CN110495469A - A kind of composition pesticide and its application - Google Patents
A kind of composition pesticide and its application Download PDFInfo
- Publication number
- CN110495469A CN110495469A CN201910954734.6A CN201910954734A CN110495469A CN 110495469 A CN110495469 A CN 110495469A CN 201910954734 A CN201910954734 A CN 201910954734A CN 110495469 A CN110495469 A CN 110495469A
- Authority
- CN
- China
- Prior art keywords
- cycolxylidin
- composition
- bromine cyanogen
- insect amide
- cyanogen insect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a kind of composition pesticide, the active constituent in composition is cycolxylidin and bromine cyanogen insect amide, and composition is suitable for preventing and treating pest agriculturally.Composition pesticide of the invention, have the following beneficial effects: that (1) present composition shows fabulous synergistic effect within a certain ratio range, the insecticidal effect of composition is significantly improved than single dose, the dosage and cost for reducing pesticide simultaneously, also reduce the adverse effect and pesticide residue to environment；(2) two kinds of effective component mechanism of action in the present composition are different, and the application of composition can delay or overcome the drug resistance of pest, extend the service life of single dose.
Description
Technical field
The present invention relates to a kind of composition pesticide and its applications, for preventing and treating pest agriculturally.
Background technique
Cycolxylidin is the 4th generation anabasine insecticide of China's initiative research and development, has selective depression insect nerveous system
Unite nicotinic acetylcholine esterase receptor acting, be a kind of wide spectrum, structure be new, pollution less, hypotoxicity, efficient anabasine desinsection
Agent can be used for preventing and treating the homoptera pest on crops.
Bromine cyanogen insect amide is second generation ryanodine receptor inhibitor insecticides, can prevent and treat the 8 class insect pests of vegetables, range
It is wide extremely rare, the insect pests such as Lepidoptera, Homoptera, Semiptera all have.
The resistance problem of agricultural pests is a global problem, is always the emphasis class of agricultural science and technology worker concern
Topic.But one novel pesticide of exploitation need to screen 10,000~1.2 ten thousand compounds, cost 1.2~1.5 hundred million dollar at present, and the development cycle is
5~10 years, it is difficult to catch up with the speed that pest generates resistance.Other methods such as crop structure adjustment, different pesticide rotations etc., In
During practical operation, it is difficult really to play apparent effect.Carrying out pest control using the novel pesticide of not cross resistance is
One good solution.
Summary of the invention
The present invention provides a kind of composition pesticides to be produced by the rational mixture of cycolxylidin and bromine cyanogen insect amide
Synergistic function improves drug effect, reduces pesticide usage amount, reduces residual quantity of the pesticide on crop, alleviate environment
Pollution；To safety of human and livestock, Environmental compatibility is good, pest is not likely to produce drug resistance.
The purpose of the present invention adopts the following technical scheme that realization:
The present invention provides a kind of composition pesticide, and the active constituent of the composition pesticide is cycolxylidin and bromine cyanogen worm acyl
The mass ratio of amine, the cycolxylidin and bromine cyanogen insect amide is 1~20:1~20.
In preferred technical solution, the mass ratio of the cycolxylidin and bromine cyanogen insect amide is 1~10:1~10.
In the present invention, the combination dosage form is any one dosage form allowed on pesticide.
The present composition can use the prior art, by the original containing these effective component cycolxylidins and bromine cyanogen insect amide
Agriculturally available any dosage form is made in medicine and auxiliary material appropriate；The present composition, can crop according to required prevention and treatment, institute
Locate environmental condition, control method, all kinds of factors such as control cost, preferred dosage form is wettable powder, aqueous emulsion, missible oil, micro-
Emulsion, water dispersion granule (or aqueous dispersion tablets), suspending agent.
Auxiliary material in the present composition includes solvent, dispersing agent, wetting agent, emulsifier, stabilizer, thickener, pH tune
Section agent, antifreezing agent, excipient, filler and it is other be beneficial to the known substance that effective component is stable in the formulation and drug effect plays,
Selection different auxiliary material is configured to corresponding dosage form as needed.Above-mentioned auxiliary material be all commonly allow in pesticidal preparations using it is various
Ingredient is not particularly limited.
In preferred technical solution, the quality of the cycolxylidin and bromine cyanogen insect amide and the composition gross mass is accounted for
5~70%.
In preferred technical solution, the cycolxylidin and bromine cyanogen insect amide quality and the 10 of the composition gross mass is accounted for
~60%.
The present invention also provides application of the composition pesticide in prevention and treatment homoptera pest.
In the present invention, the homoptera pest is aphid.
Currently, there is not been reported for the relevant report compounded about cycolxylidin and bromine cyanogen insect amide.Desinsection group of the invention
The homoptera pest that object is applied to prevention and treatment crops is closed, such as: aphid.
Compared with prior art, the beneficial effects of the present invention are:
1, the reasonable compounding of a effective amount of cycolxylidin and bromine cyanogen insect amide has significant synergistic effect, can effectively prevent
Homoptera pest in crops, especially aphid.
2, two kinds of effective component mechanism of action in the present composition are different, and the application of composition can delay or overcome evil
The drug resistance of worm extends the service life of single dose.
3, two kinds of effective component compoundings of a effective amount of cycolxylidin and bromine cyanogen insect amide, enhance drug effect, therefore reaching
In the case where same control efficiency, Pesticide use amount can be reduced, to reduce residual of the pesticide on crop, is reduced to ring
The pollution in border, to safety of human and livestock, Environmental compatibility is good, pest is not likely to produce drug resistance.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that described herein, specific examples are only used to explain the present invention, is not used to limit
The fixed present invention.
The wettable powder A of 1 cycolxylidin of embodiment and bromine cyanogen insect amide
The wettable powder A of cycolxylidin and bromine cyanogen insect amide is grouped as according to mass percentage by following group:
By raw medicine (raw medicine finger ring oxygen worm quinoline and bromine cyanogen insect amide, repeat no more below in the present invention), various auxiliary agents and fill out
Material etc. is sufficiently mixed, and after ultra-fine pulverizer disintegrating, is configured to wettable powder.
The wettable powder B of 2 cycolxylidin of embodiment and bromine cyanogen insect amide
The wettable powder B of cycolxylidin and bromine cyanogen insect amide is grouped as according to mass percentage by following group:
Raw medicine, various auxiliary agents and filler etc. are sufficiently mixed, after ultra-fine pulverizer disintegrating, are configured to wettable powder.
The missible oil A of 3 cycolxylidin of embodiment and bromine cyanogen insect amide
The missible oil A of cycolxylidin and bromine cyanogen insect amide is grouped as according to mass percentage by following group:
Cycolxylidin and bromine cyanogen insect amide missible oil A preparation method are as follows: raw medicine, emulsifier etc., mixing being added in a solvent
Uniformly, it is dissolved by heating when necessary with hot bath to get transparence missible oil is arrived.
The missible oil B of 4 cycolxylidin of embodiment and bromine cyanogen insect amide
The missible oil B of cycolxylidin and bromine cyanogen insect amide is grouped as according to mass percentage by following group:
Cycolxylidin and bromine cyanogen insect amide missible oil B preparation method are as follows: raw medicine, emulsifier etc., mixing being added in a solvent
Uniformly, it is dissolved by heating when necessary with hot bath to get transparence missible oil is arrived.
The aqueous emulsion of the aqueous emulsion cycolxylidin and bromine cyanogen insect amide of 5 cycolxylidin of embodiment and bromine cyanogen insect amide, according to
Mass percentage is grouped as by following group:
Cycolxylidin and bromine cyanogen insect amide water and milk agent compounding method are as follows: raw medicine, solvent, emulsifier being mixed, stirred into
Homogeneous oil phase.Water, antifreezing agent and defoaming agent are mixed, homogeneous aqueous phase is become.Under high velocity agitation, by oily phase, water phase
It is uniformly mixed, obtains aqueous emulsion.
The water-dispersible grain of the water dispersible granules cycolxylidin and bromine cyanogen insect amide of 6 cycolxylidin of embodiment and bromine cyanogen insect amide
Agent is grouped as according to mass percentage by following group:
Cycolxylidin and bromine cyanogen insect amide water-dispersible grain agent compounding method are as follows: raw medicine and auxiliary agent etc. are carried out mixed powder
It is broken, then after mediating, be added in the pelletizer equipped with certain specification sieve and be granulated, then (sieve is pressed through drying, screening again
Range) up to the water dispersible granules of cycolxylidin and bromine cyanogen insect amide.
The suspending agent cycolxylidin and bromine cyanogen insect amide suspending agent of 7 cycolxylidin of embodiment and bromine cyanogen insect amide, according to matter
Amount percentage composition is grouped as by following group:
The suspension agent compounding method of cycolxylidin and bromine cyanogen insect amide is as follows: using water as medium, by raw medicine, dispersing agent, helping
Suspension and antifreezing agent etc. are added in sand milling kettle, and progress is finely ground, and cycolxylidin and bromine cyanogen insect amide suspending agent is made.
The microemulsion of embodiment 8 cycolxylidin and bromine cyanogen insect amide
The microemulsion of cycolxylidin and bromine cyanogen insect amide is grouped as according to mass percentage by following group:
The preparation method of the microemulsion of cycolxylidin and bromine cyanogen insect amide is as follows: by raw medicine, solvent, emulsifier and stabilizer
It is added together, makes system at homogeneous oil phase, be then added in water, stir evenly, cycolxylidin and bromine cyanogen insect amide is made
Microemulsion.
Indoor biological activity assay and field efficacy verifying 1, cycolxylidin and the bromine cyanogen worm of 9 present composition of embodiment
The indoor joint toxicity measuring of amide and its complex composition to aphid.
Test pest: brevicoryne brassicae
Experimental design: test worm is acquired from Nanjing Liuhe District Nanjing institute, Jin Longdian ecological agriculture Science and Technology Ltd.
Belong to farm, as test worm sources after pakchoi passage 3 generations of raising of indoor uncontaminated pesticide.Indoor joint toxicity measuring side
Method referring to " People's Republic of China (PRC) agricultural industry criteria farm-chemical indoor determination test rule NY/T 1154.6-2006 " into
Row.Cycolxylidin and bromine cyanogen insect amide raw medicine acetone solution, then diluted with the aqueous solution containing 0.1% Tween 80, match respectively
Single dose mother liquor is made, and according to mixed purpose, agent activity 11 groups of proportions of design, each single dose and every group of mixture are according to equal ratios
5 series mass concentration (suitable lethasl concentration is configured to according to preliminary result) are arranged in method, are soaked using pakchoi blade
Worm method carries out virulence simultaneous determination.By blade or the tender stem tweezers into the liquid 10s of folder with wingless aphid, blotted with blotting paper
It after excessive moisture, is put into the culture dish with moisturizing filter paper, culture dish is put into 25 DEG C, the artificial climate of relative humidity 80%
In case.Each culture dish access test worm number is 30, uses the test worm of the aqueous solution for containing 0.1% Tween 80 processing as control
Group observes and records the test worm survival condition of each processing after 48h, is touched with writing brush type brush reactionless for dead worm, calculates the death rate, correction
The death rate and CTC.The results are shown in Table 1.
Using the logarithm of drug concentration (mg/L) as independent variable x, the probit value with corrected mortality is y, establishes poison respectively
Power regression equation, it is for statistical analysis with DPS 7.05, count the LC of each medicament50.Calculate the co-toxicity coefficient of compound drug mixture
(CTC).Co-toxicity coefficient CTC, calculation formula are as follows:
Survey toxicity index (ATI)=(standard agent LC50/ reagent agent LC50)×100,
Percentage composition+B the medicament of A surveys virulence in theoretical toxicity index (TTI)=A medicament survey toxicity index × mixture
The percentage composition of B in index × mixture,
Co-toxicity coefficient (CTC)=ATI/TTI × 100.
According to the criteria for classifying of co-toxicity coefficient (CTC), CTC < 80 is antagonism, and 80 < CTC < 120 are summation action,
CTC > 120 is synergistic effect.
The indoor toxicity test of 1 cycolxylidin of table and bromine cyanogen insect amide different ratio to cabbage aphid
It can be seen from the data in Table 1 that the CTC of cycolxylidin and all proportions of bromine cyanogen insect amide is all larger than 120, show
Good synergistic effect rather than simply be added effect, wherein the mass ratio of cycolxylidin and bromine cyanogen insect amide be 1:3 when CTC
Maximum, Complex synergism is best at this time, it is seen that there are reasonability and feasibility for the compounding of cycolxylidin and bromine cyanogen insect amide.
2, the field efficacy of cycolxylidin and bromine cyanogen insect amide and its complex composition to aphid.
Test pest: brevicoryne brassicae
Experimental design: test worm is acquired from Nanjing Liuhe District Nanjing institute, Jin Longdian ecological agriculture Science and Technology Ltd.
Belong to farm, the testing site of selection is for pakchoi.Test method is referring to " National Standard of the People's Republic of China GB/
T17980.15-2000 pesticide field efficacy medicine test criterion (one) ", radix investigation before being administered, 5 points of each cell samplings, every point
10 plants of label, count the aphid number in each label on all plant.Be administered 1d after, after 3d, after 7d same method check it is each
Cell remnants borer population living has simultaneously seen whether phytotoxicity, calculates Revision insect recluced rate and control efficiency.
Cell uses RANDOMIZED BLOCK DESIGN, and a cell is repeated 4 times as a repetition, each chemicals treatment.
It is tested using embodiment 1 to 8 medicament of embodiment and (corresponds to treatment region), be respectively as follows: cycolxylidin and bromine cyanogen
The wettable powder of insect amide wettable powder A (+1% bromine cyanogen insect amide of 20% cycolxylidin), cycolxylidin and bromine cyanogen insect amide
Missible oil A (10% cycolxylidin+1% of agent B (+20% bromine cyanogen insect amide of 1% cycolxylidin), cycolxylidin and bromine cyanogen insect amide
Bromine cyanogen insect amide), cycolxylidin and the missible oil B (+10% bromine cyanogen insect amide of 1% cycolxylidin) of bromine cyanogen insect amide, cycolxylidin
With the water-dispersible grain of bromine cyanogen insect amide aqueous emulsion (+9% bromine cyanogen insect amide of 3% cycolxylidin), cycolxylidin and bromine cyanogen insect amide
Agent (+30% bromine cyanogen insect amide of 30% cycolxylidin), cycolxylidin and bromine cyanogen insect amide suspending agent (12% cycolxylidin+4%
Bromine cyanogen insect amide), the microemulsion (+7% bromine cyanogen insect amide of 1% cycolxylidin) of cycolxylidin and bromine cyanogen insect amide.By with
The preventive effect of 10% bromine cyanogen insect amide suspending agent and 10% cycolxylidin wettable powder single dose compares, verifying cycolxylidin and
Synergistic effect after bromine cyanogen insect amide compounding.All controlling experiment mixed reagent total amounts and single dose dosage be all 20g a.i./
hm2.Control treatment (corresponding to check plot) is with water surrogate-data technique.The results are shown in Table 2.
Drug effect calculation method:
Insect population × 100 before Revision insect recluced rate (%)=(remaining borer population living before medicine after insect population-medicine)/medicine, preventive effect
(%)=(treatment region Revision insect recluced rate-check plot Revision insect recluced rate)/(check plot 100- Revision insect recluced rate) × 100.
2 cycolxylidin of table and bromine cyanogen insect amide composition for preventing and controlling brevicoryne brassicae test result
Note: the medicament that " embodiment 1 (20:1) " means that the test uses in table 1 is 1 Chinese medicine of embodiment, in medicament
The weight ratio of cycolxylidin and bromine cyanogen insect amide is 20:1, other and so on.
From table 2 it can be seen that embodiment 1 has significant control efficiency, 7d after medicine to brevicoryne brassicae to 8 Chinese medicine of embodiment
Preventive effect is significantly better than the preventive effect of 10% cycolxylidin and 10% bromine cyanogen insect amide, wherein the preventive effect highest of embodiment 5.The above results
Good synergistic effect is shown to cabbage aphid prevention and treatment after showing a effective amount of cycolxylidin and bromine cyanogen insect amide compounding.
Claims (8)
1. a kind of composition pesticide, it is characterised in that the active constituent of the composition pesticide is cycolxylidin and bromine cyanogen worm acyl
The mass ratio of amine, the cycolxylidin and bromine cyanogen insect amide is 1~20:1~20.
2. a kind of composition pesticide, it is characterised in that the active constituent of the composition pesticide is cycolxylidin and bromine cyanogen worm acyl
The mass ratio of amine, the cycolxylidin and bromine cyanogen insect amide is 1~10:1~10.
3. according to claim 1 to 2 described in any item composition pesticides, it is characterised in that the combination dosage form is on pesticide
Any one dosage form allowed.
4. composition pesticide according to claim 3, it is characterised in that the combination dosage form is wettable powder, water and milk
Agent, microemulsion, missible oil, suspending agent or water-dispersible granules.
5. composition pesticide according to claim 4, it is characterised in that the quality of the cycolxylidin and bromine cyanogen insect amide
With account for the 5 70% of the composition gross mass.
6. composition pesticide according to claims 1 to 5, it is characterised in that the cycolxylidin and bromine cyanogen insect amide quality
With account for the 10 60% of the composition gross mass.
7. application of the composition pesticide described in one of claim 1~6 in prevention and treatment homoptera pest.
8. being applied described in claim 7, it is characterised in that: the homoptera pest is aphid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910954734.6A CN110495469A (en) | 2019-10-09 | 2019-10-09 | A kind of composition pesticide and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910954734.6A CN110495469A (en) | 2019-10-09 | 2019-10-09 | A kind of composition pesticide and its application |
Publications (1)
| Publication Number | Publication Date |
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| CN110495469A true CN110495469A (en) | 2019-11-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910954734.6A Pending CN110495469A (en) | 2019-10-09 | 2019-10-09 | A kind of composition pesticide and its application |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103229780A (en) * | 2013-04-23 | 2013-08-07 | 中国农业科学院蔬菜花卉研究所 | Cyantraniliprole-imidacloprid pesticide composition |
-
2019
- 2019-10-09 CN CN201910954734.6A patent/CN110495469A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103229780A (en) * | 2013-04-23 | 2013-08-07 | 中国农业科学院蔬菜花卉研究所 | Cyantraniliprole-imidacloprid pesticide composition |
Non-Patent Citations (3)
| Title |
|---|
| 刘广文: "《现代农药剂型加工技术》", 31 January 2013 * |
| 巨修练 等: "环氧虫啉的晶体结构及其杀虫活性", 《武汉工程大学学报》 * |
| 顾翼东: "《化学词典》", 30 September 1989 * |
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Address after: No.158, Fenghua Road, Jiangbei new district, Nanjing, Jiangsu Province Applicant after: JIANGSU ZHONGSHAN CHEMICAL Co.,Ltd. Address before: Fenghua Road in Liuhe District of Nanjing City, Jiangsu Province, No. 158 210009 Applicant before: JIANGSU ZHONGSHAN CHEMICAL Co.,Ltd. |
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Application publication date: 20191126 |