CN110386941A - Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗 - Google Patents
Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗 Download PDFInfo
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- CN110386941A CN110386941A CN201910753548.6A CN201910753548A CN110386941A CN 110386941 A CN110386941 A CN 110386941A CN 201910753548 A CN201910753548 A CN 201910753548A CN 110386941 A CN110386941 A CN 110386941A
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- ethyl
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
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- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
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| CN201910753548.6A CN110386941A (zh) | 2019-08-15 | 2019-08-15 | Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗 |
| PCT/CN2020/105282 WO2021027567A1 (fr) | 2019-08-15 | 2020-07-28 | Combinaison d'un antagoniste du récepteur ep4 et d'un inhibiteur de pd-1 pour le traitement du cancer |
| CN202010740581.8A CN112390814B (zh) | 2019-08-15 | 2020-07-28 | Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗 |
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| CN202010740581.8A Active CN112390814B (zh) | 2019-08-15 | 2020-07-28 | Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110922415A (zh) * | 2019-11-29 | 2020-03-27 | 四川大学 | 一种新型抗肿瘤活性化合物的合成与应用 |
| WO2021027567A1 (fr) * | 2019-08-15 | 2021-02-18 | 上海宇耀生物科技有限公司 | Combinaison d'un antagoniste du récepteur ep4 et d'un inhibiteur de pd-1 pour le traitement du cancer |
| CN112870194A (zh) * | 2021-01-06 | 2021-06-01 | 广州医科大学附属肿瘤医院 | 治疗肝癌的组合物及其应用 |
| CN113087719A (zh) * | 2020-02-05 | 2021-07-09 | 上海宇耀生物科技有限公司 | 一种ep4受体拮抗剂的多晶型物及其制备方法与用途 |
| CN113318103A (zh) * | 2020-02-28 | 2021-08-31 | 华东师范大学 | 小分子化合物yj-5-41在制备抗胃癌药物中的应用 |
| WO2022111714A1 (fr) * | 2020-11-30 | 2022-06-02 | 杭州阿诺生物医药科技有限公司 | Polythérapie pour traiter un cancer à mutation pik3ca |
| WO2022257961A1 (fr) * | 2021-06-08 | 2022-12-15 | 武汉人福创新药物研发中心有限公司 | Composé benzohétérocyclique pour traiter des maladies médiées par le récepteur ep2 et ep4 |
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| CN117377471A (zh) * | 2021-05-28 | 2024-01-09 | 凯复(苏州)生物医药有限公司 | 治疗肿瘤的联合疗法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2565191T3 (da) * | 2008-05-14 | 2014-11-10 | Astellas Pharma Inc | 4-(Indol-7-ylcarbonylaminomethyl)cyclohexancarboxylsyrederivater som EP4-receptorantagonister der er anvendelige til behandlingen af kronisk nyresvigt eller diabetisk nephropati |
| WO2010019796A1 (fr) * | 2008-08-14 | 2010-02-18 | Chemietek, Llc | Dérivés d’amides hétérocycliques en tant qu’antagonistes du récepteur ep4 |
| JP6787792B2 (ja) * | 2014-05-23 | 2020-11-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | がんの処置のための併用治療 |
| BR112019000243A2 (pt) * | 2016-07-07 | 2019-04-16 | Ono Pharmaceutical Co., Ltd. | combinação compreendendo um antagonista do ep4 e um inibidor de checkpoint imunológico |
| US10342785B2 (en) * | 2016-11-04 | 2019-07-09 | Askat Inc. | Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer |
| CN109836434B (zh) * | 2017-11-27 | 2020-09-25 | 上海宇耀生物科技有限公司 | 噻吩并环类化合物及其合成方法和应用 |
| CN111936502B (zh) * | 2018-03-02 | 2024-05-31 | 深圳市原力生命科学有限公司 | 杂二环羧酸及其盐 |
| CN112292128A (zh) * | 2018-04-16 | 2021-01-29 | 阿瑞斯医疗有限公司 | Ep4抑制剂和其用途 |
| CN113301896A (zh) * | 2018-07-11 | 2021-08-24 | 阿瑞斯医疗有限公司 | Ep4抑制剂和其合成 |
| CN110386941A (zh) * | 2019-08-15 | 2019-10-29 | 上海邦耀生物科技有限公司 | Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗 |
-
2019
- 2019-08-15 CN CN201910753548.6A patent/CN110386941A/zh active Pending
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- 2020-07-28 CN CN202010740581.8A patent/CN112390814B/zh active Active
- 2020-07-28 WO PCT/CN2020/105282 patent/WO2021027567A1/fr active Application Filing
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2021027567A1 (fr) * | 2019-08-15 | 2021-02-18 | 上海宇耀生物科技有限公司 | Combinaison d'un antagoniste du récepteur ep4 et d'un inhibiteur de pd-1 pour le traitement du cancer |
| CN110922415A (zh) * | 2019-11-29 | 2020-03-27 | 四川大学 | 一种新型抗肿瘤活性化合物的合成与应用 |
| CN110922415B (zh) * | 2019-11-29 | 2021-12-07 | 四川大学 | 一种新型抗肿瘤活性化合物的合成与应用 |
| CN113087719A (zh) * | 2020-02-05 | 2021-07-09 | 上海宇耀生物科技有限公司 | 一种ep4受体拮抗剂的多晶型物及其制备方法与用途 |
| WO2021155766A1 (fr) * | 2020-02-05 | 2021-08-12 | 上海宇耀生物科技有限公司 | Polymorphe d'un antagoniste du récepteur ep4, son procédé de préparation et son utilisation |
| JP2023513176A (ja) * | 2020-02-05 | 2023-03-30 | シャンハイ ユーヤオ バイオテック リミテッド | Ｅｐ４受容体アンタゴニストの多形体、その調製方法および用途 |
| AU2021215426B2 (en) * | 2020-02-05 | 2023-11-16 | Shanghai Yuyao Biotech Ltd. | Polymorph of EP4 receptor antagonist, preparation method therefor and use thereof |
| CN113087719B (zh) * | 2020-02-05 | 2024-01-26 | 上海宇耀生物科技有限公司 | 一种ep4受体拮抗剂的多晶型物及其制备方法与用途 |
| CN113318103A (zh) * | 2020-02-28 | 2021-08-31 | 华东师范大学 | 小分子化合物yj-5-41在制备抗胃癌药物中的应用 |
| WO2022111714A1 (fr) * | 2020-11-30 | 2022-06-02 | 杭州阿诺生物医药科技有限公司 | Polythérapie pour traiter un cancer à mutation pik3ca |
| CN112870194A (zh) * | 2021-01-06 | 2021-06-01 | 广州医科大学附属肿瘤医院 | 治疗肝癌的组合物及其应用 |
| WO2022257961A1 (fr) * | 2021-06-08 | 2022-12-15 | 武汉人福创新药物研发中心有限公司 | Composé benzohétérocyclique pour traiter des maladies médiées par le récepteur ep2 et ep4 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112390814B (zh) | 2023-12-05 |
| WO2021027567A1 (fr) | 2021-02-18 |
| CN112390814A (zh) | 2021-02-23 |
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