CN110418791A - 包含苯并二氮*类化合物的注射用组合物及其制备方法 - Google Patents

包含苯并二氮*类化合物的注射用组合物及其制备方法 Download PDF

Info

Publication number
CN110418791A
CN110418791A CN201880014438.1A CN201880014438A CN110418791A CN 110418791 A CN110418791 A CN 110418791A CN 201880014438 A CN201880014438 A CN 201880014438A CN 110418791 A CN110418791 A CN 110418791A
Authority
CN
China
Prior art keywords
base
compound
benzo
pyridine
diazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201880014438.1A
Other languages
English (en)
Other versions
CN110418791B (zh
Inventor
王梦馨
周丹
韩剑锋
孔繁贵
吴灵静
赵栋
于华
蔡家强
曾宏
王利春
王晶翼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Original Assignee
Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Kelun Biotech Biopharmaceutical Co Ltd filed Critical Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Publication of CN110418791A publication Critical patent/CN110418791A/zh
Application granted granted Critical
Publication of CN110418791B publication Critical patent/CN110418791B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及注射用组合物及其制备方法。所述注射用组合物包含活性成分和至少一种药学上可接受的赋形剂，其中所述活性成分为苯并二氮化合物或其药学上可接受的盐、立体异构体、互变异构体、多晶型物、溶剂合物、代谢物或前药。本发明的注射用组合物具有足够的稳定性，更高的无菌保证水平，因而具有更低的临床使用风险。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201880014438.1A 2017-04-28 2018-04-18 包含苯并二氮䓬类化合物的注射用组合物及其制备方法 Active CN110418791B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710295486X 2017-04-28
CN201710295486 2017-04-28
PCT/CN2018/083459 WO2018196662A1 (zh) 2017-04-28 2018-04-18 包含苯并二氮䓬类化合物的注射用组合物及其制备方法

Publications (2)

Publication Number Publication Date
CN110418791A true CN110418791A (zh) 2019-11-05
CN110418791B CN110418791B (zh) 2022-07-01

Family

ID=63920213

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880014438.1A Active CN110418791B (zh) 2017-04-28 2018-04-18 包含苯并二氮䓬类化合物的注射用组合物及其制备方法

Country Status (2)

Country Link
CN (1) CN110418791B (zh)
WO (1) WO2018196662A1 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112321594A (zh) * 2020-12-07 2021-02-05 扬子江药业集团有限公司 一种苯并二氮杂*类药物的制备方法
CN114588164A (zh) * 2022-04-19 2022-06-07 天津医科大学总医院 瑞马唑仑在预防围术期低体温和寒战中的应用
CN116102557A (zh) * 2021-11-09 2023-05-12 四川大学华西医院 苯二氮卓类化合物及其制备方法和在医药上的用途

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108948018B (zh) * 2017-05-17 2021-03-30 四川科伦博泰生物医药股份有限公司 苯并二氮*衍生物及其盐和相关晶体形式、制备方法和用途
WO2020259602A1 (zh) * 2019-06-28 2020-12-30 四川大学华西医院 苯二氮卓类化合物及其制备方法和在医药上的作用
CN114456171A (zh) * 2020-11-09 2022-05-10 中国药科大学 一类用于镇静催眠的苯并二氮䓬类药物、其制备方法及应用
CN112358483A (zh) * 2020-11-09 2021-02-12 中国药科大学 一类新型苯并二氮*类化合物、其制备方法及其用途
CN113876705A (zh) * 2021-11-17 2022-01-04 石家庄四药有限公司 一种盐酸乌拉地尔注射液及其制备方法
CN114014839A (zh) * 2021-12-16 2022-02-08 上海再启生物技术有限公司 一种制备瑞马唑仑关键中间体的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000069836A1 (en) * 1999-05-14 2000-11-23 Glaxo Group Limited Short-acting benzodiazepines
CN101501019A (zh) * 2006-07-10 2009-08-05 Paion英国有限公司 短效苯并二氮杂盐及其多晶型
CN102781943A (zh) * 2009-11-05 2012-11-14 葛兰素史密丝克莱恩有限责任公司 苯并二氮杂*溴结构域抑制剂
CN103282367A (zh) * 2010-12-21 2013-09-04 詹森药业有限公司 二环苯衍生物取代的5,6-二氢-4h-吡咯并[1,2-a][1,4]苯并二氮杂*和6h-吡咯并[1,2-a][1,4]苯并二氮杂*新抗真菌剂
US20140045834A1 (en) * 2011-04-21 2014-02-13 Glaxosmithkline Llc 7-(3,5-Dimethyl-4-Isoxazolyl)-8-(Methyloxy)-1H-Imidazo[4,5-C]Quinoline Derivatives
CN106336400A (zh) * 2008-12-08 2017-01-18 萌蒂制药国际有限公司 酪氨酸激酶蛋白受体拮抗剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106892924B (zh) * 2015-12-17 2021-01-08 四川科伦博泰生物医药股份有限公司 短效苯并二氮*衍生物、其制备方法及其用途

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000069836A1 (en) * 1999-05-14 2000-11-23 Glaxo Group Limited Short-acting benzodiazepines
CN101501019A (zh) * 2006-07-10 2009-08-05 Paion英国有限公司 短效苯并二氮杂盐及其多晶型
CN106336400A (zh) * 2008-12-08 2017-01-18 萌蒂制药国际有限公司 酪氨酸激酶蛋白受体拮抗剂
CN102781943A (zh) * 2009-11-05 2012-11-14 葛兰素史密丝克莱恩有限责任公司 苯并二氮杂*溴结构域抑制剂
CN103282367A (zh) * 2010-12-21 2013-09-04 詹森药业有限公司 二环苯衍生物取代的5,6-二氢-4h-吡咯并[1,2-a][1,4]苯并二氮杂*和6h-吡咯并[1,2-a][1,4]苯并二氮杂*新抗真菌剂
US20140045834A1 (en) * 2011-04-21 2014-02-13 Glaxosmithkline Llc 7-(3,5-Dimethyl-4-Isoxazolyl)-8-(Methyloxy)-1H-Imidazo[4,5-C]Quinoline Derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
潘卫三 主编: "《工业药剂学》", 30 June 2010, 中国医药科技出版社 *
蔡煜东 等: "运用自组织人工神经网络研究弱效安定药苯并二氮杂卓恶唑烷衍生物构效关系", 《数理医药杂志》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112321594A (zh) * 2020-12-07 2021-02-05 扬子江药业集团有限公司 一种苯并二氮杂*类药物的制备方法
CN116102557A (zh) * 2021-11-09 2023-05-12 四川大学华西医院 苯二氮卓类化合物及其制备方法和在医药上的用途
CN116102557B (zh) * 2021-11-09 2024-04-26 四川大学华西医院 苯二氮卓类化合物及其制备方法和在医药上的用途
CN114588164A (zh) * 2022-04-19 2022-06-07 天津医科大学总医院 瑞马唑仑在预防围术期低体温和寒战中的应用
CN114588164B (zh) * 2022-04-19 2023-08-11 天津医科大学总医院 瑞马唑仑在预防围术期低体温和寒战中的应用

Also Published As

Publication number Publication date
WO2018196662A1 (zh) 2018-11-01
CN110418791B (zh) 2022-07-01

Similar Documents

Publication Publication Date Title
CN110418791A (zh) 包含苯并二氮*类化合物的注射用组合物及其制备方法
AU2017315682B2 (en) A crystalline 19-nor C3, 3-disubstituted C21-n-pyrazolyl steroid
CN105229008B (zh) 作为选择性NK‑3受体拮抗剂的N‑酰基‑(3‑取代)‑(8‑取代)‑5,6‑二氢‑[1,2,4]三唑并[4,3‑a]吡嗪、药物组合物、用于NK‑3受体介导的病症的方法
CN103561746B (zh) 包含脱水山梨糖醇酯的药物组合物
JP2022066289A (ja) カンナビノイド受容体モジュレーター
JP6219918B2 (ja) グリセロールエステルを含む医薬組成物
KR101627382B1 (ko) 항암 경구 제제
JP6333802B2 (ja) ベンジルアルコールを含む医薬組成物
JP6654042B2 (ja) 貯蔵安定性が改善された医薬組成物
CN112479996A (zh) 吡啶氮氧化合物及其制备方法和用途
CN108137606A (zh) 短效苯并二氮*衍生物、其制备方法及其用途
JP6471089B2 (ja) 脂肪酸エステルを含む医薬組成物
KR20120101980A (ko) 스피로-옥스인돌 화합물의 거울상이성질체 및 치료제로서의 그의 용도
HRP20050214A2 (en) Crystal for oral solid drug and oral solid drug for dysuria treatment containing the same
EA035649B1 (ru) Применение агента, активирующего рецептор гамк, для получения седативного и анестезирующего лекарственного средства
JP7368357B2 (ja) バソプレシン受容体アンタゴニストならびにそれに関連する生成物および方法
CN110386944A (zh) 用于抑制蛋白激酶活性的二(杂)芳基大环化合物
CN109890388A (zh) 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂
CN107382870A (zh) N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途
CN108137477A (zh) 治疗化合物及其使用方法
CN104640865A (zh) 作为激酶抑制剂的二氢吡咯烷子基-嘧啶
KR20210124310A (ko) 국소 포스포이노시티드 3-키나제 억제제
CN101981015A (zh) 作为hdl-胆固醇升高剂的3-三氟甲基-吡嗪-2-甲酸酰胺衍生物
KR20230020548A (ko) 환상 펩타이드 화합물을 포함하는 제제 및 그의 제조 방법
CN109651395B (zh) 一种可靶向降解fkbp12及12.6的化合物及其制备方法和应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant