CN110507567A - A kind of plant antiseptic agent and its application - Google Patents
A kind of plant antiseptic agent and its application Download PDFInfo
- Publication number
- CN110507567A CN110507567A CN201910825761.3A CN201910825761A CN110507567A CN 110507567 A CN110507567 A CN 110507567A CN 201910825761 A CN201910825761 A CN 201910825761A CN 110507567 A CN110507567 A CN 110507567A
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- CN
- China
- Prior art keywords
- antiseptic agent
- plant antiseptic
- adacrya
- makeup remover
- plant
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9739—Bryophyta [mosses]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides a kind of plant antiseptic agent and its applications, belong to cosmetic field.Plant antiseptic agent of the present invention includes pepper extract, Radix Pulsatillae extract and moss extract, there is the effect that collaboration inhibits microorganism between these three extracts.Plant antiseptic agent of the present invention has excellent Antimicrobial ability, traditional chemical preservative can be substituted as the preservative of cosmetics, not only safety, irritation are low for the adacrya makeup remover being prepared by it, anti-corrosion ability is strong, makeup removing ability is strong, and preparation method is simple, and it is easy to industrialized production.
Description
Technical field
The invention belongs to cosmetic field, it is related to a kind of plant antiseptic agent and its application.
Background technique
It phenomena such as microbial contamination can make cosmetics become turbid, precipitate, change colour, is spoiled, pH value changes, not only affects
The quality of cosmetics also affects the usage experience of user.Preservative can be all added in general cosmetics, by preservative to micro-
The inhibition or destruction of growth and the breeding of biology, prevent cosmetics from deterioration, corruption.Currently used preservative is mostly chemical conjunction
It at substance, is applied on human skin often and there are problems that safety problem or irritation, if Kathon CG series is because containing chlorine, using
Cheng Zhonghui generates certain irritation to certain skin quality；Potential estrogen and androgen have with mastocarcinoma in parabens
It closes, there is its disabling of regulation and the amount of limiting the use of in the product.
Therefore, it is necessary to develop the low preservative of a efficient, safety, irritation.
Summary of the invention
In order to overcome the disadvantages mentioned above of the prior art and insufficient, the purpose of the present invention is to provide a kind of plant antiseptic agent and
It is applied.
The object of the invention is achieved through the following technical solutions:
A kind of plant antiseptic agent, it includes pepper extract, Radix Pulsatillae extract and moss extracts.Applicant is through excessive
Amount preservation challenge test, chicken embryo villus allantois test and human body paste patch test, discovery pepper extract, Radix Pulsatillae extract and
There is the effect that apparent collaboration inhibits microorganism, the antiseptic being prepared by these three extracts between moss extract
Agent have excellent Antimicrobial ability, and it is safe to the human body, irritation is low.
As the preferred embodiment of plant antiseptic agent of the present invention, counted on the basis of the total weight of the plant antiseptic agent
It calculates, the pepper extract accounts for 15-25%, and the Radix Pulsatillae extract accounts for 55-65%, and the moss extract accounts for 15-25%.
It is found by the applicant that these three component contents of the plant antiseptic agent herein within the scope of when, when than except this range, anti-corrosion
Ability is eager to excel.
As the preferred embodiment of plant antiseptic agent of the present invention, counted on the basis of the total weight of the plant antiseptic agent
It calculates, the pepper extract accounts for 20%, and the Radix Pulsatillae extract accounts for 60%, and the moss extract accounts for 20%.In this condition
Under, the anti-corrosion ability of the plant antiseptic agent further enhances.
The present invention also provides the application of above-mentioned plant antiseptic agent, above-mentioned plant antiseptic agent can be used as preservative or bacteriostatic agent
Applied in cosmetics.
As the preferred embodiment that the present invention applies, the plant antiseptic agent accounts for the 5-10% of the cosmetics weight；
As the preferred embodiment that the present invention applies, the plant antiseptic agent accounts for the 6% of the cosmetics weight.
The present invention also provides a kind of adacrya makeup removers comprising above-mentioned plant antiseptic agent.
As the preferred embodiment of adacrya makeup remover of the present invention, the plant antiseptic agent accounts for the adacrya makeup remover weight
5-10%；As the preferred embodiment of adacrya makeup remover of the present invention, the plant antiseptic agent accounts for the adacrya makeup removing
The % of water weight.
As the preferred embodiment of adacrya makeup remover of the present invention, the adacrya makeup remover further includes following weight percent
Raw material: EDETATE SODIUM 0.01-1%, sodium chloride 0.5-1%, glycerol 5-90%, 1,2- hexylene glycol 0.5-1%, -28 1- of tween
5%, 20 carbon of Natrulon H-10, two acid esters/14 carbon, two esters of gallic acid 1-5%, water surplus.The adacrya makeup remover is with polyglycereol-
10 20 carbon, two acid esters/14 carbon, two esters of gallic acid is as main decontamination ingredient, using glycerol as auxiliary decontamination ingredient, therebetween
Decontamination is cooperateed with, it is made to have good makeup removing ability；Using above-mentioned plant antiseptic agent substitution be also easy to produce the chemical preservative of stimulation as
Preservative confirms through human trial, safe to the human body, irritation is low.
The present invention also provides a kind of preparation methods of adacrya makeup remover comprising above-mentioned plant antiseptic agent, and it includes following
Step: being added water, EDETATE SODIUM, sodium chloride and glycerol in a reservoir, stirs and is warming up to 80-85 DEG C, insulated and stirred 30min,
It is stirred for being cooled to 35 DEG C, 1,2- hexylene glycol, tween -28,20 carbon of Natrulon H-10, two acid esters/14 carbon, two esters of gallic acid is added
And plant antiseptic agent, after mixing evenly, filter cloth of looking over so as to check discharges up to the adacrya makeup remover.
As the preferred embodiment of preparation method of the present invention, the filter cloth is 200 mesh.
Compared with prior art, the present invention has the following advantages and beneficial effects:
(1) plant antiseptic agent of the present invention includes pepper extract, Radix Pulsatillae extract and moss extract, is not only had excellent
Different Antimicrobial ability, it is also safe to the human body, irritation is low.
(2) plant antiseptic agent of the present invention can be applied in cosmetics as preservative or bacteriostatic agent.
(3) adacrya makeup remover of the present invention is not only removed ornaments and formal dress, and ability is strong and safe to the human body, irritation is low.
(4) the preparation method simple process of adacrya makeup remover of the present invention, is easy to industrial production.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1-8
Embodiment 1-8 is a kind of embodiment of plant antiseptic agent of the present invention, and composition is as shown in table 1.
Composition/wt% of plant antiseptic agent in 1 embodiment 1-8 of table
| Sample | Pepper extract | Radix Pulsatillae extract | Moss extract | Water |
| Embodiment 1 | 15 | 55 | 15 | 15 |
| Embodiment 2 | 20 | 55 | 15 | 10 |
| Embodiment 3 | 25 | 55 | 15 | 5 |
| Embodiment 4 | 20 | 60 | 15 | 5 |
| Embodiment 5 | 20 | 65 | 15 | 0 |
| Embodiment 7 | 20 | 60 | 20 | 0 |
| Embodiment 8 | 20 | 55 | 25 | 0 |
Test through the test of chicken embryo villus allantois and human body patch patch test, finds the plant antiseptic agent of embodiment 1-8 to people
Body safety, irritation are low；The plant antiseptic agent of embodiment 1-8 can be as bacteriostatic agent or aseptic applications in cosmetics, such as water
Agent, lotion, cream etc..
Embodiment 9-20
Embodiment 9-20 is a kind of embodiment of adacrya makeup remover of the present invention.The adacrya makeup remover of embodiment 9-20
The step of composition is as shown in table 2, their preparation methods is as follows: water, EDETATE SODIUM, sodium chloride and glycerol are added in a kettle,
It stirs and is warming up to 80-85 DEG C, insulated and stirred 30min, be stirred for being cooled to 35 DEG C, 1,2- hexylene glycol, tween -28, poly- is added
20 carbon of glycerol -10, two acid esters/14 carbon, two esters of gallic acid and plant antiseptic agent cross 200 mesh filter clothes after mixing evenly, and discharging is
Obtain the adacrya makeup remover.
Composition/wt% of adacrya makeup remover in 2 embodiment 9-20 of table
Comparative example 1-6
Comparative example 1-6 is a kind of plant antiseptic agent, and composition is as shown in table 3.
Composition/wt% of plant antiseptic agent in 3 comparative example 1-6 of table
Comparative example 7-12
Comparative example 7-12 is a kind of makeup remover, and composition is as shown in table 4.
Composition/wt% of makeup remover in 4 comparative example 7-12 of table
In order to illustrate the effect of plant antiseptic agent of the present invention and adacrya makeup remover, following test has been carried out:
(1) preservation challenge is tested
Test sample: the makeup remover in embodiment 9-20 and comparative example 7-12.
Test method: staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and aspergillus niger are distinguished
Be inoculated in culture medium and cultivated, bacterium cultivates 48h at 37 DEG C, and mould cultivates 72h at 28 DEG C, then choosing colony in
Certain density bacterium is made in the fluid nutrient medium of sterilizing and mould suspension is spare, wherein bacterial concentration is 5 × 108CFU/
ML, mold concentrations are 3 × 108CFU/mL weighs each 100g of test sample later, is separately added into the container of sterilizing, Zhi Houfen
Not Jia Ru 1mL staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and aspergillus niger suspension, shake up, connecing
The the 0th, 7,14,21, the 28 day sampling and testing bacteria containing amount of bacterium.
Evaluation criterion: if bacteria containing amount at the 7th day in 100CFU/mL hereinafter, be reduced to 0 at the 28th day, be considered as anti-
Rotten excellent effect has passed through preservation challenge test；If at the 7th day, bacteria containing amount in 1000CFU/mL hereinafter, if be considered as reluctantly
Pass through；If bacteria containing amount was then considered as no anti-corrosion effect in 1000CFU/mL or more at the 7th day.
Test result: 4 are specifically shown in Table.
4 results of preservation challenge tests of table/CFU/mL
| Test sample | 7th day | 14th day | 21st day | 28th day |
| Embodiment 9 | 350 | 150 | 120 | 80 |
| Embodiment 10 | 280 | 130 | 100 | 50 |
| Embodiment 11 | 220 | 180 | 80 | 60 |
| Embodiment 12 | 160 | 100 | 50 | 10 |
| Embodiment 13 | 120 | 80 | 40 | 10 |
| Embodiment 14 | 100 | 60 | 20 | 5 |
| Embodiment 15 | 80 | 40 | 10 | 0 |
| Embodiment 16 | 85 | 40 | 10 | 0 |
| Embodiment 17 | 86 | 45 | 10 | 0 |
| Embodiment 18 | 60 | 30 | 0 | 0 |
| Embodiment 19 | 80 | 40 | 15 | 0 |
| Embodiment 20 | 80 | 40 | 10 | 0 |
| Comparative example 7 | 600 | 500 | 300 | 250 |
| Comparative example 8 | 500 | 350 | 250 | 150 |
| Comparative example 9 | 650 | 560 | 320 | 285 |
| Comparative example 10 | 550 | 400 | 200 | 150 |
| Comparative example 11 | 620 | 530 | 310 | 200 |
| Comparative example 12 | 550 | 400 | 205 | 150 |
(2) Ocular irritation is tested
50 volunteers are recruited, right and left eyes respectively instill the adacrya makeup remover in 0.04mL embodiment 9-20,5 are stopped in eye
It is rinsed well after minute with deionized water, the irritation of volunteer during the test is divided into 3 grades: A grade entirely to test
In the process without sense of discomfort, B grades be it is pleasing to the eye after have sense of discomfort in 10 seconds, but then sense of discomfort disappears, C grade be it is pleasing to the eye after have always not
It is suitable to feel and disappear in 30 seconds.Test result are as follows: A grades are 45 people, and B grades are 5 people, and C grades are 0 people.
(3) eye makeup removing aptitude tests
50 volunteers are recruited, standard oiliness mascara is coated in eye and informer (holds the good production of adornment ability on the market
Product), after cosmetics are dry, adacrya makeup remover in the Example 9-20 portion of wipingization mascara or informer in the same direction
Position changes makeup removing cotton later and repeats wiping step, and primary makeup removing cotton is once changed in every wiping, until not having color and range estimation on makeup removing cotton
Eye is remained without cosmetics.Volunteer's makeup removing effect is divided into 4 grades: A grade and wipes number 1-3 times and noresidue for makeup removing cotton rub, B
Grade wipes number 4-10 times and noresidue for makeup removing cotton rub, and C grades are wiped number 10-20 times and noresidue for makeup removing cotton rub, and D grades are
Makeup removing cotton rub wipes number greater than 20 times.Test result are as follows: A grades are 47 people, and B grades are 2 people, and C grades are 1 people, and D grades are 0 people.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of plant antiseptic agent, which is characterized in that the plant antiseptic agent includes pepper extract, Radix Pulsatillae extract and tongue fur
Moss extract.
2. plant antiseptic agent according to claim 1, which is characterized in that on the basis of the total weight of the plant antiseptic agent
It calculates, the pepper extract accounts for 15-25%, and the Radix Pulsatillae extract accounts for 55-65%, and the moss extract accounts for 15-
25%.
3. plant antiseptic agent according to claim 2, which is characterized in that on the basis of the total weight of the plant antiseptic agent
It calculates, the pepper extract accounts for 20%, and the Radix Pulsatillae extract accounts for 60%, and the moss extract accounts for 20%.
4. application of the plant antiseptic agent in cosmetics as described in claim any one of 1-3.
5. application according to claim 4, which is characterized in that the plant antiseptic agent accounts for the 5- of the cosmetics weight
10%, preferably 6%.
6. a kind of adacrya makeup remover comprising plant antiseptic agent described in claim any one of 1-3.
7. adacrya makeup remover according to claim 6, which is characterized in that the plant antiseptic agent accounts for the adacrya makeup remover
The 5-10% of weight, preferably 6%.
8. adacrya makeup remover according to claim 6, which is characterized in that the adacrya makeup remover further includes following weight hundred
Divide the raw material of ratio: EDETATE SODIUM 0.01-1%, sodium chloride 0.5-1%, glycerol 5-90%, 1,2- hexylene glycol 0.5-1%, tween-
28 1-5%, 20 carbon of Natrulon H-10, two acid esters/14 carbon, two esters of gallic acid 1-5%, water surplus.
9. a kind of preparation method of the adacrya makeup remover comprising plant antiseptic agent described in claim any one of 1-3, special
Sign is that the preparation method includes the following steps: that water, EDETATE SODIUM, sodium chloride and glycerol are added in a reservoir, stirs and rises
Temperature is stirred for being cooled to 35-45 DEG C to 80-85 DEG C, insulated and stirred 30-50min, be added 1,2- hexylene glycol, tween -28, gather it is sweet
Oil -10 20 two acid esters of carbon/14 carbon, two esters of gallic acid and plant antiseptic agent, after mixing evenly, filter cloth discharges up to the nothing
Tear makeup remover.
10. preparation method according to claim 9, which is characterized in that the filter cloth is 200 mesh.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910825761.3A CN110507567A (en) | 2019-08-29 | 2019-08-29 | A kind of plant antiseptic agent and its application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910825761.3A CN110507567A (en) | 2019-08-29 | 2019-08-29 | A kind of plant antiseptic agent and its application |
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| CN110507567A true CN110507567A (en) | 2019-11-29 |
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| CN201910825761.3A Pending CN110507567A (en) | 2019-08-29 | 2019-08-29 | A kind of plant antiseptic agent and its application |
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|---|---|---|---|---|
| CN105796462A (en) * | 2016-03-25 | 2016-07-27 | 无锡简玺生物科技有限公司 | Composition used for cleaning skin and preparation method thereof |
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| KR101946236B1 (en) * | 2017-09-27 | 2019-02-11 | 주식회사 익스플즌 | Cosmetical composition with antimicrobial and antioxidant using natural plant extract and cosmetics comprising thereof |
| CN109464306A (en) * | 2018-10-29 | 2019-03-15 | 江西初芙化妆品有限公司 | Mild inirritative makeup remover and preparation method thereof |
-
2019
- 2019-08-29 CN CN201910825761.3A patent/CN110507567A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105796462A (en) * | 2016-03-25 | 2016-07-27 | 无锡简玺生物科技有限公司 | Composition used for cleaning skin and preparation method thereof |
| KR101946236B1 (en) * | 2017-09-27 | 2019-02-11 | 주식회사 익스플즌 | Cosmetical composition with antimicrobial and antioxidant using natural plant extract and cosmetics comprising thereof |
| CN108113925A (en) * | 2017-12-27 | 2018-06-05 | 广州润普森化工科技有限公司 | A kind of natural antiseptic agent and preparation method thereof and the application in cosmetics |
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Application publication date: 20191129 |