KR101870589B1 - 신규 크로몬 옥심 유도체 및 대사성 글루타메이트 수용체의 알로스테릭 조절자로서의 그것의 용도 - Google Patents

신규 크로몬 옥심 유도체 및 대사성 글루타메이트 수용체의 알로스테릭 조절자로서의 그것의 용도 Download PDF

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KR101870589B1
KR101870589B1 KR1020177005768A KR20177005768A KR101870589B1 KR 101870589 B1 KR101870589 B1 KR 101870589B1 KR 1020177005768 A KR1020177005768 A KR 1020177005768A KR 20177005768 A KR20177005768 A KR 20177005768A KR 101870589 B1 KR101870589 B1 KR 101870589B1
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KR20170042624A (ko
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델핀 샤르방
밥티스트 망토
빈센트 포멜
프랑수아 콩케
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프렉스톤 테라퓨틱스 에스에이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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KR1020177005768A 2014-08-27 2015-08-27 신규 크로몬 옥심 유도체 및 대사성 글루타메이트 수용체의 알로스테릭 조절자로서의 그것의 용도 Expired - Fee Related KR101870589B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14182468.0 2014-08-27
EP14182468 2014-08-27
PCT/EP2015/069601 WO2016030444A1 (en) 2014-08-27 2015-08-27 Novel chromone oxime derivative and its use as allosteric modulator of metabotropic glutamate receptors

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KR20170042624A KR20170042624A (ko) 2017-04-19
KR101870589B1 true KR101870589B1 (ko) 2018-06-25

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US (3) US10017521B2 (https=)
EP (3) EP3186257B1 (https=)
JP (1) JP6430015B2 (https=)
KR (1) KR101870589B1 (https=)
CN (2) CN110343118A (https=)
AU (1) AU2015308438B2 (https=)
CA (1) CA2956191C (https=)
CY (1) CY1121352T1 (https=)
DK (1) DK3186257T3 (https=)
ES (1) ES2714073T3 (https=)
HR (1) HRP20190343T1 (https=)
HU (1) HUE041941T2 (https=)
IL (1) IL250287B (https=)
LT (1) LT3186257T (https=)
MA (3) MA40530A (https=)
ME (1) ME03339B (https=)
MX (1) MX369643B (https=)
NZ (1) NZ728853A (https=)
PL (1) PL3186257T3 (https=)
PT (1) PT3186257T (https=)
RS (1) RS58592B1 (https=)
RU (1) RU2672569C2 (https=)
SI (1) SI3186257T1 (https=)
SM (1) SMT201900152T1 (https=)
TR (1) TR201903332T4 (https=)
WO (1) WO2016030444A1 (https=)

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
LT3186257T (lt) * 2014-08-27 2019-04-25 Prexton Therapeutics Sa Nauji chromono oksimo dariniai ir jų panaudojimas kaip metabotropinių gliutamato receptorių alosterinių moduliatorių
RU2018110580A (ru) 2015-08-27 2019-09-30 Прекстон Терапьютикс Са Проникающее в мозг производное оксима хромона для терапии леводопа-индуцированной дискинезии
US20220089609A1 (en) 2018-07-26 2022-03-24 Domain Therapeutics Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4

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WO2011051478A1 (en) 2009-10-30 2011-05-05 Domain Therapeutics Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors

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US4777252A (en) 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
JP3993651B2 (ja) * 1994-10-21 2007-10-17 アスビオファーマ株式会社 シクロプロパクロメンカルボン酸誘導体
EP1298129A3 (en) 2001-09-28 2003-06-04 Central Glass Company, Limited Process for producing 4-sustituted benzopyran derivatives
PE20040801A1 (es) 2002-12-12 2004-11-25 Hoffmann La Roche Derivados de pirazina y piridina 5-sustituidos como activadores de glucoquinasa
WO2004092154A1 (en) 2003-04-03 2004-10-28 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
US20070027216A1 (en) 2005-07-15 2007-02-01 Bridget Larson Novel hydrochloride salts of levodopa
GB0713686D0 (en) 2007-07-13 2007-08-22 Addex Pharmaceuticals Sa New compounds 2
US20100144756A1 (en) 2007-07-13 2010-06-10 Bolea Christelle Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors
CN106883246B (zh) * 2009-12-04 2020-05-29 桑诺维恩药品公司 多环化合物及其使用方法
US20140349994A1 (en) * 2012-01-18 2014-11-27 Addex Pharma S.A. Novel 2-Amino-4,5,6,8-Tetrahydropyrazolo[3,4-b]Thiazolo [4,5-d]Azepine Derivatives and Their Use as Allosteric Modulators of Metabotropic Glutamate Receptors
LT3186257T (lt) * 2014-08-27 2019-04-25 Prexton Therapeutics Sa Nauji chromono oksimo dariniai ir jų panaudojimas kaip metabotropinių gliutamato receptorių alosterinių moduliatorių
RU2018110580A (ru) 2015-08-27 2019-09-30 Прекстон Терапьютикс Са Проникающее в мозг производное оксима хромона для терапии леводопа-индуцированной дискинезии

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WO2011051478A1 (en) 2009-10-30 2011-05-05 Domain Therapeutics Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors

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MX2017002429A (es) 2017-08-02
CA2956191A1 (en) 2016-03-03
DK3186257T3 (en) 2019-04-01
US20200024285A1 (en) 2020-01-23
RS58592B1 (sr) 2019-05-31
JP2017525776A (ja) 2017-09-07
US20170253613A1 (en) 2017-09-07
US10442818B2 (en) 2019-10-15
LT3186257T (lt) 2019-04-25
EP3186257A1 (en) 2017-07-05
US20180291034A1 (en) 2018-10-11
ES2714073T3 (es) 2019-05-27
MA48048A (fr) 2020-02-12
AU2015308438B2 (en) 2018-12-13
KR20170042624A (ko) 2017-04-19
HRP20190343T1 (hr) 2019-05-31
WO2016030444A1 (en) 2016-03-03
EP3502115A1 (en) 2019-06-26
RU2017109818A (ru) 2018-10-01
HUE041941T2 (hu) 2019-06-28
US10017521B2 (en) 2018-07-10
EP3186257B1 (en) 2019-02-06
AU2015308438A1 (en) 2017-03-02
PL3186257T3 (pl) 2019-07-31
EP3696183A1 (en) 2020-08-19
MX369643B (es) 2019-11-15
CN110343118A (zh) 2019-10-18
NZ728853A (en) 2018-04-27
MA52702A (fr) 2021-03-31
RU2672569C2 (ru) 2018-11-16
CN106715444A (zh) 2017-05-24
MA40530A (fr) 2017-07-05
TR201903332T4 (tr) 2019-03-21
IL250287B (en) 2020-02-27
JP6430015B2 (ja) 2018-11-28
SMT201900152T1 (it) 2019-05-10
RU2017109818A3 (https=) 2018-10-01
IL250287A0 (en) 2017-03-30
ME03339B (me) 2019-10-20
CN106715444B (zh) 2019-07-12
CA2956191C (en) 2020-01-28
CY1121352T1 (el) 2020-05-29
SI3186257T1 (sl) 2019-07-31
PT3186257T (pt) 2019-03-27

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