CN110393753A - A kind of Chinese medicine composition and preparation method for preventing and treating Egg Production of Laying Hens syndrome - Google Patents
A kind of Chinese medicine composition and preparation method for preventing and treating Egg Production of Laying Hens syndrome Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions and preparation method for preventing and treating Egg Production of Laying Hens syndrome, including radix scutellariae, Cortex Phellodendri, Herba Andrographitis, cape jasmine, kuh-seng, Radix Glycyrrhizae, Divine Comedy, pine needle, Radix Astragali, Herba Epimedii, motherwort, hawthorn, the present invention can effectively prevent Egg Production of Laying Hens drop syndrome, toxic side effect is small, quick, chicken immunity of organisms can also be improved, the laying rate of laying hen is improved and reduces arenaceous shell egg, white shell egg, thin eggshell, check, soft-shelled egg quantity.The traditional chinese medicine composition of the invention raw material sources are wide simultaneously, cheap, highly-safe, have the characteristics that have no toxic side effect, pollution-free, noresidue, do not generate drug resistance.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for preventing and treating Egg Production of Laying Hens drop syndrome of field of traditional Chinese veterinary and its preparation sides
Method and application, in particular to a kind of Chinese medicine composition and its preparation method and application for preventing and treating Egg Production of Laying Hens drop syndrome.
Background technique
Egg Production of Laying Hens drop syndrome is by because of immunity degradation, colibacillosis, salmonellosis, mildness influenza, newly
One kind caused by city epidemic disease, infective bronchitis, infectious laryngotracheitis, salpingitis, peritonitis etc. is declined with Egg Production of Laying Hens
Syndrome, while the death and culling rate of chicken group increases.Clinical manifestation is pale for cockscomb of laying eggs, egg production decline, and produces arenaceous shell egg, white shell
Egg, thin eggshell, check, soft-shelled egg increase, and milky egg white sample loose stools is discharged in chicken sometimes or white green loose stools, cloaca are prominent
Out, often with bloodstain on its eggshell of the egg of output.Some chicken groups are with respiratory symptom.Dissect can be seen Fallopian tube mucosa and fill
Blood, bleeding, oedema inside have a large amount of mucus white secretion, and inner product has special-shaped egg sample exudate, has 1 to 2 at cloaca
It forms intact egg and fails output, some suffers from intestinal adhesions at chicken abdominal cavity.The chicken pharyngitis bleeding of appearance respiratory symptom,
Necrosis intratracheally has sticky or hemorrhagic effusion.
Mainly there are two kinds of means of chemicals and Chinese herbal medicine to the prevention and treatment of Egg Production of Laying Hens drop syndrome.Due to Egg Production of Laying Hens
The cause of disease caused by drop syndrome is complicated, is related to bacterium, virus, mycoplasma etc..The chemicals that clinic is often used have disease-resistant
Poison Ribavirin, antibiotic are Amoxicillin, Florfenicol, Enrofloxacin, Doxycycline, daimeton etc..Change
Certain effect can be played in prevention and treatment Egg Production of Laying Hens drop syndrome by learning drug.But using laying rate capable of being caused to decline.With
The improvement of people's living standards, food safety consciousness enhancing, it is also higher and higher to the quality requirement of food.Chemicals
Use in laying hen leads to the medicament residue in egg, and different degrees of harm is produced to people's health.
Increasing with country to chemicals residue monitoring and punishment in egg, breeding layer chicken enterprise (family) is gradually
The importance for recognizing food safety controls the use of chemicals in laying cycle of laying hens as far as possible.Chinese herbal medicine is for the anti-of disease
Control to apply and have long history in China, have source it is wide, it is highly-safe, have have no toxic side effect, be pollution-free, noresidue,
Not the features such as not generating drug resistance.For Chinese medicine in terms of preventing and treating Egg Production of Laying Hens drop syndrome, dialectical according to its clinical symptoms is damp and hot
Dysentery.Therefore, Egg Production of Laying Hens drop syndrome is prevented and treated by the method for " clearing heat and expelling damp improves immunity ".Clinic common four
Yellow Zhili granule, Chinese bulbul oral solution etc. prevent and treat Egg Production of Laying Hens drop syndrome there are certain limitation, lead to the effect prevented and treated
It is bad, and temperature compensation class powder traditional Chinese powder medicine such as swashs that egg, which dissipates, benefit is female increases egg to dissipate that there is also clinical therapeutic efficacies poor, price is higher
The deficiencies of (Radix Angelicae Sinensis, Semen Cuscutae are in 40 yuan/kg or more) disadvantage.In addition market rise biological agent and probiotics again not
It is able to satisfy Egg Production of Laying Hens drop syndrome complexity state of an illness prevention and treatment needs.The overall background " subtracted anti-" during Animal husbandry production in China
Under, develop cheap, efficient, the green prevention and treatment Egg Production of Laying Hens drop syndrome Chinese materia medica preparation of one kind needs as urgent market
It asks.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese medicine compositions and preparation method for preventing and treating Egg Production of Laying Hens syndrome, in this
Drug composition can effectively prevent Egg Production of Laying Hens drop syndrome, and toxic side effect is small, quick, additionally it is possible to improve chicken body and exempt from
Epidemic disease power improves the laying rate of laying hen and reduces arenaceous shell egg, white shell egg, thin eggshell, check, soft-shelled egg quantity.The present invention simultaneously
Chinese medicine composition raw material sources are wide, cheap, highly-safe, have and have no toxic side effect, is pollution-free, noresidue, not generating
The features such as drug resistance.
To achieve the above object, the invention provides the following technical scheme: a kind of Chinese medicine group for preventing and treating Egg Production of Laying Hens syndrome
Close object, including radix scutellariae, Cortex Phellodendri, Herba Andrographitis, cape jasmine, kuh-seng, Radix Glycyrrhizae, Divine Comedy, pine needle, Radix Astragali, Herba Epimedii, motherwort, hawthorn.
Preferably, the raw material composition including following parts by weight: 1 ~ 10 part of radix scutellariae, 5 ~ 20 parts of Cortex Phellodendri, 5 ~ 30 parts of Herba Andrographitis, Cape jasmine
1 ~ 10 part of son, 0 ~ 15 part of kuh-seng, 0 ~ 10 part of Radix Glycyrrhizae, 0 ~ 10 part of Divine Comedy, 0 ~ 10 part of pine needle, 5 ~ 20 parts of Radix Astragali, 5 ~ 15 parts of Herba Epimedii,
5 ~ 20 parts of motherwort, 0 ~ 10 part of hawthorn.
Preferably, the raw material composition including following parts by weight: 6 parts of radix scutellariae, 10 parts of Cortex Phellodendri, 15 parts of Herba Andrographitis, 5 parts of cape jasmine,
10 parts of kuh-seng, 6 parts of Radix Glycyrrhizae, 4 parts of Divine Comedy, 5 parts of pine needle, 15 parts of Radix Astragali, 10 parts of Herba Epimedii, 10 parts of motherwort, 4 parts of hawthorn.
It preferably, further include surfactant or auxiliary material.
Preferably, the surfactant is lauryl sodium sulfate, dodecyl sodium sulfate, anhydro sorbitol list laurel
Acid esters, glyceryl monolaurate, Arlacel-60, Sorbitan Monooleate, Polyoxyethylene sorbitan
Alcohol monoleate, polyethenoxy sorbitan monostearate, tween, sapn, Qula are led to, in castor oil polyoxyethylene ether
One or more combinations, the surfactant adding proportion are 0.5% ~ 5%.
Another side of the invention, a kind of preparation method of Chinese medicine composition that preventing and treating Egg Production of Laying Hens syndrome, including it is following
Step:
Chinese medicine composition each component is mixed with surfactant, powder is prepared using superfine grinding method；By Chinese medicine composition
Part composition mixes the solution that alcohol-extracted extract contains ethyl alcohol with respective concentration surfactant with water extract after alcohol extracting and water mention
Conjunction is prepared into oral solution；By Chinese medicine composition part composition after alcohol extracting and water mention, alcohol-extracted extract is merged with the water extracted immersing paste, is added
Enter the surfactant and auxiliary material of corresponding proportion, is uniformly mixed and prepares granule.
Preferably, radix scutellariae, Herba Andrographitis, pine needle, kuh-seng, Herba Epimedii is cleaned, it dries, 70% alcohol reflux is added after crushing
It extracts 2 times, every time plus 5 times of amounts are extracted 1 hour, and merging filtrate recycles ethyl alcohol, obtains medicinal extract, spare；By Cortex Phellodendri, Radix Glycyrrhizae, Radix Astragali, benefit
Brittle Falsepimpernel Herb, cape jasmine, Divine Comedy, hawthorn are once purged to add water to cook 2 times, and every time plus 10 times of amount water decoct 1.5 hours, filtration, and filtrate is dense
Shorten the concentration water extract of 1 mL into；The solution that medicinal extract, water extract and a certain concentration surfactant are contained 10% ~ 40% ethyl alcohol is mixed
It closes, is prepared into the concentration oral solution of 1 mL.
Preferably, radix scutellariae, Herba Andrographitis, pine needle, kuh-seng, Herba Epimedii is cleaned, it dries, crushes plus 70% alcohol reflux mentions
It takes 2 times, every time plus 5 times of amounts are extracted 1 hour, and merging filtrate recycles ethyl alcohol, obtains medicinal extract, spare；Cortex Phellodendri, Radix Glycyrrhizae, Radix Astragali, benefit is female
Grass, cape jasmine, Divine Comedy, hawthorn are cleaned to add water to cook 2 times, and every time plus 10 times of amount water decoct 1.5 hours, filtration, filtrate concentration leaching
Cream；Alcohol-extracted extract is merged with the water extracted immersing paste, auxiliary material is added, is uniformly mixed the granule for being prepared into 10 ~ 20 mesh through granulator.
Preferably, the auxiliary material includes starch, lactose, dextrin, Icing Sugar, calcium sulfate, sucrose, mannitol, microcrystalline cellulose
Element, glucose, povidone, ethyl cellulose, hydroxypropyl cellulose, povidone, stearic acid, calcium stearate, magnesium stearate, talcum
One of powder, superfine silica gel powder, paraffin, glycerol or multiple combinations.
A kind of Chinese medicine composition preparation method for preventing and treating Egg Production of Laying Hens drop syndrome of the present invention are as follows:
1) prepared by Chinese traditional medicine composition composition powders: by Chinese medicine composition radix scutellariae, Cortex Phellodendri, Herba Andrographitis, cape jasmine, kuh-seng, Radix Glycyrrhizae, Divine Comedy, pine
Needle, Radix Astragali, Herba Epimedii, motherwort, hawthorn are cleaned, are dosed to after drying with 1 part of solid surfactant and pass through ultramicro grinding
Machine after crushing, obtains Chinese traditional medicine composition composition powders, and the partial size of composition reaches 400 mesh or more；
2) Chinese medicine composition oral liquor: radix scutellariae, Herba Andrographitis, pine needle, kuh-seng, the Herba Epimedii in Chinese medicine composition are passed through
After crushing plus 70% alcohol reflux extracts 2 times, and every time plus 5 times of amounts are extracted 1 hour, and merging filtrate recycles ethyl alcohol, obtains medicinal extract, standby
With；Cortex Phellodendri, Radix Glycyrrhizae, Radix Astragali, motherwort, cape jasmine, Divine Comedy, hawthorn in Chinese medicine composition add water to cook 2 times, and every time plus 10 times are measured
Water decocts 1.5 hours, and filtration, filtrate is condensed into the concentration water extract that 1 mL is equivalent to 8 g crude drugs；By medicinal extract, water extract and contain
There is the solution of 10% ~ 40% ethyl alcohol of 2% surfactant to mix, is prepared into the concentration oral solution that 1 mL is equivalent to 4 g crude drugs；
3) process for producing granula of Chinese medicine composition, by radix scutellariae, Herba Andrographitis, pine needle, kuh-seng, the Herba Epimedii in Chinese medicine composition
After crushed plus 70% alcohol reflux extracts 2 times, and every time plus 5 times of amounts are extracted 1 hour, and merging filtrate recycles ethyl alcohol, obtains medicinal extract, with
The concentrated extract of Cortex Phellodendri, Radix Glycyrrhizae, Radix Astragali, motherwort, cape jasmine, Divine Comedy, hawthorn in Chinese medicine composition merges, and surface-active is added
Agent and auxiliary material are uniformly mixed the granule that 10 ~ 20 mesh are prepared into through granulator.
The reasonable recipe of the traditional chinese medicine composition of the invention, preparation is easy, and at low cost, crude drug source is wide；It can effectively improve laying hen
Laying rate reduces arenaceous shell egg, white shell egg, thin eggshell, check, soft-shelled egg quantity；Meanwhile the small, noresidue with toxic side effect
The advantages that, meet the requirement of China's animal husbandry development of " sustainable, healthy, green " instantly, is mentioned for animal food safety
Technical guarantee is supplied.
In the present invention, each component flavour of a drug characteristic is as follows:
Radix scutellariae: bitter is cold in nature, return heart, liver, stomach, large intestine channel；Primary efficacy has heat-clearing and damp-drying drug, purging fire for removing toxin；Cure mainly middle burnt stomach and intestine
It is damp and hot, diarrhea, dysentery etc.；There are many baicalin, baicalein, skullcapflavones etc. for main component；
Cortex Phellodendri: bitter is cold in nature, returns kidney, bladder meridian；Primary efficacy has heat-clearing, eliminating dampness, purging intense heat, removing toxic substances；It cures mainly caused by large intestinal damp-heat
Dysentery purulence blood is often equal with the Chinese bulbul, the coptis and uses；Main component has jamaicin, jateorrhizine, magnoflorine, obakunone etc.；
Herba Andrographitis: bitter is cold in nature, return heart, lung, large intestine, bladder meridian；Primary efficacy is clearing heat and detoxicating, eliminating dampness；Damp-heat dysentery is cured mainly, it can
It is applied alone or Cortex Phellodendri compatibility；Main component has dexyandrographolide, andrographolide, Neoandrographolide, andrographon etc.；
Cape jasmine: bitter is cold in nature, return heart, lung, stomach, tri-jiao channel；Primary efficacy clearing heat-fire, choleretic effect；Cure mainly pyreticosis dysphoria not
Dormancy, bloody flux, liver and gallbladder and syndrome of dampness-heat in lower jiao；Often with the radix scutellariae compatibility of clearing heat-fire；Main component flavonoids gardenin, triterpenes
Close object crocin, crocetin etc.；
Kuh-seng: bitter is cold in nature, return heart, liver, stomach, large intestine, bladder meridian；Primary efficacy heat-clearing and damp-drying drug, desinsection, diuresis；It cures mainly and is used for
Hot dysentery, hematochezia, jaundice urodialysis, often with the Cortex Phellodendri compatibility of heat-clearing and damp-drying drug；Main component is Banlangen；
Radix Glycyrrhizae: sweet in flavor mild-natured, return heart, spleen, lung, stomach meridian；Primary efficacy removing toxic substances, heat-clearing；It cures mainly for pathopyretic ulcer, it is physically weak etc.
Disease, often with the compatibilities such as Cortex Phellodendri, kuh-seng；Main component is glycyrrhizic acid, liquiritin etc.；
Divine Comedy: it is sweet in flavor, pungent, it is warm-natured；Returns spleen, stomach meridian；Primary efficacy helps digestion stomach function regulating, antidiarrheal inducing diaphoresis；It cures mainly for accumulation of food in the stomach and intes tine due to indigestion, gastral cavity
Distention and fullness in the abdomen, do not feel like eating, often with hawthorn compatibility；Main component is saccharomycete, enzyme, vitamin B complex, ergosterol, waves
Hair oil, glycoside etc.；
Pine needle: it is sour, bitter, it is warm-natured；Return heart, spleen, Liver Channel；Primary efficacy expelling wind and activating blood flow, improving eyesight are calmed the nerves, and removing toxic substances removes pathogenic factor
Deng；It cures mainly for catching a cold, rheumatism, swelling and pain, neurasthenia；Main component is volatile oil, flavones, lignanoid, shikimic acid etc.；
Radix Astragali: sweet in flavor, slightly warm in nature；Returns spleen, lung channel；Primary efficacy tonifying Qi and lifting yang, invigorating qi for consolidating superficies, QI invigorating Li Shui, susceptible exopathogen person；
It cures mainly and is used for the sinking of qi of middle-jiao, in the heart atmospheric subsidence, the deficiency of vital energy is not solid, instability of surface, deficiency of vital energy and edema etc.；Main component is that Radix Astragali is more
Sugar；
Herba Epimedii: it is acrid flavour, sweet, it is warm-natured；Return liver and kidney channel；Primary efficacy wind-dispelling, cold dispelling, dehumidifying, kidney-replenishing, invigorating yangqi；It cures mainly
It is used for treating arthralgia due to cold and dampness simultaneous deficient and weak YANG QI person, impotence caused by decline of kidney-YANG, dam are out of heat, and waist hip is powerless etc.；Main component is
Icariin, epimedium brevicornum polysaccharide and barren wort total chromocor；
Motherwort: acrid flavour, hardship, cold nature；Return heart, liver, bladder meridian；Primary efficacy activating microcirculation and removing stasis medicinal, inducing diuresis for removing edema；It cures mainly for tire
Clothing not under, lochiorrhagia, leukorrhagia, edema and little urine；Main component leonurine, stachydrine, leonuridine, leonurinine, flax
Acid, lauric acid, rutin etc.；
Hawthorn: sour, sweet, tepor；Returns spleen, stomach, Liver Channel；Primary efficacy promoting digestion and removing indigestion, scattered stasis, convergence and dysentery activate blood circulation and disperse blood clots
Deng；It cures mainly for dyspeptic abdominal flatulence, indigestion, prolonged lochia；Main component Luteolin, Duo Zhongwei
Raw element, hawthorn acid, lipolytic enzyme etc..
Compared with prior art, beneficial effects of the present invention are as follows: the screening of the Chinese herbal medicine of the traditional chinese medicine composition of the invention be
On the basis of lot of documents, experience, there is egg drop syndrome genius morbi in conjunction with current cultivation laying hen, carry out excellent
Change combination, obtains optimal prevention and treatment Egg Production of Laying Hens drop syndrome Chinese medicine composition.The present invention can effectively prevent laying hen
Egg drop syndrome, toxic side effect are small, quick, additionally it is possible to improve chicken immunity of organisms, improve the laying rate and drop of laying hen
Low arenaceous shell egg, white shell egg, thin eggshell, check, soft-shelled egg quantity.The traditional chinese medicine composition of the invention raw material sources are wide simultaneously, valence
Lattice are cheap, highly-safe, have the characteristics that have no toxic side effect, pollution-free, noresidue, do not generate drug resistance；In Chinese herbal medicine at
Point complexity, some fat-soluble ingredients are not easy to be absorbed by organisms in enteron aisle, surfactant due to have wetting, emulsification,
The a series of physical chemical action such as solubilising, anti-corrosion, a certain proportion of surfactant is added in Chinese medicine composition, can be improved
Fat-soluble effective component is absorbed by organisms in Chinese herbal medicine, can preferably play Chinese herbal medicine to the control efficiency of disease.
Detailed description of the invention:
Fig. 1, Fig. 2 are respectively the check for testing front and back, soft-shelled egg and lopsided egg variation diagram.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
A kind of Chinese medicine composition for preventing and treating Egg Production of Laying Hens syndrome, including it is radix scutellariae, Cortex Phellodendri, Herba Andrographitis, cape jasmine, kuh-seng, sweet
Grass, Divine Comedy, pine needle, Radix Astragali, Herba Epimedii, motherwort, hawthorn.
A kind of Chinese medicine composition for preventing and treating Egg Production of Laying Hens syndrome, the raw material composition including following parts by weight: radix scutellariae 1 ~ 10
Part, 5 ~ 20 parts of Cortex Phellodendri, 5 ~ 30 parts of Herba Andrographitis, 1 ~ 10 part of cape jasmine, 0 ~ 15 part of kuh-seng, 0 ~ 10 part of Radix Glycyrrhizae, 0 ~ 10 part of Divine Comedy, pine needle 0 ~
10 parts, 5 ~ 20 parts of Radix Astragali, 5 ~ 15 parts of Herba Epimedii, 5 ~ 20 parts of motherwort, 0 ~ 10 part of hawthorn.
Embodiment 1, a kind of Chinese medicine composition for preventing and treating Egg Production of Laying Hens syndrome, the raw material composition including following parts by weight:
6 parts of radix scutellariae, 10 parts of Cortex Phellodendri, 15 parts of Herba Andrographitis, 5 parts of cape jasmine, 10 parts of kuh-seng, 6 parts of Radix Glycyrrhizae, 4 parts of Divine Comedy, 5 parts of pine needle, Radix Astragali 15
Part, 10 parts of Herba Epimedii, 10 parts of motherwort, 4 parts of hawthorn.It is dosed into according to Chinese medicine parts by weight with 1 part of dodecyl sodium sulfate super
In atomizer, after crushing, the powder of Chinese medicine composition is obtained, the partial size of composition is more than 400 mesh.
Embodiment 2
Radix scutellariae, Herba Andrographitis, pine needle, kuh-seng, Herba Epimedii in 1 Chinese medicinal component of Example is cleaned, dries, and 70% is added after crushing
Alcohol reflux extracts 2 times, and every time plus 5 times of amounts are extracted 1 hour, and merging filtrate recycles ethyl alcohol, obtains medicinal extract, spare；Chinese medicine composition
In Cortex Phellodendri, Radix Glycyrrhizae, Radix Astragali, motherwort, cape jasmine, Divine Comedy, hawthorn is once purged adds water to cook 2 times, every time plus 10 times of amount decoctings
It boils 1.5 hours, filters, filtrate is condensed into the concentration water extract that 1 mL is equivalent to 8 g crude drugs；By medicinal extract, water extract and 2% surface
Activating agent contains the solution mixing of 30% ethyl alcohol, is prepared into the concentration oral solution that 1 mL is equivalent to 4 g crude drugs.
Embodiment 3
Radix scutellariae, Herba Andrographitis, pine needle, kuh-seng, Herba Epimedii in 1 Chinese medicinal component of Example is cleaned, dries, and crushes and adds 70% second
Alcohol reflux extracts 2 times, and every time plus 5 times of amounts are extracted 1 hour, and merging filtrate recycles ethyl alcohol, obtains medicinal extract, spare；In Chinese medicine composition
Cortex Phellodendri, Radix Glycyrrhizae, Radix Astragali, motherwort, cape jasmine, Divine Comedy, hawthorn is cleaned adds water to cook 2 times, every time plus 10 times of amount water decoctions 1.5
Hour, filtration, filtrate concentrated extract；Alcohol-extracted extract is merged with the water extracted immersing paste, be added suitable starch, Icing Sugar and 1% tween
80, it is uniformly mixed the granule that 10 ~ 20 mesh are prepared into through granulator, it is raw that per kilogram granule is equivalent to 2 kg Chinese medicine compositions
Medicine.
Embodiment 4
Experimental animal
Newcastle disease occurs for Northern Huaihe River Anhui city laying hen, 2.6 ten thousand plumage Roman egghens, 170 ages in days, early period, after treatment, feeding
Normally.There is check, soft-shelled egg and lopsided egg, laying rate 80%.In order to verify the curative effect of the traditional chinese medicine composition of the invention, select
It selects 20,000 plumage laying hens and carries out clinical trial.
Test method
Test is divided into 2 groups, and a group is the traditional chinese medicine composition of the invention administration group, by the powder in embodiment 1 according to 4% addition
Amount is added in feed；Another set is Chinese medicine control group, is dissipated using four sharp eggs, is added to feed according to its dosage recommended
In；It is 5 days that test period, which has altogether, records laying rate, check, soft-shelled egg and lopsided egg quantity daily.
Test result
After feeding the traditional chinese medicine composition of the invention 3 days, the quantity of check, soft-shelled egg and lopsided egg is reduced, and the broken shell of control group
The quantity of egg, soft-shelled egg and lopsided egg there is no variation；After feeding the traditional chinese medicine composition of the invention 5 days, laying rate rises
To 93.0%, the laying rate of control group does not improve substantially, and the traditional chinese medicine composition of the invention improves 9.4% than control group；The present invention
Without check, soft-shelled egg and lopsided egg, the quantity of the check of control group, soft-shelled egg and lopsided egg does not have substantially Chinese medicine composition
It changes.Specific test result is shown in Table 1, and the check, soft-shelled egg and lopsided egg variation for testing front and back are shown in Fig. 1, Fig. 2.Table 1
Chinese traditional medicine composition composition powders clinical trial result.
Table 1
Embodiment 5
Experimental animal
Huainan City, Anhui Province Fengtai County laying hen, cultivates sea 210 age in days of blue laying hen, and breeding stock is 8000.Because of egg drop reduction
Nearly four one-tenth of the decline of syndrome egg production, and have a certain number of soft-shelled eggs, shell egg, blood cake egg, albumen is leaner.Dissect diseased chicken
Tunica mucosa tubae uterinae oedema has white cheesy exudate, and ovary hyperemia, bleeding, other organs are without obvious lesion.
Test method
Test is divided into 2 groups, and every group three are parallel, and each parallel 100；One group is the traditional chinese medicine composition of the invention administration group,
Chinese medicine composition oral solution in embodiment 2 is watered 100 kg according to 100 mL and carries out concentration drinking-water；Another set is Chinese medicine
Control group is concentrated according to its recommended dose using Ribavirin and is drunk water；It is 5 days that test period, which has altogether, counts cure rate, effectively
Rate, laying rate, good egg rate.
Test result determines
Egg production restores normal, and diseased chicken clinical symptoms disappear, and spirit is good, and no soft-shelled egg, shell egg, blood cake egg are judged as and control
More；
Egg production increases, and diseased chicken clinical symptoms make moderate progress, and produces soft-shelled egg, shell egg, blood cake egg quantity and reduces, is judged as
Effectively；
Egg production does not change substantially, and diseased chicken clinical symptoms do not have improvement, produces soft-shelled egg, shell egg, blood cake egg quantity and does not have substantially
It changes, is judged as invalid；
Good egg rate is the percentage for deducting laying hen and producing total quantity of laying eggs shared by the quantity of soft-shelled egg, shell egg, blood cake egg；
The percentage of test laying hen sum shared by chicken number and effective chicken number of the effective percentage for healing.
Test result
After test 5 days, for Chinese medicine composition of the invention compared with Ribavirin drug control group, cure rate improves 14%, lays eggs
Rate improves 17%, and good egg rate improves 12.6%.The effect of the traditional chinese medicine composition of the invention group is substantially better than Ribavirin drug pair
According to group.Specific test result is shown in Table 2.
2 Chinese medicine composition oral solution of table drinking-water clinical trial result
| Group | Laying hen/only | Cure rate (%) | Efficient (%) | Inefficiency (%) | Laying rate (%) | Good egg rate (%) |
| The traditional chinese medicine composition of the invention group | 300 | 82±1.56 | 91±2.19 | 9±1.63 | 92±1.12 | 100 |
| Ribavirin control group | 300 | 58±2.37 | 83±3.21 | 17±2.49 | 75±2.32 | 87.4 |
Embodiment 6
Experimental animal
Anhui Linquan County breeding layer chicken family cultivates sea 200 age in days of blue laying hen, and breeding stock is 20,000, and large intestine bar has occurred early period
Bacterium disease, the recent white dilute excrement of ash discharge；The eggshell color laid eggs bleaches, and the quantity for the blood cake egg, arenaceous shell egg laid eggs for nearly one week
Increase, white shell egg, blood cake egg, arenaceous shell egg ratio be respectively 1.2%, 2.3%, 0.9%；Laying hen spirit and feed intake are normal, family
Main judgement chicken group has slight salpingitis.A henhouse therein is selected to carry out the traditional chinese medicine composition of the invention defeated to laying hen
The preventive effect of oviduct inflammation is tested, and in addition one carries out hen salpingitis of laying eggs using four yellow Zhili granules as a control group
Prevent check experiment.
Test method
It tests and is divided into 2 groups, every group of henhouse, laying hen 10,000；One group is the traditional chinese medicine composition of the invention administration group, will be real
It applies the Chinese medicinal composition granules in example 3 and is watered 200 kg according to 100 g and concentrate drinking water and prevent；Another set is Chinese medicine four
Yellow Zhili granule control group is concentrated according to its recommended dose and is drunk water；Test period have altogether be 14 days, count normal egg, white shell egg,
Blood cake egg, arenaceous shell egg simultaneously observe excrement situation of change.
Test result determines
Normal egg: surface is smooth, without point, eggshell color brown, and eggshell quality is intact；
White shell egg: eggshell color is partially white, hence it is evident that variant with brown eggshell.
Blood cake egg: eggshell is more smooth, and eggshell shows there is Filamentous, mottled cerise or black bloodstain；
Arenaceous shell egg: it is sand shape that eggshell is coarse, has irregular protrusion seemingly tiny.
Normal egg, white shell egg, blood cake egg, arenaceous shell egg ratio are normal egg, lay eggs shared by white shell egg, blood cake egg, arenaceous shell egg
The percentage of sum.
Test result
After the traditional chinese medicine composition of the invention granule group medication 4 days, excrement is formed by dilute at booth shape variation for excrement, and medication 7 days
Afterwards, stool colour is by greyish white recovery normal color；White glutelin shell egg, blood cake egg, the decline of arenaceous shell egg ratio；Medication to 14 days,
The whole henhouse Egg Production of Laying Hens restores normal, without white shell egg, blood cake egg, arenaceous shell egg.And four yellow Zhili granule control group laying hens
Excrement and white shell egg, blood cake egg, the arenaceous shell egg laid eggs have certain improvement, but change unobvious；Still had to 14 days white shell egg,
Blood cake egg, arenaceous shell egg occur.Specific test result is shown in Table 3.
3 Chinese medicinal composition granules of table drinking-water prevention salpingitis test result
Embodiment 7
Experimental animal
Kind of 390 age in days of laying hen is closed in Xuancheng Profile, anhui Province breeding layer chicken field, cultivation four, and three henhouse breeding stocks are 2.7 ten thousand, average every
Its 21915 pieces of egg of laying eggs, abnormal egg number are 1586 pieces, and hen death toll is 13, and abnormal laying rate is 7.24%.Selection
To the clinical trial for hen salpingitis of laying eggs, in addition 0.9 ten thousand laying hens of a henhouse therein carry out the traditional chinese medicine composition of the invention
One is tested using four yellow Zhili granules carry out the laying eggs as a control group curative effect comparision of hen salpingitis.
Test method
Test 3 henhouses of selection, 0.9 ten thousand every；First is the traditional chinese medicine composition of the invention administration group, will be in embodiment 3
Chinese medicinal composition granules are added to one ton of feed according to 2kg and carry out spice administration；Second is the yellow Zhili granule pair of Chinese medicine four
According to group, it is administered according to its recommended dose spice；Third is not medicine-feeding test group；It is 14 days that test period, which has altogether, and statistics is laid eggs
Number, Abnormal Eggss number, hen death toll and Abnormal Eggss rate.
Test result
After the traditional chinese medicine composition of the invention granule group medication 7 days, egg number is risen, Abnormal Eggss number, hen death toll and different
Normal egg rate is declined；After medication 14 days, this henhouse is laid eggs 8160 pieces, and laying rate has original 81.16% to rise to
90.06%；The death toll exception egg number of hen has original 528 pieces, drops to 296 pieces；The death toll of hen has original 4
Only drop to 1 daily daily.Specific test result is shown in Table 4.
4 Chinese medicinal composition granules spice clinical trial result of table
To sum up, the present invention more batches, test of many times repeatedly achieve and good imitate for Egg Production of Laying Hens drop syndrome technology
Fruit shows that Chinese Herbs of the present invention are reliable and stable, there is actual application value.Inventive formulation is rigorous, curative effect really, without residual
It stays, it is easy to use, it can be effectively prevented and treated laying hen egg drop syndrome, there is good clinical value.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.
Claims (9)
1. a kind of Chinese medicine composition for preventing and treating Egg Production of Laying Hens syndrome, which is characterized in that including radix scutellariae, Cortex Phellodendri, Herba Andrographitis, Cape jasmine
Son, kuh-seng, Radix Glycyrrhizae, Divine Comedy, pine needle, Radix Astragali, Herba Epimedii, motherwort, hawthorn.
2. it is according to claim 1 it is a kind of prevent and treat Egg Production of Laying Hens syndrome Chinese medicine composition, which is characterized in that including with
The raw material of lower parts by weight forms: 1 ~ 10 part of radix scutellariae, 5 ~ 20 parts of Cortex Phellodendri, and 5 ~ 30 parts of Herba Andrographitis, 1 ~ 10 part of cape jasmine, 0 ~ 15 part of kuh-seng,
0 ~ 10 part of Radix Glycyrrhizae, 0 ~ 10 part of Divine Comedy, 0 ~ 10 part of pine needle, 5 ~ 20 parts of Radix Astragali, 5 ~ 15 parts of Herba Epimedii, 5 ~ 20 parts of motherwort, hawthorn 0 ~
10 parts.
3. it is according to claim 2 it is a kind of prevent and treat Egg Production of Laying Hens syndrome Chinese medicine composition, which is characterized in that including with
The raw material of lower parts by weight forms: 6 parts of radix scutellariae, 10 parts of Cortex Phellodendri, and 15 parts of Herba Andrographitis, 5 parts of cape jasmine, 10 parts of kuh-seng, 6 parts of Radix Glycyrrhizae, Divine Comedy 4
Part, 5 parts of pine needle, 15 parts of Radix Astragali, 10 parts of Herba Epimedii, 10 parts of motherwort, 4 parts of hawthorn.
4. a kind of Chinese medicine composition for preventing and treating Egg Production of Laying Hens syndrome according to claim 3, which is characterized in that further include
Surfactant or auxiliary material.
5. a kind of Chinese medicine composition for preventing and treating Egg Production of Laying Hens syndrome according to claim 4, which is characterized in that the table
Face activating agent be lauryl sodium sulfate, dodecyl sodium sulfate, Arlacel-20, glyceryl monolaurate,
Arlacel-60, Sorbitan Monooleate, polyoxyethylene sorbitan monooleate, polyoxyethylene are de-
Water sorbitol monostearate, tween, sapn, Qula be logical, one of castor oil polyoxyethylene ether or multiple combinations, the table
Face activating agent adding proportion is 0.5% ~ 5%.
6. a kind of preparation method for the Chinese medicine composition for preventing and treating Egg Production of Laying Hens syndrome, it is characterised in that: Chinese medicine composition is each
Component is mixed with surfactant, prepares powder using superfine grinding method；By Chinese medicine composition part composition through alcohol extracting and water
After mentioning, the solution mixing system that alcohol-extracted extract and water extract and respective concentration surfactant are contained ethyl alcohol is standby at oral solution；It will
Chinese medicine composition part composition merges after alcohol extracting and water mention, by alcohol-extracted extract with the water extracted immersing paste, and the surface of corresponding proportion is added
Activating agent and auxiliary material are uniformly mixed and prepare granule.
7. a kind of preparation method of Chinese medicine composition for preventing and treating Egg Production of Laying Hens syndrome according to claim 6, feature
It is: radix scutellariae, Herba Andrographitis, pine needle, kuh-seng, Herba Epimedii is cleaned, it dries, 70% alcohol reflux extraction 2 times is added after crushing, often
Secondary plus 5 times of amounts are extracted 1 hour, and merging filtrate recycles ethyl alcohol, obtains medicinal extract, spare；By Cortex Phellodendri, Radix Glycyrrhizae, Radix Astragali, motherwort, cape jasmine,
Divine Comedy, hawthorn are once purged to add water to cook 2 times, and every time plus 10 times of amount water decoct 1.5 hours, and filtration, filtrate is condensed into 1 mL's
Concentration water extract；Medicinal extract, water extract are mixed with the solution that a certain concentration surfactant contains 10% ~ 40% ethyl alcohol, are prepared into 1
The concentration oral solution of mL.
8. a kind of preparation method of Chinese medicine composition for preventing and treating Egg Production of Laying Hens syndrome according to claim 6, feature
It is: radix scutellariae, Herba Andrographitis, pine needle, kuh-seng, Herba Epimedii is cleaned, it dries, crushes and add 70% alcohol reflux extraction 2 times, every time
5 times of amounts are added to extract 1 hour, merging filtrate recycles ethyl alcohol, obtains medicinal extract, spare；By Cortex Phellodendri, Radix Glycyrrhizae, Radix Astragali, motherwort, cape jasmine, mind
It is bent, hawthorn is cleaned adds water to cook 2 times, every time plus 10 times of amount water decoct 1.5 hours, filter, filtrate concentrated extract；Alcohol extracting is soaked
Cream merges with the water extracted immersing paste, and auxiliary material is added, and is uniformly mixed the granule that 10 ~ 20 mesh are prepared into through granulator.
9. a kind of preparation method of the Chinese medicine composition of prevention and treatment Egg Production of Laying Hens syndrome, described according to claim 6-8
Auxiliary material include starch, lactose, dextrin, Icing Sugar, calcium sulfate, sucrose, mannitol, microcrystalline cellulose, glucose, povidone, second
It is base cellulose, hydroxypropyl cellulose, povidone, stearic acid, calcium stearate, magnesium stearate, talcum powder, superfine silica gel powder, paraffin, sweet
One of oil or multiple combinations.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112755097A (en) * | 2021-01-28 | 2021-05-07 | 江西莱瀚斯科技有限公司 | Chinese herbal medicine preparation for preventing and treating soft-shell eggs laid by hens and preparation method |
| CN115154561A (en) * | 2022-07-28 | 2022-10-11 | 郑佰有 | Traditional Chinese medicine composition for preventing chicken from having no peak egg laying after suffering from nephropathogenic infectious bronchitis before onset of parturition and preparation method thereof |
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| CN103550391A (en) * | 2013-10-31 | 2014-02-05 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for increasing laying rate of laying hens and preparation method of composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101744923A (en) * | 2008-12-12 | 2010-06-23 | 北京大北农科技集团股份有限公司 | Traditional Chinese medicine compound pharmaceutical composition used for laying fowls and preparation method and application thereof |
| CN103550391A (en) * | 2013-10-31 | 2014-02-05 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for increasing laying rate of laying hens and preparation method of composition |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112755097A (en) * | 2021-01-28 | 2021-05-07 | 江西莱瀚斯科技有限公司 | Chinese herbal medicine preparation for preventing and treating soft-shell eggs laid by hens and preparation method |
| CN115154561A (en) * | 2022-07-28 | 2022-10-11 | 郑佰有 | Traditional Chinese medicine composition for preventing chicken from having no peak egg laying after suffering from nephropathogenic infectious bronchitis before onset of parturition and preparation method thereof |
| CN115154561B (en) * | 2022-07-28 | 2023-10-20 | 郑佰有 | Traditional Chinese medicine composition for preventing chicken from suffering from kidney-type infectious bronchitis before parturition and having no peak in egg production and preparation method thereof |
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Application publication date: 20191101 |