madder root, the common monkshood mother root, the safflower and the borneol uniformly;
B. Filtering the mixed materials by alcohol percolation to obtain alcohol solution component;
C. Then the mixed raw materials in the step B are decocted to obtain a solution;
D. Mixing and filtering the solutions obtained in the step B and the step C, and concentrating the solution by industrial equipment to obtain a concentrated solution;
E. The concentrated solution is added with a proper amount of solvent to prepare a spray for use.
wherein, the solvent is an auxiliary solvent which can improve the drug effect of the concentrated solution and accords with the national drug production standard.
The invention has the beneficial effects that: the spray with the functions of diminishing inflammation, easing pain and activating blood provided by the invention directly acts on inflammation parts, and has good anti-inflammation and analgesic effects and quick response; the spray also has the function of promoting blood circulation, thereby relieving the harm and pain caused by inflammation and treating related diseases such as indication sprain, contusion, arthralgia, myalgia and the like.
For a better understanding of the features and technical content of the present invention, refer to the following detailed description of the invention.
Detailed Description
to further illustrate the technical means adopted by the present invention and the effects thereof, the following detailed description is given with reference to the preferred embodiments of the present invention.
a spray with anti-inflammatory, analgesic and blood circulation promoting effects comprises the following components in parts by weight: 10-20 parts of lycopodium clavatum root; 15-20 parts of madder; 10-15 parts of radix aconiti; 3-5 parts of safflower; 20-30 parts of borneol.
Further, the paint comprises the following components in parts by weight: 10 parts of buck grass root; 15 parts of madder; 10 parts of radix aconiti; 3 parts of safflower; 23 parts of borneol.
further, the paint comprises the following components in parts by weight: 20 parts of buck grass root; 20 parts of madder; 14 parts of radix aconiti; 5 parts of safflower; 30 parts of borneol.
further, the paint comprises the following components in parts by weight: 15 parts of lycopodium clavatum root; 17 parts of madder; 12 parts of radix aconiti; 4 parts of safflower; 24 parts of borneol.
A preparation method of a spray with the functions of diminishing inflammation, easing pain and promoting blood circulation comprises the following steps:
A. Mixing the raw materials of the root of common clubmoss herb, the India madder root, the common monkshood mother root, the safflower and the borneol uniformly;
B. Filtering the mixed materials by alcohol percolation to obtain alcohol solution component;
C. Then the mixed raw materials in the step B are decocted to obtain a solution;
D. mixing and filtering the solutions obtained in the step B and the step C, and concentrating the solution by industrial equipment to obtain a concentrated solution;
E. the concentrated solution is added with a proper amount of solvent to prepare a spray for use.
Furthermore, the solvent is an auxiliary solvent which can improve the drug effect of the concentrated solution and accords with the national drug production standard.
the spray provided by the invention can be used for treating inflammation diminishing, pain easing and blood activating, in order to further verify the curative effect of the prescription on patients, treatment tracking records are carried out on 100 cases with joint swelling and pain, the average age of the patients is 30-70 years, the average course of disease is 4.5 years, the patients are divided into mild, moderate and severe, and mild patients walk normally and particularly have slight pain feeling in rainy days; moderate patients have obvious pain feeling when walking normally, especially in rainy days; severe patients are essentially unable to walk normally. The prescription is used for treatment, the specific method is rubbing, three times a day, and massage is carried out for half an hour after rubbing, the treatment effect is shown in table 1 for patients with different degrees, and the obvious effect refers to a case that the effect is obvious and the pain is eliminated within 7 days after the medicine is taken; effective refers to the case that the effect is remarkable and the pain is eliminated within 14 days, and the ineffective refers to the case that the effect is basically not realized and the pain cannot be eliminated within 30 days; recovery refers to a case with remarkable effect within 7 days and no relapse within 180 days.
TABLE 1 therapeutic data of patients with different degrees of swelling and pain of joints using the drug of the present invention
Degree of Recovery method Show effect is effective Invalidation Total up to High efficiency
Mild degree of 20 29 8 3 60 95.0%
of moderate degree 6 12 4 3 25 88.0%
Severe degree 3 5 4 3 15 80.0%
In order to further verify the safety of the prescription, simultaneously, the medicine treatment contrast tracking record is carried out on another batch of patients, 100 patients are also selected, the average age of the patients is 30-70 years, the average course of disease is 4.5 years, the treatment group adopts the medicine administration treatment, the contrast group adopts the general pain-relieving medicine administration treatment, the medicine is periodically administered, the liver function examination is periodically carried out, the contrast treatment result proves that the liver function examination of the treatment group adopting the medicine is normal, the transaminase suddenly rises, and the state of the patients is stable; the patients who adopt the control administration have the phenomenon of transaminase rise in liver function detection, and simultaneously have the phenomenon of vertigo and vomit of some patients, thereby proving the safety of the use of the medicine.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (6)

1. The spray with the effects of diminishing inflammation, easing pain and activating blood circulation is characterized by comprising the following components in parts by weight: 10-20 parts of lycopodium clavatum root; 15-20 parts of madder; 10-15 parts of radix aconiti; 3-5 parts of safflower; 20-30 parts of borneol.
2. The spray with the effects of diminishing inflammation, easing pain and activating blood circulation as claimed in claim 1 is characterized by comprising the following components in parts by weight: 10 parts of buck grass root; 15 parts of madder; 10 parts of radix aconiti; 3 parts of safflower; 23 parts of borneol.
3. The spray with the effects of diminishing inflammation, easing pain and activating blood circulation as claimed in claim 1 is characterized by comprising the following components in parts by weight: 20 parts of buck grass root; 20 parts of madder; 14 parts of radix aconiti; 5 parts of safflower; 30 parts of borneol.
4. The spray with the effects of diminishing inflammation, easing pain and activating blood circulation as claimed in claim 1 is characterized by comprising the following components in parts by weight: 15 parts of lycopodium clavatum root; 17 parts of madder; 12 parts of radix aconiti; 4 parts of safflower; 24 parts of borneol.
5. The preparation method of the spray with the effects of diminishing inflammation, easing pain and promoting blood circulation as claimed in claim 1, is characterized by comprising the following steps:
A. mixing the raw materials of the root of common clubmoss herb, the India madder root, the common monkshood mother root, the safflower and the borneol uniformly;
B. Filtering the mixed materials by alcohol percolation to obtain alcohol solution component;
C. Then the mixed raw materials in the step B are decocted to obtain a solution;
D. mixing and filtering the solutions obtained in the step B and the step C, and concentrating the solution by industrial equipment to obtain a concentrated solution;
E. The concentrated solution is added with a proper amount of solvent to prepare a spray for use.
6. The spray with the effects of diminishing inflammation, easing pain and promoting blood circulation as claimed in claim 5, wherein the solvent is an auxiliary solvent which can improve the drug effect of the concentrated solution and meets the national drug production standard.
CN201910966358.2A 2019-10-11 2019-10-11 Spray with anti-inflammatory, analgesic and blood circulation promoting effects Pending CN110575472A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910966358.2A CN110575472A (en) 2019-10-11 2019-10-11 Spray with anti-inflammatory, analgesic and blood circulation promoting effects

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Application Number Priority Date Filing Date Title
CN201910966358.2A CN110575472A (en) 2019-10-11 2019-10-11 Spray with anti-inflammatory, analgesic and blood circulation promoting effects

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CN110575472A true CN110575472A (en) 2019-12-17

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101301339A (en) * 2008-06-20 2008-11-12 牛天卓 Babu far infrared medicinal plaster for treating arthralgia and myalgia, and wind-cold syndrome and numbness
CN103230430A (en) * 2013-04-07 2013-08-07 广东恒诚制药有限公司 Traditional Chinese medicine gel cream for treating lumbar disc herniation
CN105748625A (en) * 2016-03-30 2016-07-13 青岛百瑞吉生物工程有限公司 Pain-relieving liniment high in stability and preparation method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101301339A (en) * 2008-06-20 2008-11-12 牛天卓 Babu far infrared medicinal plaster for treating arthralgia and myalgia, and wind-cold syndrome and numbness
CN103230430A (en) * 2013-04-07 2013-08-07 广东恒诚制药有限公司 Traditional Chinese medicine gel cream for treating lumbar disc herniation
CN105748625A (en) * 2016-03-30 2016-07-13 青岛百瑞吉生物工程有限公司 Pain-relieving liniment high in stability and preparation method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘远军,等: "复方威灵仙酊的制备与应用", 中国医院药学杂志, vol. 22, no. 02, pages 113 *
鲁寒: "散瘀止痛膏治疗急性踝扭伤200例", 实用中医内科杂志, vol. 21, no. 03, pages 99 *

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