CN110494431A - 氮杂环类衍生物、其制备方法及其医药用途 - Google Patents

氮杂环类衍生物、其制备方法及其医药用途 Download PDF

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Publication number
CN110494431A
CN110494431A CN201880023997.9A CN201880023997A CN110494431A CN 110494431 A CN110494431 A CN 110494431A CN 201880023997 A CN201880023997 A CN 201880023997A CN 110494431 A CN110494431 A CN 110494431A
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alkyl
halogen
compound
cycloalkyl
general formula
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CN110494431B (zh
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段茂圣
熊艳林
刘佳乐
田世鸿
戴权
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Suzhou Puhe Pharmaceutical Technology Co ltd
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Beijing Yuezhikangtai Biomedicines Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

本发明涉及一种氮杂环类衍生物、其制备方法及其医药用途。特别地，本发明涉及通式(I)所示的氮杂环类衍生物、其制备方法、含有该衍生物的药物组合物，以及其作为SMO拮抗剂，特别是在治疗与Hedgehog信号通路相关的疾病如癌症中的用途。其中通式(I)中的各基团的定义与说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (35)

  1. PCT国内申请，权利要求书已公开。
CN201880023997.9A 2017-09-30 2018-09-21 氮杂环类衍生物、其制备方法及其医药用途 Active CN110494431B (zh)

Applications Claiming Priority (3)

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CN2017109145122 2017-09-30
CN201710914512 2017-09-30
PCT/CN2018/106885 WO2019062657A1 (zh) 2017-09-30 2018-09-21 氮杂环类衍生物、其制备方法及其医药用途

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CN110494431B CN110494431B (zh) 2022-11-04

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WO (1) WO2019062657A1 (zh)

Cited By (1)

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CN114235976A (zh) * 2021-11-09 2022-03-25 暨南大学 一种含氮杂环有机化合物中间产物的合成和分析方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114790177B (zh) * 2021-01-26 2024-03-26 首都医科大学附属北京天坛医院 新型Hedgehog信号通路抑制剂
WO2023247670A1 (en) * 2022-06-24 2023-12-28 F. Hoffmann-La Roche Ag New heterocyclic-carbonyl-cyclic compounds as magl inhibitors

Citations (5)

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Publication number Priority date Publication date Assignee Title
CN101083996A (zh) * 2004-10-28 2007-12-05 Irm责任有限公司 作为hedgehog途径调节剂的化合物和组合物
CN101896472A (zh) * 2007-12-13 2010-11-24 锡耶纳生物技术股份公司 Hedgehog途径拮抗剂及其治疗应用
CN102803246A (zh) * 2009-06-11 2012-11-28 锡耶纳生物技术股份公司 Hedgehog途径拮抗剂及其治疗应用
CN103214456A (zh) * 2013-04-20 2013-07-24 郎恒元 具有抗肿瘤活性的苯并咪唑类化合物、制备方法及其应用
CN105085406A (zh) * 2014-05-16 2015-11-25 中国医学科学院药物研究所 含苯并咪唑环丙炔酰胺类衍生物及其制法和药物组合物与用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101083996A (zh) * 2004-10-28 2007-12-05 Irm责任有限公司 作为hedgehog途径调节剂的化合物和组合物
CN101896472A (zh) * 2007-12-13 2010-11-24 锡耶纳生物技术股份公司 Hedgehog途径拮抗剂及其治疗应用
CN102803246A (zh) * 2009-06-11 2012-11-28 锡耶纳生物技术股份公司 Hedgehog途径拮抗剂及其治疗应用
CN103214456A (zh) * 2013-04-20 2013-07-24 郎恒元 具有抗肿瘤活性的苯并咪唑类化合物、制备方法及其应用
CN105085406A (zh) * 2014-05-16 2015-11-25 中国医学科学院药物研究所 含苯并咪唑环丙炔酰胺类衍生物及其制法和药物组合物与用途

Non-Patent Citations (3)

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Title
STN: "《STN》", 29 March 2022 *
顾寿胜: "Hedgehog通路抑制剂HhAntag的合成", 《山东工业技术》 *
顾寿胜: "Hedgehog通路抑制剂HhAntag的合成", 《山东工业技术》, 1 January 2018 (2018-01-01), pages 117 - 118 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114235976A (zh) * 2021-11-09 2022-03-25 暨南大学 一种含氮杂环有机化合物中间产物的合成和分析方法
CN114235976B (zh) * 2021-11-09 2023-11-03 暨南大学 一种含氮杂环有机化合物中间产物的合成和分析方法

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WO2019062657A1 (zh) 2019-04-04

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