CN101617995B - Composition with sweat-restricting, deodorization and washing functions - Google Patents
Composition with sweat-restricting, deodorization and washing functions Download PDFInfo
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- CN101617995B CN101617995B CN2009100894681A CN200910089468A CN101617995B CN 101617995 B CN101617995 B CN 101617995B CN 2009100894681 A CN2009100894681 A CN 2009100894681A CN 200910089468 A CN200910089468 A CN 200910089468A CN 101617995 B CN101617995 B CN 101617995B
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Abstract
The invention discloses a composition with sweat-restricting, deodorization and washing functions. The composition comprises the following components of 0.02-5 percent of bactericide, 2-50 percent of washing agent and 1-10 percent of antiperspirant, wherein the bactericide is selected from triclosan, triclocarban, a combination of triclosan and chlorhexidine and a combination of triclocarban and chlorhexidine. The product has the effects of sweat-restricting, deodorization and washing and is suitable for families or bath industries.
Description
Technical field
The present invention relates to washing and cosmetic field, particularly a kind of compositions that has the anti-perspirant deodorizing washing function simultaneously.
Background technology
People's whole body is covered with sweat gland, constantly secretes perspiration, and is moistening and drain refuse in the body to keep skin surface.Hands and foot be the human body position of easy perspiration normally.The situation of everyone sweat secretion is different, and some people perspires less at ordinary times, and some people's body constitution is special, and it is just a lot of to perspire at ordinary times.Same individual also changes because of the difference at food, motion, the mental status, external environment and position.Fresh perspiration excretes and does not have stink from the skin of cleaning, and perspiration rests on the skin, through the bacterial fermentation decomposition, great variety generation stink takes place just with material such as the fatty acid of smegma, protein and epidermis dead cell, dirt etc.Sweaty foot is not volatile because of stopping of shoes, above-mentioned effect often takes place and stinks, and is commonly called as " foot odor ".If foot's sweat gland is flourishing, sweaty foot is many, or the motion perspiration is many, causes the chance of foot odor bigger.Also have a kind of special body odor, be commonly called as " bromhidrosis ", it be since under the axillary fossa material of apocrine gland abnormal secretion become SCFA through bacterial decomposition, produce stench.Hyperhidrosis or fetid sweat (like foot odor and bromhidrosis) learn especially for people's life and work social communication brings worry, even become and other people alternative obstacle, influenced work and life.
According to the reason that fetid sweat produces, alleviate or eliminates fetid sweat and can set about from two aspects: the one, the excessive discharge of inhibition perspiration; The 2nd, prevent or eliminate the stink of generation.
Antiperspirant in the anti-perspirant deodorizing composition has cohesion to protein, and the sweat gland mouth is expanded and the circulation of obstruction perspiration, suppresses perspire, thereby reaches the purpose that reduces the sweat secretion amount.The chemical compound that contains aluminum, zinc, zirconium is the antiperspirant of using always.But simple slaine such as aluminum chloride or aluminum sulfate, meeting produces the highly acid of chafe and tissue after dissociating, thereby less employing.Modern antiperspirant is mainly the one-tenth salt complex of aluminum or zirconium; Like polymeric aluminum chloride, polymeric aluminum chloride propylene glycol complex, polymeric aluminum chloride allantoin complex, chlorination aluminum zirconium glycine, tetrachloro hydration aluminum zirconium glycine, glycine aluminum chloride, zirconyl hydroxychloride, they can dissociate chloride ion in suitable solvent (for example water).
Killing or suppressing local antibacterial also is a main method eliminating fetid sweat.Anti-perspirant deodorizing composition antibacterial commonly used comprises triclosan (trichloro hydroxyl diphenyl ether), triclocarban (3 in open source information and the product at present; 4; 4 '-the trichlorine diphenylurea), chlordene biphenol methylmethane, 2; 2 '-sulfo--two (4, the 6-chlorophenesic acid), benzalkonium chloride, benzalkonium bromide, chlorhexidine.Triclosan is the high-efficiency broad spectrum antibacterial; Gram positive bacteria, negative bacterium, yeast and virus are all killed and inhibitory action; With human body skin the good compatibility is arranged; Animal toxicology experiment widely for a long time proves that also it under the suggestion scope of application and consumption, can reach the world today to the toxic international standard of chemicals, is the safe and efficient broad spectrum antimicrobicide of praising highly in the world at present.Triclocarban (TCC) is the antibacterial agent of a kind of efficient, wide spectrum, safety.
For perspiration and local dirt, the best method of removing is washing.When this local illness of treatment fetid sweat, people also often clean part (like foot) earlier through the mode of washing earlier, carry out antiperspirant or antibacterial again and treat.But also do not find at present product that antiperspirant, deodorization, washing function are rolled into one.
Summary of the invention
The inventor find unexpectedly with some antibacterial and detergent and antiperspirant with the certain proportion combination after, have fine washing anti-perspirant deodorizing effect, very convenient people use.Therefore the inventor designs and discloses this invention.
The invention discloses the compositions that has the anti-perspirant deodorizing washing function simultaneously; It is characterized in that containing 0.02～5% antibacterial, 2～50% detergent, 1～20% antiperspirant; Preferably contain 0.1～2% antibacterial; 5～20% detergent, 2～10% antiperspirant, same antibacterial is selected from the combination of combination, triclocarban and the chlorhexidine of triclosan, triclocarban, triclosan and chlorhexidine; Most preferably contain 0.1～1% antibacterial, 5～10% detergent, 2～5% antiperspirant.The compositions that has the anti-perspirant deodorizing washing function simultaneously provided by the invention, wherein antibacterial is selected from the combination of combination, triclocarban and the chlorhexidine of triclosan, triclocarban, triclosan and chlorhexidine; Preferably from the combination of combination, triclocarban and the chlorhexidine of triclosan and chlorhexidine.The chlorhexidine that the present invention adopts is selected from the various salt of chlorhexidine, preferably from chlorhexidine acetate, chlorhexidine gluconate.Triclosan and triclocarban are wide-spectrum bactericides, but fungus is had more special killing action, and chlorhexidine is all effective to gram positive bacteria and negative bacterium, but stronger to the gram positive bacteria effect.Therefore triclosan or triclocarban and chlorhexidine are made up, stronger to the killing effect of various mushrooms.
The detergent that the present invention adopts adopts surfactant; And be selected from ionic surfactant and nonionic surfactant; Wherein ionic surfactant is selected from anionic surfactant, cationic surface active agent, amphoteric ionic surfactant, preferably from amphoteric ionic surfactant.The anionic surfactant that the present invention adopts is selected from fatty acid soaps, sarcosinate, alkyl sulfate, sulfosuccinate, alkyl ether sulfate, aminoethane sulfonic acid salt, fatty acyl polypeptide condensation substance, glycerine monofatty ester sulfate, phosphate ester, preferably from fatty acid soaps, alkyl sulfate, fatty acyl polypeptide condensation substance, glycerine monofatty ester sulfate.The amphoteric ionic surfactant that the present invention adopts is selected from imidazolidine derivatives, betaines, amino acids, oxidation of fat amine, preferably from betaines, oxidation of fat amine, and autoxidation fat amine most preferably.The oxidation of fat amine amphoteric ionic surfactant that the present invention adopts is selected from alkyl dimethyl amine oxide, alkyl diethyl alcohol radical amine oxide, alkane acyl Propylamino dimethyl oxidation amine, preferably from alkane acyl Propylamino dimethyl oxidation amine.The alkane acyl Propylamino dimethyl oxidation amine that the present invention adopts is preferably from cocoyl propyl group amine oxide, lauroyl propyl group amine oxide.
The antiperspirant that the present invention adopts is selected from polymeric aluminum chloride, zirconyl hydroxychloride, polymeric aluminum chloride propylene glycol complex, polymeric aluminum chloride allantoin complex, glycine aluminum chloride, chlorination aluminum zirconium glycine or tetrachloro hydration aluminum zirconium glycine, preferably from polymeric aluminum chloride, polymeric aluminum chloride propylene glycol complex, polymeric aluminum chloride allantoin complex.
The compositions that has the anti-perspirant deodorizing washing function in the time of among the present invention, its dosage form are solution, Emulsion, suspension, gel, preferably gel.Gel is prone to preserve, stablizes, can flows, the convenient use.Gel and skin contact are bigger, can give full play to drug effect, and have reduced use cost.
The compositions that has the anti-perspirant deodorizing washing function in the time of among the present invention except containing antibacterial, detergent, antiperspirant, also contains the relevant essential composition of dosage form of other preparations.These compositions are selected from solvent, cosolvent, solubilizing agent, suspending agent, penetrating agent, wetting agent, skin-nourishing agent, pH regulator agent, pruritus, emollient, aromatic, pigment.Select these compositions or wherein one or more according to preparation prescription and arts demand.
The solvent that the present invention adopts or be called disperse medium is when preparation solution, suspension, gel dosage form, for water or is the solution of main (water accounts for mass ratio more than 50%) with water through allotment; During Emulsion, solvent can be an oils and fats in preparation, dissolve water-fast composition after, in being dispersed in water or aqueous solution.The oils and fats that the present invention adopts is unrestricted, so long as can the water insoluble active ingredient dissolving that relate among the present invention is just passable, specifically can be selected from liquid paraffin, vegetable oil, vaseline, spermol, stearyl alcohol, lanoline, Cera Flava.
The cosolvent that the present invention adopts is selected from propylene glycol, ethanol, glycerol, Macrogol 200, PEG400, dimethyl sulfoxide, preferably from propylene glycol, ethanol, Macrogol 200, most preferably propylene glycol.When the present invention relates to, have in the compositions of anti-perspirant deodorizing washing function and add cosolvent; Can be earlier with water insoluble active ingredient; Like triclosan and triclocarban solvent, redispersion can reach solute effect like this or form very thin particle in aqueous solvent.Very thin particle as at micron order, can promote the wherein water dissolution of composition.Therefore adopt cosolvent to help using the position to obtain higher concentration of sterilant, thereby obtain better bactericidal effect.
Nonionic surfactant is mainly adopted in the solubilizing agent that the present invention adopts, and is selected from tween, span, poloxamer, Bian Ze, Myrij, peregal, preferably from tween; Wherein tween is selected from polysorbas20, Tween 80, polysorbate60.
The suspending agent that the present invention adopts mainly is a macromolecule, and the latter comprises natural polymer and synthetic high polymer.The natural polymer that the present invention adopts is selected from arabic gum, guar gum, tragcanth, Resina persicae, xanthan gum, locust bean gum, sodium alginate, pectin, chitosan, Pullulan, preferably from arabic gum, xanthan gum.The synthetic high polymer that the present invention adopts is selected from methylcellulose, hypromellose, hydroxypropyl cellulose, hydroxyethyl-cellulose, carbomer, polyvidone, sodium carboxymethyl cellulose, polyvinyl alcohol; Preferably from methylcellulose, hypromellose, hydroxypropyl cellulose, carbomer, most preferably hypromellose.
The penetrating agent that the present invention adopts is selected from surfactant, dimethyl sulfoxide, azone, alcohol compound, and preferably from dimethyl sulfoxide, alcohol compound, wherein alcohol compound is selected from menthol, Oleum menthae, Borneolum Syntheticum, eucalyptus oil, Oleum Terebinthinae, tea tree oil.The wetting agent that the present invention adopts is selected from propylene glycol, glycerol, sorbitol.The skin-nourishing agent that the present invention adopts comprises allantoin, vitamin, hyaluronic acid, epidermal growth factor, cod-liver oil, ampeptide elemente.
The pH regulator agent that the present invention adopts for example is selected from lactic acid, acetic acid, citric acid, tartaric acid, phosphoric acid hydrogen or dihydric salt, aminoacid, carbonic acid from various weak acid or weak base and their salt thereof, and their salt, but is not limited to this.O'clock antibacterial activity is the strongest in pH5～7 owing to chlorhexidine, so adjust the pH value of composition system sometimes, can obtain better bactericidal effect.
The pruritus that the present invention adopts can be selected from Borneolum Syntheticum, menthol, Camphora.The emollient that the present invention adopts can be selected from vaseline, high triacontanol, steroid, silicone oil, glyceride, lanoline.The aromatic that the present invention adopts derives from various essence that can on skin, use or spice.These essence or spice is from natural extract or synthetic, and can carry out various combinations according to product needed.The pigment that the present invention adopts is also unrestricted, as long as can be used for can adopting of skin.
Above-mentioned additive and consumption thereof are selected according to dosage form, method for preparing, subjective demand, just can obtain the compositions of satisfied good stability with reference to open source information or with this professional field existing conventional technology.
Concrete prescription, the dosage form according to the present invention can design different preparation technologies.The preparation of solution often need be dissolved in all the components together or respectively certain solvent or adds in the solvent of cosolvent, solubilizing agent, possibly also need operations such as stirring, heating in the preparation process.The preparation and the solution of suspensoid are similar, but certain or several kinds of compositions are insoluble state, but are the high degree of dispersion state, can stable for extended periods of time in the suspending agent environment.Gel mainly is that the composition that forms gel is arranged in the additive, some macromolecular material for example, and all the components becomes not flow or the sluggish flow state therein, and stability is also better.
Human body uses the efficacy test result to prove; The compositions that has the anti-perspirant deodorizing washing function simultaneously disclosed by the invention has ideal washing, antiperspirant, deodorizing effect, and it is obvious to be used for effects such as bromhidrosis, foot odor, sweaty foot, hand perspiration; Access times are few, the effect length of holding time.
Further specify the present invention through some embodiment below.
The specific embodiment
Embodiment 1, anti-perspirant deodorizing solution
Triclosan 0.05g
Polymeric aluminum chloride 2g
Oleic acid base ethyl sulfonic acid sodium 5g
Propylene glycol 25g
Tween 80 5g
Allantoin 0.1g
Water solublity Camellia sinensis oil 0.1g
Deionized water adds to 100ml
Get triclosan and add propylene glycol, heating, dissolving under agitation adds Tween 80, oleic acid base ethyl sulfonic acid sodium, allantoin, water solublity Camellia sinensis oil, deionized water then gradually in proper order, obtains solution.
Embodiment 2, anti-perspirant deodorizing Emulsion
Triclocarban 0.3g
Chlorination aluminum zirconium glycine 10g
Sodium dioctyl sulfosuccinate 15g
Liquid paraffin 10g
Propylene glycol 10g
Chlorhexidine gluconate 0.2g
Glyceryl monostearate 2g
Tween 80 10g
Vitamin A acetate 0.1g
Menthol is an amount of
Tea tree oil is an amount of
Essence is an amount of
Deionized water adds to 100ml
Liquid paraffin, propylene glycol, Tween 80, glyceryl monostearate, vitamin A acetate are heated to 70 ℃; All the dissolving back adds menthol and triclocarban, and dissolving adds 1% chlorhexidine gluconate aqueous solution then; And stir frequently; Become even solvent, add all the other compositions and water then, be cooled to room temperature and obtain even Emulsion.
Embodiment 3, anti-perspirant deodorizing suspensoid
Triclocarban 0.3g
Polymeric aluminum chloride 20g
Sodium lauroyl sarcosine 20g
Chlorhexidine acetate 0.2g
Propylene glycol 5g
Ethanol 5g
Stearic acid monoethanolamide 5g
Sodium carboxymethyl cellulose 5g
Borneolum Syntheticum 0.5g
Hyaluronic acid 5g
Essence is an amount of
Deionized water adds to 100ml
Triclocarban is added heating for dissolving in propylene glycol and the ethanol; Add stearic acid monoethanolamide, sodium lauroyl sarcosine, polymeric aluminum chloride, chlorhexidine acetate, hyaluronic acid; Add 20% sodium carboxymethyl cellulose gradually, heating also continues to stir, and adds Borneolum Syntheticum and essence; Fixed with deionized water at last to 100ml, obtain even suspension.
Embodiment 4, anti-perspirant deodorizing gel
Triclosan 0.2g
Aluminium chlorhydroxide 5g
Lauroyl propyl group amine oxide 10g
Propylene glycol 5g
Hypromellose 2.5g
Chlorhexidine acetate 0.1g
Lactic acid 5g
Borneolum Syntheticum is an amount of
Allantoin is an amount of
Pigment is an amount of
Water solublity Camellia sinensis oil is an amount of
Essence is an amount of
Deionized water adds to 100g
Get triclosan, lauroyl propyl group amine oxide, Borneolum Syntheticum, propylene glycol heating dissolving fully; Add 5% hypromellose aqueous solution gradually; Stir, add aluminium chlorhydroxide and all the other compositions more gradually, stir; Last water adds to total amount, but is evenly flow-gel attitude after being cooled to room temperature.
Claims (10)
1. compositions that has the anti-perspirant deodorizing washing function simultaneously; It is characterized in that containing 0.02～5% antibacterial; 2～50% detergent; 1～20% antiperspirant; Wherein antibacterial is selected from the combination of triclosan, triclosan and chlorhexidine, and detergent is selected from ionic surfactant, nonionic surfactant, and antiperspirant is selected from polymeric aluminum chloride, zirconyl hydroxychloride, polymeric aluminum chloride propylene glycol complex, polymeric aluminum chloride allantoin complex, glycine aluminum chloride, chlorination aluminum zirconium glycine, tetrachloro hydration aluminum zirconium glycine.
2. the compositions that has the anti-perspirant deodorizing washing function simultaneously as claimed in claim 1, chlorhexidine is selected from chlorhexidine acetate, chlorhexidine gluconate.
3. the compositions that has the anti-perspirant deodorizing washing function simultaneously as claimed in claim 1, ionic surfactant is selected from anionic surfactant, cationic surface active agent, amphoteric ionic surfactant.
4. the compositions that has the anti-perspirant deodorizing washing function simultaneously as claimed in claim 3, anionic surfactant are selected from fatty acid soaps, sarcosinate, alkyl sulfate, sulfosuccinate, alkyl ether sulfate, aminoethane sulfonic acid salt, fatty acyl polypeptide condensation substance, glycerine monofatty ester sulfate, phosphate ester.
5. the compositions that has the anti-perspirant deodorizing washing function simultaneously as claimed in claim 3, amphoteric ionic surfactant are selected from imidazolidine derivatives, betaines, amino acids, oxidation of fat amine.
6. the compositions that has the anti-perspirant deodorizing washing function simultaneously as claimed in claim 1, its dosage form are solution, Emulsion, suspension, gel.
7. the compositions that has the anti-perspirant deodorizing washing function simultaneously as claimed in claim 1 contains cosolvent.
8. the compositions that has the anti-perspirant deodorizing washing function simultaneously as claimed in claim 8, cosolvent are propylene glycol.
9. compositions that has the anti-perspirant deodorizing washing function simultaneously, it is characterized in that anti-perspirant deodorizing solution, and method for preparing is following: adopt prescription as follows,
Adopting process is following, and get triclosan and add propylene glycol, heating, dissolving under agitation adds Tween 80, oleic acid base ethyl sulfonic acid sodium, allantoin, water solublity Camellia sinensis oil, deionized water then gradually in proper order, obtains solution.
10. compositions that has the anti-perspirant deodorizing washing function simultaneously, it is characterized in that the anti-perspirant deodorizing gel, and method for preparing is following: adopt prescription as follows,
Adopting process is following; Get triclosan, lauroyl propyl group amine oxide, Borneolum Syntheticum, propylene glycol heating dissolving fully, add 5% hypromellose aqueous solution gradually, stir; Add aluminium chlorhydroxide and all the other compositions more gradually; Stir, last water adds to total amount, but is evenly flow-gel attitude after being cooled to room temperature.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100894681A CN101617995B (en) | 2009-07-21 | 2009-07-21 | Composition with sweat-restricting, deodorization and washing functions |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100894681A CN101617995B (en) | 2009-07-21 | 2009-07-21 | Composition with sweat-restricting, deodorization and washing functions |
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| CN101617995B true CN101617995B (en) | 2012-01-11 |
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| CN2009100894681A Expired - Fee Related CN101617995B (en) | 2009-07-21 | 2009-07-21 | Composition with sweat-restricting, deodorization and washing functions |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104887545A (en) * | 2015-05-29 | 2015-09-09 | 苏州市贝克生物科技有限公司 | Deodorant and preparation method thereof |
| CN104958192A (en) * | 2015-06-26 | 2015-10-07 | 江苏奇力康皮肤药业有限公司 | Deodorization aromatic antiperspirant and preparation method thereof |
| CN106215212A (en) * | 2016-08-23 | 2016-12-14 | 启东市桦永机电设备制造厂 | A kind of deodorant used in shoes agent |
| CN106265128A (en) * | 2016-09-14 | 2017-01-04 | 青岛雅各仕生物技术有限公司 | For cleaning the compositions of house pet foot |
| CN109810811A (en) * | 2019-01-11 | 2019-05-28 | 澳宝化妆品（惠州）有限公司 | A kind of solid cleaning composition and preparation method thereof |
| CN109730059A (en) * | 2019-01-22 | 2019-05-10 | 宁波翔神生化有限公司 | It is a kind of efficiently to wash shield bacteriostatic agent and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1483394A (en) * | 2002-09-18 | 2004-03-24 | 中国人民解放军军事医学科学院放射医 | Anti-perspirant deodorizing composition and preparation process thereof |
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- 2009-07-21 CN CN2009100894681A patent/CN101617995B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1483394A (en) * | 2002-09-18 | 2004-03-24 | 中国人民解放军军事医学科学院放射医 | Anti-perspirant deodorizing composition and preparation process thereof |
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