CN103055069A - External Chinese medicine composition for treating postherpetic neuralgia and preparation method of composition - Google Patents
External Chinese medicine composition for treating postherpetic neuralgia and preparation method of composition Download PDFInfo
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Abstract
The invention discloses an external Chinese medicine composition for treating postherpetic neuralgia and a preparation method of the composition. The external Chinese medicine composition is prepared from the following crude medicaments in parts by weight: 10-25 parts of spina gleditsiae, 3-9 parts of pseudo-ginseng, 3-6 parts of chrysanthemum, 3-6 parts of basil leaves, 3-15 parts of cortex lycii radicis, 3-9 parts of semen armeniacae amarae, 3-6 parts of rhizoma cimicifugae, 3-15 parts of red paeonia, 3-15 parts of toad, 3-6 parts of felwort, 1-3 parts of periostracum cicada, 10-30 parts of calcined concha margaritifera, 3-9 parts of lithospermum purpurocaeruleum, 3-9 parts of rhizoma arisaematis, 3-12 parts of angelica, 3-15 parts of cortex lycii radicis, 3-15 parts of radix sophorae flavescentis, 3-9 parts of angelica, 1-3 parts of wild ginger, 3-9 parts of corydalis tuber, 3-9 parts of Chinese lobelia, 1-3 parts of mint, 3-15 parts of ash bark, 3-15 parts of phellodendron amurense and 0.5-1.0 parts of borneol. A preparation method of the external Chinese medicine composition comprises the following steps: crushing the above raw materials into fine powder; and soaking in vegetable oil, and filtering to obtain oil. The external Chinese medicine composition has the advantages of remarkable curative effect, no adverse reaction, short treatment period, and is convenient for medical use and low expense.
Description
Technical field
The present invention relates to a kind of external medicine composition for the treatment of post-herpetic neuralgia and preparation method thereof.
Background technology
Herpes zoster is commonly called as " skirt-roof dragon ", " herpes zoster ", " herpes zoster " by a kind of disease that varicella zoster virus causes.Virus enters human body by respiratory mucosa, and this virus can be along peripheral nerve fiber generation herpes for having a liking for nerve.After varicella zoster virus infected, patient's pain time of 10% surpassed one month, as can not get in time treatment or malpractice, and pain can still exist after herpes disappears, the case pain that has even surpass many decades.Post-herpetic neuralgia is that herpes disappears, forms to still have in the zone of herpes zoster after the skin lesion 3～6 months and continues intractable pain and surpass 1 month person.Post-herpetic neuralgia is the clinical more common disease of Dermatology Outpatient Department and pain.But 10% Patients with Herpes Zoster Herpes Zoster post herpetic neuralgia is arranged approximately, and with gerontal patient's post-herpetic neuralgia incidence rate more than 60 years old for the highest, can reach 50%-75%.Along with the aging of population, the sickness rate of post-herpetic neuralgia can significantly increase.
The allodynia of post-herpetic neuralgia and the treatment of allodynia are very difficult, bring huge, long-term injury for patient's spirit and psychology.The postherpes neuralgia PHN patient that some is serious, light stimulation can cause the pain outbreak, the patient who has stimulates for reducing clothes, dare not wear the clothes.This allodynia reaction also can show as idiopathic pain, does not namely stimulate to touch pain also occurs often.The patient who also has is because of long-term pain emotion hypertonicity, and the spirit depressing that has is desperate.
Modern medicine thinks that post-herpetic neuralgia is because virus causes nervous dysfunction caused.Chinese medicine thinks that herpes zoster is that the spleen damp-stagnancy is of a specified duration because liver and gall fire is contained, and the diseases caused by exogenous pathogenic factor poison is evil and send out.Healthy energy interior-deficiency, evil malicious delay, qi depression to blood stasis, damp-heat accumulation, the stagnant resistance in network road then cause post-herpetic neuralgia, and add again the patient and be mostly old and the weakling, obstinate disease, asthenia of qi and blood declines, and does not support venation, has caused " to empty part, being the ground that stays heresy ".
The Therapeutic Method of doctor trained in Western medicine at present commonly used comprises: oral antiviral agents, non-steroidal anti-inflammatory analgesics, opiates medicine (slow releasing agent), antidepressants, antuepileptic, tranquilizer; Nerve block; The neural therapy etc. of damaging.And the traditional Chinese medical science often adopts the methods such as blood circulation promoting and blood stasis dispelling, dredging the meridian, poison holding putrefaction removing, heat-clearing and toxic substances removing, inrigorating qi and promoting blood circulation to be treated by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.But most of traditional analgesic is all not satisfactory to the therapeutic effect of post-herpetic neuralgia, and treatment cost and appointed condition are higher.So that the doctor feels a delicacy about to the treatment of post-herpetic neuralgia for a long time.This pain has the bad reputation of " not dead cancer ".
Summary of the invention
For addressing the above problem, the present invention is based on the traditional Chinese medical science to understanding and the rule for the treatment of of post-herpetic neuralgia, employing has the Chinese medicine of the effects such as blood circulation promoting and blood stasis dispelling, dredging the meridian, poison holding putrefaction removing, heat-clearing and toxic substances removing, cooling blood and relieving pain, according to the theory of Chinese medical science prescription, a kind of external medicine composition for the treatment of post-herpetic neuralgia is provided, and preparation method thereof.
The objective of the invention is provides a kind of evident in efficacy, with low cost, preparation and uses the external medicine composition simple, that side effect is little, relapse rate is low for post-herpetic neuralgia.
Compositions of the present invention is made by following raw materials in part by weight: 10～25 parts of Spina Gleditsiaes, 3～9 parts of Radix Notoginseng, 3～6 parts of Flos Chrysanthemis, 3～6 parts of Folium Perillaes, 3～15 parts of Cortex Lycii, 3～9 parts of Semen Armeniacae Amarums, 3～6 parts of Rhizoma Cimicifugaes, 3～15 parts of Radix Paeoniae Rubra, 3～15 parts of Bufo siccuss, 3～6 parts of Radix Gentianaes, 1～3 part of Periostracum Cicadae, 10～30 parts of calcined Concha Margaritifera, 3～9 parts of Radix Arnebiae (Radix Lithospermi)s, 3～9 parts of Rhizoma Arisaematiss, 3～12 parts of Radix Angelicae Sinensis, 3～15 parts of Cortex Lycii, 3～15 parts of Radix Sophorae Flavescentiss, 3～9 parts of Radix Angelicae Sinensis, 1～3 part of Herba Asari, 3～9 parts of Rhizoma Corydalis, 3～9 parts of Herba Lobeliae Chinensis, 1～3 part of Herba Menthae, 3～15 parts of Cortex Fraxinis, 3～15 parts of Cortex Phellodendris, 0.5～1.0 part of Borneolum Syntheticum.
Wherein, optimization formula is: 15 parts of Spina Gleditsiaes, 6 parts of Radix Notoginseng, 3 parts of Flos Chrysanthemis, 3 parts of Folium Perillaes, 9 parts of Cortex Lycii, 9 parts of Semen Armeniacae Amarums, 6 parts of Rhizoma Cimicifugaes, 9 parts of Radix Paeoniae Rubra, 9 parts of Bufo siccuss, 6 parts of Radix Gentianaes, 3 parts of Periostracum Cicadaes, 20 parts of calcined Concha Margaritifera, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 3 parts of Rhizoma Arisaematiss, 6 parts of Radix Angelicae Sinensis, 9 parts of Cortex Lycii, 9 parts of Radix Sophorae Flavescentiss, 6 parts of Radix Angelicae Sinensis, 3 parts of Herba Asaris, 6 parts of Rhizoma Corydalis, 6 parts of Herba Lobeliae Chinensis, 3 parts of Herba Menthaes, 9 parts of Cortex Fraxinis, 9 parts of Cortex Phellodendris, 1 part of Borneolum Syntheticum.
Preferred dosage form most preferably is the oil preparation of being made by the vegetable oil lixiviate for being fit to the exterior-applied formulations such as oil preparation, unguentum, liniment, tincture or gel of clinical practice.
Preparation method step of the present invention is as follows: above-mentioned raw materials is ground into fine powder by proportioning crosses 200 mesh sieves, place 50 ℃ of vegetable oil of 6 times of volumes to soak 5 hours the fine powder after sieving, cross leaching oil, cooling gets target product.
Described vegetable oil is Oleum Sesami, Oleum Arachidis hypogaeae semen, Oleum Glycines, safflower oil.
Make other exterior-applied formulations such as need, can be by making according to a conventional method the dosage form that needs behind the lixiviating effective components.
Using method of the present invention can be: get an amount of affected part of exterior coating.
Medicine and method with respect to existing treatment post-herpetic neuralgia have the following advantages:
The used raw material of Chinese medicine medicine of the present invention all is conventional Chinese medicines of putting down in writing in the state-promulgated pharmacopoeia, buys from the Chinese medicine shop easily; And preparation method is simple.
The external curing that the present invention is directed to post-herpetic neuralgia is very effective, this Chinese medicine composition is according to the principle-method-recipe-medicines principle of whole prescription of the traditional Chinese medical science, various crude drug coordinate at utmost to bring into play drug effect mutually, can blood circulation promoting and blood stasis dispelling, dredging the meridian, poison holding putrefaction removing, heat-clearing and toxic substances removing, cooling blood and relieving pain, significantly alleviate post-herpetic neuralgia and suppress recurrence, in addition, have also that analgesic effect is rapid-action and lasting, cure rate is high, relapse rate is low, have no adverse reaction, short treating period, the advantage such as medication is convenient, expense is cheap.Observe through 120 routine post-herpetic neuralgia patient clinicals, the average onset time of pain relieving is 25 minutes, and cure rate is 72%, total effective rate 92%, and relapse rate is 5%.
The specific embodiment
The present invention is described further below in conjunction with embodiment.
Embodiment 1: the preparation of external medicine composition
Take by weighing each raw medicinal material by following weight portion: 15 parts of Spina Gleditsiaes, 6 parts of Radix Notoginseng, 3 parts of Flos Chrysanthemis, 3 parts of Folium Perillaes, 9 parts of Cortex Lycii, 9 parts of Semen Armeniacae Amarums, 6 parts of Rhizoma Cimicifugaes, 9 parts of Radix Paeoniae Rubra, 9 parts of Bufo siccuss, 6 parts of Radix Gentianaes, 3 parts of Periostracum Cicadaes, 20 parts of calcined Concha Margaritifera, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 3 parts of Rhizoma Arisaematiss, 6 parts of Radix Angelicae Sinensis, 9 parts of Cortex Lycii, 9 parts of Radix Sophorae Flavescentiss, 6 parts of Radix Angelicae Sinensis, 3 parts of Herba Asaris, 6 parts of Rhizoma Corydalis, 6 parts of Herba Lobeliae Chinensis, 3 parts of Herba Menthaes, 9 parts of Cortex Fraxinis, 9 parts of Cortex Phellodendris, 1 part of Borneolum Syntheticum.Above-mentioned raw materials is ground into fine powder by proportioning crosses 200 mesh sieves, place 50 ℃ of Oleum Sesami of 6 times of volumes to soak 5 hours the fine powder after sieving, cross leaching oil, cooling gets target product.
External medicine composition is used for 120 routine post-herpetic neuralgia patients' clinical treatment and sums up
1, physical data: treatment group 120 examples, male 76 examples, women 44 examples.Minimum 46 years old of age, maximum 83 years old, average 66.5 years old; The course of disease is the shortest 65 days, and is the longest 62 months, and pathological changes is positioned at Head And Face 38 examples, upper limb 18 examples, back breast abdomen 64 examples.Selected lesions of patients is all fully recovered, without open wound, and equal readme skin lesion place pain endurable.And before treatment, all accepted multiple Comprehensive Treatment.
2, case is selected
2.1 inclusion criteria: pain person was still left in 4 all parts after the clinical skin lesion that meets 5 traditional Chinese medical science disease Standardization of diagnosis and curative effects, 6 diagnosis of herpes zoster standards disappeared.
2.2 exclusion standard: get rid of autoimmune disease, malignant tumor, severe infections etc.
3, Therapeutic Method: along herpes pain band coating, every day 3 times, the person of having an intense pain is every 4 hours coatings 1 time, and 15 days is 1 course for the treatment of, carries out the curative effect statistics after treating continuously 2 courses for the treatment of.
4, observation index: with reference to the criterion of therapeutical effect of herpes zoster in " traditional Chinese medical science disease Standardization of diagnosis and curative effect ", carry out efficacy evaluation according to indexs such as pain disappearing times behind pain, sleep, daily life situation and the each coating.Recovery from illness: pain disappears substantially, and sleep is normal, and the daily life situation is normal; Produce effects: pain obviously alleviates, and sleep, daily life situation are significantly improved; Take a turn for the better: pain relief, sleep, daily life situation slightly are improved; Invalid: pain is not improved, and sleep, the daily life situation is poor.Count effective percentage with recovery from illness, produce effects and improvement.And average pain disappearing time behind the statistics coating.
5, untoward reaction and prognosis: the clinical adverse of patient's changes of vital signs and appearance in the record therapeutic process.And at treatment further consultation in rear 1 year and Effect of follow-up visit by telephone to observe patient's prognosis.
6, therapeutic outcome: when 120 routine patients finished through 2 courses for the treatment of, 86 examples of fully recovering; Produce effects 14; 10 examples take a turn for the better; Invalid 10 examples.Cure rate is 72%, total effective rate 92%.Pain disappearing time is 25 minutes behind each coating.In treatment, there is 1 example the reversibility untoward reaction to occur, main manifestations is the slight erythema of medication local skin, burning sensation, occurs in treatment the 3rd day, reduces the coating number of times and does not do special handling, disappears voluntarily continual cure after 3 days.After 2 course of therapy 1 year, 6 example recurrences are arranged, relapse rate is 5%, but pain degree obviously alleviates before treating, and continuing the medication symptom can very fast alleviation.
Experimental results show that above-mentioned composition still has preferably curative effect with Oleum Arachidis hypogaeae semen, Oleum Glycines, the lixiviate of Semen Flos Carthami wet goods vegetable oil.
Claims (5)
1. external medicine composition for the treatment of post-herpetic neuralgia, it is characterized in that: described compositions is made by following raw materials in part by weight: 10～25 parts of Spina Gleditsiaes, 3～9 parts of Radix Notoginseng, 3～6 parts of Flos Chrysanthemis, 3～6 parts of Folium Perillaes, 3～15 parts of Cortex Lycii, 3～9 parts of Semen Armeniacae Amarums, 3～6 parts of Rhizoma Cimicifugaes, 3～15 parts of Radix Paeoniae Rubra, 3～15 parts of Bufo siccuss, 3～6 parts of Radix Gentianaes, 1～3 part of Periostracum Cicadae, 10～30 parts of calcined Concha Margaritifera, 3～9 parts of Radix Arnebiae (Radix Lithospermi)s, 3～9 parts of Rhizoma Arisaematiss, 3～12 parts of Radix Angelicae Sinensis, 3～15 parts of Cortex Lycii, 3～15 parts of Radix Sophorae Flavescentiss, 3～9 parts of Radix Angelicae Sinensis, 1～3 part of Herba Asari, 3～9 parts of Rhizoma Corydalis, 3～9 parts of Herba Lobeliae Chinensis, 1～3 part of Herba Menthae, 3～15 parts of Cortex Fraxinis, 3～15 parts of Cortex Phellodendris, 0.5～1.0 part of Borneolum Syntheticum.
2. compositions according to claim 1, it is characterized in that: the weight portion proportioning of described raw material is: 15 parts of Spina Gleditsiaes, 6 parts of Radix Notoginseng, 3 parts of Flos Chrysanthemis, 3 parts of Folium Perillaes, 9 parts of Cortex Lycii, 9 parts of Semen Armeniacae Amarums, 6 parts of Rhizoma Cimicifugaes, 9 parts of Radix Paeoniae Rubra, 9 parts of Bufo siccuss, 6 parts of Radix Gentianaes, 3 parts of Periostracum Cicadaes, 20 parts of calcined Concha Margaritifera, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 3 parts of Rhizoma Arisaematiss, 6 parts of Radix Angelicae Sinensis, 9 parts of Cortex Lycii, 9 parts of Radix Sophorae Flavescentiss, 6 parts of Radix Angelicae Sinensis, 3 parts of Herba Asaris, 6 parts of Rhizoma Corydalis, 6 parts of Herba Lobeliae Chinensis, 3 parts of Herba Menthaes, 9 parts of Cortex Fraxinis, 9 parts of Cortex Phellodendris, 1 part of Borneolum Syntheticum.
3. the dosage form of compositions according to claim 1 and 2 is external-use oil preparation, unguentum, liniment, tincture or gel.
4. the preparation method of claim 1 or 2 described compositionss, comprise the steps: that above-mentioned raw materials is ground into fine powder by proportioning crosses 200 mesh sieves, place 50 ℃ of vegetable oil of 6 times of volumes to soak 5 hours the fine powder after sieving, cross leaching oil, cooling gets target product.
5. preparation method according to claim 4 is characterized in that described vegetable oil is Oleum Sesami, Oleum Arachidis hypogaeae semen, Oleum Glycines or safflower oil.
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Cited By (3)
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| CN103705614A (en) * | 2013-12-16 | 2014-04-09 | 李慧 | Traditional Chinese medicine for treating herpes zoster |
| CN103961425A (en) * | 2014-05-16 | 2014-08-06 | 姚学文 | Gentian-arenobufagin herpes diminishing external liquid and application thereof |
| CN105902715A (en) * | 2016-07-13 | 2016-08-31 | 王云龙 | Externally applied traditional Chinese medicine for treating herpes zoster |
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| CN101773651A (en) * | 2010-04-19 | 2010-07-14 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composition for treating headache and preparation method thereof |
| CN102430099A (en) * | 2012-01-04 | 2012-05-02 | 揭静华 | Life-prolonging essence |
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| CN101773651A (en) * | 2010-04-19 | 2010-07-14 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composition for treating headache and preparation method thereof |
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Non-Patent Citations (1)
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705614A (en) * | 2013-12-16 | 2014-04-09 | 李慧 | Traditional Chinese medicine for treating herpes zoster |
| CN103705614B (en) * | 2013-12-16 | 2015-03-25 | 李慧 | Traditional Chinese medicine for treating herpes zoster |
| CN103961425A (en) * | 2014-05-16 | 2014-08-06 | 姚学文 | Gentian-arenobufagin herpes diminishing external liquid and application thereof |
| CN103961425B (en) * | 2014-05-16 | 2016-08-24 | 姚学文 | Dragon toad bleb disappears external use liquid and application thereof |
| CN105902715A (en) * | 2016-07-13 | 2016-08-31 | 王云龙 | Externally applied traditional Chinese medicine for treating herpes zoster |
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| CN103055069B (en) | 2014-04-23 |
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