CN1915371A - Medication for treating burn and scald, frostbite, and preparation method - Google Patents
Medication for treating burn and scald, frostbite, and preparation method Download PDFInfo
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Abstract
A Chinese medicine for treating burn, scald and cold injury is prepared from the oil of plant or animal, and 9 Chinese-medicinal materials including Chinese angelica root, arnebia root, sanguisorba root, myrrh, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to treat frosted medicine of burn and scald and preparation method thereof, particularly relating to a kind of is the frosted medicine of treatment burn and scald and preparation method thereof of feedstock production with the Chinese herbal medicine.
Background technology
Burn and scald is one of commonly encountered diseases of surgery, and therefore, the medicine that is used for the treatment of burn and scald also is of a great variety, but curative effect exists than big-difference, and wherein curative effect is comparatively outstanding silver sulfadiazine (Sulfadiazine Silver) and moist expose burn ointment.
Silver sulfadiazine is external-use burn medicine commonly used, to I, II degree burn and scald: with 1-2% ointment coating wound surface, changed dressings 1 time in 1-2 days; To III degree burn and scald: with 1-2% ointment coating wound surface.After the medication, the aggressive infection rate that causes because of the shallow II of large tracts of land, dark III degree burn obviously descends, this medicine can make burn wound's transudate obviously reduce, wound surface is dry, but the antibacterial that does not kill fully still can go into blood, thereby patient's toxemic symptoms is obvious, the intractable hyperpyrexia often occurs, and price is comparatively expensive.In addition, after dark II and III degree fire victim medication, it is also very slow that eschar is separated, and gerontal patient's incrustation needed just can come off sometimes in 2-3 month.
Moist expose burn ointment to shallow II and deep ii degree burn analgesic effect a little less than, though the patient feels comfortable behind the topical agent, should not wrap up, and the misconvergence effect, anti-infection ability is poor, thereby causes traumatic infection, and is restive; In addition, a little less than the exudation effect of this medicine, hypovolemic shock incidence rate after patient's medication rises, and wound surface often forms III degree and chronic inflammatory disease wound surface because of can not in time healing, thereby the course of disease is prolonged, increased treat difficult.
Based on the weak point of existing treatment burn and scald medicine, press for a kind of determined curative effect, have antiinflammatory, pain relieving and promoting muscle growth functions concurrently, and treatment cycle is short, the medicine of non-pigmented treatment burn and scald.
Cold injury is to have seasonality, regional commonly encountered diseases, but because this disease is violated when freezing, warm fashion, thereby its treatment is often out in the cold also presses for a kind of good effect, cold injury medicine that cure rate is high.
Summary of the invention
The frosted medicine of treatment burn and scald that the purpose of this invention is to provide a kind of determined curative effect.
For achieving the above object, the present invention takes following design: the frosted medicine of a kind of treatment burn and scald, and its composition and effectiveness is to be made by the raw material that comprises following ratio of weight and number: Radix Angelicae Sinensis 150-250 part, Radix Arnebiae (Radix Lithospermi) 100-200 part, Radix Ampelopsis 20-30 part, Radix Sanguisorbae 25-35 part, Fructus Schisandrae Chinensis 25-35 part, Olibanum 30-40 part, Myrrha 30-40 part, Membrana Follicularis ovi 20-30 part, Borneolum Syntheticum 35-45 part, animal and vegetable oil 2000-3000 part.
The selection of the described animal and vegetable oil in the prescription is diversified, all is fine such as Oleum sesami (Oleum sesami), Oleum Glycines, olive oil, Oyster sauce or Adeps melis, wherein is preferably Oleum sesami.What animal and vegetable oil mainly play is the substrate effect, certainly also has the effect of certain moistening, protection wound surface.
In order to strengthen the curative effect of medicine of the present invention, also can comprise the composition of following portions by weight ratio in the pharmaceutical formulation of the present invention: Herba Artemisiae Anomalae 20-30 part, Caulis Lonicerae 15-25 part.
In order further to strengthen the curative effect of medicine of the present invention, also can comprise the crude drug of following portions by weight ratio in its prescription: Radix Et Rhizoma Rhei 20-30 part, Sanguis Draxonis 15-25 part, Radix Angelicae Dahuricae 15-25 part, Rhizoma Coptidis 15-25 part, Radix Astragali 15-25 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-30 part, Radix Codonopsis 25-35 part.
In addition, at the comparatively serious patient of the state of an illness, also can comprise the crude drug of following portions by weight ratio in the pharmaceutical formulation of the present invention: Corium elephatis 15-25 part, Radix Glycyrrhizae 15-25 part.
For the form that makes medicine of the present invention more helps using, can comprise also in the pharmaceutical formulation of the present invention that ratio of weight and number is the Cera Flava of 450-550 part.
The preferred parts by weight proportioning of each crude drug is in the composition and effectiveness of medicine of the present invention: 200 parts of Radix Angelicae Sinensis, 150 parts of Radix Arnebiae (Radix Lithospermi)s, 25 parts of Radix Ampelopsis, 30 parts of Radix Sanguisorbaes, 30 parts of Fructus Schisandrae Chinensis, 35 parts of Olibanums, 35 parts of Myrrhas, 25 parts of Herba Artemisiae Anomalaes, 25 parts of Radix Et Rhizoma Rhei, 20 parts of Sanguis Draxonis, 20 parts of the Radixs Angelicae Dahuricae, 20 parts of Caulis Loniceraes, 20 parts of Rhizoma Coptidis, 25 parts of Membrana Follicularis ovis, 20 parts of Corium elephatiss, 20 parts in Radix Glycyrrhizae, 20 parts of the Radixs Astragali, 25 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 30 parts of Radix Codonopsis, 40 parts of Borneolum Syntheticums, 500 parts in Cera Flava, 2500 parts of animal and vegetable oil.
When needing, can also add one or more acceptable accessories in said medicine, described adjuvant comprises diluent, excipient, filler, binding agent, wetting agent, absorption enhancer, surfactant, lubricant or the stabilizing agent etc. of pharmaceutical field routine.
This medicine can be made the medicament forms that unguentum, Emulsion, powder etc. are suitable for external, and wherein, unguentum is preferred dosage form.
Said medicine can directly be applied in the wound or the cold injury position of skin in use, changes dressings once in general 1-3 days, and 6-12 days is a course of treatment.
Second purpose of the present invention provides a kind of method for preparing above-mentioned unguentum treatment burn and scald cold injury medicine.
Preparation method provided by the present invention may further comprise the steps:
1) gets material by following parts by weight proportioning: Radix Angelicae Sinensis 150-250 part, Radix Arnebiae (Radix Lithospermi) 100-200 part, Radix Ampelopsis 20-30 part, Radix Sanguisorbae 25-35 part, Fructus Schisandrae Chinensis 25-35 part, Olibanum 30-40 part, Myrrha 30-40 part, Herba Artemisiae Anomalae 20-30 part, Radix Et Rhizoma Rhei 20-30 part, Sanguis Draxonis 15-25 part, Radix Angelicae Dahuricae 15-25 part, Caulis Lonicerae 15-25 part, Rhizoma Coptidis 15-25 part, Membrana Follicularis ovi 20-30 part, Corium elephatis 15-25 part, Radix Glycyrrhizae 15-25 part, Radix Astragali 15-25 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-30 part, Radix Codonopsis 25-35 part, Borneolum Syntheticum 35-45 part, Cera Flava 450-550 part, animal and vegetable oil 2000-3000 part;
2) with animal and vegetable oil the group's medicine except that Borneolum Syntheticum and Cera Flava was soaked slow fire boiling 10-60 minute then 12-48 hour;
3) filter, collect filtrate, add Borneolum Syntheticum and Cera Flava, stir, cooling, the frosted medicine of the burn and scald that obtains medical treatment.
In manufacturing method for above mentioned medicine, the animal and vegetable oil in the step 1) can be Oleum sesami, Oleum Glycines, olive oil, Oyster sauce or Adeps melis etc., is preferably Oleum sesami.
Step 2) soak time in is preferably 24 hours.
The present invention is on the basis of motherland's traditional medicine, in conjunction with the clinical research of modern medicine to burn and scald cold injury treatment aspect, and with reference to the modern pharmacology achievement in research, to heat-clearing and toxic substances removing, pain relieving blood stasis dispelling, the antiinflammatory convergence that filters out, the Chinese herb medicine reasonable compatibility of consolidating skin granulation promoting and Glycerin, the frosted Chinese Traditional Medicines of a kind of treatment burn and scald have been obtained.Radix Angelicae Sinensis in this pharmaceutically active ingredient has the effect of promoting blood circulation and stopping pain; Radix Arnebiae (Radix Lithospermi) has removing heat from blood, invigorates blood circulation, the effect of detoxifcation rash; Radix Ampelopsis has heat-clearing and toxic substances removing, the effect of eliminating carbuncle eliminating stagnation; Radix Sanguisorbae has cooling blood for hemostasis, and the effect of skin ulcer is held back in detoxifcation, can reduce the permeability of blood capillary, and minimizing is oozed out, and alleviates tissue edema, and can suppress the growth of antibacterial, the generation of protecting from infection; Fructus Schisandrae Chinensis has antimicrobial effect; Olibanum has invigorates blood circulation, analgesic therapy, detumescence, the effect of granulation promoting; Myrrha has the effect of promoting blood circulation and stopping pain; Herba Artemisiae Anomalae has hemostasis, and the effect of skin ulcer is held back in detumescence; Radix Et Rhizoma Rhei has antibiotic, antiviral and eliminate endotoxic effect; Sanguis Draxonis has promoting blood circulation to remove blood stasis, analgesic therapy, hemostasia and promoting granulation and the effect of holding back skin ulcer; The Radix Angelicae Dahuricae has diffusing wind dehumidifying, understand things pain-stopping, the effect of detumescence and apocenosis; Caulis Lonicerae has heat-clearing and toxic substances removing, the effect of anti-inflammation and sterilization; Rhizoma Coptidis has heat clearing and damp drying, the effect of eliminating fire and detoxication; Membrana Follicularis ovi has the effect of heat clearing and damp drying; Corium elephatis has hemostasis, holds back the effect of skin ulcer; Radix Glycyrrhizae has the effect of heat-clearing and toxic substances removing; The Radix Astragali has invigorating QI to consolidate the body surface resistance, the effect of diuresis poison holding and evacuation of pus; The Pseudobulbus Bletillae (Rhizoma Bletillae) has tonifying the lung hemostasis, the effect of detumescence and promoting granulation; Radix Codonopsis has invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting; Borneolum Syntheticum has removing the necrotic tissue and promoting granulation, the effect of anti-inflammatory analgetic.Clinical test results shows, this medicine all has significant curative effect to diseases such as burn, scald, cold injury, wound (hindering as knife injury, scratch, traumatic injury), ulcer, erosion and decubital ulcers, and has medication conveniently, need not skin-grafting, short treating period, instant effect, effect is lasting, no cicatrix is difficult for recurrence, the advantage of no contraindication and toxic and side effects.In thousands of burn and scald cold injury cases with the treatment of this medicine, total effective rate reaches 100%, and II degree burn and scald cure rate reaches 99%, and III degree burn and scald cure rate reaches 98.5%, and the cold injury cure rate reaches 99%.In addition, the preparation method of medicine of the present invention is simple, and is with low cost, and each component is common Chinese herbal medicine, when having alleviated patient's slight illness, also can reduce patient's financial burden, thereby be convenient to apply.The present invention will play a great role in the treatment of burn and scald cold injury and relevant disease.
The invention will be further described below in conjunction with specific embodiment.
The specific embodiment
Method therefor is conventional method if no special instructions among the following embodiment.
The preparation and the curative effect thereof of embodiment 1, treatment burn and scald cold injury medicine are identified
One, preparation treatment burn and scald cold injury medicine
The present invention treats the preparation method of burn and scald cold injury medicine, may further comprise the steps:
1) takes by weighing raw material: Radix Angelicae Sinensis 150g, Radix Arnebiae (Radix Lithospermi) 100g, Radix Ampelopsis 20g, Radix Sanguisorbae 25g, Fructus Schisandrae Chinensis 25g, Olibanum 30g, Myrrha 30g, Membrana Follicularis ovi 20g, Borneolum Syntheticum 35g, Oyster sauce 2000g;
2) with Oyster sauce the group's medicine except that Borneolum Syntheticum was soaked slow fire boiling 30 minutes (color is degree of being with golden yellow, does not fry in shallow oil Jiao) then 12 hours;
3) filter, collect filtrate, add Borneolum Syntheticum, stir, cooling, the frosted medicine of the burn and scald that obtains medical treatment seals standby.
Two, curative effect is identified
1, the clinical trial of treatment burn and scald
Three degree quarterings international and that China is general are adopted in the diagnosis of depth of burn, and standard is as follows:
I degree burn: only damage the skin shallow-layer, do not need special handling.
II degree burn (comprising dark II degree, shallow II degree): reach part corium, rely on basal layer cell or skin appendages epithelial cell, promptly reliable self wound repairing of cell need not performed the operation and can be healed.
III degree burn: reach the skin holostrome, comprise the burn of the following various tissues of dark and skin, organ, must adopt skin-grafting to wait surgical wound surface to heal.
Selection is because of the I due to flame, the hot water etc., dark II, shallow II, III degree burn and scald case totally 585 examples, burn and scald cold injury medicine with the step 1 preparation is treated above-mentioned burn and scald patient, be contrast with Scald Ointment and silver sulfadiazine simultaneously, to detect the curative effect of medicine of the present invention to burn and scald.Medication: medicine of the present invention is spread on the burn and scald position outward, every day or the next day change dressings once.Observe conditions of patients every day, and do ASSOCIATE STATISTICS.
The situation of protecting from infection to II, III degree burn and scald case is as shown in table 1, obvious effective rate and cure rate statistical result are as shown in table 2, wherein the statistical result of II degree burn and scald patient healing time is as shown in table 3, burn and scald cold injury medicine of the present invention all has curative effect preferably to I, II, III degree burn and scald, and do not see obvious adverse reaction, moist expose burn ointment and the silver sulfadiazine of being better than evident in efficacy, wherein moist expose burn ointment is poor because of its infection and convergence capabilities, often will add with the antibiotic medicine wound surface and could heal in the course of disease later stage.Chinese medicine and modern pharmacology studies show that, the Radix Angelicae Sinensis that is contained in the medicine of the present invention, Radix Arnebiae (Radix Lithospermi), effective ingredient such as pleased and Borneolum Syntheticum, thereby have multiple efficacies such as Glycerin, heat-clearing and toxic substances removing, pain relieving, convergence, blood stasis dispelling, granulation promoting and solid skin, this medicine is to the wound surface nonirritant, there is not pain, infection rate is low, and is not hemorrhage, and the granulation growth is vigorous, healing is fast, and drug safety does not have any toxicity, side effect, can be used as the drug use for the treatment of burn and scald clinically.
The situation of protecting from infection of table 1 couple II, III degree burn and scald case
| Group | Total routine number | There is not the routine number of infection | Low-grade infection example number | Severe infections example number |
| Moist expose burn ointment | 90 | 31 | 50 | 9 |
| Silver sulfadiazine | 90 | 45 | 41 | 4 |
| Medicine of the present invention | 180 | 152 | 28 | 0 |
Table 2 obvious effective rate and cure rate statistical result
| The I degree | The II degree | The III degree | |||||||||
| Group | The example number | Obvious effective rate | Cure rate | Group | The example number | Obvious effective rate | Cure rate | Group | The example number | Obvious effective rate | Cure rate |
| Moist expose burn ointment | 55 | 100％ | 97％ | Moist expose burn ointment | 50 | 96％ | 70％ | Moist expose burn ointment | 40 | 93％ | 60％ |
| Silver sulfadiazine | 70 | 100％ | 98％ | Silver sulfadiazine | 50 | 97％ | 80％ | Silver sulfadiazine | 40 | 95％ | 78％ |
| Medicine of the present invention | 100 | 100％ | 100％ | Medicine of the present invention | 100 | 100％ | 98％ | Medicine of the present invention | 80 | 100％ | 95％ |
The statistical result of table 3 II degree burn and scald patient healing time
| Group | Total routine number | Shallow II degree (my god) | Average natural law | Dark II degree (my god) | Average natural law |
| Moist expose burn ointment | 50 | 15-25 | 20 | 30-50 | 40 |
| Silver sulfadiazine | 50 | 8-16 | 12 | 25-45 | 35 |
| Medicine of the present invention | 100 | 4-8 | 6 | 20-25 | 22.5 |
2, treat frosted clinical trial
Once choose, two degree, three each 50 example of degree cold injury cases, use the burn and scald cold injury medicine of step 1 preparation treated above-mentioned cold injury patient, to detect medicine of the present invention frosted curative effect.Medication is: after the cold injury position is cleaned, borrow the temperature of infrared ray, electric heater or stove etc., medicine of the present invention is applied in the cold injury position, it is roasting that the limit is close to, and continues 15-30 minute.Medication as a result can take effect the same day, and affected part has that hotness, sufferings disappear, the exposed no sense of cold in the cold wind; Next day sufferings not repeatedly, redness begins to disappear, form a scab gradually in the ulceration place of cold injury degree severe patient.On average once the about 1-4 of cold injury days, two degree cold injury about 3-6 days, the red and swollen ulceration cold injury of three degree can be cured in about 6-10 days.Therapeutic effect is added up, and statistical result shows that up to a hundred per cent, cure rate is also more than 95%, and drug safety, does not have any toxicity, side effect, can be used as and treats frosted drug use clinically with the frosted obvious effective rate of Drug therapy of the present invention.
The preparation and the curative effect thereof of embodiment 2, treatment burn and scald cold injury medicine are identified
One, preparation treatment burn and scald cold injury medicine
The present invention treats the preparation method of burn and scald cold injury medicine, may further comprise the steps:
1) takes by weighing raw material: Radix Angelicae Sinensis 250g, Radix Arnebiae (Radix Lithospermi) 200g, Radix Ampelopsis 30g, Radix Sanguisorbae 35g, Fructus Schisandrae Chinensis 35g, Olibanum 40g, Myrrha 40g, Herba Artemisiae Anomalae 20g, Caulis Lonicerae 15g, Membrana Follicularis ovi 30g, Borneolum Syntheticum 45g, Oleum Glycines 3000g;
2) with Oleum Glycines the group's medicine except that Borneolum Syntheticum was soaked slow fire boiling 40 minutes (color is degree of being with golden yellow, does not fry in shallow oil Jiao) then 24 hours;
3) filter, collect filtrate, add Borneolum Syntheticum, stir, cooling, the frosted medicine of the burn and scald that obtains medical treatment seals standby.
Two, curative effect is identified
1, the clinical trial of treatment burn and scald
With the method identical with embodiment 1 to 605 because of I, dark II, shallow II, III degree burn and scald patient due to flame, the hot water etc. treat with the burn and scald cold injury medicine of step 1 preparation, to detect the curative effect of medicine of the present invention to burn and scald.
The situation of protecting from infection to II, III degree burn and scald case is as shown in table 4, obvious effective rate and cure rate statistical result are as shown in table 5, wherein the statistical result of II degree burn and scald patient healing time is as shown in table 6, burn and scald cold injury medicine of the present invention all has curative effect preferably to I, II, III degree burn and scald, and do not see obvious adverse reaction, moist expose burn ointment and the silver sulfadiazine of being better than evident in efficacy, wherein the curative effect of moist expose burn ointment is the poorest, poor because of its infection and convergence capabilities, often to add with the antibiotic medicine wound surface and could heal in the course of disease later stage.This medicine does not have pain to the wound surface nonirritant, and infection rate is low, and is not hemorrhage, and the granulation growth is vigorous, and healing is fast, and drug safety, does not have any toxicity, side effect, can be used as the drug use for the treatment of burn and scald clinically.
The situation of protecting from infection of table 4 couple II, III degree burn and scald case
| Group | Total routine number | There is not the routine number of infection | Low-grade infection example number | Severe infections example number |
| Moist expose burn ointment | 90 | 31 | 50 | 9 |
| Silver sulfadiazine | 90 | 45 | 41 | 4 |
| Medicine of the present invention | 200 | 175 | 25 | 0 |
Table 5 obvious effective rate and cure rate statistical result
| The I degree | The II degree | The III degree | |||||||||
| Group | The example number | Obvious effective rate | Cure rate | Group | The example number | Obvious effective rate | Cure rate | Group | The example number | Obvious effective rate | Cure rate |
| Moist expose burn ointment | 55 | 100％ | 97％ | Moist expose burn ointment | 50 | 96％ | 70％ | Moist expose burn ointment | 40 | 93％ | 60％ |
| Silver sulfadiazine | 70 | 100％ | 98％ | Silver sulfadiazine | 50 | 97％ | 80％ | Silver sulfadiazine | 40 | 95％ | 78％ |
| Medicine of the present invention | 100 | 100％ | 100％ | Medicine of the present invention | 90 | 100％ | 98.5％ | Medicine of the present invention | 110 | 100％ | 96％ |
The statistical result of table 6 II degree burn and scald patient healing time
| Group | Total routine number | Shallow II degree (my god) | Average natural law | Dark II degree (my god) | Average natural law |
| Moist expose burn ointment | 50 | 15-25 | 20 | 30-50 | 40 |
| Silver sulfadiazine | 50 | 8-16 | 12 | 25-45 | 35 |
| Medicine of the present invention | 90 | 3.5-7.5 | 5.5 | 19-24 | 21.5 |
2, treat frosted clinical trial
Once choose, two degree, three each 60 example of degree cold injury cases, use the method identical that the burn and scald cold injury medicine of step 1 preparation is treated above-mentioned cold injury patient, to detect medicine of the present invention to frosted curative effect with embodiment 1.Medication as a result can take effect the same day, and affected part has that hotness, sufferings disappear, the exposed no sense of cold in the cold wind; Next day sufferings not repeatedly, redness begins to disappear, form a scab gradually in the ulceration place of cold injury degree severe patient.On average once the about 1-3 of cold injury days, two degree cold injury about 3-5 days, the red and swollen ulceration cold injury of three degree can be cured in about 6-8 days.Therapeutic effect is added up, and statistical result shows that up to a hundred per cent, cure rate is also more than 96%, and drug safety, does not have any toxicity, side effect, can be used as and treats frosted drug use clinically with the frosted obvious effective rate of Drug therapy of the present invention.
The preparation and the curative effect thereof of embodiment 3, treatment burn and scald cold injury medicine are identified
One, preparation treatment burn and scald cold injury medicine
The present invention treats the preparation method of burn and scald cold injury medicine, may further comprise the steps:
1) takes by weighing raw material: Radix Angelicae Sinensis 250g, Radix Arnebiae (Radix Lithospermi) 200g, Radix Ampelopsis 30g, Radix Sanguisorbae 35g, Fructus Schisandrae Chinensis 35g, Olibanum 40g, Myrrha 40g, Herba Artemisiae Anomalae 30g, Caulis Lonicerae 25g, Membrana Follicularis ovi 30g, Borneolum Syntheticum 45g, Radix Et Rhizoma Rhei 20g, Sanguis Draxonis 15g, Radix Angelicae Dahuricae 15g, Rhizoma Coptidis 15g, Radix Astragali 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Codonopsis 25g, Oleum sesami 3000g;
2) with Oleum sesami the group's medicine except that Borneolum Syntheticum was soaked slow fire boiling 15 minutes (color is degree of being with golden yellow, does not fry in shallow oil Jiao) then 36 hours;
3) filter, collect filtrate, add Borneolum Syntheticum, stir, cooling, the frosted medicine of the burn and scald that obtains medical treatment seals standby.
Two, curative effect is identified
1, the clinical trial of treatment burn and scald
With the method identical with embodiment 1 to 505 because of I, dark II, shallow II, III degree burn and scald patient due to flame, the hot water etc. treat with the burn and scald cold injury medicine of step 1 preparation, to detect the curative effect of medicine of the present invention to burn and scald.
The situation of protecting from infection to II, III degree burn and scald case is as shown in table 7, obvious effective rate and cure rate statistical result are as shown in table 8, wherein the statistical result of II degree burn and scald patient healing time is as shown in table 9, burn and scald cold injury medicine of the present invention all has curative effect preferably to I, II, III degree burn and scald, and do not see obvious adverse reaction, moist expose burn ointment and the silver sulfadiazine of being better than evident in efficacy, wherein the curative effect of moist expose burn ointment is the poorest, poor because of its infection and convergence capabilities, often to add with the antibiotic medicine wound surface and could heal in the course of disease later stage.This medicine does not have pain to the wound surface nonirritant, and infection rate is low, and is not hemorrhage, and the granulation growth is vigorous, and healing is fast, and drug safety, does not have any toxicity, side effect, can be used as the drug use for the treatment of burn and scald clinically.
The situation of protecting from infection of table 7 couple II, III degree burn and scald case
| Group | Total routine number | There is not the routine number of infection | Low-grade infection example number | Severe infections example number |
| Moist expose burn ointment | 90 | 31 | 50 | 9 |
| Silver sulfadiazine | 90 | 45 | 41 | 4 |
| Medicine of the present invention | 200 | 180 | 20 | 0 |
Table 8 obvious effective rate and cure rate statistical result
| The I degree | The II degree | The III degree | |||||||||
| Group | The example number | Obvious effective rate | Cure rate | Group | The example number | Obvious effective rate | Cure rate | Group | The example number | Obvious effective rate | Cure rate |
| Moist expose burn ointment | 55 | 100％ | 97％ | Moist expose burn ointment | 50 | 96％ | 70％ | Moist expose burn ointment | 40 | 93％ | 60％ |
| Silver sulfadiazine | 70 | 100％ | 98％ | Silver sulfadiazine | 50 | 97％ | 80％ | Silver sulfadiazine | 40 | 95％ | 78％ |
| Medicine of the present invention | 100 | 100％ | 100％ | Medicine of the present invention | 90 | 100％ | 99％ | Medicine of the present invention | 110 | 100％ | 97％ |
The statistical result of table 9 II degree burn and scald patient healing time
| Group | Total routine number | Shallow II degree (my god) | Average natural law | Dark II degree (my god) | Average natural law |
| Moist expose burn ointment | 50 | 15-25 | 20 | 30-50 | 40 |
| Silver sulfadiazine | 50 | 8-16 | 12 | 25-45 | 35 |
| Medicine of the present invention | 90 | 3-7 | 5 | 18-24 | 21 |
2, treat frosted clinical trial
Once choose, two degree, three each 55 example of degree cold injury cases, use the method identical that the burn and scald cold injury medicine of step 1 preparation is treated above-mentioned cold injury patient, to detect medicine of the present invention to frosted curative effect with embodiment 1.Medication as a result can take effect the same day, and affected part has that hotness, sufferings disappear, the exposed no sense of cold in the cold wind; Next day sufferings not repeatedly, redness begins to disappear, form a scab gradually in the ulceration place of cold injury degree severe patient.On average once the about 1-2.5 of cold injury days, two degree cold injury about 3-4.5 days, the red and swollen ulceration cold injury of three degree can be cured in about 6-7.5 days.Therapeutic effect is added up, and statistical result shows that up to a hundred per cent, cure rate is also more than 97%, and drug safety, does not have any toxicity, side effect, can be used as and treats frosted drug use clinically with the frosted obvious effective rate of Drug therapy of the present invention.
The preparation and the curative effect thereof of embodiment 4, treatment burn and scald cold injury medicine are identified
One, preparation treatment burn and scald cold injury medicine
The present invention treats the preparation method of burn and scald cold injury medicine, may further comprise the steps:
1) takes by weighing raw material: Radix Angelicae Sinensis 250g, Radix Arnebiae (Radix Lithospermi) 200g, Radix Ampelopsis 30g, Radix Sanguisorbae 35g, Fructus Schisandrae Chinensis 35g, Olibanum 40g, Myrrha 40g, Herba Artemisiae Anomalae 30g, Caulis Lonicerae 25g, Membrana Follicularis ovi 30g, Borneolum Syntheticum 45g, Radix Et Rhizoma Rhei 30g, Sanguis Draxonis 25g, Radix Angelicae Dahuricae 25g, Rhizoma Coptidis 25g, Radix Astragali 25g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30g, Radix Codonopsis 35g, Corium elephatis 15g, Radix Glycyrrhizae 15g, Oleum sesami 3000g;
2) with Oleum sesami the group's medicine except that Borneolum Syntheticum was soaked slow fire boiling 10 minutes (color is degree of being with golden yellow, does not fry in shallow oil Jiao) then 48 hours;
3) filter, collect filtrate, add Borneolum Syntheticum, stir, cooling, the frosted medicine of the burn and scald that obtains medical treatment seals standby.
Two, curative effect is identified
1, the clinical trial of treatment burn and scald
With the method identical with embodiment 1 to 505 because of I, dark II, shallow II, III degree burn and scald patient due to flame, the hot water etc. treat with the burn and scald cold injury medicine of step 1 preparation, to detect the curative effect of medicine of the present invention to burn and scald.
The situation of protecting from infection to II, III degree burn and scald case is as shown in table 10, obvious effective rate and cure rate statistical result are as shown in table 11, wherein the statistical result of II degree burn and scald patient healing time is as shown in table 12, burn and scald cold injury medicine of the present invention all has curative effect preferably to I, II, III degree burn and scald, and do not see obvious adverse reaction, moist expose burn ointment and the silver sulfadiazine of being better than evident in efficacy, wherein the curative effect of moist expose burn ointment is the poorest, poor because of its infection and convergence capabilities, often to add with the antibiotic medicine wound surface and could heal in the course of disease later stage.This medicine does not have pain to the wound surface nonirritant, and infection rate is low, and is not hemorrhage, and the granulation growth is vigorous, and healing is fast, and drug safety, does not have any toxicity, side effect, can be used as the drug use for the treatment of burn and scald clinically.
The situation of protecting from infection of table 10 couple II, III degree burn and scald case
| Group | Total routine number | There is not the routine number of infection | Low-grade infection example number | Severe infections example number |
| Moist expose burn ointment | 90 | 31 | 50 | 9 |
| Silver sulfadiazine | 90 | 45 | 41 | 4 |
| Medicine of the present invention | 200 | 184 | 16 | 0 |
Table 11 obvious effective rate and cure rate statistical result
| The I degree | The II degree | The III degree | |||||||||
| Group | The example number | Obvious effective rate | Cure rate | Group | The example number | Obvious effective rate | Cure rate | Group | The example number | Obvious effective rate | Cure rate |
| Moist expose burn ointment | 55 | 100％ | 97％ | Moist expose burn ointment | 50 | 96％ | 70％ | Moist expose burn ointment | 40 | 93％ | 60％ |
| Silver sulfadiazine | 70 | 100％ | 98％ | Silver sulfadiazine | 50 | 97％ | 80％ | Silver sulfadiazine | 40 | 95％ | 78％ |
| Medicine of the present invention | 100 | 100％ | 100％ | Medicine of the present invention | 90 | 100％ | 99％ | Medicine of the present invention | 110 | 100％ | 98％ |
The statistical result of table 12 II degree burn and scald patient healing time
| Group | Total routine number | Shallow II degree (my god) | Average natural law | Dark II degree (my god) | Average natural law |
| Moist expose burn ointment | 50 | 15-25 | 20 | 30-50 | 40 |
| Silver sulfadiazine | 50 | 8-16 | 12 | 25-45 | 35 |
| Medicine of the present invention | 90 | 3-6 | 4.5 | 18-22 | 20 |
2, treat frosted clinical trial
Once choose, two degree, three each 55 example of degree cold injury cases, use the method identical that the burn and scald cold injury medicine of step 1 preparation is treated above-mentioned cold injury patient, to detect medicine of the present invention to frosted curative effect with embodiment 1.Medication as a result can take effect the same day, and affected part has that hotness, sufferings disappear, the exposed no sense of cold in the cold wind; Next day sufferings not repeatedly, redness begins to disappear, form a scab gradually in the ulceration place of cold injury degree severe patient.On average once the about 1-2 of cold injury days, two degree cold injury about 3-4 days, the red and swollen ulceration cold injury of three degree can be cured in about 6-7 days.Therapeutic effect is added up, and statistical result shows that up to a hundred per cent, cure rate is also more than 99%, and drug safety, does not have any toxicity, side effect, can be used as and treats frosted drug use clinically with the frosted obvious effective rate of Drug therapy of the present invention.
The preparation and the curative effect thereof of embodiment 5, treatment burn and scald cold injury medicine are identified
One, preparation treatment burn and scald cold injury medicine
The present invention treats the preparation method of burn and scald cold injury medicine, may further comprise the steps:
1) takes by weighing raw material: Radix Angelicae Sinensis 200g, Radix Arnebiae (Radix Lithospermi) 150g, Radix Ampelopsis 25g, Radix Sanguisorbae 30g, Fructus Schisandrae Chinensis 30g, Olibanum 35g, Myrrha 35g, Herba Artemisiae Anomalae 25g, Radix Et Rhizoma Rhei 25g, Sanguis Draxonis 20g, Radix Angelicae Dahuricae 20g, Caulis Lonicerae 20g, Rhizoma Coptidis 20g, Membrana Follicularis ovi 25g, Corium elephatis 20g, Radix Glycyrrhizae 20g, Radix Astragali 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 25g, Radix Codonopsis 30g, Borneolum Syntheticum 40g, Cera Flava 500g, Oleum sesami 2500g;
2) with Oleum sesami the group's medicine except that Borneolum Syntheticum and Cera Flava was soaked slow fire boiling 60 minutes (color is degree of being with golden yellow, does not fry in shallow oil Jiao) then 24 hours;
3) filter, collect filtrate, add Borneolum Syntheticum and Cera Flava, stir, cooling, the frosted medicine of the burn and scald that obtains medical treatment seals standby.
Two, curative effect is identified
1, the clinical trial of treatment burn and scald
With the method identical with embodiment 1 to 505 because of I, dark II, shallow II, III degree burn and scald patient due to flame, the hot water etc. treat with the burn and scald cold injury medicine of step 1 preparation, to detect the curative effect of medicine of the present invention to burn and scald.
The situation of protecting from infection to II, III degree burn and scald case is as shown in table 13, obvious effective rate and cure rate statistical result are as shown in table 14, wherein the statistical result of II degree burn and scald patient healing time is as shown in Table 15, burn and scald cold injury medicine of the present invention all has curative effect preferably to I, II, III degree burn and scald, and do not see obvious adverse reaction, moist expose burn ointment and the silver sulfadiazine of being better than evident in efficacy, wherein the curative effect of moist expose burn ointment is the poorest, poor because of its infection and convergence capabilities, often to add with the antibiotic medicine wound surface and could heal in the course of disease later stage.This medicine does not have pain to the wound surface nonirritant, and infection rate is low, and is not hemorrhage, and the granulation growth is vigorous, and healing is fast, and drug safety, does not have any toxicity, side effect, can be used as the drug use for the treatment of burn and scald clinically.
The situation of protecting from infection of table 13 couple II, III degree burn and scald case
| Group | Total routine number | There is not the routine number of infection | Low-grade infection example number | Severe infections example number |
| Moist expose burn ointment | 90 | 31 | 50 | 9 |
| Silver sulfadiazine | 90 | 45 | 41 | 4 |
| Medicine of the present invention | 200 | 185 | 15 | 0 |
Table 14 obvious effective rate and cure rate statistical result
| The I degree | The II degree | The III degree | |||||||||
| Group | The example number | Obvious effective rate | Cure rate | Group | The example number | Obvious effective rate | Cure rate | Group | The example number | Obvious effective rate | Cure rate |
| Moist expose burn ointment | 55 | 100％ | 97％ | Moist expose burn ointment | 50 | 96％ | 70％ | Moist expose burn ointment | 40 | 93％ | 60％ |
| Silver sulfadiazine | 70 | 100％ | 98％ | Silver sulfadiazine | 50 | 97％ | 80％ | Silver sulfadiazine | 40 | 95％ | 78％ |
| Medicine of the present invention | 100 | 100％ | 100％ | Medicine of the present invention | 90 | 100％ | 99％ | Medicine of the present invention | 110 | 100％ | 98.5％ |
The statistical result of table 15 II degree burn and scald patient healing time
| Group | Total routine number | Shallow II degree (my god) | Average natural law | Dark II degree (my god) | Average natural law |
| Moist expose burn ointment | 50 | 15-25 | 20 | 30-50 | 40 |
| Silver sulfadiazine | 50 | 8-16 | 12 | 25-45 | 35 |
| Medicine of the present invention | 90 | 3-5 | 4 | 18-20 | 19 |
2, treat frosted clinical trial
Once choose, two degree, three each 70 example of degree cold injury cases, use the method identical that the burn and scald cold injury medicine of step 1 preparation is treated above-mentioned cold injury patient, to detect medicine of the present invention to frosted curative effect with embodiment 1.Medication as a result can take effect the same day, and affected part has that hotness, sufferings disappear, the exposed no sense of cold in the cold wind; Next day sufferings not repeatedly, redness begins to disappear, form a scab gradually in the ulceration place of cold injury degree severe patient.On average once the about 1-2 of cold injury days, two degree cold injury about 3-4 days, the red and swollen ulceration cold injury of three degree can be cured in about 6-7 days.Therapeutic effect is added up, and statistical result shows that up to a hundred per cent, cure rate is also more than 99%, and drug safety, does not have any toxicity, side effect, can be used as and treats frosted drug use clinically with the frosted obvious effective rate of Drug therapy of the present invention.
Claims (10)
1, the frosted medicine of a kind of treatment burn and scald, its composition and effectiveness is to be made by the raw material that comprises following ratio of weight and number: Radix Angelicae Sinensis 150-250 part, Radix Arnebiae (Radix Lithospermi) 100-200 part, Radix Ampelopsis 20-30 part, Radix Sanguisorbae 25-35 part, Fructus Schisandrae Chinensis 25-35 part, Olibanum 30-40 part, Myrrha 30-40 part, Membrana Follicularis ovi 20-30 part, Borneolum Syntheticum 35-45 part, animal and vegetable oil 2000-3000 part.
2, medicine according to claim 1 is characterized in that: described animal and vegetable oil is Oleum sesami, Oleum Glycines, olive oil, Oyster sauce or Adeps melis.
3, medicine according to claim 1 and 2 is characterized in that: also comprise following components by weight portion in the described composition of raw materials: Herba Artemisiae Anomalae 20-30 part, Caulis Lonicerae 15-25 part.
4, medicine according to claim 3 is characterized in that: also comprise following components by weight portion in the described composition of raw materials: Radix Et Rhizoma Rhei 20-30 part, Sanguis Draxonis 15-25 part, Radix Angelicae Dahuricae 15-25 part, Rhizoma Coptidis 15-25 part, Radix Astragali 15-25 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-30 part, Radix Codonopsis 25-35 part.
5, medicine according to claim 4 is characterized in that: also comprise following components by weight portion in the described composition of raw materials: Corium elephatis 15-25 part, Radix Glycyrrhizae 15-25 part.
6, medicine according to claim 5 is characterized in that: also comprise following components by weight portion in the described composition of raw materials: Cera Flava 450-550 part.
7, medicine according to claim 6 is characterized in that: the parts by weight proportioning of each crude drug is in the described composition of raw materials: 200 parts of Radix Angelicae Sinensis, 150 parts of Radix Arnebiae (Radix Lithospermi)s, 25 parts of Radix Ampelopsis, 30 parts of Radix Sanguisorbaes, 30 parts of Fructus Schisandrae Chinensis, 35 parts of Olibanums, 35 parts of Myrrhas, 25 parts of Herba Artemisiae Anomalaes, 25 parts of Radix Et Rhizoma Rhei, 20 parts of Sanguis Draxonis, 20 parts of the Radixs Angelicae Dahuricae, 20 parts of Caulis Loniceraes, 20 parts of Rhizoma Coptidis, 25 parts of Membrana Follicularis ovis, 20 parts of Corium elephatiss, 20 parts in Radix Glycyrrhizae, 20 parts of the Radixs Astragali, 25 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 30 parts of Radix Codonopsis, 40 parts of Borneolum Syntheticums, 500 parts in Cera Flava, 2500 parts of animal and vegetable oil.
8, according to claim 6 or 7 described medicines, it is characterized in that: described medicine is a unguentum.
9, a kind of method for preparing the frosted medicine of the described treatment burn and scald of claim 8 may further comprise the steps:
1) gets material by following parts by weight proportioning: Radix Angelicae Sinensis 150-250 part, Radix Arnebiae (Radix Lithospermi) 100-200 part, Radix Ampelopsis 20-30 part, Radix Sanguisorbae 25-35 part, Fructus Schisandrae Chinensis 25-35 part, Olibanum 30-40 part, Myrrha 30-40 part, Herba Artemisiae Anomalae 20-30 part, Radix Et Rhizoma Rhei 20-30 part, Sanguis Draxonis 15-25 part, Radix Angelicae Dahuricae 15-25 part, Caulis Lonicerae 15-25 part, Rhizoma Coptidis 15-25 part, Membrana Follicularis ovi 20-30 part, Corium elephatis 15-25 part, Radix Glycyrrhizae 15-25 part, Radix Astragali 15-25 part, 2030 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, Radix Codonopsis 25-35 part, Borneolum Syntheticum 35-45 part, Cera Flava 450-550 part, animal and vegetable oil 2000-3000 part;
2) with animal and vegetable oil the group's medicine except that Borneolum Syntheticum and Cera Flava was soaked slow fire boiling 10-60 minute then 12-48 hour;
3) filter, collect filtrate, add Borneolum Syntheticum and Cera Flava, stir, cooling, the frosted medicine of the burn and scald that obtains medical treatment.
10, method according to claim 9 is characterized in that: the animal and vegetable oil in the described step 1) is Oleum sesami, Oleum Glycines, olive oil, Oyster sauce or Adeps melis; Step 2) soak time in is 24 hours.
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| CN101284109B (en) * | 2007-04-09 | 2010-11-17 | 王兴礼 | Medicine for curing the burnt, scalded and frostbited corium to regenerate |
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| CN102274371B (en) * | 2011-08-12 | 2013-04-17 | 冉好强 | Ointment for treating burn, traumatic infection and pressure sore |
| CN102357203A (en) * | 2011-10-21 | 2012-02-22 | 张忠田 | Cortex ulmis burn ointment for curing burns |
| CN102872199A (en) * | 2012-09-29 | 2013-01-16 | 李惠斌 | Externally used paste for treating burn |
| CN103127342A (en) * | 2013-01-30 | 2013-06-05 | 吴殿信 | Ointment capable of curing scald and preparation method thereof |
| CN103191307A (en) * | 2013-04-11 | 2013-07-10 | 宋奇仓 | Herbal ointment for treating cauterization and scald and preparation method of herbal ointment |
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