CN1103786C - 由n－苄基－n－甲基丙烯酰胺聚合物和共聚物制备的高折射率水凝胶 - Google Patents

由n－苄基－n－甲基丙烯酰胺聚合物和共聚物制备的高折射率水凝胶 Download PDF

Info

Publication number
CN1103786C
CN1103786C CN97194731A CN97194731A CN1103786C CN 1103786 C CN1103786 C CN 1103786C CN 97194731 A CN97194731 A CN 97194731A CN 97194731 A CN97194731 A CN 97194731A CN 1103786 C CN1103786 C CN 1103786C
Authority
CN
China
Prior art keywords
dimethacrylate
divinyl
acrylamide
diacrylate
methacrylamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97194731A
Other languages
English (en)
Chinese (zh)
Other versions
CN1219179A (zh
Inventor
廖秀高
王亚丁
周青山
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia - Elvis Johnson Co
Original Assignee
Pharmacia - Elvis Johnson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia - Elvis Johnson Co filed Critical Pharmacia - Elvis Johnson Co
Publication of CN1219179A publication Critical patent/CN1219179A/zh
Application granted granted Critical
Publication of CN1103786C publication Critical patent/CN1103786C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/52—Amides or imides
    • C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/924—Material characteristic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Materials For Medical Uses (AREA)
  • Eyeglasses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN97194731A 1996-03-25 1997-03-17 由n－苄基－n－甲基丙烯酰胺聚合物和共聚物制备的高折射率水凝胶 Expired - Fee Related CN1103786C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/622,527 US5717049A (en) 1996-03-25 1996-03-25 High refractive index hydrogels prepared from polymers and copolymers of N-benzyl-N-methylacrylamide
US08/622,527 1996-03-25

Publications (2)

Publication Number Publication Date
CN1219179A CN1219179A (zh) 1999-06-09
CN1103786C true CN1103786C (zh) 2003-03-26

Family

ID=24494514

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97194731A Expired - Fee Related CN1103786C (zh) 1996-03-25 1997-03-17 由n－苄基－n－甲基丙烯酰胺聚合物和共聚物制备的高折射率水凝胶

Country Status (15)

Country Link
US (1) US5717049A (enExample)
EP (1) EP0889916B1 (enExample)
JP (1) JP2000507298A (enExample)
KR (1) KR100482946B1 (enExample)
CN (1) CN1103786C (enExample)
AT (1) ATE239758T1 (enExample)
AU (1) AU712171B2 (enExample)
BR (1) BR9708263A (enExample)
CA (1) CA2249991A1 (enExample)
DE (1) DE69721750T2 (enExample)
DK (1) DK0889916T3 (enExample)
ES (1) ES2200160T3 (enExample)
NZ (1) NZ331946A (enExample)
PT (1) PT889916E (enExample)
WO (1) WO1997035896A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329485B1 (en) 1998-12-11 2001-12-11 Bausch & Lomb Incorporated High refractive index hydrogel compositions for ophthalmic implants
AUPP939299A0 (en) 1999-03-23 1999-04-15 University Of Melbourne, The Polymer gels and methods for their preparation
AU2002356295A1 (en) * 2001-12-19 2003-06-30 First Water Limited Hydrogel compositions comprising an acryloyl morpholine polymer
US20030223954A1 (en) * 2002-05-31 2003-12-04 Ruscio Dominic V. Polymeric materials for use as photoablatable inlays
US6737448B2 (en) * 2002-06-03 2004-05-18 Staar Surgical Company High refractive index, optically clear and soft hydrophobic acrylamide copolymers
JP4349776B2 (ja) * 2002-06-04 2009-10-21 株式会社ニデック 眼内レンズの製造方法
DE102006028507A1 (de) * 2006-06-21 2007-12-27 *Acri.Tec AG Gesellschaft für ophthalmologische Produkte Ophthalmologische Zusammensetzung und ihre Verwendung
ES2365290T3 (es) * 2007-07-25 2011-09-28 Alcon, Inc. Materiales para dispositivo oftálmico de alto índice de refracción.
DE102011112778A1 (de) * 2011-09-09 2013-03-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Die Primärwaschkraft verbessernde polymere Wirkstoffe
CN104558403B (zh) * 2013-10-28 2016-09-07 中国石油化工股份有限公司 交联渐变溶胀型聚合物微球及其制备方法
CN103655003A (zh) * 2013-12-13 2014-03-26 无锡合众信息科技有限公司 一种可折叠后房室固定型人工晶体及其制备方法
US12127934B2 (en) 2014-09-09 2024-10-29 Staar Surgical Company Method of Providing Modified Monovision to a Subject with a First Lens and a Second Lens
CN111265331B (zh) 2014-09-09 2022-09-09 斯塔尔外科有限公司 具有扩展的景深和增强的远距视力的眼科植入物
JP6924696B2 (ja) * 2014-10-17 2021-08-25 キー メディカル テクノロジーズ インコーポレイテッド 眼適用のためのポリマーおよび方法
AU2017229594B2 (en) 2016-03-09 2022-06-16 Staar Surgical Company Ophthalmic implants with extended depth of field and enhanced distance visual acuity
EP3837571B1 (en) 2018-08-17 2023-08-02 Staar Surgical Company Polymeric composition exhibiting nanogradient of refractive index
CA3234381A1 (en) 2021-10-04 2023-04-13 Staar Surgical Company Ophthalmic implants for correcting vision with a tunable optic, and methods of manufacture and use
DE102022125341B3 (de) * 2022-09-30 2024-01-04 Carl Zeiss Meditec Ag Ophthalmologische Zusammensetzung mit mehreren Comonomergruppen und ophthalmologische Linse

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1134341A (en) * 1965-04-01 1968-11-20 Ciba Ltd New polymerisable carboxylic acid arylmethylamides, new polymerisation products, and process for the manufacture of these compounds
US5480950A (en) * 1992-09-28 1996-01-02 Kabi Pharmacia Ophthalmics, Inc. High refractive index hydrogels and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2541930A (en) * 1946-11-16 1951-02-13 Geigy Ag J R Amides of monocarboxylic acids having acaricidal and disinfecting properties
GB855741A (en) * 1958-08-30 1960-12-07 British Nylon Spinners Ltd Improvements in or relating to polyacrylamide derivatives
US3716467A (en) * 1968-07-05 1973-02-13 Agency Ind Science Techn Process for the radiation insolubilization of n-(vinyl) phenylacrylamide
US4337332A (en) * 1981-04-09 1982-06-29 Minnesota Mining And Manufacturing Company Latently curable organosilicone compositions
DE4023578A1 (de) * 1990-07-25 1992-01-30 Chemie Linz Deutschland Copolymere von hydroxyethyl(meth)acrylat und n-substituierten (meth)acrylamiden
US5439950A (en) * 1994-06-27 1995-08-08 Kabi Pharmacia Ophthalmics, Inc. Water miscible non-hydrolyzable cross-linkers and high refractive index hydrogels prepared therewith
DE4423303C2 (de) * 1994-07-02 2000-05-31 Woehlk Contact Linsen Gmbh Hydrophile, vernetzte Copolymere auf der Basis von N-Vinylformamid, Verfahren zu ihrer Herstellung und ihre Verwendung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1134341A (en) * 1965-04-01 1968-11-20 Ciba Ltd New polymerisable carboxylic acid arylmethylamides, new polymerisation products, and process for the manufacture of these compounds
US5480950A (en) * 1992-09-28 1996-01-02 Kabi Pharmacia Ophthalmics, Inc. High refractive index hydrogels and uses thereof

Also Published As

Publication number Publication date
KR20040084954A (ko) 2004-10-06
WO1997035896A1 (en) 1997-10-02
DE69721750T2 (de) 2003-11-13
CA2249991A1 (en) 1997-10-02
BR9708263A (pt) 2000-01-04
EP0889916B1 (en) 2003-05-07
AU712171B2 (en) 1999-10-28
EP0889916A4 (en) 2000-06-28
DE69721750D1 (de) 2003-06-12
NZ331946A (en) 2000-03-27
CN1219179A (zh) 1999-06-09
US5717049A (en) 1998-02-10
JP2000507298A (ja) 2000-06-13
PT889916E (pt) 2003-08-29
ES2200160T3 (es) 2004-03-01
DK0889916T3 (da) 2003-07-28
ATE239758T1 (de) 2003-05-15
KR100482946B1 (ko) 2005-04-15
AU2040497A (en) 1997-10-17
EP0889916A1 (en) 1999-01-13

Similar Documents

Publication Publication Date Title
CN1103786C (zh) 由n－苄基－n－甲基丙烯酰胺聚合物和共聚物制备的高折射率水凝胶
AU696001B2 (en) Improved high refractive index ophthalmic lens materials
JP3544975B2 (ja) 高い屈折率のヒドロゲル及びその使用
AU754155B2 (en) Polymerizable hydrophilic ultraviolet light absorbing monomers
US9820850B2 (en) Polymers and methods for ophthalmic applications
AU766397B2 (en) Ophthalmic and otorhinolaryngological device materials
US6465588B1 (en) Four component copolymers and the ocular lens made thereof
US20150038612A1 (en) Polymers and methods for ophthalmic applications
KR100470247B1 (ko) N-벤질-n-메틸아크릴아미드의중합체및공중합체로제조된고굴절율의하이드로겔

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee