CN110412001B - 一种动态监测凝血酶生成能力的试剂盒 - Google Patents
一种动态监测凝血酶生成能力的试剂盒 Download PDFInfo
- Publication number
- CN110412001B CN110412001B CN201910707364.6A CN201910707364A CN110412001B CN 110412001 B CN110412001 B CN 110412001B CN 201910707364 A CN201910707364 A CN 201910707364A CN 110412001 B CN110412001 B CN 110412001B
- Authority
- CN
- China
- Prior art keywords
- reagent
- thrombin
- kit
- thrombin generation
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000190 Thrombin Proteins 0.000 title claims abstract description 82
- 229960004072 thrombin Drugs 0.000 title claims abstract description 81
- 238000012544 monitoring process Methods 0.000 title claims abstract description 15
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 63
- 241000283973 Oryctolagus cuniculus Species 0.000 claims abstract description 26
- 238000006243 chemical reaction Methods 0.000 claims abstract description 25
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 21
- 239000001110 calcium chloride Substances 0.000 claims abstract description 21
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 21
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 18
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims abstract description 15
- 108010000499 Thromboplastin Proteins 0.000 claims abstract description 15
- 102000002262 Thromboplastin Human genes 0.000 claims abstract description 15
- 229940098773 bovine serum albumin Drugs 0.000 claims abstract description 15
- 210000004556 brain Anatomy 0.000 claims abstract description 14
- 210000005013 brain tissue Anatomy 0.000 claims abstract description 14
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 14
- 239000011535 reaction buffer Substances 0.000 claims abstract description 13
- 239000000243 solution Substances 0.000 claims abstract description 10
- 239000004471 Glycine Substances 0.000 claims abstract description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 239000007983 Tris buffer Substances 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 4
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 19
- 230000008569 process Effects 0.000 abstract description 14
- 230000023555 blood coagulation Effects 0.000 abstract description 13
- 238000002474 experimental method Methods 0.000 abstract description 7
- 239000013589 supplement Substances 0.000 abstract description 3
- 238000003759 clinical diagnosis Methods 0.000 abstract description 2
- 210000002381 plasma Anatomy 0.000 description 26
- 238000012360 testing method Methods 0.000 description 15
- 238000001514 detection method Methods 0.000 description 14
- 230000015271 coagulation Effects 0.000 description 10
- 238000005345 coagulation Methods 0.000 description 10
- 239000007850 fluorescent dye Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000008213 purified water Substances 0.000 description 9
- UPSFMJHZUCSEHU-JYGUBCOQSA-N n-[(2s,3r,4r,5s,6r)-2-[(2r,3s,4r,5r,6s)-5-acetamido-4-hydroxy-2-(hydroxymethyl)-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Chemical compound CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OC=2C=C3OC(=O)C=C(C)C3=CC=2)O[C@@H]1CO UPSFMJHZUCSEHU-JYGUBCOQSA-N 0.000 description 7
- GLNDAGDHSLMOKX-UHFFFAOYSA-N coumarin 120 Chemical compound C1=C(N)C=CC2=C1OC(=O)C=C2C GLNDAGDHSLMOKX-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 238000011084 recovery Methods 0.000 description 5
- 238000003556 assay Methods 0.000 description 4
- 238000011088 calibration curve Methods 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 238000001917 fluorescence detection Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 101800004937 Protein C Proteins 0.000 description 3
- 102000017975 Protein C Human genes 0.000 description 3
- 108010094028 Prothrombin Proteins 0.000 description 3
- 102100027378 Prothrombin Human genes 0.000 description 3
- 101800001700 Saposin-D Proteins 0.000 description 3
- 108010071390 Serum Albumin Proteins 0.000 description 3
- 102000007562 Serum Albumin Human genes 0.000 description 3
- 208000034158 bleeding Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 229960000856 protein c Drugs 0.000 description 3
- 229940039716 prothrombin Drugs 0.000 description 3
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 210000004623 platelet-rich plasma Anatomy 0.000 description 2
- 239000003805 procoagulant Substances 0.000 description 2
- 238000012421 spiking Methods 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- CFWRDBDJAOHXSH-SECBINFHSA-N 2-azaniumylethyl [(2r)-2,3-diacetyloxypropyl] phosphate Chemical compound CC(=O)OC[C@@H](OC(C)=O)COP(O)(=O)OCCN CFWRDBDJAOHXSH-SECBINFHSA-N 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 241000025414 Pentalagus furnessi Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000005877 Peptide Initiation Factors Human genes 0.000 description 1
- 108010044843 Peptide Initiation Factors Proteins 0.000 description 1
- 241000798077 Poelagus marjorita Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 102000012607 Thrombomodulin Human genes 0.000 description 1
- 108010079274 Thrombomodulin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000001994 activation Methods 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000003989 endothelium vascular Anatomy 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
加样顺序 | 试剂 | 加样量 |
1 | 待测血浆 | 40ul |
2 | 反应试剂 | 10ul |
3 | 反应缓冲液 | 15ul |
4 | 荧光试剂 | 50ul |
5 | 氯化钙试剂 | 35ul |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910707364.6A CN110412001B (zh) | 2019-08-01 | 2019-08-01 | 一种动态监测凝血酶生成能力的试剂盒 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910707364.6A CN110412001B (zh) | 2019-08-01 | 2019-08-01 | 一种动态监测凝血酶生成能力的试剂盒 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110412001A CN110412001A (zh) | 2019-11-05 |
CN110412001B true CN110412001B (zh) | 2022-02-11 |
Family
ID=68365084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910707364.6A Active CN110412001B (zh) | 2019-08-01 | 2019-08-01 | 一种动态监测凝血酶生成能力的试剂盒 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110412001B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111196838A (zh) * | 2020-02-21 | 2020-05-26 | 重庆医药高等专科学校 | 一种精氨酸衍生物Cbz-Phe-Arg-AMC的合成方法及应用 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101171519A (zh) * | 2005-04-29 | 2008-04-30 | 瑟纳普斯有限责任公司 | 测量全血中的凝血酶活性 |
CN101438146A (zh) * | 2006-04-04 | 2009-05-20 | 神谷来克斯公司 | 高灵敏标志物分析和分子检测的方法和组合物 |
EP1975622B1 (en) * | 2007-03-28 | 2011-06-01 | Sysmex Corporation | Method for stabilizing tissue factor |
CN102608337B (zh) * | 2011-04-22 | 2014-05-14 | 武汉塞力斯生物技术有限公司 | 凝血酶原时间测定试剂盒及其制备方法 |
CN105264385A (zh) * | 2013-06-28 | 2016-01-20 | 豪夫迈·罗氏有限公司 | 用于抗因子Xa试验通用校准的工具和方法 |
CN105445478A (zh) * | 2015-11-12 | 2016-03-30 | 武汉中太生物技术有限公司 | 活化部分凝血活酶时间测定试剂盒及其制备方法 |
CN108226538A (zh) * | 2017-12-29 | 2018-06-29 | 广州万孚生物技术股份有限公司 | 活化部分凝血活酶时间测定试剂 |
CN108760695A (zh) * | 2018-04-27 | 2018-11-06 | 天津师范大学 | 一种基于pret的磷光探针定量检测凝血酶的方法 |
EP3537158A1 (en) * | 2016-11-30 | 2019-09-11 | Obschestvo S Ogranichennoy Otvetstvennostyu "Hemacore Labs" | Device for monitoring the spatial and temporal dynamics of thrombin |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050221414A1 (en) * | 2004-03-31 | 2005-10-06 | Katalin Varadi | Kit for measuring the thrombin generation in a sample of a patient's blood or plasma |
-
2019
- 2019-08-01 CN CN201910707364.6A patent/CN110412001B/zh active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101171519A (zh) * | 2005-04-29 | 2008-04-30 | 瑟纳普斯有限责任公司 | 测量全血中的凝血酶活性 |
CN101438146A (zh) * | 2006-04-04 | 2009-05-20 | 神谷来克斯公司 | 高灵敏标志物分析和分子检测的方法和组合物 |
EP1975622B1 (en) * | 2007-03-28 | 2011-06-01 | Sysmex Corporation | Method for stabilizing tissue factor |
CN102608337B (zh) * | 2011-04-22 | 2014-05-14 | 武汉塞力斯生物技术有限公司 | 凝血酶原时间测定试剂盒及其制备方法 |
CN105264385A (zh) * | 2013-06-28 | 2016-01-20 | 豪夫迈·罗氏有限公司 | 用于抗因子Xa试验通用校准的工具和方法 |
CN105445478A (zh) * | 2015-11-12 | 2016-03-30 | 武汉中太生物技术有限公司 | 活化部分凝血活酶时间测定试剂盒及其制备方法 |
EP3537158A1 (en) * | 2016-11-30 | 2019-09-11 | Obschestvo S Ogranichennoy Otvetstvennostyu "Hemacore Labs" | Device for monitoring the spatial and temporal dynamics of thrombin |
CN108226538A (zh) * | 2017-12-29 | 2018-06-29 | 广州万孚生物技术股份有限公司 | 活化部分凝血活酶时间测定试剂 |
CN108760695A (zh) * | 2018-04-27 | 2018-11-06 | 天津师范大学 | 一种基于pret的磷光探针定量检测凝血酶的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN110412001A (zh) | 2019-11-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4234682A (en) | Method and reagent for determining biologically active heparin in plasma | |
JP4176157B2 (ja) | 凝固パラメーターの決定方法 | |
JP3055933B2 (ja) | 改良された安定な凝固対照 | |
CN102539355B (zh) | 用于同时测定多种凝固蛋白酶的方法 | |
JP4361980B2 (ja) | サンプルの潜在的抗血液凝固能の測定法 | |
JPH0275953A (ja) | 血液凝固因子安定化法 | |
JP6461125B2 (ja) | 抗第Xa因子試験のユニバーサル較正のための手段および方法 | |
US20030044871A1 (en) | Coagulation assay reagents containing lanthanides and a protein C assay using such a lanthanide-containing reagent | |
JP3533012B2 (ja) | プロテインc/プロテインs系の障害を検出する方法 | |
KR20090085666A (ko) | 세포를 포함한 복합 생체물질에서 단백용해 활성도를 측정하는 방법 | |
NL8201987A (nl) | Werkwijze voor het bepalen van de activiteit van plasminogeenactivator van het weefseltype, alsmede voor gebruik bij deze werkwijze geschikte combinatie van het "kit"-type. | |
CA2238814A1 (en) | Factor v ratio blood test for susceptibility to thromboembolism | |
CN110412001B (zh) | 一种动态监测凝血酶生成能力的试剂盒 | |
AU2009265315A1 (en) | Method for measuring activated factor VII level in a sample | |
Mattsson et al. | Effect of melagatran on prothrombin time assays depends on the sensitivity of the thromboplastin and the final dilution of the plasma sample | |
EP0360871B1 (en) | Method for measuring biological activity of antithrombin iii and reagents for the measurement | |
Corrigan Jr et al. | Factor II antigen in liver disease and warfarin‐induced vitamin K deficiency: Correlation with coagulant activity using echis venom | |
JPH04501460A (ja) | 触媒活性セリンプロテアーゼに関する免疫検定法 | |
Henderson et al. | Response of factor VIII and IX-deficient blood to wild type and high membrane affinity mutant factor VIIa in an in vitro whole blood clotting assay: possible correlation to clinical outcome | |
CA2039173C (en) | Factor ix chromogenic assay | |
JP2008530992A (ja) | 血液または血漿の試料の総凝固活性の測定方法 | |
Gandrille et al. | Association of inherited dysfibrinogenaemia and protein C deficiency in two unrelated families | |
CA2162432C (en) | Calibrator for use in test methods for detecting a defective coagulation factor v | |
US4784940A (en) | Quantitation of cancer procoagulant activity in serum | |
JP2548349B2 (ja) | タンパク質加水分解で活性な成分の測定 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A kit for dynamic monitoring of thrombin generation ability Effective date of registration: 20220823 Granted publication date: 20220211 Pledgee: Guanggu Branch of Wuhan Rural Commercial Bank Co.,Ltd. Pledgor: WUHAN THALYS BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2022420000268 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230825 Granted publication date: 20220211 Pledgee: Guanggu Branch of Wuhan Rural Commercial Bank Co.,Ltd. Pledgor: WUHAN THALYS BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2022420000268 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A dynamic monitoring kit for thrombin production ability Effective date of registration: 20230830 Granted publication date: 20220211 Pledgee: Guanggu Branch of Wuhan Rural Commercial Bank Co.,Ltd. Pledgor: WUHAN THALYS BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2023980054708 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20220211 Pledgee: Guanggu Branch of Wuhan Rural Commercial Bank Co.,Ltd. Pledgor: WUHAN THALYS BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2023980054708 |