CN110494228A - 微球及用于生产微球的方法 - Google Patents

微球及用于生产微球的方法 Download PDF

Info

Publication number
CN110494228A
CN110494228A CN201780069626.XA CN201780069626A CN110494228A CN 110494228 A CN110494228 A CN 110494228A CN 201780069626 A CN201780069626 A CN 201780069626A CN 110494228 A CN110494228 A CN 110494228A
Authority
CN
China
Prior art keywords
microballoon
microspheres
property surface
superoleophobic
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780069626.XA
Other languages
English (en)
Chinese (zh)
Inventor
丹·莱维图斯
塔·施皮格尔施陶伯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenkal Institute Of Engineering And Design Art
Original Assignee
Shenkal Institute Of Engineering And Design Art
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenkal Institute Of Engineering And Design Art filed Critical Shenkal Institute Of Engineering And Design Art
Publication of CN110494228A publication Critical patent/CN110494228A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
    • A61K35/06—Mineral oils, e.g. paraffinic oils or aromatic oils based on aromatic hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
CN201780069626.XA 2016-09-11 2017-09-11 微球及用于生产微球的方法 Pending CN110494228A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662393033P 2016-09-11 2016-09-11
US62/393,033 2016-09-11
US201762556459P 2017-09-10 2017-09-10
US62/556,459 2017-09-10
PCT/IL2017/051022 WO2018047185A1 (en) 2016-09-11 2017-09-11 Microspheres and method for producing them

Publications (1)

Publication Number Publication Date
CN110494228A true CN110494228A (zh) 2019-11-22

Family

ID=61562719

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780069626.XA Pending CN110494228A (zh) 2016-09-11 2017-09-11 微球及用于生产微球的方法

Country Status (10)

Country Link
US (2) US10967346B2 (https=)
EP (1) EP3509763A4 (https=)
JP (1) JP2019529545A (https=)
KR (1) KR20190082197A (https=)
CN (1) CN110494228A (https=)
AU (1) AU2017325041A1 (https=)
CA (1) CA3036271A1 (https=)
IL (1) IL265264A (https=)
SG (1) SG10202102517XA (https=)
WO (1) WO2018047185A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112939611A (zh) * 2021-01-28 2021-06-11 中国船舶重工集团公司第七二五研究所 一种采用直接滴定成型技术制备陶瓷微球的方法
CN113307635A (zh) * 2021-05-24 2021-08-27 中国船舶重工集团公司第七二五研究所 一种通过轨道的凝胶注模直接滴定成型陶瓷微球的方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190082197A (ko) * 2016-09-11 2019-07-09 쉔카르 엔지니어링 디자인 아트 미소 구체 및 그 제조 방법
EP3943530A4 (en) * 2019-03-18 2022-10-26 Daicel Corporation CELLULOSIC ACETATE PARTICLES, COSMETIC COMPOSITION AND PROCESS FOR PRODUCTION OF CELLULOSIC ACETATE PARTICLES
CN110721636A (zh) * 2019-11-20 2020-01-24 河南天纳图实业有限公司 微囊包被颗粒类药物的热熔法制粒系统
CN111632563A (zh) * 2020-05-21 2020-09-08 扬州大学 基于微流控技术的水凝胶微球及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130147074A1 (en) * 2011-11-21 2013-06-13 Dr. Hielscher Gmbh Method and apparatus for generating particles
US20140205804A1 (en) * 2012-06-25 2014-07-24 Ross Technology Corporation Elastomeric Coatings Having Hydrophobic and/or Oleophobic Properties
US20150375429A1 (en) * 2013-02-14 2015-12-31 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Process and device for particle synthesis on a superamphiphobic or superoleophobic surface

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
CA2507769C (en) * 2002-11-27 2013-10-01 Kobo Products, Inc. Density-controlled particulate suspensions for foodstuff, cosmetic, pharmaceutical and other uses
US8652529B2 (en) 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
GB0711952D0 (en) 2007-06-20 2007-08-01 King S College London Microspheres
US20140147510A1 (en) * 2010-10-28 2014-05-29 The Regents Of The University Of Michigan Multiphasic polymeric particles capable of shape-shifting via environmental stimulation
JP6328149B2 (ja) 2013-02-25 2018-05-23 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 粒状マイクロカプセル組成物
WO2015081310A1 (en) 2013-11-27 2015-06-04 Trustees Of Boston University Stretch release drug delivery materials
JP2016087479A (ja) * 2014-10-29 2016-05-23 国立大学法人 鹿児島大学 微小カプセル又はビーズの製造方法
KR20190082197A (ko) * 2016-09-11 2019-07-09 쉔카르 엔지니어링 디자인 아트 미소 구체 및 그 제조 방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130147074A1 (en) * 2011-11-21 2013-06-13 Dr. Hielscher Gmbh Method and apparatus for generating particles
US20140205804A1 (en) * 2012-06-25 2014-07-24 Ross Technology Corporation Elastomeric Coatings Having Hydrophobic and/or Oleophobic Properties
US20150375429A1 (en) * 2013-02-14 2015-12-31 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Process and device for particle synthesis on a superamphiphobic or superoleophobic surface

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MILIONIS A, ET AL.: "Recent advances in oil-repellent surfaces", 《INTERNATIONAL MATERIALS REVIEWS》 *
RIAL-HERMIDA M I, ET AL.: "Bioinspired superamphiphobic surfaces as a tool for polymer- and solvent-independent preparation of drug-loaded spherical particles", 《ACTA BIOMATERIALIA》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112939611A (zh) * 2021-01-28 2021-06-11 中国船舶重工集团公司第七二五研究所 一种采用直接滴定成型技术制备陶瓷微球的方法
CN113307635A (zh) * 2021-05-24 2021-08-27 中国船舶重工集团公司第七二五研究所 一种通过轨道的凝胶注模直接滴定成型陶瓷微球的方法

Also Published As

Publication number Publication date
SG10202102517XA (en) 2021-04-29
EP3509763A1 (en) 2019-07-17
CA3036271A1 (en) 2018-03-15
US20190270060A1 (en) 2019-09-05
JP2019529545A (ja) 2019-10-17
AU2017325041A1 (en) 2019-04-11
WO2018047185A1 (en) 2018-03-15
US10967346B2 (en) 2021-04-06
IL265264A (en) 2019-05-30
KR20190082197A (ko) 2019-07-09
US20210260546A1 (en) 2021-08-26
EP3509763A4 (en) 2020-05-27

Similar Documents

Publication Publication Date Title
CN110494228A (zh) 微球及用于生产微球的方法
US6669961B2 (en) Microparticles
KR101823706B1 (ko) 마이크로입자 또는 나노입자의 제조 방법 및 제조 장치
EP2061434A2 (en) Engineering shape of polymeric micro-and nanoparticles
US11850851B2 (en) Process and device for in-air production of single droplets, compound droplets, and shape-controlled (compound) particles or fibers
WO1996003979A1 (en) Apparatus and method for preparing solid forms with controlled release of the active ingredient
Wang et al. Fabrication of monolayers of uniform polymeric particles by inkjet printing of monodisperse emulsions produced by microfluidics
JP6092777B2 (ja) 固体ビーズを作製するための装置及び方法
AU2016222641A1 (en) Methods of preparing solid particle solutions for forming textured surfaces
CN108837778A (zh) 一种制备核壳结构载药纳米粒的方法
Vladisavljević et al. Fabrication of biodegradable poly (lactic acid) particles in flow-focusing glass capillary devices
CN209791507U (zh) 用于将液体物料产生微滴的转盘装置及制造微球的设备
ES2821761T3 (es) Proceso de preparación de micropartículas de copolímero de poli(glicolida-co-lactida)
AU2006287499A1 (en) Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates
CN109772240B (zh) 一种用于将液体物料产生微滴的转盘装置及用于制造微球的设备
US7901606B2 (en) Production of porous materials by supercritical fluid processing
CA2986456C (en) Process for preparing poly(glycolide-co-lactide) copolymer microparticles
EP4162930A1 (en) Preparation of drug-loaded micro- and nanoparticles by jet impingement
Song et al. Effect of processing variables on the release and particulate properties of sustained release amoxicillin microcapsules prepared by emulsion solvent evaporation
Elzhry Elyafi Single-Stream Spray Drying Process to Generate Uniform and Functional Powder Particles
Ekanem et al. Structured biodegradable microparticles produced using glass microfluidic flow focussing devices
HK1247631A1 (en) Process for preparing poly(glycolide-co-lactide) copolymer microparticles
Rahman et al. Hot Melt Extrusion and Freeze Pelletization: Better Alternative for Drugs Having Stability Problem Due to Presence of Water
JP2011255304A (ja) カプセル型粒子の製造方法およびカプセル型粒子

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20191122

WD01 Invention patent application deemed withdrawn after publication