CN110368334A - Chinese-medicinal skin-protecting product with crease-resistant skin lightening effect - Google Patents

Chinese-medicinal skin-protecting product with crease-resistant skin lightening effect Download PDF

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CN110368334A
CN110368334A CN201910444600.XA CN201910444600A CN110368334A CN 110368334 A CN110368334 A CN 110368334A CN 201910444600 A CN201910444600 A CN 201910444600A CN 110368334 A CN110368334 A CN 110368334A
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skin
chinese
crease
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CN110368334B (en
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林旭红
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Henan university huaihe hospital
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638Ligustrum, e.g. Chinese privet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9717Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/18Antioxidants, e.g. antiradicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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Abstract

The present invention relates to a kind of Chinese-medicinal skin-protecting products with crease-resistant skin lightening effect.It including following components in percentage by weight by being prepared: Chinese herbal medicine extract 3%-8%;Chondrus crispus extract 1.1%-4.4%;Hydrolyze avenin 0.2%-0.8%;Argireline 0.2%-3%;Auxiliary agent 76.6%-93.7%;The herbal composite includes: Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root extract, fruit of glossy privet seed extract and licorice root extract.The skin care item can profound level play smoothing wrinkle, smooth microgroove, desalinate pore, restore skin elastic, improve the effect of skin moisture content.

Description

Chinese-medicinal skin-protecting product with crease-resistant skin lightening effect
Technical field
The present invention relates to the technical fields of skin care item, more particularly to the Chinese-medicinal skin-protecting product with crease-resistant skin lightening effect.
Background technique
Wrinkle is the years in the trace left on the face, is the performance of people's aging, and it's 30 years old has past people, at fiber finer in human body The quantity of born of the same parents gradually decreases, therefore the collagen of its secretion and elastic fibers albumen also gradually decrease, break because being oxidized It splits, skin corium starts thinning, and skin elasticity is deteriorated, and wrinkle also starts gradually to generate.When the collagen of skin corium is oxidized, After fracture, the supporting role of epidermis is just disappeared, thus cause it is inhomogenous collapse, such wrinkle just produces.
Nowadays smoothing wrinkle product in the market continues to bring out, and advertisement sentence sentence is tempting, but effect allows people to sigh.Many skin cares Face beautifying health keeping product can only largely be absorbed by skin surface, can not actually enter skin corium, reach profound level It updates and to the purpose that collagen supplements, plays the effect of wrinkle anti-aging.
Summary of the invention
Based on this, the present invention provides a kind of Chinese-medicinal skin-protecting product with crease-resistant skin lightening effect, which being capable of deep layer It is secondary to play smoothing wrinkle, microgroove is smoothed, pore is desalinated, restores skin elastic, improves the effect of skin water content.
The specific technical proposal is:
A kind of Chinese-medicinal skin-protecting product with crease-resistant skin lightening effect, by include following components in percentage by weight preparation and At:
The herbal composite includes: Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root extract, glossy privet Sub- seed extract and licorice root extract.
The skin care item with crease-resistant skin lightening effect are by including following weight percent in one of the embodiments, Component be prepared:
The Chinese-medicinal skin-protecting product with crease-resistant skin lightening effect is by including following weight in one of the embodiments, The component of percentage is prepared:
In one of the embodiments, based on parts by weight, the herbal composite includes:
The auxiliary agent includes in solvent, chelating agent, moisturizer, preservative and thickener in one of the embodiments, It is one or more of.
The weight ratio of the solvent, chelating agent, moisturizer and thickener in one of the embodiments, are as follows: (66.4- 91.34): (0.01-0.1): (2.05-9.3): (0.1-0.3).
In one of the embodiments, the moisturizer in glycerol, butanediol and acetylation Sodium Hyaluronate one Kind or two kinds.
It is (2-9): the butanediol and second of (0.05-0.3) that the moisturizer, which is weight ratio, in one of the embodiments, Acylated Sodium Hyaluronate.
The thickener is xanthan gum in one of the embodiments,.
The chelating agent is EDTA-2Na in one of the embodiments,.
The auxiliary agent further includes preservative in one of the embodiments,.
The preservative is selected from one of Phenoxyethanol and Sensiva SC50 or several in one of the embodiments, Kind.
Compared with existing scheme, the invention has the following advantages:
In above-mentioned skin care item, Chinese herbal medicine extract is a with activating blood circulation and supplementing qi effect based on theory of traditional Chinese medical science development Anti-aging plant prescription is monarch with Radix Angelicae Sinensis, Radix Notoginseng according to " monarch minister, helps, makes " principles of formulating prescriptions, blood circulation promoting and enriching of advocating, hemostasis Dissipate the function of the stasis of blood;Using Radix Astragali as minister, the benefits of auxiliary monarch's invigorating qi for consolidating superficies;It is assistant with the fruit of glossy privet, takes the wonderful of its help enriching yin;Make with Radix Glycyrrhizae, Concoct all medicines.Five tastes Chinese herbal medicine is mutually coordinated, activating blood circulation and supplementing qi, unimpeded skin nutrition channel and energy channel, is conducive to restore flesh Skin elastic force improves skin brilliant white degree, increases surface thickness and skin corium cell density, keeps skin young healthy vibrant.Together When, collocation is conducive to skin and is generated instantaneous tight feeling using hydrolysis avenin, moreover, hydrolysis avenin is not only Protein containing different molecular weight has significant film forming ability and moistening effect, assigns the skin sense of skin smooth, also have Have and promotes fibroblast proliferation ability, it can effectively delay skin aging.Meanwhile skin care item of the invention are also added into second Acyl group hexapeptide -8 and Chondrus crispus extract, can be compatible with said components, plays crease-resistant, anti-oxidant and moisturizing effect. And by the synergistic effect between said components, skin care item preferably crease-resistant, moistening effect is assigned, quick compact skin smooths Microgroove desalinates pore, and effect is vertical to see.Of the invention skin care item one day is sooner or later respectively using once, and dosage is few, and skin sense is good, and effect is bright It is aobvious, it is the optimal selection of crease-resistant skin lightening.
Specific embodiment
The Chinese-medicinal skin-protecting product with crease-resistant skin lightening effect of the invention is made below in conjunction with specific embodiment further detailed Thin explanation.The invention can be realized in many different forms, however it is not limited to embodiments described herein.On the contrary Ground, the purpose of providing these embodiments is that making to understand the disclosure of invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention The normally understood meaning of technical staff it is identical.Term as used herein in the specification of the present invention is intended merely to retouch State the purpose of specific embodiment, it is not intended that in the limitation present invention.Term as used herein "and/or" include one or Any and all combinations of multiple relevant listed items.
Royal Treat (imperial support glad beautiful) is purchased from Beijing Orient Miao Sen Biotechnology Co., Ltd, and it includes 1 part -2 parts Angelica roots, 1 part -2 parts of Radix Notoginseng root extract, 0.5 part -1 part of Astragalus membranacus root extract, 0.5 part -1 part Fruit of glossy privet seed extract, 0.5 part -1 part of licorice root extract and auxiliary material.
Oat Glair Taut (OGT) (oat Firm albumen) is purchased from Beijing Orient Miao Sen Biotechnology Co., Ltd, In, hydrolyzing weight ratio shared by avenin is 10%, remaining is auxiliary material.
Embodiment 1
The present embodiment provides a kind of Chinese-medicinal skin-protecting product, raw material, dosage and following preparation methods referring to shown in table 1 It is prepared:
(1) A phase materials are sequentially added in emulsion pot, is heated to 80-82 DEG C, uniformly mixed B group is added, middling speed is equal Matter keeps the temperature 15min, stirring cooling to being completely dispersed uniformly;
(2) it when cooling to 45 DEG C, sequentially adds C phase substance and is pre-mixed uniform D phase, with moderate-speed mixer, stirring To clear;
(3) 40 DEG C are cooled to hereinafter, and confirming that formula pH value within the scope of 4-6, is added E phase, stirs evenly;
(4) it samples, detection, after qualified, discharging at 38 degree.
Table 1
The appearance and physical and chemical index of the present embodiment skin care item are as follows:
Appearance: glassy yellow transparency liquid;
PH value (1:10 aqueous solution): 4.81;
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception;
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception;
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Embodiment 2
The present embodiment provides a kind of Chinese-medicinal skin-protecting products, identical as the preparation method of embodiment 1, raw material and its dosage ginseng According to table 2.
Table 2
The appearance and physical and chemical index of the present embodiment skin care item are as follows:
Appearance: glassy yellow transparency liquid;
PH value (1:10 aqueous solution): 4.81;
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception;
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception;
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Embodiment 3
The present embodiment provides a kind of Chinese-medicinal skin-protecting products, identical as the preparation method of embodiment 1, raw material and its dosage ginseng According to table 3.
Table 3
The appearance and physical and chemical index of the present embodiment skin care item are as follows:
Appearance: glassy yellow transparency liquid;
PH value (1:10 aqueous solution): 4.81;
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception;
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception;
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Embodiment 4
The present embodiment provides a kind of Chinese-medicinal skin-protecting products, identical as the preparation method of embodiment 1, raw material and its dosage ginseng According to table 4.
Table 4
The appearance and physical and chemical index of the present embodiment skin care item are as follows:
Appearance: glassy yellow transparency liquid;
PH value (1:10 aqueous solution): 4.81;
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception;
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception;
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Comparative example 1
The present embodiment provides a kind of Chinese-medicinal skin-protecting products, identical as the preparation method of embodiment 1, raw material and its dosage ginseng According to table 4.
Table 4
Comparative example 2
The present embodiment provides a kind of Chinese-medicinal skin-protecting products, identical as the preparation method of embodiment 1, raw material and its dosage ginseng According to table 5.
Table 5
Performance test
The effect of crease-resistant skin lightening of the Chinese-medicinal skin-protecting product of embodiment 1-4 and comparative example 1-2, is tested, specific side Method and test result is as follows:
1, volunteer is chosen by the following conditions:
Number: 180 people;Age: 35-50 one full year of life;Feature: there is wrinkle or microgroove around forehead, eye tail and mouth.
2, above-mentioned 180 volunteers are randomly divided into 6 groups, every group of 30 people, and the age of 6 groups of volunteers, gender, skin Situation is statistically analyzed, and no significant difference (P > 0.05) is comparable.
3,6 groups of volunteers respectively correspond the skin care item to be measured for smearing that 6 kinds of numbers are A-F, the skin care item to be measured of number A-F Correspond respectively to skin care item made from embodiment 1-4 and comparative example 1-2.Volunteer need to carry out in daily two periods sooner or later Facial cleansing after facial cleansing, uniformly smears test sample, applying amount 1-2mg/cm2, it is used continuously test sample 30 weeks, During experiment, face, which should be avoided, contacts any other skin care item.
4, anti-wrinkle effect is tested:
Instrument: VISA face-image analysis system
Test method: volunteer selects respectively using before test sample and after volunteer's continuous use test sample 30 weeks Take 5 test points: glabella line, forehead line, crow's feet, nasolabial groove and lip week wrinkle are tested, every time when test, to the greatest extent The skin of same area is measured, when test loosens.Each region is surveyed 3 times every time, is counted everyone each area test value, is asked Skin elasticity increase rate and wrinkle decrease rate, as a result as shown in table 6.
Table 6
Skin elasticity increase rate Wrinkle decrease rate
Embodiment 1 28% 40%
Embodiment 2 23% 33%
Embodiment 3 25% 36%
Embodiment 4 20% 31%
Comparative example 1 10% 22%
Comparative example 2 18% 24%
5, moistening effect is tested
Instrument: corneometer CM825
Test method: volunteer uses survey using before test sample and after volunteer's continuous use test sample 30 weeks Probe header measures the moisture content of each volunteer's cheek skin respectively, surveys 3 times, is averaged, then proprietary by every group Measured value summarizes, and is averaged, and records and the results are shown in Table 7.
Table 7
As table 6 and table 7 it is found that Chinese-medicinal skin-protecting product made from embodiment 1-4 can play crease-resistant, anti-oxidant and moisturizing Effect, obvious to the improvement of skin, wherein the ratio of each raw material is best in embodiment 1.And in embodiment 4, due to not Acetylation Sodium Hyaluronate is added, moistening effect is by great influence.Compared with Example 1, documents 1 will hydrolyze oat Albumen replaces with fibroin albumen, and crease-resistant moisture-keeping efficacy is by a degree of influence;Documents 2 are by Argireline Oligopeptides -3 is replaced with, anti-wrinkle effect is slightly weak.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to of the invention Protection scope.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims (10)

1. a kind of Chinese-medicinal skin-protecting product with crease-resistant skin lightening effect, which is characterized in that by the group including following weight percent Divide and be prepared:
The herbal composite includes: Angelica roots, Radix Notoginseng root extract, Astragalus membranacus root extract, fruit of glossy privet seed Extract and licorice root extract.
2. the Chinese-medicinal skin-protecting product according to claim 1 with crease-resistant skin lightening effect, which is characterized in that by including following The component of weight percent is prepared:
3. the Chinese-medicinal skin-protecting product according to claim 2 with crease-resistant skin lightening effect, which is characterized in that by including following The component of weight percent is prepared:
4. the Chinese-medicinal skin-protecting product according to claim 1 with crease-resistant skin lightening effect, which is characterized in that with parts by weight Meter, the herbal composite include:
5. the Chinese-medicinal skin-protecting product according to claim 1-4 with crease-resistant skin lightening effect, which is characterized in that institute Stating auxiliary agent includes one or more of solvent, chelating agent, moisturizer, preservative and thickener.
6. the Chinese-medicinal skin-protecting product according to claim 5 with crease-resistant skin lightening effect, which is characterized in that the solvent, The weight ratio of chelating agent, moisturizer and thickener are as follows: (66.4-91.34): (0.01-0.1): (2.05-9.3): (0.1-0.3).
7. the Chinese-medicinal skin-protecting product according to claim 6 with crease-resistant skin lightening effect, which is characterized in that the moisturizer Selected from one or both of glycerol, butanediol and acetylation Sodium Hyaluronate.
8. the Chinese-medicinal skin-protecting product according to claim 7 with crease-resistant skin lightening effect, which is characterized in that the moisturizer It is (2-9) for weight ratio: the butanediol and acetylation Sodium Hyaluronate of (0.05-0.3).
9. the Chinese-medicinal skin-protecting product according to claim 6 with crease-resistant skin lightening effect, which is characterized in that the thickener For xanthan gum.
10. the Chinese-medicinal skin-protecting product according to claim 6 with crease-resistant skin lightening effect, which is characterized in that the chelating Agent is EDTA-2Na.
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110693780A (en) * 2019-10-31 2020-01-17 广东密尚生物科技有限公司 Skin nourishing composition and application thereof, and skin nourishing mask liquid
CN111568831A (en) * 2020-06-19 2020-08-25 上海相宜本草化妆品股份有限公司 Composition of Chinese herbal medicine extract for skin cosmetics and preparation method thereof
CN116077409A (en) * 2022-12-31 2023-05-09 杭州纽龙日尚生物制品有限公司 Collagen activator and preparation method and application thereof

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