CN104940297B - A kind of Chinese medicine nasal cavity anti-inflammatory preparation and preparation method thereof - Google Patents
A kind of Chinese medicine nasal cavity anti-inflammatory preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine nasal cavity anti-inflammatory preparations and preparation method thereof, belong to technical field of traditional Chinese medicine pharmacy.Chinese medicine nasal cavity anti-inflammatory preparation of the present invention, including following raw material and its mass percent：Xanthohumate 0.1% 20%, honeysuckle 5% 20%, Radix Glycyrrhizae 1% 5%, Fructus Forsythiae 1% 5%, the root of Dahurain angelica 1% 15%, asarum 1% 15%, alstonia-leaf 1% 10%, borneol 1% 5%, peppermint extract 1% 5%, surplus is customary adjuvant.Chinese medicine nasal cavity anti-inflammatory preparation of the present invention can be prepared as nasal mist, gelling agent and nasal drop, local treatment nose and nasal sinus portion inflammatory disease.Chinese medicine nasal cavity anti-inflammatory preparation of the present invention has rapid-action, and curative for effect, compliance is good, mild in medicine property and, it is safe and reliable the features such as, facilitate clinical and patient to use.
Description
Technical field
The present invention relates to a kind of Chinese medicine nasal cavity anti-inflammatory preparations and preparation method thereof, belong to technical field of traditional Chinese medicine pharmacy.
Background technology
It is scorching that rhinitis refers to bronchia mucosal caused by virus, bacterium, allergen, various physical and chemical factors and certain systemic diseases
Disease, clinical symptoms are different, and main pathological change is bronchia mucosal hyperemia, swelling, exudation, hyperplasia, atrophy or necrosis etc..Nasosinusitis
Refer to sinus mucosa inflammation.Rhinitis, nasosinusitis are ear nose larynx surgical common disease, frequently-occurring disease, and Yi Fa, difficult radical cure, harm is greatly.Work as influence
When physiology of the nose function, there is respiratory disorder, influence the function and metabolism of its hetero-organization and organ, headache, dizzy, chest occurs
Bored, pectoralgia, apathetic etc., or even cause pulmonary emphysema, pulmonary heart disease, asthma complication.When rhinitis, the prolonged and repeated hair of nasosinusitis
Make, inflammation may diffuse to adjacent organs, tissue, concurrent such as osteomyelitis of frontal bone, retrobulbar neuritis, purulent meningitis, brain
The critical acute disease such as abscess.Domestic and international medical research more confirms that about ninety percent nasopharyngeal carcinoma is caused by rhinitis obstinate deteriorates.
It is more to rhinitis, the therapy of nasosinusitis at present, according to state of an illness difference, relative medicine or laser, micro- can be used
The supplementary means such as wave are treated.Its medicine with Western medicine be it is more, such as：The steroids such as dexamethasone, budesonide, can
The symptoms such as nasal obstruction, sneeze, rhiocnesmus are relieved, for clinical choice drug；The mast cell stabilizers such as nasmil；Chlorpheniramine,
The symptoms such as nasal obstruction, sneeze can be effectively relieved in the antihistamines such as Loratadine；It has concurrently and prevents the effect of medium cell degranulation and anti-H1
The Ketotifen of histamine receptor antagonists effect, anti-allergic effects are strong, and duration of efficacy is long；In addition, some patientss also need for a long time
Use antibiosis extract for treating.Said medicine is mostly palliative, needs to be used for a long time, be discontinued easily rebound, antihistamine, antibiotic and
There is also different degrees of side effect, steroids safety dispute biggers for Ketotifen etc..And the Chinese medicine of rhinitis, nasosinusitis is controlled
It treats there is also many problems, medicine is mostly oral traditional Chinese medicine preparation, and the effective dense of nasal cavity position is reached after oral absorption metabolism
It spends low, works slow, effect unobvious；External used medicine then mostly contain vessel retraction drug Chinese ephedra, in fact it could happen that anxiety, tremble,
The side effects such as headache, insomnia, hectic fever, insanity, epilepsy, apoplexy and cardiovascular system, should not be excessively used for a long time.
The present invention be based on Present clinical drug there are the problem of and Traditional Chinese medical theory, for rhinitis, nasosinusitis
Pathogenesis carries out reasonable formula.
Fulvic acid is the remains by animals and plants, by the decomposition and conversion of microorganism and a system of physical chemistry of the earth
A kind of organic substance that row process is formed and accumulated, containing various active group, such as carboxyl, phenolic hydroxyl group, alcoholic extract hydroxyl group, quinone
Base, carbonyl etc. have multiple biological activities, the applicating history in terms of traditional Chinese medicine long.Domestic and international lot of experiments and
Clinical efficacy shows that Xanthohumate has the remarkable efficacies such as promoting blood circulation and removing blood stasis, anti-inflammatory, antibacterial.
In recent years, mucosa delivery becomes extensive due to that can reach the bioavilability almost equal with intravenously administrable
The treatment new direction of concern is one of the hot spot of current medical preparation research.Nasal mucosa medicine administration is to apply more mucosa delivery
Approach, the bioavilability and maximum plasma concentration absorbed are nearly identical to be injected intravenously, have：Convenient drug administration, compliance
Good, patient can independently voluntarily medication；Drug absorption is rapid, rapid-action；Safety, without pain；Liver first-pass effect is avoided, it can be preferably
The advantages that playing locally or systemically drug effect.
The present invention is based on traditional Chinese medicine theories, are prepared in conjunction with nasal administration new technology using natural traditional Chinese medicine raw material
A kind of Xanthohumate nasal cavity anti-inflammatory preparation（Spray, gelling agent and nasal drop）, local treatment nose, nasal sinus portion inflammation, to add
The fast drug effect time, curative effect of medication is improved, reduce adverse reaction, clinical and patient is facilitated to use, there are preferable market prospects.
Invention content
The Chinese medicine nasal cavity of the local treatment nose, nasal sinus portion inflammation that the purpose of the present invention is to provide a kind of containing Xanthohumate
Anti-inflammatory preparation, including following raw material and its mass percent：Xanthohumate 0.1%-20%, honeysuckle 5%-20%, Radix Glycyrrhizae 1%-5%,
Fructus Forsythiae 1%-5%, root of Dahurain angelica 1%-15%, asarum 1%-15%, alstonia-leaf 1%-10%, borneol 1%-5%, peppermint extract 1%-5%, surplus are
Customary adjuvant.
The preparation method of Chinese medicine nasal cavity anti-inflammatory preparation of the present invention, specifically includes following steps：
（1）Weigh honeysuckle, Radix Glycyrrhizae, Fructus Forsythiae, the root of Dahurain angelica, asarum, alstonia-leaf, borneol be put into container add water to cook it is secondary,
0.5 ~ 2h is decocted every time, and extracting solution filtration is concentrated under reduced pressure into 1g crude drugs/ml extracting solutions；
（2）1 ~ 2h is placed at room temperature, adds pure water mixing, wherein the volume that pure water is added is 2-3 times of extracting liquid volume, it will
The pH of solution is adjusted to 5.5-6.5, filters；Activated carbon is added in filtrate, wherein the quality of activated carbon is filtrate quality
0.5%-0.8% boils 15-30min after stirring evenly, and is filtered again when letting cool to 50 DEG C, and 1 ~ 2h is set in the decentralization of filtrate room temperature, is carried
Take liquid；
（3）By step（2）Obtained extracting solution is mixed and stirred for uniformly, being added conventional with Xanthohumate, peppermint extract
Auxiliary material is produced in conventional fashion as the anti-inflammatory spray of part nasal cavity, gelling agent and nasal drop.
When Chinese medicine nasal cavity anti-inflammatory preparation is prepared as spray or nasal drop, the component and mass percent of customary adjuvant
For：Preservative 0.01%-5%, pH adjusting agent 0-5%, sorbefacient 0.01%-2%, surplus are pure water.
When Chinese medicine nasal cavity anti-inflammatory preparation is prepared as gelling agent, the component and mass percent of customary adjuvant are：Preservative
0.01%-5%, gel-type vehicle 0.5%-20%, moisturizer 1-10%, pH adjusting agent 0-5%, sorbefacient 0.01%-2%, surplus are
Pure water.
The preservative is one or more of benzalkonium chloride, ethyl hydroxy benzoate, benzyl carbinol, EDTA.
The pH adjusting agent is one or more of triethanolamine, sodium hydroxide, potassium hydroxide, borax.
The sorbefacient be cholic acid salt, fitter acids and its ester class, glycoside, one kind in polyethenoxy ether class or
It is several.
The gel-type vehicle is carbomer, chitosan, cellulose derivative, polyvinyl alcohol, polyoxyethylene, alginic acid
The one or more of sodium, xanthans, beta-cyclodextrin.
The moisturizer is one or more of sorbierite, glycerine, propylene glycol.
Xanthohumate of the present invention is SODLUM FULVATE or potassium fulvate, and commercially available quality standard meets medical requirement
SODLUM FULVATE or potassium fulvate, or by medical xanthonumic acid and H2O2Catalyzing oxidizing degrading legal system obtains fulvic acid（Such as：With reference to Shen
It please number 200810233669.X " method that oxidation and degradation of brown coal produces humic acid and its salt "）Obtained by adjusting PH with base to 7-8.
Traditional Chinese medicine, which is particular about, sincerely to be examined negative and positive place and adjusts it, is scheduled to last with flat, middle disease is to stop, and focuses on integral syndrome differentiation opinion and controls；This hair
Bright to be based on traditional Chinese medicine theory, reasonable formula, each Chinese medicine material pharmacological effect is：Xanthohumate have it is promoting blood circulation and removing blood stasis, anti-inflammatory,
The remarkable efficacies such as antibacterial play anti-inflammatory, convergence, antibacterial action；Honeysuckle is clearing heat and detoxicating, thoroughly evil outgoing；The root of Dahurain angelica, Fructus Forsythiae wind-dispelling remove
It is wet, sensible analgesic, detumescence and apocenosis；Asarum wind-expelling pain-stopping, warm lung are sensible；Alstonia-leaf anti-inflammatory analgesic；The borneol open hole powder stasis of blood, anti-inflammatory stop
Bitterly；Radix Glycyrrhizae relieving spasm to stop pain, invigorating middle warmer and replenishing QI；Peppermint extract wind-dispelling heat-dissipating, head clearing, soothing the liver promoting the circulation of qi.To nose, sinus portion inflammation
It is significant in efficacy, it can not only treat the nose caused by virus, bacterium, allergen, various physical and chemical factors and certain systemic diseases
Chamber, sinus mucosa inflammation also have good medical treatment effect to the patients such as apathetic caused by prolonged illness, headache, uncomfortable in chest.
Chinese medicine nasal cavity anti-inflammatory preparation of the present invention can spray passes through nasal-cavity administration with the form of collunarium.
Beneficial effects of the present invention are：
（1）The present invention is based on Present clinical drug there are the problem of and Traditional Chinese medical theory, for the hair of rhinitis, nasosinusitis
Anttdisease Mechanism carries out reasonable formula, using natural traditional Chinese medicine raw material：It is Xanthohumate, honeysuckle, peppermint extract, Radix Glycyrrhizae, Fructus Forsythiae, white
The ingredients such as the root of Dahurian angelica, asarum, alstonia-leaf, borneol；It is significant in efficacy to nose, sinus portion inflammation, it can not only treat by virus, bacterium, allergic effect
Nasal cavity, sinus mucosa inflammation, also wither to spirit caused by prolonged illness caused by former, various physical and chemical factors and certain systemic diseases
The patients such as wasting, have a headache, is uncomfortable in chest has good medical treatment effect.
（2）Main pharmacodynamics substance Xanthohumate in the present invention, containing various active group, such as carboxyl, phenolic hydroxyl group, alcohol hydroxyl
Base, quinonyl, carbonyl etc. have multiple biological activities, the applicating history in terms of traditional Chinese medicine long.It resists with powerful
It is scorching, impervious go out, antibacterial the effects that, with rhinitis, nasosinusitis often use medicine steroids, antihistamine, antibiotic and
Ketotifen etc. is compared, not only significant in efficacy, and safe, non-stimulated.
（3）Mucosa delivery is by the treatment new direction of extensive concern, is one of the hot spot of current medical preparation research, and nose is viscous
Film administration is to apply more mucosal delivery options, is had：Convenient drug administration, compliance is good, and patient can independently voluntarily medication；Drug
It absorbs rapidly, it is rapid-action；Safety, without pain；Liver first-pass effect is avoided, it is excellent can preferably to play locally or systemically drug effect etc.
Point.The present invention is based on traditional Chinese medicine theories, using natural traditional Chinese medicine raw material, in conjunction with nasal administration new technology, local treatment
Nose, nasal sinus portion inflammation, rapid-action, curative for effect, compliance is good, mild in medicine property and, securely and reliably, clinical and patient is facilitated to make
With.
（4）Drug of the present invention is natural component, cheap and easy to get, and preparation process is easy, easy to use, dosage
Accurately, a kind of comparatively ideal part Chinese medicine nasal cavity anti-inflammatory preparation is provided for clinic.
Specific implementation mode
With reference to embodiment, invention is further described in detail, but the scope of the present invention be not limited to it is described
Content.
Agents useful for same is conventional commercial reagent unless otherwise specified or the reagent for preparing according to a conventional method in embodiment, is made
Method is conventional method unless otherwise specified.
Embodiment 1
Chinese medicine nasal cavity anti-inflammatory preparation described in the present embodiment includes following raw material and its mass percent：Xanthohumate 0.1%,
Honeysuckle 20%, Radix Glycyrrhizae 5%, Fructus Forsythiae 2%, the root of Dahurain angelica 15%, asarum 10%, alstonia-leaf 1%, borneol 5%, peppermint extract 1%, surplus are normal
Advise auxiliary material.
The preparation method of Chinese medicine nasal cavity anti-inflammatory preparation of the present invention, specifically includes following steps：
（1）Weigh honeysuckle, Radix Glycyrrhizae, Fructus Forsythiae, the root of Dahurain angelica, asarum, alstonia-leaf, borneol be put into container add water to cook it is secondary,
0.5h is decocted every time, and extracting solution filtration is concentrated under reduced pressure into 1g crude drugs/ml extracting solutions；
（2）1h is placed at room temperature, and it is 2 times of extracting liquid volume to add pure water mixing, the volume of pure water, adds sodium hydroxide will be molten
The pH of liquid is adjusted to 5.5, filters, activated carbon is added in filtrate（The quality of activated carbon is the 0.5% of filtrate quality）, stir evenly
After boil 15min, filtered again when letting cool to 50 DEG C, the decentralization of filtrate room temperature sets 1 h and obtains extracting solution；
（3）Said extracted liquid is mixed with recipe quantity SODLUM FULVATE/sylvite, peppermint extract, and mass percent is added and is
0.01%-5% ethyl hydroxy benzoates, mass percent are the glycerine of 0.01%-2%, and stirring, mixing stand 24 hours, filtering, repeated hydrogenation
Sodium oxide molybdena tune pH value adds pure water to 500ml to 6.5-7.5, filling to obtain spray, every bottle of 10ml liquid.
Usage and dosage：External spray nose sprays a 2-3 per side nostril every time and presses, 2-3 times on the one.
Embodiment 2
Chinese medicine nasal cavity anti-inflammatory preparation described in the present embodiment includes following raw material and its mass percent：Xanthohumate 10%, gold
Honeysuckle flower 12%, Radix Glycyrrhizae 1%, Fructus Forsythiae 5%, the root of Dahurain angelica 10%, asarum 1%, alstonia-leaf 5%, borneol 3%, peppermint extract 5%, surplus are conventional
Auxiliary material.
The preparation method of Chinese medicine nasal cavity anti-inflammatory preparation of the present invention, specifically includes following steps：
（1）Weigh honeysuckle, Radix Glycyrrhizae, Fructus Forsythiae, the root of Dahurain angelica, asarum, alstonia-leaf, borneol be put into container add water to cook it is secondary,
1h is decocted every time, and extracting solution filtration is concentrated under reduced pressure into 1g crude drugs/ml extracting solutions；
（2）1.5h is placed at room temperature, and it is 3 times of extracting liquid volume to add pure water mixing, the volume of pure water, adds potassium hydroxide will
The pH of solution is adjusted to 6, filters, activated carbon is added in filtrate（The quality of activated carbon is the 0.7% of filtrate quality）, stir evenly
After boil 20min, filtered again when letting cool to 50 DEG C, the decentralization of filtrate room temperature sets 1.5h and obtains extracting solution；
（3）Said extracted liquid is mixed with recipe quantity SODLUM FULVATE/sylvite, peppermint extract, and mass percent is added and is
The benzalkonium chloride of 0.01%-5%, the 0.01%-2% cholyltaurine salt that mass percent is are stirred, are mixed, and stand 24 hours, filtering,
Again plus part borax tune pH value is to 6.5-7.5, adds pure water to 500ml, filling to obtain nasal drop, every bottle of 10ml liquid.
Usage and dosage：Collunarium drips 2-4 drops, 3-5 times daily, 7 days as one therapeutic course per side nostril every time.
Embodiment 3
Chinese medicine nasal cavity anti-inflammatory preparation described in the present embodiment includes following raw material and its mass percent：Xanthohumate 20%, gold
Honeysuckle flower 5%, Radix Glycyrrhizae 3%, Fructus Forsythiae 1%, the root of Dahurain angelica 1%, asarum 15%, alstonia-leaf 10%, borneol 1%, peppermint extract 3%, surplus are conventional
Auxiliary material.
The preparation method of Chinese medicine nasal cavity anti-inflammatory preparation of the present invention, specifically includes following steps：
（1）Weigh honeysuckle, Radix Glycyrrhizae, Fructus Forsythiae, the root of Dahurain angelica, asarum, alstonia-leaf, borneol be put into container add water to cook it is secondary,
2h is decocted every time, and extracting solution filtration is concentrated under reduced pressure into 1g crude drugs/ml extracting solutions；
（2）2h is placed at room temperature, and it is 2 times of extracting liquid volume to add pure water mixing, the volume of pure water, adds triethanolamine will be molten
The pH of liquid is adjusted to 6.5, filters, activated carbon is added in filtrate（The quality of activated carbon is the 0.8% of filtrate quality）, stir evenly
After boil 30min, filtered again when letting cool to 50 DEG C, the decentralization of filtrate room temperature sets 2 h and obtains extracting solution；
（3）It is prepared by -930 gel of carbomer：The carbomer powder for taking 0.5%-20% adds pure water to stand 24 hours, it is made to fill
Divide swelling；
（4）Extracting solution is mixed with recipe quantity SODLUM FULVATE/sylvite, peppermint extract, and addition mass percent is 0.01%-
5% EDTA, mass percent are the sodium laurate of 0.01%-2%, are stirred evenly；It is solidifying to be added slowly with stirring Carbomer-940
Gel matrix is added the sorbierite that mass percent is 1-10%, is stirred, then adds part triethanolamine tune pH value to 6.5-
7.5, add pure water to 500ml, it is filling, obtain gelling agent, every 10g.
Usage and dosage：External application, each extrusion in every side nasal cavity and make it be uniformly distributed a little, 2-3 times on the one.
Embodiment 4
The anti-inflammatory zoopery of the anti-inflammatory spray of Xanthohumate nasal cavity
The present embodiment is anti-inflammatory using mice caused by dimethylbenzene xylene ear swelling experimental check Xanthohumate nasal cavity of the present invention
The anti-inflammatory activity of spray acts on.
The experiment material used in the present embodiment is as follows：
（1）Xanthohumate：Using lignite H2O2Catalyzing oxidizing degrading method, which is prepared and purified, is made fulvic acid（Method is with reference to Shen
It please number 200810233669.X " method that oxidation and degradation of brown coal produces humic acid and its salt "）, obtained by adjusting PH with base to 7-8.
（2）Experimental animal：Healthy male mice in kunming 40, weight 18-22g is randomly divided into four groups, every group 10.
（3）It is prepared by experimental drug：
It weighs recipe quantity honeysuckle, Radix Glycyrrhizae, Fructus Forsythiae, the root of Dahurain angelica, asarum, alstonia-leaf, borneol Chinese medicine material to be put into container, add
6-10 times measure water decoct it is secondary, it is 0.5-2 hour each, extracting solution filter, be concentrated under reduced pressure into 1g crude drugs/ml extracting solutions；
Room temperature is placed, adds 2-3 times of volume pure water mixing, pH5.5-6.5 is adjusted to recipe quantity pH adjusting agent, is filtered, filtrate
Activated carbon is added by the weight of 0.5%-0.8%, boils 15-30 minutes, is filtered again when letting cool to 50 DEG C, holding chamber after stirring evenly
Temperature；Said extracted liquid is mixed with recipe quantity Xanthohumate, peppermint extract, is stirred evenly, and pharmacy customary adjuvant is added, routinely
Technique is prepared as the anti-inflammatory spray of part nasal cavity.
（4）Experiment packet：
Blank control group（Bare substrate group）；Positive controls（Containing 0.5% aspirin）；Potassium fulvate formulation samples group
（Containing 0.5% SODLUM FULVATE potassium）；SODLUM FULVATE formulation samples group（Containing 0.5% SODLUM FULVATE）.
Concrete operations are as follows：40 microlitres of dimethylbenzene are applied with micro sample adding appliance at every mouse right ear of each group, left ear is not done
Any processing.Start to be administered after causing inflammation 15min.Every mouse is administered 0.1ml/ times, is administered 2 times.It is put to death after cause inflammation 90min small
Mouse cuts ears, is punched in same position with internal diameter 6mm card punch, takes auricle to be placed in assay balance and weigh.Data carry out t inspections
It tests.It the results are shown in Table 1.
Swelling=auris dextra weight-left ear weight,
Inhibiting rate %=（The blank group swelling-that is averaged is averaged swelling）/ blank group is averaged swelling * 100%
1 different experiments group paraxylene of table causes the influence of mice ear（N=10,±s）
In table：Compared with blank group, * indicates P<0.05, there is statistical significance.
The experimental results showed that the anti-inflammatory spray group of Xanthohumate nasal cavity and aspirin positive controls can obviously inhibit
Dimethylbenzene induced mice ear swelling Ii _ i_iLLci _ i_ model has apparent anti-inflammatory effect, wherein：Potassium fulvate formulation samples group and Ah
Department woods positive controls effect is close, and the effect of SODLUM FULVATE formulation samples group is better than aspirin positive controls, can play
Powerful anti-inflammatory effect.This for Xanthohumate nasal cavity anti-inflammatory preparation clinical treatment nose, nasal sinus portion inflammation provide pharmacology according to
According to.
Claims (5)
1. a kind of Chinese medicine nasal cavity anti-inflammatory preparation, which is characterized in that be prepared by following raw material and its mass percent：Fulvic acid
Salt 0.1%-20%, honeysuckle 5%-20%, Radix Glycyrrhizae 1%-5%, Fructus Forsythiae 1%-5%, root of Dahurain angelica 1%-15%, asarum 1%-15%, alstonia-leaf 1%-
10%, borneol 1%-5%, peppermint extract 1%-5%, surplus is customary adjuvant.
2. the preparation method of Chinese medicine nasal cavity anti-inflammatory preparation described in claim 1, which is characterized in that specifically include following steps：
（1）Weigh honeysuckle, Radix Glycyrrhizae, Fructus Forsythiae, the root of Dahurain angelica, asarum, alstonia-leaf, borneol be put into container add water to cook it is secondary, every time
0.5 ~ 2h is decocted, extracting solution filtration is concentrated under reduced pressure into 1g crude drugs/ml extracting solutions；
（2）1 ~ 2h is placed at room temperature, adds pure water mixing, wherein the volume that pure water is added is 2-3 times of extracting liquid volume, by solution
PH be adjusted to 5.5-6.5, filter, activated carbon is added in filtrate, wherein the quality of activated carbon be filtrate quality 0.5%-
0.8%, 15-30min is boiled after stirring evenly, is filtered again when letting cool to 50 DEG C, 1 ~ 2h is set in the decentralization of filtrate room temperature, obtains extracting solution；
（3）By step（2）Obtained extracting solution is mixed and stirred for uniformly, customary adjuvant being added with Xanthohumate, peppermint extract,
It is produced in conventional fashion as the anti-inflammatory spray of part nasal cavity, gelling agent and nasal drop.
3. the preparation method of Chinese medicine nasal cavity anti-inflammatory preparation according to claim 2, it is characterised in that：When Chinese medicine nasal cavity is anti-inflammatory
When preparation is prepared as spray or nasal drop, the component and mass percent of customary adjuvant are：Preservative 0.01%-5%, pH
Conditioning agent 0-5%, sorbefacient 0.01%-2%, surplus are pure water.
4. the preparation method of Chinese medicine nasal cavity anti-inflammatory preparation according to claim 2, it is characterised in that：When Chinese medicine nasal cavity is anti-inflammatory
When preparation is prepared as gelling agent, the component and mass percent of customary adjuvant are：Preservative 0.01%-5%, gel-type vehicle 0.5%-
20%, moisturizer 1-10%, pH adjusting agent 0-5%, sorbefacient 0.01%-2%, surplus are pure water.
5. the preparation method of Chinese medicine nasal cavity anti-inflammatory preparation according to claim 3 or 4, it is characterised in that：The preservative
For one or more of benzalkonium chloride, ethyl hydroxy benzoate, benzyl carbinol, EDTA；The pH adjusting agent is triethanolamine, hydroxide
One or more of sodium, potassium hydroxide, borax；The sorbefacient is cholic acid salt, fitter acids and its ester class, glucosides
One or more of class, polyethenoxy ether class；The gel-type vehicle is carbomer, chitosan, cellulose derivative, poly- second
The one or more of enol, polyoxyethylene, sodium alginate, xanthans, beta-cyclodextrin；The moisturizer is sorbierite, glycerine, third
One or more of glycol.
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| CN105963347A (en) * | 2016-05-27 | 2016-09-28 | 昆明理工大学 | Traditional Chinese medicine preparation for treating throat inflammation |
| CN105998481A (en) * | 2016-06-20 | 2016-10-12 | 昆明理工大学 | Chinese herbal medicine compound preparation for relieving cough and eliminating phlegm and preparation method thereof |
| CN107951930A (en) * | 2017-11-30 | 2018-04-24 | 海南金香远药业科技有限公司 | It is a kind of to be used to treat spray of allergic rhinitis and preparation method thereof |
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| CN1488368A (en) * | 2002-10-09 | 2004-04-14 | 冯肖滨 | Medicine for treating nasitis |
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| CN1488368A (en) * | 2002-10-09 | 2004-04-14 | 冯肖滨 | Medicine for treating nasitis |
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| Title |
|---|
| 黄腐酸钠抗炎作用的初步研究;陈霞等;《白求恩医科大学学报》;19970831;第23卷(第4期);361-362 * |
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