CN110179681A - A kind of nano silver shower cream and preparation method thereof for capableing of antibiotic and sterilizing - Google Patents
A kind of nano silver shower cream and preparation method thereof for capableing of antibiotic and sterilizing Download PDFInfo
- Publication number
- CN110179681A CN110179681A CN201910345390.9A CN201910345390A CN110179681A CN 110179681 A CN110179681 A CN 110179681A CN 201910345390 A CN201910345390 A CN 201910345390A CN 110179681 A CN110179681 A CN 110179681A
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- extract
- shower cream
- nano
- silver
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 31
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 30
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses the nano silver shower creams that one kind is capable of antibiotic and sterilizing, by weight, including following component: 5 ~ 20 parts of purple ball algae extract, flat 5 ~ 20 parts of leaf Vanilla annamica berry extract, 5 ~ 20 parts of Pterospermi Heterophylli extract, 5 ~ 20 parts of bletilla striata extract, 1 ~ 5 part of nano-silver powder, 5 ~ 10 parts of laruyl alcohol sodium sulfovinate, 6 ~ 12 parts of Cocoamidopropyl betaine, 1 ~ 5 part of lauryl alcohol ammonium sulfate, 1 ~ 5 part of lauryl alcohol mono sulfosuccinates, 1 ~ 5 part of lauroyl amido propyl betaine, 0.5 ~ 2 part of citric acid, 1 ~ 6 part of glycerol, 1 ~ 5 part of rose oil, 0.05 ~ 1 part of preservative, enough water.Sense organ, physics and chemistry and the Biological indicators for testing the nano silver prepared reach professional standard, show that this shower cream has certain practicability, functional importance through volunteer is on probation, it solves the problems, such as nano silver application difficult in shower cream, industrialization promotion can be carried out.
Description
Technical field
The present invention relates to daily chemical products technical field, in particular to a kind of nano silver shower creams for capableing of antibiotic and sterilizing.
Background technique
Necessity of the shower cream as people's daily life uses when taking a shower for people, its main feature is that various function can be incorporated
Energy property raw material improves the microcirculation situation of skin by the Transdermal absorption of effective component, enhances the disease-resistant of skin and repairs energy
Power reaches cleaning skin, nursing skin, the multipurpose for promoting skin health.
With the improvement of people ' s living standards and the increase of job and life stress, people also proposed the quality of shower cream
The alkalinity of higher requirement, common soap base type shower cream product is strong, washes that rear skin ph value is higher, and sense is tightened in generation, easily leads to
Dry and astringent, coarse, itch of skin etc., is unable to satisfy the development trend of consumer's use demand and cosmetic industry.With daily necessities
Development, the shower cream product containing plant extracts is loved by consumers, occurs in the market various containing different plants
The shower cream product of extract, and existing functional shower cream, such as fluorine-containing sterilization shower cream, have preferable sterilizing function and
Effect, but common bacterium can only be killed, for pathogenic bacteria of drug-resistant such as antibiotic-resistance E. coli, resistant Staphylococcus aureus, resistance to
Medicine Pseudomonas aeruginosa, streptococcus pyogenes, drug resistance enterococcus, anaerobic bacteria or fungi, trichomonad, branch/Chlamydia, gonococcus etc. are caused a disease
The bactericidal effect of microorganism is with regard to undesirable.General disinfection and sterilization liquid medicine has a heavier flavour of a drug, can be more bright in use process
It is aobvious to be different from daily chemical products, it is not liked by people, therefore receive it is necessary to develop one kind convenient for people, and sterilize antibacterial effect
Preferable daily chemical products.
Summary of the invention
The purpose of the present invention is to provide the nano silver shower creams that one kind is capable of antibiotic and sterilizing.
Another goal of the invention of the invention provides the preparation method of the above-mentioned nano silver shower cream for capableing of antibiotic and sterilizing.
The present invention is achieved through the following technical solutions: one kind capableing of the nano silver shower cream of antibiotic and sterilizing, by weight,
Including following component:
It is 5~20 parts of purple ball algae extract, flat 5~20 parts of leaf Vanilla annamica berry extract, 5~20 parts of Pterospermi Heterophylli extract, white
5~20 parts of splendid achnatherum extract, 1~5 part of nano-silver powder, 5~10 parts of laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine 6~12
Part, 1~5 part of lauryl alcohol ammonium sulfate, 1~5 part of lauryl alcohol mono sulfosuccinates, lauroyl aminocarbonyl propyl beet
1~5 part of alkali, 0.5~2 part of citric acid, 1~6 part of glycerol, 1~5 part of rose oil, 0.05~1 part of preservative, enough water.
Flat leaf Vanilla annamica berry extract is the water extract of flat leaf Vanilla annamica fruit, (is containing high-efficiency antioxidant agent catechin
A kind of Polyphenols), free radical can be eliminated, inhibits the activity of matrix metalloproteinase to have the function of anti-oxidant and anti-inflammatory, to suppression
Skin processed itches and has positive effect, it can also be used to skin anti-aging.Raw material contains nature fragrance, and also can be used as natural perfume material makes
With so product is without adding daily chemical essence.
Purple ball algae: for Zi Qiu algae section, Porphyridium, fresh water algae plant.It is unicellular, often irregularly flock together,
It is outer by one layer of pellicle, red or beige thin slice is often formed on slowly drained soil and wall；It is in cot shape when dry.Purple ball algae
EPA rich in, have phycoerythrin, polysaccharide.Wherein purple ball polysaccharides it is intracellular it is extracellular have, and have content it is high, point
The advantages that son amount is big, sulfonated.Purple ball polysaccharides, which are applied to skin surface, can form highly uniform coating, and performance is better than saturating
The polysaccharide such as bright matter acid, anti-wrinkle effect are very strong.In addition, purple ball algae can increase skin to skin moisture-keeping moisturizing significant effect
Water-retaining property, the humidity of skin is improved, so that it is tender to allow skin to become more water.
The antibacterial mechanisms of nano silver: partial size is exactly accomplished nanoscale metallic silver simple substance by nano silver.Nano silver partial size is big
Mostly in 25 rans, nano-Ag particles are directly entered bacterium in conjunction with oxygen metabolism enzyme, and thallus is made to be choked to death；It can be thin with bacterium
The peptide glycan reaction of exposure on cell wall, generates moldable compound, prevents germ activity, kills germ；Silver can and pathogen
DNA combine, lead to DNA of bacteria structure variation, it is suppressed that DNA replication dna causes germ to lose vigor.This unique effect
Mechanism can kill the microorganisms such as most of bacteriums, mould, the spore being in contact with it.
Nano silver clean-keeping sterilized shower cream benefit: when in use, nano silver is to pathogenic bacteria of drug-resistant, such as: drug resistance large intestine bar
Bacterium, drug resistance Staphylococcus aureus, drug-resistant pseudomonas aeruginosa, drug resistance streptococcus, drug resistance enterococcus, anaerobic bacteria etc. have stronger antibacterial
Activity；The bacterium common to burn and scald and wound surface, such as: staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, white are read
Pearl bacterium and other pathogenic bacteria have bactericidal effect；Also powerful sterilization makees the gonococcus of chlamydia trachomatis, sexually transmitted disease
With having strong inhibition and killing effect to the tens of kinds of pathogenic microorganisms such as Escherichia coli, gonococcus, and will not generate resistance to
Pharmacological property.Meanwhile it also has promotion repair to impaired epithelial cell.It is noted that the product meets water antibacterial effect
More enhance, more conducively the treatment of disease.Scientists discovery, it is general that being imprinted under nm regime, which has extremely strong bactericidal effect,
Hundreds times of logical silver.
In order to which the present invention is better achieved, further, the ingredient of each component is defined:
10 parts of purple ball algae extract, flat 10 parts of leaf Vanilla annamica berry extract, 10 parts of Pterospermi Heterophylli extract, bletilla striata extract 10
Part, 2 parts of nano-silver powder, 8 parts of laruyl alcohol sodium sulfovinate, 9 parts of Cocoamidopropyl betaine, 2 parts of lauryl alcohol ammonium sulfate, laurel
2 parts of alcohol ether mono sulfosuccinates, 2 parts of lauroyl amido propyl betaine, 1 part of citric acid, 2 parts of glycerol, rose
2 parts of oil, 0.5 part of preservative, enough water.
In order to which the present invention is better achieved, further, the preservative is Kathon CG or ethylparaben.
In order to which the present invention is better achieved, further, water used in the shower cream is deionized water or purified water.
Above-mentioned one kind is capable of the preparation method of the nano silver shower cream of antibiotic and sterilizing, comprising the following steps:
(1) purple ball algae, flat leaf Vanilla annamica fruit are extracted using the method that water mentions respectively, is used double of method of alcohol extracting
Maple lotus, the bletilla striata extract, then the medicinal extract that will be extracted respectively, and 1:2:2:1 in mass ratio is uniformly mixed, and cross 15 meshes, standby
With；
It (2) is silver-colored source with silver nitrate, polyvinyl chloride alcohol is stabilizer, prepares partial size under the cavitation of ultrasonic vibration and exists
The ball-type nano-silver powder of 15~25nm, and glycerol and rose oil is added in the nano-silver powder of preparation, prepare the outstanding of nano-silver powder
Turbid；
(3) deionized water dissolving laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, lauryl alcohol ammonium sulfate are used,
After its complete dissolution, lauryl alcohol mono sulfosuccinates, lauroyl amido propyl betaine are added, heating water bath is extremely
50 DEG C, constant temperature, and with the speed of 38r/min, average rate stirs 30min, obtains mixed liquor I；
(4) after it is cooled to 40 DEG C, extract spare in step (1) is added, with the speed of 28r/min, average rate is stirred
30min is mixed, mixed liquor I I is made；
(5) then mixed liquor I I being placed in fermentor, fermentation process is kept for 50~60 DEG C of temperature, it is sealed by fermentation, every
Stirring in three hours is primary, and every time with the speed of 28r/min, average rate stirs 30min；
(6) it ferments after 80~96h, collects fermentation liquid, the use of the pH that citric acid adjusts fermentation liquid is 7.0~7.5；
It (7) is injection liquid with the fermentation liquid in step (6), suspension is attachment liquid in step (2), passes through jet mixing
Mode mixed fermentation liquid and suspension containing nano-silver powder are to get final shower cream finished product；
(8) preservative is added in shower cream finished product, is sent into production line encapsulation.
Technical essential in the shower cream preparation process is as follows:
First, the extracting mode of plant component, purple ball algae, flat leaf Vanilla annamica fruit must in such a way that water mentions, Pterospermi Heterophylli,
The bletilla striata only must just be had and can preferably be acted on by the medicinal extract that two kinds of extracting modes respectively extract by the way of alcohol extracting；
Second, the proportion composition of plant component, in order to guarantee that each plant extract component can play useful effect, through excessive
Secondary verification experimental verification, optimum proportioning are purple ball algae extract, flat leaf Vanilla annamica berry extract, Pterospermi Heterophylli extract, bletilla striata extraction
The use ratio of object is 1:2:2:1；
Third, the preparation of nano-silver powder, the present invention equally tested the preparation method of a variety of silver powder, including electronation
Method, photochemical method, electrochemical process, radiation method and prepares nano-silver powder by reverse micelle method, can not preferably pass through it
Glycerol, attar of rose are prepared into the suspension of nano-silver powder；
4th, this important technical of fermenting is used in the preparation process of shower cream, and non-traditional be stirred
It uniformly obtains, for plant extract component after everfermentation, what is become is more soft, it is easier to allow the skin of human body to absorb this and wash one's hair
Plant extract component essence in bath lotion, in addition, fermentation after, inside substantially reduced containing oxidizing substance, substantially will not
The nano-silver powder of rear addition is impacted；
5th, pH adjusting agent is acted on using citric acid, is found during the experiment, to the stability for improving nano-silver powder
Great good effect is played；
6th, the technological means that the suspension of nano-silver powder is mixed with fermentation liquid, due to the particularity of nano-silver powder,
Suspension cannot mix in such a way that tradition is stirred with fermentation liquid, therefore especially select high-pressure injection method, use mixing
Injector is swiftly flowing fluid (i.e. injection liquid) with fermentation liquid, and suspension is passive mixed liquor (i.e. attachment liquid), can will
The suspension and fermentation liquid of nano-silver powder are sufficiently mixed, and keep stable.
In order to which preparation method of the present invention is better achieved, further, in the step (1), the water of purple ball algae
The process of mentioning is to take air-dried purple ball algae to shred to read into coarse powder, crosses 40 meshes, it is placed in flask, deionized water is added, completely
The purple ball algae of submergence, immersion 12~for 24 hours, 1~2h is boiled in heating, and condenser pipe, lasting condensation is arranged in flask opening；It is completely cooling to it
Afterwards, impurity is filtered off, is directly distilled, obtained medicinal extract is the water extract of purple ball algae.
In order to which preparation method of the present invention is better achieved, further, in the step (1), flat leaf Vanilla annamica
It is to take air-dried flat leaf Vanilla annamica fruit to shred to read into coarse powder that the water of fruit, which proposes process, crosses 40 meshes, it is placed in flask, be added
Deionized water soaks flat leaf Vanilla annamica fruit completely and does not have a purple ball algae, impregnate 12~for 24 hours, 1~2h is boiled in heating, and flask opening setting is cold
Solidifying pipe, it is lasting to condense；After it is completely cooling, impurity is filtered off, is directly distilled, obtained medicinal extract is the water of flat leaf Vanilla annamica fruit
Extract.
In order to which preparation method of the present invention is better achieved, further, in the step (1), the alcohol of Pterospermi Heterophylli
The process of mentioning is to take air-dried Pterospermi Heterophylli to shred to read into coarse powder, crosses 40 meshes, it is placed in flask, what 5-15 times of addition was measured
80% alcohol dipping, and heating water bath is used, keeping temperature is 60 DEG C, extracts 3h, and solid-liquid ratio 1:30 obtains the leaching of Pterospermi Heterophylli
Cream.
In order to which preparation method of the present invention is better achieved, further, in the step (1), the alcohol extracting of the bletilla striata
Process is to take the air-dried bletilla striata to shred to read into coarse powder, crosses 40 meshes, it is placed in flask, 5-15 times of 95% second measured is added
Alcohol dipping, and heating water bath is used, keeping temperature is 70 DEG C, extracts 3h, and solid-liquid ratio 1:25 obtains the medicinal extract of the bletilla striata.
Compared with prior art, the present invention have the following advantages that and the utility model has the advantages that
(1) present invention especially choose purple ball algae, flat leaf Vanilla annamica fruit, Pterospermi Heterophylli, bletilla striata Four Plants extract, and it is logical
Cross different extracting methods, obtain corresponding extract, then after being used in compounding, can whitening to human skin, it is anti-oxidant, dispel
Wrinkle, moisturizing, moisturizing have preferable effect, and have pleasant fragrance, improve user experience；
(2) present invention is greatly improved the antibiotic and sterilizing ability of the shower cream, is made by the way that nano-silver powder is added
Shower cream can further play its bactericidal effect after meeting water, the bactericidal effect geometry grade of shower cream be promoted, Ren Men
It is equivalent to using the shower cream and has used germ killing drugs, discomfort will not be brought to human body, provide guarantee for the health of human body；
(3) the present invention provides reach professional standard in sense organ, physics and chemistry and Biological indicators the shower being prepared；Through
Volunteer is on probation to show that this shower cream has certain practicability, functional importance, and which solve nano silvers in shower cream
The technical problem of application can carry out industrialized production, be suitable for wide popularization and application.
Specific embodiment
The present invention is described in further detail below with reference to embodiment, embodiments of the present invention are not limited thereto,
Without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, various replace is made
It changes and changes, should all be included within the scope of the invention.
For the purpose of the present invention, process conditions and advantage effect is more clearly understood, in conjunction with following embodiment, to this
Invention is described in further detail, and specific implementation example described herein only to explain the present invention, is not used to limit this
Invention.
Embodiment 1:
The present embodiment discloses a kind of nano silver shower cream for capableing of antibiotic and sterilizing, and by weight, including purple ball algae is extracted
10 parts of object, flat 10 parts of leaf Vanilla annamica berry extract, 10 parts of Pterospermi Heterophylli extract, 10 parts of bletilla striata extract, nano-silver powder 2 part, month
8 parts of cinnamic alcohol sodium sulfovinate, 9 parts of Cocoamidopropyl betaine, 2 parts of lauryl alcohol ammonium sulfate, lauryl alcohol sulfosuccinic acid list
2 parts of ester disodium salt, 2 parts of lauroyl amido propyl betaine, 1 part of citric acid, 2 parts of glycerol, 2 parts of rose oil, preservative 0.5
Part, enough water.
Wherein, the preservative is Kathon CG or ethylparaben, and the water used is deionized water or purified water.
Its specific preparation process is,
(1) purple ball algae, flat leaf Vanilla annamica fruit are extracted using the method that water mentions respectively, is used double of method of alcohol extracting
Maple lotus, the bletilla striata extract, then the medicinal extract that will be extracted respectively, and 1:2:2:1 in mass ratio is uniformly mixed, and cross 15 meshes, standby
With；
It (2) is silver-colored source with silver nitrate, polyvinyl chloride alcohol is stabilizer, prepares partial size under the cavitation of ultrasonic vibration and exists
The ball-type nano-silver powder of 15~25nm, and glycerol and rose oil is added in the nano-silver powder of preparation, prepare the outstanding of nano-silver powder
Turbid；
(3) deionized water dissolving laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, lauryl alcohol ammonium sulfate are used,
After its complete dissolution, lauryl alcohol mono sulfosuccinates, lauroyl amido propyl betaine are added, heating water bath is extremely
50 DEG C, constant temperature, and with the speed of 38r/min, average rate stirs 30min, obtains mixed liquor I；
(4) after it is cooled to 40 DEG C, extract spare in step (1) is added, with the speed of 28r/min, average rate is stirred
30min is mixed, mixed liquor I I is made；
(5) then mixed liquor I I being placed in fermentor, fermentation process is kept for 50~60 DEG C of temperature, it is sealed by fermentation, every
Stirring in three hours is primary, and every time with the speed of 28r/min, average rate stirs 30min；
(6) it ferments after 80~96h, collects fermentation liquid, the use of the pH that citric acid adjusts fermentation liquid is 7.0~7.5；
It (7) is injection liquid with the fermentation liquid in step (6), suspension is attachment liquid in step (2), passes through jet mixing
Mode mixed fermentation liquid and suspension containing nano-silver powder are to get final shower cream finished product；
(8) preservative is added in shower cream finished product, is sent into production line encapsulation.
The nano silver shower cream finished product for the antibiotic and sterilizing being prepared is surveyed according to " QB/T1994-2013 " bath agent standard
It is fixed.
1, appearance detects
The colourless wide mouth glass bottle with plug after being cleaned and dried is taken, the nano silver that the 200ml antibiotic and sterilizing is added is taken a shower
Dew observes the state of shower cream by non-direct light.
2, odor detection
Using 20 volunteers as standard, the appropriate shower cream is taken to be identified with smell.
3, Detection of Stability
Take 3 be cleaned and dried after the colourless wide mouth glass bottle with plug, respectively plus people's 100ml Yao medicine bath shower cream,
Wherein 1 wide mouth glass bottle is put into -5 DEG C of refrigerators；1 wide mouth glass bottle is put into 40 DEG C of insulating box；Other 1 wide-mouth glass
Glass bottle is put at room temperature.Take out 3 parts of samples afterwards for 24 hours, wait 3 parts restore to after room temperature, compare 3 parts of samples whether have layering,
The variation such as precipitating.
4, total effective analyte detection
It is measured by the 7th chapter regulation A method in " QB/T1994-2013 ".
5, pH is detected
When test temperature is 25 DEG C, sample is diluted to 10% with freshly prepared distilled water, stirring to sample is completely dissolved, and is used
PH meter measures pH.
6, test result
Sense organ, physics and chemistry and the Biological indicators of shower cream are shown in Table 1.Acquired results show that this Yao medicine bath shower cream reaches and wash one's hair
Bathe agent professional standard.
Sense organ, physics and chemistry and the Biological indicators testing result of 1 shower cream of table
Embodiment 2:
The present embodiment is directed to the nano silver shower cream for capableing of antibiotic and sterilizing that above-described embodiment is prepared, and carries out toxicology
Test, including acute ocular irritation test and multiple skin irritation test.
One, acute ocular irritation test,
1, tested material:
The nano silver shower cream of the antibiotic and sterilizing is as former state.
2, animal and feeding environment
2.1 animal
Healthy big rabbit 3, the ear of Japan, regular grade are provided by farm, experimental animal administration commission, Sichuan Province, before test at least
It adapts to 3 days.
2.2 feeding environment
20~22 DEG C of temperature, 40~70%, 12/12 hour light and shade of relative humidity alternately illuminates.Single cage raising, it is autonomous to drink
Water.Full-valence pellet feed.
3, major experimental instrument and reagent
KJ5S3 type hand-held slit-lamp microscope；
Phosphor strip, specification: every 1.0mg containing fluorescein sodium, built-in 10 of every box.
4, test method
4.1 test the preceding moon for 24 hours, are checked (including using fluorescein sodium inspection) to two eyes of experimental animal.Have
The animal of irritation, corneal defect and conjunctival damage cannot be used for testing.
4.2 gently pull open the palpebra inferior of rabbit side eyes, and tested material 0.1ml is instilled in conjunctival sac, upper and lower eyelid is made
Passive closure 1s is to prevent tested material from losing.With enough, flow velocity is very fast but not the water flow of animal eye injury is caused to be rushed when to 30s
Wash 30s.
4.3 clinical examinations and scoring: instill 1 after tested material again, 24,48,72h and 4d and 7d be to animal eyes
It is checked.If 72h does not occur stimulate the reaction, experiment can be terminated.If it find that involving cornea or thering are other stimulations to make
With not recuperator in 7d is usually no more than 21d simultaneously to determine that invertibity or the irreversibility of the damage need to extend time observation
The visual report of 7d, 14d, 21d are provided.Other than observing cornea, iris, conjunctiva, other detrimental effects should all
It records and reports.
Then " cosmetics health specification " acute eye irritation/corrosion test table Scoring System such as table 2 is pressed:
2 tested material of table is to Rabbits with Acute eye irritation result (30s flushing)
Tested material is microstimulation to Rabbits with Acute eye irritation.
Two, multiple skin irritation test
1, tested material:
Shower cream finished product stoste, 0.5ml/2.5cm × 2.5cm/ is only.
2, animal and feeding environment
2.1 animal
Healthy big rabbit 4, the ear of Japan, regular grade, male and female are provided by farm, experimental animal administration commission, Sichuan Province, examination
It is at least adapted to 3 days before testing.
2.2 feeding environment
20~22 DEG C of temperature, 40~70%, 12/12 hour light and shade of relative humidity alternately illuminates.Single cage raising, it is autonomous to drink
Water.Full-valence pellet feed.
3. test method
Before test about for 24 hours, experimental animal back backbone diamond wool is cut, epidermis can not be damaged, unhairing range is left and right each
About 3cm × 3cm takes tested material 0.5ml directly to smear (area about 2.5cm × 2.5cm) on the skin, smears 1 time every time, even
Continuous to smear 14d, since 2d, cropping before smearing every time removes residual tested material with warm water.1 as a child observation is as a result, press
" cosmetics health specification " (version in 2007) skin irritation/corrosion test table scoring, check plot and trial zone are equally handled,
Every animal average integral daily is calculated according to respective formula, skin irritatin intensity is determined from table.It is as shown in table 3:
3 tested material of table is to the multiple skin irritation test result of rabbit
Tested material is nonirritant to the multiple skin irritation of rabbit
Three, toxicology test the result shows that:
Acute ocular irritation test result: microstimulation
Multiple skin irritation test result: nonirritant
Therefore, can be with this product stimulation harmless to the human body, it can be safe to use.
Embodiment 3:
The present embodiment carries out health chemical testing to the nano silver shower cream of the antibiotic and sterilizing made from the method for the present invention,
As a result such as table 4.
4 hygienic chemistry testing result of table
Health chemical testing the result shows that, lead in this product, arsenic, mercury content meet national standard, can use safely.
Embodiment 4:
By 300 volunteers using the nano silver shower cream is investigated, 300 volunteers fill in the present embodiment after
Using effect evaluation table, score are set as 0~10 part, and nano silver shower cream using effect evaluation average mark is shown in Table 5.
The nano silver shower cream using effect of table 5 evaluates average mark
| Test item | Nano silver shower cream | Common shower cream |
| Odor type | 9.1 | 7.8 |
| Foaming abundancy degree | 8.5 | 8.4 |
| Cleannes | 8.8 | 8.5 |
| Comfort level | 9.1 | 8.1 |
| Anti-inflammatory anti-itch effect | 9.9 | 6.0 |
| Skin whitening effects | 9.2 | 7.5 |
| Common sensation scoring | 9.4 | 7.0 |
As shown in Table 5, it is higher to test the banishing the feeling of languor of nano silver shower cream, anti-inflammatory anti-itch effect isodisperse by volunteer,
Show that nano silver shower cream has certain practical and industrial value.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that: not
A variety of change, modification, replacement and modification can be carried out to these embodiments by being detached under the principle of the present invention and objective, of the invention
Range is defined by the claims and their equivalents.
Claims (9)
1. the nano silver shower cream that one kind is capable of antibiotic and sterilizing, which is characterized in that by weight, including following component:
5 ~ 20 parts of purple ball algae extract, flat 5 ~ 20 parts of leaf Vanilla annamica berry extract, 5 ~ 20 parts of Pterospermi Heterophylli extract, bletilla striata extract
5 ~ 20 parts, 1 ~ 5 part of nano-silver powder, 5 ~ 10 parts of laruyl alcohol sodium sulfovinate, 6 ~ 12 parts of Cocoamidopropyl betaine, lauryl alcohol sulphur
1 ~ 5 part of sour ammonium, 1 ~ 5 part of lauryl alcohol mono sulfosuccinates, 1 ~ 5 part of lauroyl amido propyl betaine, citric acid
0.5 ~ 2 part, 1 ~ 6 part of glycerol, 1 ~ 5 part of rose oil, 0.05 ~ 1 part of preservative, enough water.
2. the nano silver shower cream that one kind according to claim 1 is capable of antibiotic and sterilizing, which is characterized in that by weight
Meter, including following component:
10 parts of purple ball algae extract, flat 10 parts of leaf Vanilla annamica berry extract, 10 parts of Pterospermi Heterophylli extract, 10 parts of bletilla striata extract,
2 parts of nano-silver powder, 8 parts of laruyl alcohol sodium sulfovinate, 9 parts of Cocoamidopropyl betaine, 2 parts of lauryl alcohol ammonium sulfate, laruyl alcohol
2 parts of ether sulfosuccinic acid monoester disodium salt, 2 parts of lauroyl amido propyl betaine, 1 part of citric acid, 2 parts of glycerol, rose oil 2
Part, 0.5 part of preservative, enough water.
3. the nano silver shower cream that one kind according to claim 1 or 2 is capable of antibiotic and sterilizing, which is characterized in that described anti-
Rotten agent is Kathon CG or ethylparaben.
4. the nano silver shower cream that one kind according to claim 1 or 2 is capable of antibiotic and sterilizing, which is characterized in that described to wash one's hair
Water used in bath lotion is deionized water or purified water.
5. described in any item one kind are capable of the preparation method of the nano silver shower cream of antibiotic and sterilizing according to claim 1 ~ 4,
It is characterized in that, comprising the following steps:
(1) purple ball algae, flat leaf Vanilla annamica fruit are extracted using the method that water mentions respectively, uses double of maple of method of alcohol extracting
Lotus, the bletilla striata extract, then the medicinal extract that will be extracted respectively, and 1:2:2:1 in mass ratio is uniformly mixed, and cross 15 meshes, spare；
(2) be silver-colored source with silver nitrate, polyvinyl chloride alcohol is stabilizer, prepared under the cavitation of ultrasonic vibration partial size 15 ~
The ball-type nano-silver powder of 25nm, and glycerol and rose oil is added in the nano-silver powder of preparation, prepare the suspension of nano-silver powder；
(3) deionized water dissolving laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, lauryl alcohol ammonium sulfate are used, to it
After complete dissolution, lauryl alcohol mono sulfosuccinates, lauroyl amido propyl betaine, heating water bath to 50 is added
DEG C, constant temperature, and with the speed of 38r/min, average rate stirs 30min, obtains mixed liquor I；
(4) after it is cooled to 40 DEG C, extract spare in step (1) is added, with the speed of 28r/min, average rate stirring
Mixed liquor I I is made in 30min；
(5) then mixed liquor I I is placed in fermentor, fermentation process is kept for 50 ~ 60 DEG C of temperature, is sealed by fermentation, every three hours
Stirring is primary, and every time with the speed of 28r/min, average rate stirs 30min；
(6) it ferments after 80 ~ 96h, collects fermentation liquid, the use of the pH that citric acid adjusts fermentation liquid is 7.0 ~ 7.5；
It (7) is injection liquid with the fermentation liquid in step (6), suspension is attachment liquid in step (2), by way of jet mixing
Mixed fermentation liquid and suspension containing nano-silver powder are to get final shower cream finished product；
(8) preservative is added in shower cream finished product, is sent into production line encapsulation.
6. the preparation method that one kind according to claim 5 is capable of the nano silver shower cream of antibiotic and sterilizing, which is characterized in that
In the step (1), it is to take air-dried purple ball algae to shred to read into coarse powder that the water of purple ball algae, which proposes process, crosses 40 meshes, it is placed in
In flask, deionized water is added, is totally submerged purple ball algae, impregnate 12 ~ for 24 hours, 1 ~ 2h, flask opening setting condensation are boiled in heating
Pipe, it is lasting to condense；After it is completely cooling, impurity is filtered off, is directly distilled, obtained medicinal extract is the water extract of purple ball algae.
7. one kind according to claim 5 or 6 is capable of the preparation method of the nano silver shower cream of antibiotic and sterilizing, feature exists
In in the step (1), it is to take air-dried flat leaf Vanilla annamica fruit to shred to read into coarse powder, mistake that the water of flat leaf Vanilla annamica fruit, which proposes process,
40 meshes, it is placed in flask, and deionized water is added, and soaks flat leaf Vanilla annamica fruit completely and does not have a purple ball algae, impregnate 12 ~ for 24 hours, heating
1 ~ 2h is boiled, flask opening setting condenser pipe is lasting to condense；After it is completely cooling, impurity is filtered off, directly distills, obtains
Medicinal extract is the water extract of flat leaf Vanilla annamica fruit.
8. one kind according to claim 5 or 6 is capable of the preparation method of the nano silver shower cream of antibiotic and sterilizing, feature exists
In in the step (1), the alcohol extracting process of Pterospermi Heterophylli is to take air-dried Pterospermi Heterophylli to shred to read into coarse powder, 40 meshes is crossed, by it
It is placed in flask, 5-15 times of 80% alcohol dipping measured is added, and use heating water bath, keeping temperature is 60 DEG C, extracts 3h, material
Liquor ratio is 1:30, obtains the medicinal extract of Pterospermi Heterophylli.
9. one kind according to claim 5 or 6 is capable of the preparation method of the nano silver shower cream of antibiotic and sterilizing, feature exists
In in the step (1), the alcohol extracting process of the bletilla striata is to take the air-dried bletilla striata to shred to read into coarse powder, crosses 40 meshes, it is placed in
In flask, 5-15 times of 95% alcohol dipping measured is added, and use heating water bath, keeping temperature is 70 DEG C, extracts 3h, solid-liquid ratio
For 1:25, the medicinal extract of the bletilla striata is obtained.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113662007A (en) * | 2021-06-30 | 2021-11-19 | 南京凯创协同纳米技术有限公司 | Preparation and application of low-temperature freezing disinfectant |
| CN115137681A (en) * | 2022-06-23 | 2022-10-04 | 深圳市黄田荔枝品牌发展有限公司 | Litchi mask and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416924A (en) * | 2008-12-05 | 2009-04-29 | 卓鸿思 | Nano silver clean-keeping sterilizing bath lotion and its preparing method |
| CN104083315A (en) * | 2014-07-31 | 2014-10-08 | 王红亚 | Skin whitening and moistening bath lotion |
| CN104083292A (en) * | 2014-07-31 | 2014-10-08 | 王红亚 | Rich-foam bath gel |
| CN105232432A (en) * | 2015-11-18 | 2016-01-13 | 李爱冰 | Traditional Chinese medicine bath cream and preparation method thereof |
| CN106214589A (en) * | 2016-09-06 | 2016-12-14 | 广西大学 | Salubrious itching-relieving shower dew and preparation method thereof |
| CN108785179A (en) * | 2018-08-17 | 2018-11-13 | 常州市飞腾工业自动化技术有限公司 | A kind of salubrious shower cream |
-
2019
- 2019-04-26 CN CN201910345390.9A patent/CN110179681A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416924A (en) * | 2008-12-05 | 2009-04-29 | 卓鸿思 | Nano silver clean-keeping sterilizing bath lotion and its preparing method |
| CN104083315A (en) * | 2014-07-31 | 2014-10-08 | 王红亚 | Skin whitening and moistening bath lotion |
| CN104083292A (en) * | 2014-07-31 | 2014-10-08 | 王红亚 | Rich-foam bath gel |
| CN105232432A (en) * | 2015-11-18 | 2016-01-13 | 李爱冰 | Traditional Chinese medicine bath cream and preparation method thereof |
| CN106214589A (en) * | 2016-09-06 | 2016-12-14 | 广西大学 | Salubrious itching-relieving shower dew and preparation method thereof |
| CN108785179A (en) * | 2018-08-17 | 2018-11-13 | 常州市飞腾工业自动化技术有限公司 | A kind of salubrious shower cream |
Non-Patent Citations (3)
| Title |
|---|
| ，宝拉•培冈等著，童文煦等译: "《美丽圣经：升级版》", 30 April 2017, 广西师范大学出版社 * |
| 付云芝等: "《应用化学综合实验教程》", 31 August 2012, 中国财富出版社 * |
| 汪多仁: "《绿色化工助剂》", 31 January 2006, 科学技术文献出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113662007A (en) * | 2021-06-30 | 2021-11-19 | 南京凯创协同纳米技术有限公司 | Preparation and application of low-temperature freezing disinfectant |
| CN113662007B (en) * | 2021-06-30 | 2022-08-02 | 南京凯创协同纳米技术有限公司 | Preparation and application of low-temperature freezing disinfectant |
| CN115137681A (en) * | 2022-06-23 | 2022-10-04 | 深圳市黄田荔枝品牌发展有限公司 | Litchi mask and preparation method thereof |
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