CN110446713B - 一种吡唑嘧啶衍生物及其用途和药物组合物 - Google Patents
一种吡唑嘧啶衍生物及其用途和药物组合物 Download PDFInfo
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- CN110446713B CN110446713B CN201980001001.9A CN201980001001A CN110446713B CN 110446713 B CN110446713 B CN 110446713B CN 201980001001 A CN201980001001 A CN 201980001001A CN 110446713 B CN110446713 B CN 110446713B
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- pyrazolopyrimidine derivative
- alkyl
- pharmaceutically acceptable
- substituted
- acceptable salt
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Classifications
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018105857156 | 2018-06-06 | ||
| CN201810585715 | 2018-06-06 | ||
| PCT/CN2019/090095 WO2019233434A1 (zh) | 2018-06-06 | 2019-06-05 | 一种吡唑嘧啶衍生物及其用途和药物组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110446713A CN110446713A (zh) | 2019-11-12 |
| CN110446713B true CN110446713B (zh) | 2022-05-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980001001.9A Active CN110446713B (zh) | 2018-06-06 | 2019-06-05 | 一种吡唑嘧啶衍生物及其用途和药物组合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210253576A1 (ja) |
| EP (1) | EP3805219A4 (ja) |
| JP (1) | JP7083203B2 (ja) |
| CN (1) | CN110446713B (ja) |
| WO (1) | WO2019233434A1 (ja) |
Citations (10)
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|---|---|---|---|---|
| CN101448826A (zh) * | 2005-12-13 | 2009-06-03 | 因塞特公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡咯和吡咯并[2,3-b]嘧啶 |
| CN102026999A (zh) * | 2008-03-11 | 2011-04-20 | 因塞特公司 | 作为jak抑制剂的氮杂环丁烷和环丁烷衍生物 |
| CN102574863A (zh) * | 2009-08-27 | 2012-07-11 | 拜奥克里斯特制药公司 | 作为janus激酶抑制剂的杂环化合物 |
| CN103180322A (zh) * | 2010-04-30 | 2013-06-26 | 塞尔佐姆有限公司 | 作为jak抑制剂的吡唑化合物 |
| CN103797010A (zh) * | 2011-06-20 | 2014-05-14 | 因塞特公司 | 作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物 |
| CN103936757A (zh) * | 2013-01-18 | 2014-07-23 | 上海昀怡健康管理咨询有限公司 | 五元并六元杂环化合物、其制备方法、药物组合物和应用 |
| CN103987713A (zh) * | 2011-10-12 | 2014-08-13 | 阵列生物制药公司 | 5,7-取代的咪唑并[1,2-c]嘧啶 |
| CN104024256A (zh) * | 2011-09-07 | 2014-09-03 | 因塞特公司 | 用于制备jak抑制剂的方法和中间体 |
| CN105837577A (zh) * | 2015-02-02 | 2016-08-10 | 四川大学 | 1-(嘧啶-4-基)3-胺基哌啶衍生物及其制备方法和用途 |
| WO2016173484A1 (zh) * | 2015-04-29 | 2016-11-03 | 南京明德新药研发股份有限公司 | Jak抑制剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2649907C2 (ru) | 2013-08-07 | 2018-04-05 | Конинклейке Филипс Н.В. | Беспроводная индуктивная передача мощности |
| CN104844566B (zh) | 2014-12-12 | 2018-05-18 | 合肥中科普瑞昇生物医药科技有限公司 | 一种新型结构的激酶抑制剂 |
| CN106749338A (zh) * | 2015-11-19 | 2017-05-31 | 青岛正大海尔制药有限公司 | 1,3-二取代1H-吡咯并[3,2-c]吡啶化合物及其用途 |
-
2019
- 2019-06-05 WO PCT/CN2019/090095 patent/WO2019233434A1/zh unknown
- 2019-06-05 CN CN201980001001.9A patent/CN110446713B/zh active Active
- 2019-06-05 JP JP2021517894A patent/JP7083203B2/ja active Active
- 2019-06-05 US US16/972,605 patent/US20210253576A1/en active Pending
- 2019-06-05 EP EP19814600.3A patent/EP3805219A4/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101448826A (zh) * | 2005-12-13 | 2009-06-03 | 因塞特公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡咯和吡咯并[2,3-b]嘧啶 |
| CN102026999A (zh) * | 2008-03-11 | 2011-04-20 | 因塞特公司 | 作为jak抑制剂的氮杂环丁烷和环丁烷衍生物 |
| CN102574863A (zh) * | 2009-08-27 | 2012-07-11 | 拜奥克里斯特制药公司 | 作为janus激酶抑制剂的杂环化合物 |
| CN103180322A (zh) * | 2010-04-30 | 2013-06-26 | 塞尔佐姆有限公司 | 作为jak抑制剂的吡唑化合物 |
| CN103797010A (zh) * | 2011-06-20 | 2014-05-14 | 因塞特公司 | 作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物 |
| CN104024256A (zh) * | 2011-09-07 | 2014-09-03 | 因塞特公司 | 用于制备jak抑制剂的方法和中间体 |
| CN103987713A (zh) * | 2011-10-12 | 2014-08-13 | 阵列生物制药公司 | 5,7-取代的咪唑并[1,2-c]嘧啶 |
| CN103936757A (zh) * | 2013-01-18 | 2014-07-23 | 上海昀怡健康管理咨询有限公司 | 五元并六元杂环化合物、其制备方法、药物组合物和应用 |
| CN105837577A (zh) * | 2015-02-02 | 2016-08-10 | 四川大学 | 1-(嘧啶-4-基)3-胺基哌啶衍生物及其制备方法和用途 |
| WO2016173484A1 (zh) * | 2015-04-29 | 2016-11-03 | 南京明德新药研发股份有限公司 | Jak抑制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20210253576A1 (en) | 2021-08-19 |
| EP3805219A1 (en) | 2021-04-14 |
| JP7083203B2 (ja) | 2022-06-10 |
| CN110446713A (zh) | 2019-11-12 |
| WO2019233434A1 (zh) | 2019-12-12 |
| EP3805219A4 (en) | 2022-03-23 |
| JP2021526557A (ja) | 2021-10-07 |
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