CN111166803B - Pure traditional Chinese medicine mask for relieving rash related to tumor-targeted medicine and preparation method thereof - Google Patents
Pure traditional Chinese medicine mask for relieving rash related to tumor-targeted medicine and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pure traditional Chinese medicine mask for relieving rash related to tumor-targeted drugs, which comprises the following traditional Chinese medicine components in parts by mass: 30-40 parts of dandelion, 20-30 parts of radix sophorae flavescentis, 15-25 parts of honeysuckle, 15-20 parts of fructus forsythiae, 20-25 parts of radix rehmanniae, 15-20 parts of lithospermum and 10-12 parts of raw liquorice. The invention is designed by the diagnosis of medical experts in oncology, aiming at the characteristics of excessive dampness and heat in the body of a rash patient caused by a targeted medicament and the like, and obtains good effect in early-stage tests. Therefore, the invention is more suitable for the rash caused by the targeted medicament. Because the traditional Chinese medicine ointment is mainly applied to the face of a patient, the long-term effect after treatment must be considered, compared with the traditional hormone and antibacterial ointment, the traditional Chinese medicine ointment is a pure traditional Chinese medicine component, does not cause adverse reactions such as allergy, pigmentation and the like, and can avoid worries of the patient. The invention is easy to be decocted, has low price and is suitable for more patients to use.
Description
Technical Field
The invention relates to a pure traditional Chinese medicine mask for relieving rash related to tumor-targeted drugs and a preparation method thereof.
Background
Currently, targeted therapy for epidermal growth factor brings improvement of curative effect and survival period to more and more tumor patients, but simultaneously, brings side reactions such as rash, mainly manifested as rash/acne-like rash, dry skin, pruritus and the like, bleeding and infection can occur due to careless treatment, the image and comfort of the patients are seriously affected, and meanwhile, interruption of subsequent treatment can also be caused when the rash is serious. At present, hormone and anti-inflammatory ointment are mainly smeared as a relieving means for the part of patients, and side effects such as potential pigmentation exist. The pure traditional Chinese medicine mask is used for relieving the rash and the discomfort of a patient, relieving the psychological burden of the patient, increasing the comfort, increasing the chances for subsequent treatment of the patient and having small safety side effects. Because of the specificity of the patient population and the special mechanism of rash formation, the current facial mask scheme on the market is not designed for the patients, the only similar facial mask is only for the common acne patients, and the research shows that the medicine for the acne type has no effect on the patients, such as the condition that the improper application can aggravate the infection.
At present, a mask aiming at the rash caused by the targeted medicament is not found, only partial mask scheme design aiming at the common acne is provided, the mechanism and the expression of the two are different, the common acne is mostly caused by the exuberant secretion of grease, a T-shaped area is the main part, the rash caused by the targeted medicament is caused by the excessive growth of the epidermis to cause the internal heat and the excessive dampness, although the acne expression exists, the acne expression is dry, itchy and heat in the expression, the area of the rash is wider, the rash can be seen on the whole face, and the degree is heavier.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a pure traditional Chinese medicine mask for relieving rash related to tumor-targeted drugs and a preparation method thereof.
In order to solve the technical problems, the invention provides the following technical scheme:
the invention discloses a pure traditional Chinese medicine mask for relieving rash related to tumor-targeted drugs, which comprises the following traditional Chinese medicine components in parts by weight: 30-40 parts of dandelion, 20-30 parts of radix sophorae flavescentis, 15-25 parts of honeysuckle, 15-20 parts of fructus forsythiae, 20-25 parts of radix rehmanniae, 15-20 parts of lithospermum and 10-12 parts of raw liquorice.
Preferably, the traditional Chinese medicine components in the mask comprise the following components in parts by weight: 30 parts of dandelion, 20 parts of sophora flavescens, 15 parts of honeysuckle, 15 parts of fructus forsythiae, 20 parts of radix rehmanniae, 15 parts of lithospermum and 10 parts of raw liquorice.
Preferably, the traditional Chinese medicine components in the mask comprise the following components in parts by weight: 40 parts of dandelion, 30 parts of sophora flavescens, 25 parts of honeysuckle, 20 parts of forsythia, 25 parts of radix rehmanniae, 20 parts of lithospermum and 12 parts of raw liquorice.
Preferably, the traditional Chinese medicine components in the mask comprise the following components in parts by weight: 35 parts of dandelion, 25 parts of radix sophorae flavescentis, 20 parts of honeysuckle, 18 parts of fructus forsythiae, 22 parts of radix rehmanniae, 18 parts of lithospermum and 11 parts of raw liquorice.
The invention also discloses a preparation method of the pure traditional Chinese medicine mask for relieving the rash related to the tumor-targeted drug, which comprises the following steps:
s1, adding radix sophorae flavescentis, fructus forsythiae, radix rehmanniae, lithospermum and raw liquorice into clear water in proportion, and decocting for 15-25 minutes with strong fire;
s2, adding honeysuckle and dandelion, decocting the honeysuckle and the dandelion together with slow fire for 8-12 minutes, and decocting the mixture to form mask liquid;
and S3, soaking the facial mask paper in the facial mask liquid for 5 minutes, and taking out the facial mask paper.
In step S1, the temperature of the strong fire is 300-380 ℃; in the step S2, the temperature of the slow fire is 150-180 ℃; in step S2, the mask liquid is decocted and filtered through a 50-80 mesh screen.
Preferably, step S2 further includes: and (3) placing the facial mask liquid at room temperature for 1 hour, and then placing at the temperature of 0-5 ℃ for storage.
The Chinese medicine experts look to find out and diagnose the skin rash of the patients caused by internal heat and excessive dampness. In the invention: the dandelion, the honeysuckle, the forsythia, the radix rehmanniae, the lithospermum and the raw liquorice have the effects of clearing heat and removing toxicity, and the efficacies are mutually enhanced in a synergistic way. The dandelion and the radix rehmanniae are monarch drugs, and the dandelion is the most important drug for clearing heat, detoxifying, reducing swelling and dissipating stagnation mainly aiming at heat symptoms, and is beneficial to relieving heat manifestations such as dry itching and heat. The dried rehmannia root plays a role in eliminating dampness and nourishing yin aiming at dampness, and is also beneficial to relieving dryness and itching. The lithospermum is a ministerial drug, has the curative effects of cooling blood and promoting eruption, and is beneficial to promoting the repair of rash. Fructus forsythiae and flos Lonicerae can be used for clearing heat, and radix Sophorae Flavescentis can be used for eliminating dampness. In the invention, the raw licorice is a guiding drug, and mainly plays a role in harmonizing various drugs to enable the drugs to play a role more synergistically and relieve the toxicity and the intensity of other drugs.
The invention has the following beneficial effects:
the invention is designed aiming at the characteristics of in vivo heat, excessive dampness and the like of a rash patient caused by a targeted medicament, and obtains good effect in early-stage tests. Therefore, the invention is more suitable for the rash caused by the targeted medicament. Because the traditional Chinese medicine ointment is mainly applied to the face of a patient, the long-term effect after treatment must be considered, compared with the traditional hormone and antibacterial ointment, the traditional Chinese medicine ointment is a pure traditional Chinese medicine component, does not cause adverse reactions such as allergy, pigmentation and the like, and can avoid worries of the patient. The invention is easy to be decocted, has low price and is suitable for more patients to use.
Drawings
FIG. 1 is a graph showing the rash before and after the application of the mask to patient 1 in this example;
FIG. 2 is a graph showing the rash before and after the application of the mask by patient 2 in this example;
figure 3 is a graph of the rash before and after the patient 3 applied the mask of this example.
Detailed Description
The following description of the preferred embodiments of the present invention is provided for the purpose of illustration and description, and is in no way intended to limit the invention.
Example 1
Adding 20 parts of radix sophorae flavescentis, 15 parts of fructus forsythiae, 20 parts of radix rehmanniae, 15 parts of lithospermum and 10 parts of raw liquorice into 500ml of clear water, decocting the mixture in an earthen pot for 20 minutes by strong fire, then adding 15 parts of honeysuckle and 30 parts of dandelion, decocting the mixture for 10 minutes by slow fire, and finally decocting 150 ml of mask liquid with 200 ml of water. After being left at room temperature for 1 hour, the mixture was stored in a 4 ℃ refrigerator. When in use, 30ml of the facial mask is taken out of a refrigerator and placed in a facial mask bowl, the facial mask paper with good absorption performance is soaked for 5 minutes and taken out, and the facial mask paper is applied to the face for 15-20 minutes 2 times a day. The medicine is used for 1 week.
Example 2
30 parts of radix sophorae flavescentis, 20 parts of fructus forsythiae, 25 parts of radix rehmanniae, 20 parts of lithospermum and 12 parts of raw liquorice are added into 500ml of clear water, after the clear water is decocted for 20 minutes in an earthen pot by strong fire, 25 parts of honeysuckle and 40 parts of dandelion are added, the mixture is decocted for 10 minutes by slow fire, and finally, 200 ml of mask liquid is decocted. After being left at room temperature for 1 hour, the mixture was stored in a 4 ℃ refrigerator. When in use, 30ml of the facial mask is taken out of a refrigerator and placed in a facial mask bowl, the facial mask paper with good absorption performance is soaked for 5 minutes and taken out, and the facial mask paper is applied to the face for 15-20 minutes 2 times a day. The medicine is used for 1 week.
Example 3
Adding 25 parts of radix sophorae flavescentis, 18 parts of fructus forsythiae, 22 parts of radix rehmanniae, 18 parts of lithospermum and 11 parts of raw liquorice into 500ml of clear water, decocting the mixture in an earthen pot for 20 minutes by strong fire, then adding 20 parts of honeysuckle and 35 parts of dandelion, decocting the mixture for 10 minutes by slow fire, and finally decocting 150 ml of mask liquid with 200 ml of water. After being left at room temperature for 1 hour, the mixture was stored in a 4 ℃ refrigerator. When in use, 30ml of the facial mask is taken out of a refrigerator and placed in a facial mask bowl, the facial mask paper with good absorption performance is soaked for 5 minutes and taken out, and the facial mask paper is applied to the face for 15-20 minutes 2 times a day. The medicine is used for 1 week.
In order to verify the effectiveness of the formula, 40 cases of patients who apply targeted drugs such as cetuximab (erbitux) and tyrosine kinase inhibitor (afatinib) in 7-11 months in 2019 are selected, 20 patients are used as a control group and treated by a traditional method (care is taken to prevent sun and preserve moisture, local anti-inflammatory drugs are used when the sun and the moisture are severe), 20 patients are used as a facial mask group, and the facial mask is applied for 2 times per day by applying the formula. Both groups of symptoms and rash were observed and compared 2 weeks after application of the targeted drug. Before intervention, the gender, age, dosing schedule, dosing period of the two groups were comparable. The results after intervention show that the cases of dryness, itching, red swelling, heat, rash existence time, ulceration infection and the like of the mask group are obviously less than those of the control group, and the specific cases are as follows:
comparison of rash in the group of facial masks with that in the control group (after 2 weeks of administration)
Meanwhile, for the mask group itself, the relief is obvious mostly about 1 week of the mask. FIG. 1 is a graph showing the rash before and after the application of the mask to patient 1 in this example; FIG. 2 is a graph showing the rash before and after the application of the mask by patient 2 in this example; figure 3 is a graph of the rash before and after the patient 3 applied the mask of this example. Fig. 1-3 are three patients as examples, which show that the rash of the patients before and after applying the facial mask is obviously improved.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention shall fall within the protection scope of the present invention.
Claims (6)
1. The pure traditional Chinese medicine mask for relieving the rash related to the tumor-targeted medicine is characterized by being prepared from the following traditional Chinese medicine components in parts by mass: 30-40 parts of dandelion, 20-30 parts of radix sophorae flavescentis, 15-25 parts of honeysuckle, 15-20 parts of fructus forsythiae, 20-25 parts of radix rehmanniae, 15-20 parts of lithospermum and 10-12 parts of raw liquorice.
2. The pure traditional Chinese medicine mask for relieving the rash related to the tumor-targeted medicine according to claim 1, which is characterized by being prepared from the following traditional Chinese medicine components in parts by mass: 30 parts of dandelion, 20 parts of sophora flavescens, 15 parts of honeysuckle, 15 parts of fructus forsythiae, 20 parts of radix rehmanniae, 15 parts of lithospermum and 10 parts of raw liquorice.
3. The pure traditional Chinese medicine mask for relieving the rash related to the tumor-targeted medicine according to claim 1, which is characterized by being prepared from the following traditional Chinese medicine components in parts by mass: 40 parts of dandelion, 30 parts of sophora flavescens, 25 parts of honeysuckle, 20 parts of forsythia, 25 parts of radix rehmanniae, 20 parts of lithospermum and 12 parts of raw liquorice.
4. The pure traditional Chinese medicine mask for relieving the rash related to the tumor-targeted medicine according to claim 1, which is characterized by being prepared from the following traditional Chinese medicine components in parts by mass: 35 parts of dandelion, 25 parts of radix sophorae flavescentis, 20 parts of honeysuckle, 18 parts of fructus forsythiae, 22 parts of radix rehmanniae, 18 parts of lithospermum and 11 parts of raw liquorice.
5. A preparation method of the pure traditional Chinese medicine mask for relieving the rash related to the tumor-targeted drug, which is disclosed by any one of claims 1 to 4, is characterized by comprising the following steps of:
s1, adding radix sophorae flavescentis, fructus forsythiae, radix rehmanniae, lithospermum and raw liquorice into clear water in proportion, and decocting for 15-25 minutes with strong fire;
s2, adding honeysuckle and dandelion, decocting the honeysuckle and the dandelion together with slow fire for 8-12 minutes, and decocting the mixture to form mask liquid;
and S3, soaking the facial mask paper in the facial mask liquid for 5 minutes, and taking out the facial mask paper.
6. The preparation method of the pure traditional Chinese medicine mask for relieving the rash related to the tumor targeted drug, according to claim 5, wherein the step S2 further comprises: and (3) placing the facial mask liquid at room temperature for 1 hour, and then placing at the temperature of 0-5 ℃ for storage.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107198718A (en) * | 2017-05-04 | 2017-09-26 | 常州桐树生物科技有限公司 | A kind of Chinese medicine composition of external curing fash and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107198718A (en) * | 2017-05-04 | 2017-09-26 | 常州桐树生物科技有限公司 | A kind of Chinese medicine composition of external curing fash and its preparation method and application |
Non-Patent Citations (3)
| Title |
|---|
| 中医药治疗表皮生长因子受体抑制剂所致皮疹用药分析;居尚等;《河南中医》;20180831;第38卷(第8期);第1271-1274页 * |
| 肺癌靶向药物相关性皮疹的中医治疗及护理研究进展;凡国华等;《护理与康复》;20180930;第17卷(第9期);第42-44页 * |
| 靶向治疗，出现皮疹怎么办？;何裕民;《https://www.sohu.com/a/432325450_364175》;20201117;第1-5页 * |
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