CN110559244A - Bletilla striata hand cream and preparation method and application thereof - Google Patents
Bletilla striata hand cream and preparation method and application thereof Download PDFInfo
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- CN110559244A CN110559244A CN201910979150.4A CN201910979150A CN110559244A CN 110559244 A CN110559244 A CN 110559244A CN 201910979150 A CN201910979150 A CN 201910979150A CN 110559244 A CN110559244 A CN 110559244A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention discloses a bletilla striata hand cream which is prepared from the following raw and auxiliary materials in parts by weight: 30-50 parts of bletilla, 8-12 parts of glycerol, 6-10 parts of white oil, 4-6 parts of caprylic/capric triglyceride, 0.2-2 parts of stearic acid, 1-2 parts of white vaseline, 0.5-1.5 parts of lanolin, 0.5-1.5 parts of cetyl alcohol, 0. 200.10-0.20 part of carbomer, 0.5 part of triethanolamine, 0.2 part of essence, 0.2 part of methyl paraben and 14.4-49.3 parts of distilled water. The bletilla striata hand cream is prepared by selecting the raw and auxiliary materials and adopting an emulsification method, the sensory, physicochemical indexes, moisture retention and other properties of the bletilla striata hand cream accord with the national light industry standard, and the bletilla striata hand cream has the advantages of small side effect, high safety and the like compared with artificially synthesized chemical substance cosmetics, accords with the development trend requirements of naturalization, nutrition and curative effect of the cosmetics, and has good market application prospect.
Description
Technical Field
the invention relates to a common bletilla pseudobulb hand cream and a preparation method and application thereof.
Background
The modern society develops and the material life is more and more abundant, and people's great pursuit to beauty creates a huge cosmetic market. The use of traditional Chinese medicines in cosmetics has a long history, and many traditional Chinese medicines have the effects of maintaining beauty and keeping young, and more than 100 kinds of medicines with the curative effect of maintaining beauty in Shen nong Ben Cao Jing can be obtained. Compared with artificially synthesized chemical cosmetics, the traditional Chinese medicine cosmetics have the advantages of small side effect, high safety and the like, and become a hotspot of cosmetic research and a breakthrough point of development of new cosmetic products.
the bletilla striata is a dried tuber of bletilla striata (Thunb.) Reichb.f. of the orchid family, can astringe to stop bleeding, reduce swelling and promote tissue regeneration, and has been recorded in ancient times for whitening, removing spots and preventing and treating rhagadia manus et pedis. Modern researches show that polysaccharides in water extracts of rhizoma bletillae have the effects of resisting oxidation, resisting aging, whitening and the like, can prevent skin aging, promote external wound healing, reduce the irritation of the environment to the skin, and have the effect of protecting or assisting in treating the skin.
The invention discloses a preparation method of a bletilla striata skin moisturizer (publication number: CN 106924143A), which comprises the following steps: "comprises the following steps: a. preparing materials: cleaning fresh rhizoma bletillae tubers, drying in the sun, and longitudinally slicing to obtain rhizoma bletillae slices for later use; b. treating rhizoma bletillae cellulose; c. microwave-assisted extraction: weighing treated rhizoma bletillae slices, crushing, putting into a primary extraction flask, adding an 80% ethanol solution according to a material-liquid ratio of 1:40, performing microwave-assisted extraction for 2 times, centrifuging, and taking supernatant liquid to place in a beaker; d. volatilizing ethanol; e. preparing skin lotion: mixing 1 part of bletilla striata collagen liquid, 3-3 parts of vitamin E2, 3-5 parts of ferment, 10-20 parts of glycerol and 10-20 parts of water to obtain the bletilla striata skin care liquid. The invention is a liquid nursing liquid prepared by ethanol extract of bletilla striata and auxiliary materials, which is not particularly suitable for daily use habit of hand nursing; secondly, the spreading, penetration, absorption and the like on the skin still have space for optimization and improvement.
Therefore, aiming at the problems, the common bletilla pseudobulb is taken as a raw material, the preparation method and the product form are optimized, so that a new common bletilla pseudobulb nursing product meeting the development requirements of cosmetics of 'naturalization', 'nutrition', 'curative effect' in the market is developed, and the market development prospect is good.
Disclosure of Invention
The invention aims to provide common bletilla rubber hand cream for daily hand care.
The invention also aims to provide a preparation method of the hand cream.
the invention provides a traditional Chinese medicine hand cream which is prepared by adding auxiliary materials or auxiliary components acceptable for daily cosmetics into traditional Chinese medicine bletilla striata.
Further, the medicine is prepared from the following raw and auxiliary materials in parts by weight: 30-50 parts of bletilla, 8-12 parts of glycerol, 6-10 parts of white oil, 4-6 parts of caprylic/capric triglyceride, 0.2-2 parts of stearic acid, 1-2 parts of white vaseline, 0.5-1.5 parts of lanolin, 0.5-1.5 parts of hexadecanol, 0. 200.10-0.20 part of carbomer, 0.5 part of triethanolamine, 0.2 part of essence, 0.2 part of methyl paraben, and distilled water for supplementing the weight to 100 parts.
Further, the feed additive is prepared from the following raw materials in parts by weight: 40 parts of common bletilla pseudobulb, 10 parts of glycerin, 8 parts of white oil, 5 parts of caprylic/capric triglyceride, 2 parts of stearic acid, 1.5 parts of white vaseline, 1 part of lanoline, 1 part of cetyl alcohol, 200.2 parts of carbomer U, 0.5 part of triethanolamine, 0.2 part of essence and 0.2 part of methylparaben, and distilled water is added to complement the weight to 100 parts.
Further, the medicine is prepared from the following raw and auxiliary materials in parts by weight: 30-50 parts of bletilla, 8-12 parts of glycerol, 3-5 parts of white oil, 4-6 parts of caprylic/capric triglyceride, 0.2-2 parts of stearic acid, 1-2 parts of white vaseline, 0.5-1.5 parts of lanolin, 0.5-1.5 parts of cetyl alcohol, 0. 200.10-0.20 part of carbomer, 0.5 part of triethanolamine, 0.2 part of essence, 0.2 part of methyl paraben, and distilled water for supplementing the weight to 100 parts.
Further, the medicine is prepared from the following raw and auxiliary materials in parts by weight: 30-50 parts of bletilla, 8-12 parts of glycerol, 5 parts of white oil, 4-6 parts of caprylic/capric triglyceride, 0.2-2 parts of stearic acid, 1-2 parts of white vaseline, 0.5-1.5 parts of lanolin, 0.5-1.5 parts of cetyl alcohol, 0. 200.10-0.20 part of carbomer, 0.5 part of triethanolamine, 0.2 part of essence, 0.2 part of methyl paraben, and distilled water for supplementing the weight to 100 parts.
Further, the preparation method comprises the following steps:
(1) Extracting rhizoma bletillae: extracting rhizoma Bletillae with water to obtain rhizoma Bletillae extractive solution;
(2) Melting of oil phase: mixing white vaseline, lanolin, white oil, caprylic/capric triglyceride, cetyl alcohol and stearic acid, and heating to completely melt to obtain oil phase mixed phase;
(3) Dissolution of the aqueous phase: dispersing carbomer U20 powder in distilled water, swelling for 7 hr, mixing with glycerol and rhizoma bletilla water extract, stirring, and heating to obtain water phase mixed phase;
(4) Emulsification and mixing: quickly pouring the water phase mixed phase into the oil phase mixed phase, stirring with an electric stirrer, adding triethanolamine during stirring, emulsifying, adding essence, triethanolamine and methyl hydroxybenzoate, and continuously stirring to cool the paste to room temperature.
Further, in the step (1), the extraction of rhizoma bletillae comprises the following steps: extracting rhizoma Bletillae powder with water under reflux for 2 times (3 hr each time), adding 10 times of water to the rhizoma Bletillae powder for the first time, adding 8 times of water to the rhizoma Bletillae powder for the second time, mixing the two extractive solutions, centrifuging in a 2500r/min centrifuge for 20min, collecting supernatant, and concentrating to 0.1g rhizoma Bletillae powder/mL;
And/or, in the step (2), the temperature of heating to complete melting is 75 ℃;
and/or, in the step (3), the heating temperature is 75 ℃;
And/or, in the step (4), the emulsifying temperature is 75 ℃, and the emulsifying time is 20 min.
The invention also provides a preparation method of the traditional Chinese medicine hand cream, which comprises the following steps:
(1) extracting rhizoma bletillae: extracting rhizoma Bletillae with water to obtain rhizoma Bletillae extractive solution;
(2) Melting of oil phase: mixing white vaseline, lanolin, white oil, caprylic/capric triglyceride, cetyl alcohol and stearic acid, and heating to completely melt to obtain oil phase mixed phase;
(3) dissolution of the aqueous phase: dispersing carbomer U20 powder in distilled water, swelling for 7 hr, mixing with glycerol and rhizoma bletilla water extract, stirring, and heating to obtain water phase mixed phase;
(4) Emulsification and mixing: quickly pouring the water phase mixed phase into the oil phase mixed phase, stirring with an electric stirrer, adding triethanolamine during stirring, emulsifying, adding essence, triethanolamine and methyl hydroxybenzoate, and continuously stirring to cool the paste to room temperature.
further, in the step (1), the extraction of rhizoma bletillae comprises the following steps: extracting rhizoma Bletillae powder with water under reflux for 2 times (3 hr each time), adding 10 times of water to the rhizoma Bletillae powder for the first time, adding 8 times of water to the rhizoma Bletillae powder for the second time, mixing the two extractive solutions, centrifuging in a 2500r/min centrifuge for 20min, collecting supernatant, and concentrating to 0.1g rhizoma Bletillae powder/mL;
and/or, in the step (2), the temperature of heating to complete melting is 75 ℃;
and/or, in the step (3), the heating temperature is 75 ℃;
And/or, in the step (4), the emulsifying temperature is 75 ℃, and the emulsifying time is 20 min.
the invention also provides application of the traditional Chinese medicine hand cream in preparing a hand care product.
Caprylic/capric triglyceride, GTCC.
according to the invention, the water extract with better moisturizing effect is preferably selected by comparing the white water extract with the water extract and the ethanol extract, and the hand cream is prepared by adding the preferable daily-use cosmetic common auxiliary materials or auxiliary components and emulsifying, wherein the sensory, physicochemical and moisturizing properties of the hand cream accord with the national light industry standard, and the hand cream has the advantages of small side effect, high safety and the like compared with artificially synthesized chemical substance cosmetics. Compared with the care solution, the hand cream is more in line with the use habit of daily hand care use of people to product physical state, and the dispersed state prepared by emulsifying and mixing the oil phase and the water phase, so that the product is easier to spread, permeate and absorb on the hand, has better hand care effect, and is in line with the development trend requirements of cosmetics such as naturalization, nutrition and curative effect. Meanwhile, the traditional Chinese medicine hand cream prepared by the invention is easy to smear and spread, does not generate white stripes after being unfolded, is uniform and stable in cream, does not have transparent small particles, is proper in viscosity, is good in moisturizing type, improves the moisture of the smeared skin, can be kept for a long time, and has good market application prospect.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
the present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
drawings
FIG. 1 is a graph of water loss of alcohol and water extracts of bletilla striata on skin.
Detailed Description
EXAMPLE 1 formulation and preparation of the product of the invention
1. The formula is as follows: 30 parts of common bletilla pseudobulb, 8 parts of glycerin, 6 parts of white oil, 4 parts of caprylic/capric triglyceride, 0.2 part of stearic acid, 1 part of white vaseline, 0.5 part of lanolin, 0.5 part of cetyl alcohol, 200.10 parts of carbomer U, 0.5 part of triethanolamine, 0.2 part of essence, 0.2 part of methylparaben and distilled water which are added to make up to 100 parts by weight.
2. The preparation method comprises the following steps:
(1) extracting rhizoma bletillae: reflux-extracting rhizoma Bletillae for 1 time, each time for 1 hr, adding 10 times of water to the first time and 8 times of water to the second time, placing the two extractive solutions in a beaker, centrifuging in a 2500r/min centrifuge for 20min, collecting supernatant, concentrating in a rotary evaporator, and concentrating to 0.1g medicinal material/mL;
(2) Melting of oil phase: mixing white vaseline, lanolin, white oil, caprylic/capric triglyceride, cetyl alcohol and stearic acid, and heating in a water bath at 70 deg.C to completely melt to obtain oil phase mixed phase;
(3) Dissolution of the aqueous phase: dispersing carbomer U20 powder in distilled water, swelling for 7 hr, mixing with glycerol and rhizoma bletilla water extract, stirring, and heating at 70 deg.C in water bath to obtain water phase mixture;
(4) Emulsification and mixing: quickly pouring the water phase mixed phase into the oil phase mixed phase, stirring with an electric stirrer, adding a small amount of triethanolamine during stirring to emulsify more completely, emulsifying at 70 deg.C for 15min, adding essence and antiseptic (antiseptic is triethanolamine and methyl hydroxybenzoate in the formula), and continuously stirring to cool the ointment to room temperature.
EXAMPLE 2 formulation and preparation of the product of the invention
1. The formula is as follows: 40 parts of common bletilla pseudobulb, 10 parts of glycerin, 8 parts of white oil, 5 parts of caprylic/capric triglyceride, 2 parts of stearic acid, 1.5 parts of white vaseline, 1 part of lanoline, 1 part of cetyl alcohol, 200.2 parts of carbomer U, 0.5 part of triethanolamine, 0.2 part of essence, 0.2 part of methyl paraben, 30.9 parts of distilled water and the balance of distilled water to 100 parts.
2. The preparation method comprises the following steps:
(1) Extracting rhizoma bletillae: reflux-extracting rhizoma Bletillae for 2 times, each for 3 hr, adding 10 times of water to the first time and 8 times of water to the second time, placing the two extractive solutions in a beaker, centrifuging in a 2500r/min centrifuge for 20min, collecting supernatant, concentrating in a rotary evaporator, and concentrating to 0.1g medicinal material/mL;
(2) Melting of oil phase: mixing white vaseline, lanolin, white oil, caprylic/capric triglyceride, cetyl alcohol and stearic acid, and heating in a water bath at 75 deg.C to completely melt to obtain oil phase mixed phase;
(3) Dissolution of the aqueous phase: dispersing carbomer U20 powder in distilled water, swelling for 7 hr, mixing with glycerol and rhizoma bletilla water extract, stirring, and heating at 75 deg.C in water bath to obtain water phase mixture;
(4) emulsification and mixing: quickly pouring the water phase mixed phase into the oil phase mixed phase, stirring with an electric stirrer, adding a small amount of triethanolamine during stirring to emulsify more completely, emulsifying at 70 deg.C for 20min, adding essence and antiseptic (antiseptic is triethanolamine and methyl hydroxybenzoate in the formula), and continuously stirring to cool the ointment to room temperature.
EXAMPLE 3 formulation and preparation of the product of the invention
1. the formula is as follows: 50 parts of common bletilla pseudobulb, 12 parts of glycerin, 10 parts of white oil, 6 parts of caprylic/capric triglyceride, 2 parts of stearic acid, 2 parts of white vaseline, 1.5 parts of lanolin, 1.5 parts of cetyl alcohol, 200.20 parts of carbomer U, 0.5 part of triethanolamine, 0.2 part of essence and 0.2 part of methyl paraben, and distilled water is added to complement the weight to 100 parts.
2. The preparation method comprises the following steps:
(1) Extracting rhizoma bletillae: extracting rhizoma Bletillae under reflux for 3 times, each time for 2 hr, adding 10 times of water to the first time and 8 times of water to the second time, placing the two extractive solutions in a beaker, centrifuging in a 2500r/min centrifuge for 20min, collecting supernatant, concentrating in a rotary evaporator, and concentrating to 0.1g medicinal material/mL;
(2) Melting of oil phase: mixing white vaseline, lanolin, white oil, caprylic/capric triglyceride, cetyl alcohol and stearic acid, and heating in water bath at 85 deg.C to completely melt to obtain oil phase mixed phase;
(3) dissolution of the aqueous phase: dispersing carbomer U20 powder in distilled water, swelling for 7 hr, mixing with glycerol and rhizoma bletilla water extract, stirring, and heating at 85 deg.C in water bath to obtain water phase mixture;
(4) Emulsification and mixing: quickly pouring the water phase into the oil phase, stirring with an electric stirrer, adding a small amount of triethanolamine during stirring to complete emulsification, emulsifying at 70 deg.C for 25min, adding essence and antiseptic (antiseptic is triethanolamine and methyl hydroxybenzoate in the formula), and continuously stirring to cool the ointment to room temperature.
EXAMPLE 4 formulation and preparation of the product of the invention
1. The formula is as follows: 40 parts of common bletilla pseudobulb, 10 parts of glycerin, 5 parts of white oil, 5 parts of caprylic/capric triglyceride, 2 parts of stearic acid, 1.5 parts of white vaseline, 1 part of lanoline, 1 part of cetyl alcohol, 200.2 parts of carbomer U, 0.5 part of triethanolamine, 0.2 part of essence, 0.2 part of methyl paraben, 30.9 parts of distilled water and the balance of distilled water to 100 parts.
2. The preparation method comprises the following steps:
(1) Extracting rhizoma bletillae: reflux-extracting rhizoma Bletillae for 2 times, each for 3 hr, adding 10 times of water to the first time and 8 times of water to the second time, placing the two extractive solutions in a beaker, centrifuging in a 2500r/min centrifuge for 20min, collecting supernatant, concentrating in a rotary evaporator, and concentrating to 0.1g medicinal material/mL;
(2) melting of oil phase: mixing white vaseline, lanolin, white oil, caprylic/capric triglyceride, cetyl alcohol and stearic acid, and heating in a water bath at 75 deg.C to completely melt to obtain oil phase mixed phase;
(3) Dissolution of the aqueous phase: dispersing carbomer U20 powder in distilled water, swelling for 7 hr, mixing with glycerol and rhizoma bletilla water extract, stirring, and heating at 75 deg.C in water bath to obtain water phase mixture;
(4) Emulsification and mixing: quickly pouring the water phase mixed phase into the oil phase mixed phase, stirring with an electric stirrer, adding a small amount of triethanolamine during stirring to emulsify more completely, emulsifying at 70 deg.C for 20min, adding essence and antiseptic (antiseptic is triethanolamine and methyl hydroxybenzoate in the formula), and continuously stirring to cool the ointment to room temperature.
experimental example 1 comparison of moisturizing effects of water and ethanol extracts of rhizoma bletillae
1. preparation method of rhizoma bletillae extracting solution
Water extract of rhizoma bletillae: taking 10g of rhizoma bletillae powder, adding water, extracting under reflux for 2 times, each time for 3h, adding 1000mL of water for the first time and 800mL of water for the second time, placing the two extractive solutions in a beaker, centrifuging for 20min in a 2500r/min centrifuge, leaving supernatant, concentrating in a rotary evaporator, concentrating to 100mL, and filling into a volumetric flask for later use.
alcohol extract of rhizoma bletillae: taking 10g of rhizoma bletillae powder, adding 70% ethanol, extracting under reflux for 2 times, each time for 3h, adding 1000mL of 70% ethanol for the first time and 800mL of 70% ethanol for the second time, placing the two extracting solutions in a beaker, centrifuging for 20min in a centrifuge of 2500r/min, leaving supernatant, concentrating in a rotary evaporator, concentrating to 100mL, and then filling into a volumetric flask for later use.
2. moisture retention test of aqueous and alcoholic extract solutions of bletilla striata
20 volunteers (male and female halves) were selected as test subjects, and the water extract and alcohol extract of bletilla were applied to the same position of the upper limb of the hand, and after the application, 2 hours after the application, and 5 hours after the application, the loss of water in the skin of the part was measured with a skin tester and counted, and the results are shown in fig. 1: the water extract of rhizoma bletillae has better moisture retention performance than the alcohol extract.
experimental example 2 examination of the amount of carbomer U20
1. Experimental methods
Carbomer U20 is used as a thickening agent in the water phase, and a small amount of triethanolamine can increase the consistency of the emulsion to a certain extent, thereby being beneficial to paste forming. In a preliminary experiment, the dosage of carbomer U20 is examined by controlling the other ingredients to be unchanged (1.5 g of white vaseline, 1.0g of lanolin, 8.0g of white oil, 5.0g of GTCC, 1.0g of hexadecanol, 2.0g of stearic acid, 10.0g of glycerol, 0.5g of triethanolamine, 0.2g of essence, 0.2g of methyl paraben, 40g of rhizoma bletillae water extract and 30.9ml of distilled water). The dosage of carbomer U20 is adjusted to be 0.05g, 0.10g, 0.15g, 0.20g and 0.25g respectively, and the appropriate dosage of carbomer U20 is selected by taking the stability and viscosity of the prepared paste as indexes.
2. Results of the experiment
The experimental results are shown in table 1, and according to the stability, viscosity and human body use effect of the ointment obtained by the experiment, the optimal mass fraction of carbomer U20 can be determined to be 0.20%.
TABLE 1 analysis of carbomer U20 dosage
Note: more "+" indicates greater viscosity
Experimental example 3 examination of emulsifier species
1. Experimental methods
The emulsifier is a substance which converts two immiscible phases into a uniform dispersion phase, and the addition of a small amount of proper emulsifier can obviously reduce the interfacial tension of the oil-water two phases, thereby generating better emulsification effect and forming a stable system. In a preliminary experiment, 1 percent of cetyl alcohol and/or 2 percent of stearic acid are/is added as an emulsifier, the prepared hand cream is centrifuged at 2000r/min for 30min, the layering condition is observed, the less obvious the layering phenomenon is, the more reasonable the scheme is, and the results are expressed by excellent, good and poor.
2. Results of the experiment
The results are shown in Table 2. As can be seen from the table, the best emulsification effect could not be obtained by any emulsifier alone, the emulsification effect was especially not good by cetyl alcohol alone, and the emulsification effect was the best when 1% cetyl alcohol and 2% stearic acid were used together.
TABLE 2 influence of emulsifier type on the emulsifying Effect
note "/" indicates no addition
experimental example 4 investigation of the amount of the remaining ingredients
1. experimental methods
The final components of the hand cream are white vaseline, lanolin, white oil, GTCC, cetyl alcohol, carbomer U20, stearic acid, glycerol, bletilla striata water extract, triethanolamine, essence, methyl paraben and distilled water, the amount of carbomer U20 is determined to be 0.2g according to experimental example 2, meanwhile, the amount of bletilla striata water extract is controlled to be 40.0g, the amount of triethanolamine is 0.5g, the amount of essence is 0.2g, the amount of methyl paraben is 0.2g, and the amount of distilled water is 30.9mL, the proportion of the remaining 7 components is changed according to the dosage shown in Table 4, and the best scheme of the hand cream is respectively prepared by adopting the preparation method of example 4. 2. Evaluation index
the color, the spreadability, the paste stability and the moisture retention of the hand cream are tested according to 4 indexes, and each type of hand cream is evaluated according to feedback grading, wherein the grading standard is shown in a table 3. The 4 indices are each measured for 25 points, and the moisture retention can be converted from the retention of moisture after one hour of application by testing the same position of the subject's hand (center of back of hand). The score is 100, 20 human test objects are selected, and the male and the female are half. Measuring the water loss value by a skin tester and scoring, wherein the water loss value is 10%, and the score is 23-25; 10% -20% of 18-22; 20% -30% and score 15-18.
Table 3 hand cream scoring criteria
3. Results of the experiment
table 4 experimental results (n ═ 20)
the total score was averaged over the 20-person score results, which are shown in Table 4.
The results show that the optimal components obtained according to the percentage content calculated by the dosage are carbomer U200.2%, white vaseline 1.5%, lanolin 1%, GTCC caprylic/capric triglyceride 5%, white oil 5%, cetyl alcohol 1%, stearic acid 2%, glycerin 10%, bletilla striata water extract 40.0%, triethanolamine 0.5%, essence 0.2%, methyl paraben 0.2% and distilled water 30.9%.
Experimental example 5 examination of emulsification temperature and emulsification time of hand cream
1. experimental methods
The quality of the cosmetic is directly determined by the quality of the emulsification process, and the emulsification temperature and the emulsification time play a crucial role in the emulsification system. The optimal components are adopted, and single-factor investigation is respectively carried out on the emulsification temperature and the emulsification time: (1) firstly, controlling the emulsification time to be 20min, setting the emulsification temperatures to be 65 ℃, 70 ℃, 75 ℃, 80 ℃ and 85 ℃ respectively, and preparing the hand cream; (2) and (2) setting the emulsification time to be 5min, 10min, 15min, 20min and 25min respectively at the optimal emulsification temperature selected by the method (1), and preparing the hand cream. And respectively centrifuging the obtained cream at 3000r/min for 30min, observing the stability condition of the cream, taking the condition with unobvious layering as an optimal process, and evaluating the effects by using the advantages, the advantages and the disadvantages. On the premise that the emulsification effect can meet the requirement, the optimal process conditions are selected to be lower temperature and shorter time.
2. Results of the experiment
The results are given in Table 5 below.
TABLE 5 influence of temperature and emulsification time on the emulsification Effect
The result shows that when the emulsification time is 20min, under the five test temperature conditions, the emulsification capacity is weaker when the temperature is 65 ℃, the speed of forming paste by emulsion is slow when the emulsion is thinner, the bottom tube is layered after centrifugation, and the paste is not easy to smear after being formed; when the temperature reaches 70 ℃, the emulsifying capacity is improved, but the formed paste is still soft; when the temperature is 75 ℃, the emulsifying capacity is better, and no obvious layering phenomenon exists; the emulsification conditions at 80 ℃ and 85 ℃ are not greatly different, but the paste is too thin; therefore, 75 ℃ is the optimum process.
according to the experimental result, the emulsifying temperature is controlled to be 75 ℃, the emulsifying time of five groups in the experiment is transversely compared, when the emulsifying time is insufficient (less than or equal to 15min), the emulsifying process speed is slow, the obtained paste is not completely emulsified, and the effect of the paste is poor; meanwhile, when the emulsification time is too long (more than or equal to 25min), the paste is too thick after the reaction. Only when the emulsification time is 20min, the emulsification capacity is good, and no obvious layering phenomenon exists, so that the effect under the condition is good when the selected emulsification time is 20 min.
And (3) combining the experimental results to determine the optimal emulsification process as follows: the emulsification time is 20min, and the emulsification temperature is 75 ℃.
experimental example 6 quality investigation
1. Experimental methods
Three batches of rhizoma bletillae extract hand cream were prepared repeatedly according to the best prescription process (i.e., the formulation and preparation method of example 4). According to the cosmetic inspection rule of the light industry standard QB/T1857-2013 of the people's republic of China, the sensory and physicochemical indexes of the hand cream are comprehensively evaluated. In addition, the moisturizing effect of the cosmetic is evaluated by referring to the light industry standard QB/T4256-2011 skin-care cream of the people's republic of China.
2. Results of the experiment
the results are shown in Table 6 below. Tests show that three groups of hand cream samples prepared under the optimal formula process pass the tests of sense, physicochemical property and moisture retention.
table 6 composition verification test results (n ═ 3)
In conclusion, the product is the hand cream prepared by adding the preferred common bletilla striata water extract with better moisturizing effect into the preferred daily cosmetic common auxiliary materials or auxiliary components for emulsification, the sensory, physicochemical indexes, moisturizing and other properties of the hand cream accord with the national light industrial standard, the hand cream has the advantages of small side effect, high safety and the like compared with artificially synthesized chemical substance cosmetics, compared with a care solution, the hand cream better accords with the use habit of daily hand care use on product physical state of people, and the product is easier to spread, permeate and absorb on hands due to the dispersed state prepared by emulsifying and mixing the oil phase and the water phase, thereby playing better hand care effect and meeting the development trend requirements of 'naturalization', 'nutrition', 'curative effect' of cosmetics. Meanwhile, the traditional Chinese medicine hand cream prepared by the invention is easy to smear and spread, does not generate white stripes after being unfolded, is uniform and stable in cream, does not have transparent small particles, is proper in viscosity, is good in moisturizing type, improves the moisture of the smeared skin, can be kept for a long time, and has good market application prospect.
Claims (10)
1. A traditional Chinese medicine hand cream is characterized in that: the hand cream is prepared by adding auxiliary materials or auxiliary components which are acceptable for daily cosmetics into traditional Chinese medicine common bletilla pseudobulb.
2. The traditional Chinese medicine hand cream as claimed in claim 1, which is characterized in that: the medicament is prepared from the following raw and auxiliary materials in parts by weight: 30-50 parts of bletilla, 8-12 parts of glycerol, 6-10 parts of white oil, 4-6 parts of caprylic/capric triglyceride, 0.2-2 parts of stearic acid, 1-2 parts of white vaseline, 0.5-1.5 parts of lanolin, 0.5-1.5 parts of hexadecanol, 0. 200.10-0.20 part of carbomer, 0.5 part of triethanolamine, 0.2 part of essence, 0.2 part of methyl paraben, and distilled water for supplementing the weight to 100 parts.
3. The traditional Chinese medicine hand cream as claimed in claim 2, which is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 40 parts of common bletilla pseudobulb, 10 parts of glycerin, 8 parts of white oil, 5 parts of caprylic/capric triglyceride, 2 parts of stearic acid, 1.5 parts of white vaseline, 1 part of lanoline, 1 part of cetyl alcohol, 200.2 parts of carbomer U, 0.5 part of triethanolamine, 0.2 part of essence and 0.2 part of methylparaben, and distilled water is added to complement the weight to 100 parts.
4. The traditional Chinese medicine hand cream as claimed in claim 1, which is characterized in that: the medicament is prepared from the following raw and auxiliary materials in parts by weight: 30-50 parts of bletilla, 8-12 parts of glycerol, 3-5 parts of white oil, 4-6 parts of caprylic/capric triglyceride, 0.2-2 parts of stearic acid, 1-2 parts of white vaseline, 0.5-1.5 parts of lanolin, 0.5-1.5 parts of cetyl alcohol, 0. 200.10-0.20 part of carbomer, 0.5 part of triethanolamine, 0.2 part of essence, 0.2 part of methyl paraben, and distilled water for supplementing the weight to 100 parts.
5. The traditional Chinese medicine hand cream as claimed in claim 4, which is characterized in that: the medicament is prepared from the following raw and auxiliary materials in parts by weight: 30-50 parts of bletilla, 8-12 parts of glycerol, 5 parts of white oil, 4-6 parts of caprylic/capric triglyceride, 0.2-2 parts of stearic acid, 1-2 parts of white vaseline, 0.5-1.5 parts of lanolin, 0.5-1.5 parts of cetyl alcohol, 0. 200.10-0.20 part of carbomer, 0.5 part of triethanolamine, 0.2 part of essence, 0.2 part of methyl paraben, and distilled water for supplementing the weight to 100 parts.
6. The traditional Chinese medicine hand cream according to any one of claims 1 to 5, which is characterized in that: the preparation method comprises the following steps:
(1) extracting rhizoma bletillae: extracting rhizoma Bletillae with water to obtain rhizoma Bletillae extractive solution;
(2) Melting of oil phase: mixing white vaseline, lanolin, white oil, caprylic/capric triglyceride, cetyl alcohol and stearic acid, and heating to completely melt to obtain oil phase mixed phase;
(3) dissolution of the aqueous phase: dispersing carbomer U20 powder in distilled water, swelling for 7 hr, mixing with glycerol and rhizoma bletilla water extract, stirring, and heating to obtain water phase mixed phase;
(4) Emulsification and mixing: quickly pouring the water phase mixed phase into the oil phase mixed phase, stirring with an electric stirrer, adding triethanolamine during stirring, emulsifying, adding essence, triethanolamine and methyl hydroxybenzoate, and continuously stirring to cool the paste to room temperature.
7. the traditional Chinese medicine hand cream as claimed in claim 6, which is characterized in that:
in the step (1), the extraction of rhizoma bletillae comprises the following steps: extracting rhizoma Bletillae powder with water under reflux for 2 times (3 hr each time), adding 10 times of water to the rhizoma Bletillae powder for the first time, adding 8 times of water to the rhizoma Bletillae powder for the second time, mixing the two extractive solutions, centrifuging in a 2500r/min centrifuge for 20min, collecting supernatant, and concentrating to 0.1g rhizoma Bletillae powder/mL;
And/or, in the step (2), the temperature of heating to complete melting is 75 ℃;
And/or, in the step (3), the heating temperature is 75 ℃;
And/or, in the step (4), the emulsifying temperature is 75 ℃, and the emulsifying time is 20 min.
8. the preparation method of the traditional Chinese medicine hand cream as claimed in any one of claims 1 to 7, which is characterized in that: it comprises the following steps:
(1) Extracting rhizoma bletillae: extracting rhizoma Bletillae with water to obtain rhizoma Bletillae extractive solution;
(2) melting of oil phase: mixing white vaseline, lanolin, white oil, caprylic/capric triglyceride, cetyl alcohol and stearic acid, and heating to completely melt to obtain oil phase mixed phase;
(3) Dissolution of the aqueous phase: dispersing carbomer U20 powder in distilled water, swelling for 7 hr, mixing with glycerol and rhizoma bletilla water extract, stirring, and heating to obtain water phase mixed phase;
(4) Emulsification and mixing: quickly pouring the water phase mixed phase into the oil phase mixed phase, stirring with an electric stirrer, adding triethanolamine during stirring, emulsifying, adding essence, triethanolamine and methyl hydroxybenzoate, and continuously stirring to cool the paste to room temperature.
9. the method of claim 8, wherein:
In the step (1), the extraction of rhizoma bletillae comprises the following steps: extracting rhizoma Bletillae powder with water under reflux for 2 times (3 hr each time), adding 10 times of water to the rhizoma Bletillae powder for the first time, adding 8 times of water to the rhizoma Bletillae powder for the second time, mixing the two extractive solutions, centrifuging in a 2500r/min centrifuge for 20min, collecting supernatant, and concentrating to 0.1g rhizoma Bletillae powder/mL;
And/or, in the step (2), the temperature of heating to complete melting is 75 ℃;
And/or, in the step (3), the heating temperature is 75 ℃;
and/or, in the step (4), the emulsifying temperature is 75 ℃, and the emulsifying time is 20 min.
10. use of the traditional Chinese medicine hand cream as claimed in any one of claims 1 to 7 in the preparation of a hand care product.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811198289 | 2018-10-15 | ||
| CN2018111982897 | 2018-10-15 |
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| Publication Number | Publication Date |
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| CN110559244A true CN110559244A (en) | 2019-12-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910979150.4A Pending CN110559244A (en) | 2018-10-15 | 2019-10-15 | Bletilla striata hand cream and preparation method and application thereof |
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| CN (1) | CN110559244A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300408A (en) * | 2022-08-31 | 2022-11-08 | 仲恺农业工程学院 | Skin moisturizing composition, hand cream and preparation method thereof |
| CN115844994A (en) * | 2022-12-29 | 2023-03-28 | 遵义医科大学 | Rhizoma bletillae ointment and preparation method and application thereof |
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| CN101467940A (en) * | 2007-12-27 | 2009-07-01 | 天津天阜康生物技术发展有限公司 | Chinese medicine hand cream and preparation method thereof |
| CN104055700A (en) * | 2014-06-04 | 2014-09-24 | 上海欣富生物科技有限公司 | Anti-crack hand cream and preparation method thereof |
| CN104739741A (en) * | 2015-03-03 | 2015-07-01 | 陈红旗 | Skin-whitening hand cream |
| CN105769637A (en) * | 2014-12-25 | 2016-07-20 | 天长市地震办公室 | Anti-cracking hand cream |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101467940A (en) * | 2007-12-27 | 2009-07-01 | 天津天阜康生物技术发展有限公司 | Chinese medicine hand cream and preparation method thereof |
| CN104055700A (en) * | 2014-06-04 | 2014-09-24 | 上海欣富生物科技有限公司 | Anti-crack hand cream and preparation method thereof |
| CN105769637A (en) * | 2014-12-25 | 2016-07-20 | 天长市地震办公室 | Anti-cracking hand cream |
| CN104739741A (en) * | 2015-03-03 | 2015-07-01 | 陈红旗 | Skin-whitening hand cream |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300408A (en) * | 2022-08-31 | 2022-11-08 | 仲恺农业工程学院 | Skin moisturizing composition, hand cream and preparation method thereof |
| CN115844994A (en) * | 2022-12-29 | 2023-03-28 | 遵义医科大学 | Rhizoma bletillae ointment and preparation method and application thereof |
| CN115844994B (en) * | 2022-12-29 | 2024-02-02 | 遵义医科大学 | Bletilla striata ointment and preparation method and application thereof |
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Application publication date: 20191213 |