CN110343118A - 新型色酮肟衍生物以及其作为代谢型谷氨酸受体的别构调节剂的用途 - Google Patents

新型色酮肟衍生物以及其作为代谢型谷氨酸受体的别构调节剂的用途 Download PDF

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Publication number
CN110343118A
CN110343118A CN201910567865.9A CN201910567865A CN110343118A CN 110343118 A CN110343118 A CN 110343118A CN 201910567865 A CN201910567865 A CN 201910567865A CN 110343118 A CN110343118 A CN 110343118A
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disease
compound
purposes
formula
illness
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德尔菲娜·沙尔万
巴蒂斯特·曼特奥
文森特·波梅尔
弗兰乔斯·孔凯
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Purex Dayton Medical Co Ltd
Prexton Therapeutics SA
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    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33Heterocyclic compounds
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    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/4365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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CN201910567865.9A 2014-08-27 2015-08-27 新型色酮肟衍生物以及其作为代谢型谷氨酸受体的别构调节剂的用途 Pending CN110343118A (zh)

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EP14182468.0 2014-08-27
EP14182468 2014-08-27
CN201580045432.7A CN106715444B (zh) 2014-08-27 2015-08-27 新型色酮肟衍生物以及其作为代谢型谷氨酸受体的别构调节剂的用途

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CN201580045432.7A Expired - Fee Related CN106715444B (zh) 2014-08-27 2015-08-27 新型色酮肟衍生物以及其作为代谢型谷氨酸受体的别构调节剂的用途

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EP (3) EP3186257B1 (https=)
JP (1) JP6430015B2 (https=)
KR (1) KR101870589B1 (https=)
CN (2) CN110343118A (https=)
AU (1) AU2015308438B2 (https=)
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Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
LT3186257T (lt) * 2014-08-27 2019-04-25 Prexton Therapeutics Sa Nauji chromono oksimo dariniai ir jų panaudojimas kaip metabotropinių gliutamato receptorių alosterinių moduliatorių
RU2018110580A (ru) 2015-08-27 2019-09-30 Прекстон Терапьютикс Са Проникающее в мозг производное оксима хромона для терапии леводопа-индуцированной дискинезии
US20220089609A1 (en) 2018-07-26 2022-03-24 Domain Therapeutics Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4

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WO2004092154A1 (en) * 2003-04-03 2004-10-28 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
CN102812014A (zh) * 2009-10-30 2012-12-05 多美恩医疗公司 新颖的肟衍生物及其作为代谢型谷氨酸受体的别构调节剂的用途
CN106715444B (zh) * 2014-08-27 2019-07-12 普雷克斯顿医疗股份公司 新型色酮肟衍生物以及其作为代谢型谷氨酸受体的别构调节剂的用途

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EP0787723A1 (en) * 1994-10-21 1997-08-06 Suntory Limited Cyclopropachromenecarboxylate derivatives
WO2004092154A1 (en) * 2003-04-03 2004-10-28 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
CN102812014A (zh) * 2009-10-30 2012-12-05 多美恩医疗公司 新颖的肟衍生物及其作为代谢型谷氨酸受体的别构调节剂的用途
CN106715444B (zh) * 2014-08-27 2019-07-12 普雷克斯顿医疗股份公司 新型色酮肟衍生物以及其作为代谢型谷氨酸受体的别构调节剂的用途

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COLLEEN M. NISWENDER ET AL.: ""Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators"", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *
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CA2956191A1 (en) 2016-03-03
DK3186257T3 (en) 2019-04-01
US20200024285A1 (en) 2020-01-23
RS58592B1 (sr) 2019-05-31
JP2017525776A (ja) 2017-09-07
US20170253613A1 (en) 2017-09-07
US10442818B2 (en) 2019-10-15
LT3186257T (lt) 2019-04-25
EP3186257A1 (en) 2017-07-05
US20180291034A1 (en) 2018-10-11
ES2714073T3 (es) 2019-05-27
MA48048A (fr) 2020-02-12
AU2015308438B2 (en) 2018-12-13
KR20170042624A (ko) 2017-04-19
HRP20190343T1 (hr) 2019-05-31
WO2016030444A1 (en) 2016-03-03
EP3502115A1 (en) 2019-06-26
RU2017109818A (ru) 2018-10-01
HUE041941T2 (hu) 2019-06-28
US10017521B2 (en) 2018-07-10
EP3186257B1 (en) 2019-02-06
AU2015308438A1 (en) 2017-03-02
PL3186257T3 (pl) 2019-07-31
EP3696183A1 (en) 2020-08-19
MX369643B (es) 2019-11-15
NZ728853A (en) 2018-04-27
MA52702A (fr) 2021-03-31
RU2672569C2 (ru) 2018-11-16
CN106715444A (zh) 2017-05-24
MA40530A (fr) 2017-07-05
TR201903332T4 (tr) 2019-03-21
IL250287B (en) 2020-02-27
JP6430015B2 (ja) 2018-11-28
KR101870589B1 (ko) 2018-06-25
SMT201900152T1 (it) 2019-05-10
RU2017109818A3 (https=) 2018-10-01
IL250287A0 (en) 2017-03-30
ME03339B (me) 2019-10-20
CN106715444B (zh) 2019-07-12
CA2956191C (en) 2020-01-28
CY1121352T1 (el) 2020-05-29
SI3186257T1 (sl) 2019-07-31
PT3186257T (pt) 2019-03-27

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