CN110339076A - A kind of sunscreen composition and the preparation method and application thereof with broad-spectrum light protective action - Google Patents
A kind of sunscreen composition and the preparation method and application thereof with broad-spectrum light protective action Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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Abstract
The invention discloses a kind of sunscreen composition and the preparation method and application thereof with broad-spectrum light protective action.For sunscreen composition provided by the invention by formulation optimization, each functional component can be realized synergistic effect, and effectively antiultraviolet, anti-blue light, damage of the anti-near infrared ray to skin has the function that wide spectrum protects.The functional components of sunscreen composition provided by the invention derive from naturally, do not add chemical synthesis ingredient, mild, stable, non-stimulated.Sunscreen composition preparation method provided by the invention is simple, easy to operate, passes through heating, stirring and homogeneous, it can make to mix well between the effective component of each component, be conducive to functional component and fill suspending stabilized, the final emulsus product for obtaining stable homogeneous, suitable for standardized production and popularization and application.
Description
Technical field
The present invention relates to cosmetic technical field, in particular to a kind of sunscreen composition with broad-spectrum light protective action and
Preparation method and application.
Background technique
There are natural source and artificial light source in nature, wherein natural source is solar spectrum.About 10% in solar spectrum
For ultraviolet light, remaining about 90% is visible light and infrared ray, ultraviolet light be to the injury of skin it is generally acknowledged, wherein UVB can be with
Cause skin burn, UVA may cause tanned.Traditional sunscreen product is all to absorb ultraviolet light with chemical ultraviolet absorbers,
Or scatters ultraviolet is shielded with physical sunscreen agent, to reach sun-proof effect.However chemical sun has permeability, and
And it is unstable after illumination, it is easy that skin allergy etc. is brought to injure；Physical sunscreen agent smears whiting, thick and heavy airtight, and has light
Catalytic activity, and less make us trusting.General sunscreen product is protected just for ultra-violet bands, and for indigo plant
The light of the more long-wave band such as light and near infrared ray is not protected.Ultraviolet light, blue light, near infrared ray can all damage skin health,
And blue light and near infrared ray optical wavelength are bigger, and energy is high, and penetration power is stronger, and it is loose, too early to may cause pigementation, skin
Aging etc..50% free radical generated because sunlight irradiates is as caused by the blue light in infrared ray and visible light.
Therefore, develop the natural, mild of a wide spectrum protective action with antiultraviolet, blue light and near infrared ray and
Salubrious sunscreen product is very necessary.
Summary of the invention
The primary purpose of the present invention is that the shortcomings that overcoming the prior art and deficiency, provide a kind of with wide spectrum photoprotection work
Sunscreen composition.Sunscreen composition of the invention has protectiving ultraviolet, blue light, infrared ray, increase skin water-retaining property etc.
Multi-efficiency, sunscreen composition ingredient origin provided by the invention is natural, safety is mild, skin sense is salubrious, non-greasy, not bellding
Light has a vast market foreground.
Another object of the present invention is to provide the systems by the above-mentioned sunscreen composition with broad-spectrum light protective action
Preparation Method.
A further object of the present invention is to provide answering by the above-mentioned sunscreen composition with broad-spectrum light protective action
With.
The purpose of the invention is achieved by the following technical solution:
A kind of sunscreen composition with broad-spectrum light protective action, includes component as follows by mass percentage:
Preferably comprise following component by mass percentage:
The water soluble oxidized cerium is preferably the compound of water, ceria, metal platinum powder；More preferably water, dioxy
Change cerium, metal platinum powder (87.95~91.99) in mass ratio: (8~12): (0.01~0.05) matches obtained compound；It is optimal
It is selected as the compound that water, ceria, metal platinum powder 89.97:10:0.03 in mass ratio are matched.
The purity that the borsal calcium is 100%.
The pot marigold flower extract is preferably pot marigold flower extract, the compound for synthesizing saualane；More preferably
Pot marigold flower extract synthesizes saualane in mass ratio (35~45): (55~65) match obtained compound；It is most preferably golden
The compound that small cup flower flower extract, synthesis saualane 40:60 in mass ratio are matched.
The flower coconut palm element be Italian cabbage extract, ascorbic acid, soybean lecithin, caprylic/capric triglyceride,
The compound of maltodextrin, modified corn starch；It is more preferably Italian cabbage extract, ascorbic acid, soybean lecithin, pungent
Acid/Triglyceride DDD, maltodextrin, modified corn starch (0.5~0.6) in mass ratio: (0.1~0.2): (1~5): (20
~40): (30~50): (4.2~48.4) match obtained compound；Most preferably Italian cabbage extract, ascorbic acid,
Soybean lecithin, caprylic/capric triglyceride, maltodextrin, modified corn starch are matched according to 0.6:0.1:5:20:30:44.3
Than obtained compound.
Plant agent of releiving is preferably glycyrrhiza glabra extract, turmeric root extract, rhizoma cyperi seed extract, 1,3- fourth
Glycol, 1,2- hexylene glycol, Sensiva SC50, water compound；More preferably glycyrrhiza glabra extract, turmeric root extract,
Rhizoma cyperi seed extract, 1,3-BDO, 1,2- hexylene glycol, Sensiva SC50, water (0.1~10) in mass ratio: (0~1): (0
~1): (8~10): (0.5~2): (0~0.1): (84.9~91.22) match obtained compound；Most preferably glycyrrhiza glabra
Extract, turmeric root extract, rhizoma cyperi seed extract, 1,3-BDO, 1,2- hexylene glycol, Sensiva SC50, water press quality
The compound matched than 0.3:0.35:0.35:10:1:0.1:87.9.
The sunscreen composition also includes auxiliary agent.
The auxiliary agent is surplus.
The auxiliary agent be preferably in deionized water, moisturizer, emulsifier, suspension thickener, Hua Shui and preservative extremely
Few one kind.
The sunscreen composition is preferably made of following raw material by mass percentage:
Surplus is deionized water；
Preferably comprise following component by mass percentage:
The moisturizer is preferably one of butanediol, methyl polyethers -10 and methyl polyethers -20 or extremely
It is two kinds few, moisturizing can be played the role of, increase product low-temperature stability.
The suspension thickener is preferably hydroxyethyl cellulose, xanthan gum and acryloyldimethyl taurine by/VP
One of copolymer or at least two can play the role of suspending stabilized sun-screening agent.
The emulsifier is preferably cetostearyl alcohol+cetearyl glucoside, arachidic alcohol+docosyl alcohol+arachidic alcohol Portugal
Glucosides, stearoyl mammary gland sodium lactate+stearine+cetostearyl alcohol and cetostearyl alcohol olive oleate+sorb are smooth
One of olive oleate or at least two can play emulsification.
The flower water is preferably rose wate, lavandulae flos water or lotus flower flower water.Hua Shui has strong fragrance, Ke Yiqi
To the effect for adjusting product odour.
The preservative be preferably Phenoxyethanol, Sensiva SC50, methylparaben, propylben, to hydroxyl
One of acetophenone and pungent glycol or at least two can play the role of protecting product, inhibit microbial growth.
The preparation method of the above-mentioned sunscreen composition with broad-spectrum light protective action, comprising the following steps:
(1) moisturizer, suspension thickener and deionized water are mixed, is sufficiently swollen, then heats, as water phase；
(2) emulsifier and pot marigold flower extract are heated under mixing, stirring is to transparent, as oily phase；
(3) oil is mutually put into water phase, homogeneous, cooling obtain mixture A；
(4) borsal calcium and Hua Yesu are sequentially added into mixture A, after mixing evenly homogeneous, obtain mixture B；
(5) plant is added in mixture B to releive agent, Hua Shui and preservative, stirring makes to be uniformly mixed, and obtains mixture C；
(6) water soluble oxidized cerium is added in mixture C, stirring makes to be uniformly mixed, and what is obtained there is wide spectrum photoprotection to make
Sunscreen composition.
The preparation method of the above-mentioned sunscreen composition with broad-spectrum light protective action, further comprising the steps of:
(7) after detection is qualified, filtering is filling.
Heating temperature described in step (1) is 75~80 DEG C；Preferably 80 DEG C.
Heating temperature described in step (2) is 70~75 DEG C；Preferably 75 DEG C.
Processing condition described in step (3) is preferably 2800~6000r/min, 3~5 minutes；Preferably 4000r/min
Homogeneous 5 minutes.
Cooling described in step (3) is preferably cooled to 40~55 DEG C；Preferably 45 DEG C.
Processing condition described in step (4) is preferably 1500~3000r/min, 3~5 minutes；Preferably 2500r/min
Homogeneous 4 minutes.
The degree of stirring described in step (6) is preferably stirred to room temperature and stops stirring.
The room temperature is preferably 10~35 DEG C；More preferably 20~30 DEG C；Most preferably 24~26 DEG C.
Detection qualification described in step (7) refers between pH value 5.5~7.
The filter-cloth filtering by filter mesh number for 100~300 mesh is selected as in filtering described in step (7)；More preferably pass through
Filter the filter-cloth filtering that mesh number is 200 mesh.
Above-mentioned sunscreen composition is preparing the application in skin care item.
The skin care item are functional skin care item, including daily sun-proof class, protection class, whitening class, anti-ageing class and bottom adornment
Class skin care item.
The present invention has the following advantages and effects with respect to the prior art:
1. sunscreen composition provided by the invention, by formulation optimization, each functional component can be realized synergistic work
With the effectively damage of antiultraviolet, anti-blue light, anti-near infrared ray to skin has the function that wide spectrum protects.
2. the functional components of sunscreen composition provided by the invention derive from naturally, chemical synthesis ingredient is not added,
Mildly, stable, non-stimulated.
3. sunscreen composition preparation method provided by the invention is simple, easy to operate, pass through heating, stirring and homogeneous, energy
Enough make to mix well between the effective component of each component, is conducive to functional component and fills suspending stabilized, the final stable homogeneous that obtains
Emulsus product are suitable for standardized production and popularization and application.
4. sunscreen composition provided by the invention is during the preparation process, in strict accordance with the requirement of GMP technique, 100,000 grades of car for cleaning
Between produce, ensure that the sunscreen it is pure with it is safe.
5. sunscreen composition provided by the invention both can be used alone, it can be used as raw material and be added in cosmetics,
Supplied for skin it is sun-proof, the effect of protection.
Detailed description of the invention
Fig. 1 is the spf value comparing result figure for the sunscreen composition that embodiment 3 and comparative example 1-5 are prepared.
Fig. 2 is the ir transmissivity comparing result figure for the sunscreen composition that embodiment 3 and comparative example 1-5 are prepared.
Fig. 3 is the thermo-effect of infrared radiation comparing result figure for the sunscreen composition that embodiment 3 and comparative example 1-2 are prepared.
Fig. 4 is that the influence to skin hydration effect for the sunscreen composition that embodiment 3 and comparative example 2,4 are prepared compares
Result figure.
Fig. 5 is the erythema inhibiting rate comparing result figure for the sunscreen composition that embodiment 3 and comparative example 3-4 are prepared.
Fig. 6 is the blue light protection effect comparing result figure for the sunscreen composition that embodiment 3 and comparative example 1-2 are prepared.
Specific embodiment
In order to further appreciate that the present invention, below with reference to specific embodiment and attached drawing to product of the present invention method and effect
It elaborates.Each ingredient of the present invention can be obtained by purchase.
In the formula that embodiment of the present invention provides:
Water soluble oxidized cerium is light yellow impermeable aqueous solution, without obvious smell.It is to make the cerium of one of rare earth element
For raw material.Ceria is dispersed in water preparation by platinum nano-dispersed technology.Its ultraviolet screener range is 190~
500 nanometers, UVA and UVB wave band and blue wave band are covered, can effectively obstruct ultraviolet light and blue light, therefore is a with sun-proof
The new raw material of function.The phenomenon that other tradition sun-screening agents are unstable under solar irradiation, can generate xanthochromia or brown stain, but dioxy
Change cerium and belong to metal substance, very stable, product will not change colour.Water soluble oxidized cerium used is Japan XINYUE in embodiment
It provides, trade name: Aquaceria Basic.
Borsal calcium is that white has mobility powder, tasteless.It is a kind of inert inorganic powders, there is absorption grease, is hidden
The flaw, soft and smooth, soft focus effec.It is more to be commonly used in color make-up, is used as skin sense regulator.It and water-soluble oxygen are found in the present invention
Changing cerium has synergistic effect, can the sun-proof ability of synergy significantly.Borsal calcium used provides in embodiment for Sen Xin company, France, quotient
The name of an article: COVABEAD CRYSTAL.
Pot marigold flower extract is light yellow clear liquid.It is by extracting inside pure pot marigold, to synthesize spiny dogfish
Alkane is solvent, and low temperature micro jetting technology extracts, and remains the full ingredient essence of pot marigold.It has antibacterial anti-inflammatory, promotes wound
Healing, calm effect of releiving, can be used for treating burn, skin infection, infantile eczema etc..Find in the present invention, it with
Water soluble oxidized cerium has synergistic effect, can enhance the effect of anti-blue light.Pot marigold flower extract is by Guangzhou network used in the present invention
Prompt company provides, trade name: the molten calendula extract of oil.
Flower coconut palm element is buff powder, it is extracted by Italian wild cabbage, and handles to obtain with maltodextrin package, its master
Wanting active constituent is Italian cabbage extract, it mainly has anti-light aging, anti-inflammatory, and free radical resisting and enhancing skin are anti-light according to energy
Power.Flower coconut palm element used in embodiment provides for Ganzhou Hua Han Biotechnology Co., Ltd, commodity famous flower coconut palm element.
Plant releives agent as light yellow clear liquid, it is that glycyrrhiza glabra extract, turmeric root extract and the rhizome of nutgrass flatsedge mention
The compound for taking object, by the way that by Radix Glycyrrhizae, turmeric, rhizome of nutgrass flatsedge extraction and cleaning compression is dissolved in polyalcohol and is prepared.It can help
Skin is helped to fight external and internal pressure, balance skin temperature helps skin to reduce skin injury caused by heat, creasy surface and corium wrinkle
Line, inhibition inflammation etc., can also reduce the cold damage for skin.Plant used in the present invention releives agent as Guangzhou Hui Lang company
It provides, trade name: nine gas soup of angle.
Moisturizer is butanediol.
Emulsifier is arachidic alcohol and docosyl alcohol and arachidic alcohol glucoside, matches BIC Corp from France, trade name:
MONTANOV 202。
Suspension thickener is ammonium acryloyl taurate/VP copolymer.From Switzerland's Clariant Corporation.Trade name:
Aristoflex AVC。
Hua Shuiwei rose wate.
Preservative is Phenoxyethanol and Sensiva SC50, trade name preservative PE 9010.
By selecting specific mixing speed, mixing time, homogeneous speed, mean time, whipping temp, can effectively protect
It demonstrate,proves each functional components and is sufficiently mixed the using effect for uniformly avoiding influencing sunscreen composition, it is uniform that property is finally prepared
Stablize and have both wide spectrum protection, mild salubrious sunscreen composition.
Embodiment 1
A kind of sunscreen composition with broad-spectrum light protective action is grouped as by following group by mass percentage:
Sunscreen composition the preparation method is as follows:
(1) by the deionized water of formula ratio, moisturizer, suspension thickener, sufficiently swelling, is then heated to 80 at room temperature
DEG C, as water phase；
(2) 75 DEG C are heated under the emulsifier of formula ratio and pot marigold flower extract being mixed, stirring to transparent, work
For oily phase；
(3) oil is mutually put into water phase, 4000r/min homogeneous 5 minutes, then cools to 45 DEG C；
(4) borsal calcium and Hua Yesu are sequentially added into mixture A, after mixing evenly homogeneous (2500r/min, 4 points
Clock), obtain mixture B；
(5) plant is added in mixture B to releive agent, Hua Shui and preservative, stirring makes to be uniformly mixed, and obtains mixture C；
(6) water soluble oxidized cerium is added in mixture C, stirring makes to be uniformly mixed, and what is obtained there is wide spectrum photoprotection to make
Sunscreen composition.
(7) detection pH value is qualification, discharging 6 or so；
It (8) is the filter-cloth filtering of 200 mesh by filter mesh number；
(9) filling.
Embodiment 2
A kind of sunscreen composition with broad-spectrum light protective action is grouped as by following group by mass percentage:
The preparation method of sunscreen composition, with embodiment 1.
Embodiment 3
A kind of sunscreen composition with broad-spectrum light protective action is grouped as by following group by mass percentage:
The preparation method of sunscreen composition, with embodiment 1.
Embodiment 4
A kind of sunscreen composition with broad-spectrum light protective action is grouped as by following group by mass percentage:
The preparation method of sunscreen composition, with embodiment 1.
Comparative example 1
A kind of sunscreen composition with broad-spectrum light protective action is grouped as by following group by mass percentage:
The preparation method of sunscreen composition, with embodiment 1.
Comparative example 2
A kind of sunscreen composition with broad-spectrum light protective action is grouped as by following group by mass percentage:
The preparation method of sunscreen composition, with embodiment 1.
Comparative example 3
A kind of sunscreen composition with broad-spectrum light protective action is grouped as by following group by mass percentage:
The preparation method of sunscreen composition, with embodiment 1.
Comparative example 4
A kind of sunscreen composition with broad-spectrum light protective action is grouped as by following group by mass percentage:
The preparation method of sunscreen composition, with embodiment 1.
Comparative example 5
A kind of sunscreen composition with broad-spectrum light protective action is grouped as by following group by mass percentage:
The preparation method of sunscreen composition, with embodiment 1.
Comparative example 1 is not added with borsal calcium compared with the sunscreen composition of embodiment 3, other do not make to change；Comparative example
2 compared with the sunscreen composition of embodiment 3, is not added with pot marigold flower extract, other do not make to change；Comparative example 3 and embodiment 3
Sunscreen composition compare, be not added with Hua Yesu, other do not make to change；Comparative example 4 compared with the sunscreen composition of embodiment 3,
It is not added with plant to releive agent, other do not make to change；Comparative example 5 is not added with water-soluble oxygen compared with the sunscreen composition of embodiment 3
Change cerium, other do not make to change.
Effect example
1, skin sensing is commented
10 volunteers are selected, the age 18-60 years old, an equal amount of sample component are taken respectively, in respective the back of the hand/arm
Inside or cheek smear sunscreen composition sample in a manner of (10 circle) to draw a circle, and when smearing, alternately, record smears sense
By table 1 is statistical result.
1 skin sense evaluating result of table
| Appraise through comparison index | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Spreadability | 7.5 | 7 | 7.5 | 6 |
| Infiltration rate | 7 | 8 | 8.2 | 8.5 |
| Smearing process smooth degree | 8 | 7 | 8 | 6.9 |
| Salubrious degree | 7 | 8 | 8 | 8 |
| Moisturizing sense after absorption | 7.5 | 7 | 8.2 | 7.8 |
| Comprehensive score | 37 | 37 | 39.9 | 37.2 |
As it can be seen from table 1 the skin sensing examination comprehensive score of embodiment 1-4 is all higher, the wherein comprehensive score of embodiment 3
Highest, skin sense is the critically important performance indicator of sunlight screening skin-protecting product, therefore the performance of the sunscreen composition of embodiment 1-4 is all excellent,
Especially embodiment 3.
2, sun-proof function spf value is tested
Select 10 volunteers, the age 19-57 years old, with solar simulator xenon arc lamp, with reference to cosmetics safety technical specification
Specific spf value tests method in 2015 editions, and subject takes the loxosis that leans forward, takes its back to be irradiated, one of them is taken to be not less than
30cm2Normal skin region, press (2.00 ± 0.05) mg/cm2Amount of samples sample to be tested is uniformly applied to above-mentioned zone
It is interior, suitable ultraviolet irradiating dose is then selected, is irradiated.It records minimal erythema dose (med value).Spf value=anti- sheath
The med value of skin/non-protecting skin med value.As a result as shown in Figure 1.
It will be seen from figure 1 that the spf value of embodiment 3 be it is highest, remove borsal calcium therein, pot marigold mentions
Any one of object, Hua Yesu, water soluble oxidized cerium is taken, spf value has reduction, it is seen that between the component of the application sunscreen composition
With good synergistic function.
3, ir transmissivity tests %
By the sunscreen composition without the emulsion matrix of active constituent, embodiment 3 and comparative example 1-5 according to 2mg/cm2's
Amount is applied to respectively on the PMMA plate of 5 × 5.2cm size, with the near-infrared of the LT1400-A radiometer measurement substrate (0.75 μm-
1.35 μm) transmissivity of IR-A wave band.Light source used isInfrared (IR) lamp is (apart from lamp 35cm, luminous intensity
100mW/cm2).It is several with other by the ir transmissivity positioning datum 100% (blank group) of the emulsion matrix without active constituent
A sample comparison, as a result as shown in Figure 2.
Infrared penetration rate is lower, accordingly can be small to the deep layer damage of skin, figure it is seen that embodiment 3 is red
Outer transmissivity is will be low than comparative example 1-5, it is seen that the transmissivity of infrared ray can be influenced by cutting any one ingredient all.
4, the cooling effect of thermo-effect of infrared radiation
5 volunteers (I to III type of skin type) is selected, 2 sample of embodiment 3, comparative example 1 and comparative example is tried out.With general
Logical lotion (i.e. without water soluble oxidized cerium, borsal calcium, pot marigold flower extract, flower coconut palm element and plant by the ingredient of embodiment 3
Object is releived agent, blank emulsion) test comparison is carried out as blank control group.The each sample 2mg/cm of applying amount2.First test skin
The temperature of (face) is then irradiated skin 5 minutes with 125W infrared lamp, 11 inches of irradiation distance, tests skin after irradiation again
It is poor to calculate skin temperature for temperature.As a control group with ordinary emulsion, temperature difference is calculated.It is red to assess each sample blocking with this
The ability of outer light.As a result as shown in Figure 3.
From figure 3, it can be seen that the temperature difference of embodiment 3 is maximum, illustrate that he is best to the barrier action of infrared ray.With blank
Lotion compares, and comparative example 1 and comparative example 2 also have certain cooling effect, but all strong without the function of embodiment 3, explanation
Borsal calcium and pot marigold flower extract have good synergistic effect.
5, to the influence of skin hydration effect
Test equipment is the survey of 3 moisture of Germany Courage+Khazaka electronic GmbH Derma Unit SSC
Try instrument.5 readmes are selected to have the volunteer of dry skin problem.Each volunteer tester marks 4 different skin regions.Often
A region 2cm*2cm..According to 0.002g/cm2Sample size smears embodiment 3, comparative example 2, comparative example 4, and a region is stayed not apply
Any product smears 20 circles as blank control respectively, then tests the region moisturizing angle value, and same position adheres to smearing one day
Twice, the moisturizing angle value of 1d, 3d, 7d, 14d after smearing test sample, the moisturizing degree after moisturizing degree=each smearing are then tested
Moisturizing angle value before each smearing of value-.Each moisturizing degree is surveyed 5 times, and the smallest three numerical value of error is taken, when to take its average value be this
Carve moisturizing angle value.As a result as shown in Figure 4.
From fig. 4, it can be seen that embodiment 3 can be very good to promote the increase of skin hydration degree, comparative example 2 and comparative example 4
Pot marigold flower extract therein and plant are releived after agent changes, skin water and degree have different degrees of reduction.
6, erythema inhibiting rate is tested
Lighttight vinyl diaphragm plate is accurately fixed on to the lower back portion of 5 volunteers (I to III type of skin type), is set
2 groups of parallel holes are opened in rouge template, (4 pairs totally 8 hole), for three days on end, 1 time/for 24 hours, administration group embodiment 3, comparative example 3, comparative example
4 sample is smeared, and applying amount is according to 2mg/cm2Amount, control group is blank emulsion, after washing away.4th day purple with UVR-254 type
Outside line irradiatometer, according to 500mj/cm2UVR is irradiated, and is with color evaluating (model C R-400, Ke Ni Minolta company) measurement
When erythema dose (ED).It calculates, instant erythema inhibiting rate=erythema dose (ED) after erythema dose (ED)-administration group irradiation after control group irradiation)/control group
Erythema dose (ED) after irradiation } * 100.As a result as shown in Figure 5.
From fig. 5, it can be seen that embodiment 3 has good inhibitory effect for the erythema that irradiation generates, can inhibit about
80% erythema generates.Comparative example 3 and comparative example 4 have certain erythema inhibitory effect, but its inhibitory effect is far below implementation
Example 3.This experiment also illustrates that erythema caused by embodiment 3 can be irradiated with rapid regression has maintenance before shining well and shines
Repair afterwards.
7, anti-blue light is tested
Principle: it using the human skin epidermis (abbreviation RHE) rebuild, is irradiated under different conditions with blue light, and measure
The degree (being characterized with the content of malonaldehyde) of RHE oxidation out.
Processing method: negative control product (untreated RHE, be not exposed under blue light), (RHE is straight for positive control product
Connect exposure under blue light), R product (RHE is pre-processed in advance before being exposed to blue light): product 1 (embodiment 3), product 2
(comparative example 1), product 3 (comparative example 2).The 0-7 days RHE of test method are generated from the keratinocyte of donor, are cultivated
It arrives, in triplicate.8th day negative control, the product of positive control and and embodiment 3, comparative example 1, the sample of comparative example 2
(2mg/cm is applied on RHE respectively2), and it is exposed to 40J/cm2In the blue light of (427nm), after exposure 24 hours, product is removed
Residual, then measure malonaldehyde (the MDA- oxidation label) analysis in REH, as a result as shown in Figure 6.
Malonaldehyde is a kind of oxide that blue light illumination can generate, can secondary indication skin degree of oxidation, malonaldehyde contains
Amount is higher, indicates that skin is oxidized degree height, the injury that skin is subject to is bigger.It is compared from the test result of Fig. 6, embodiment 3
Anti-blue light irradiation generate malonaldehyde effect it is most strong, it is all better than comparative example 1, comparative example 2.
It can be seen that sunscreen composition sun-proof result provided by the invention is good from above 7 test results, there is UV resistance
The wide spectrums protective actions such as line, anti-blue light, barrier infrared ray, there are also the effects that can effectively increase skin moisturizing degree.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of sunscreen composition with broad-spectrum light protective action, it is characterised in that include group as follows by mass percentage
Point:
2. the sunscreen composition according to claim 1 with broad-spectrum light protective action, it is characterised in that:
The water soluble oxidized cerium is the compound of water, ceria, metal platinum powder；
The pot marigold flower extract is pot marigold flower extract, the compound for synthesizing saualane；
The flower coconut palm element is Italian cabbage extract, ascorbic acid, soybean lecithin, caprylic/capric triglyceride, malt
The compound of dextrin, modified corn starch；
The plant releive agent be glycyrrhiza glabra extract, turmeric root extract, rhizoma cyperi seed extract, 1,3-BDO, 1,
2- hexylene glycol, Sensiva SC50, water compound.
3. the sunscreen composition according to claim 1 with broad-spectrum light protective action, it is characterised in that:
The water soluble oxidized cerium is water, ceria, metal platinum powder (87.95~91.99) in mass ratio: (8~12):
(0.01~0.05) obtained compound is matched；
The pot marigold flower extract is pot marigold flower extract, synthesizes saualane in mass ratio (35~45): (55~65)
Match obtained compound；
The flower coconut palm element is Italian cabbage extract, ascorbic acid, soybean lecithin, caprylic/capric triglyceride, malt
Dextrin, modified corn starch (0.5~0.6) in mass ratio: (0.1~0.2): (1~5): (20~40): (30~50): (4.2
~48.4) obtained compound is matched；
The plant releive agent be glycyrrhiza glabra extract, turmeric root extract, rhizoma cyperi seed extract, 1,3-BDO, 1,
2- hexylene glycol, Sensiva SC50, water (0.1~10) in mass ratio: (0~1): (0~1): (8~10): (0.5~2): (0~
0.1): (84.9~91.22) match obtained compound.
4. the sunscreen composition according to claim 1 with broad-spectrum light protective action, it is characterised in that: also comprising helping
Agent；
The auxiliary agent is surplus；
The auxiliary agent is deionized water, moisturizer, emulsifier, suspension thickener, Hua Shui and at least one of the preservatives.
5. the sunscreen composition according to claim 4 with broad-spectrum light protective action, it is characterised in that:
The moisturizer is one of butanediol, methyl polyethers -10 and methyl polyethers -20 or at least two；
The suspension thickener is hydroxyethyl cellulose, xanthan gum and acryloyldimethyl taurine by in/VP copolymer
One kind or at least two；
The emulsifier is cetostearyl alcohol+cetearyl glucoside, arachidic alcohol+docosyl alcohol+arachidic alcohol glucoside, tristearin
Acyl mammary gland sodium lactate+stearine+cetostearyl alcohol and cetostearyl alcohol olive oleate+smooth olive oleic acid of sorb
At least one of ester or at least two；
Hua Shuiwei rose wate, lavandulae flos water or the lotus flower flower water；
The preservative be Phenoxyethanol, Sensiva SC50, methylparaben, propylben, parahydroxyacet-ophenone and
One of pungent glycol or at least two.
6. the sunscreen composition according to claim 4 with broad-spectrum light protective action, it is characterised in that: by following raw material
It forms by mass percentage:
Surplus is deionized water.
7. the preparation method of the described in any item sunscreen compositions with broad-spectrum light protective action of claim 4~6, feature
It is: the following steps are included:
(1) moisturizer, suspension thickener and deionized water are mixed, is sufficiently swollen, then heats, as water phase；
(2) emulsifier and pot marigold flower extract are heated under mixing, stirring is to transparent, as oily phase；
(3) oil is mutually put into water phase, homogeneous, cooling obtain mixture A；
(4) borsal calcium and Hua Yesu are sequentially added into mixture A, are stirred evenly simultaneously homogeneous, are obtained mixture B；
(5) plant is added in mixture B to releive agent, Hua Shui and preservative, stirring makes to be uniformly mixed, and obtains mixture C；
(6) water soluble oxidized cerium is added in mixture C, stirring makes to be uniformly mixed, and obtains having the anti-of broad-spectrum light protective action
Shine composition.
8. the preparation method of the sunscreen composition according to claim 7 with broad-spectrum light protective action, it is characterised in that:
It is further comprising the steps of:
(7) after detection is qualified, filtering is filling.
9. the preparation method of the sunscreen composition according to claim 8 with broad-spectrum light protective action, it is characterised in that:
Heating temperature described in step (1) is 75~80 DEG C；
Heating temperature described in step (2) is 70~75 DEG C；
Processing condition described in step (3) is 2800~6000r/min, 3~5 minutes；
Cooling described in step (3) is to be cooled to 50~55 DEG C；
Processing condition described in step (4) be 1500~3000r/min, 3~5 minutes；
Detection qualification refers between pH value 5.5~7.0 in step (7)；
The filter-cloth filtering by filter mesh number for 100~300 mesh is filtered into described in step (7).
10. the described in any item sunscreen compositions with broad-spectrum light protective action of claim 1~6 are in preparing skin care item
Using.
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| CN112294667A (en) * | 2020-11-09 | 2021-02-02 | 西安润玉医疗科技有限公司 | Composition with broad-spectrum light protection effect and application thereof |
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| JP2021080229A (en) * | 2019-11-22 | 2021-05-27 | 株式会社ノエビア | Topical skin preparation |
| JP2021080230A (en) * | 2019-11-22 | 2021-05-27 | 株式会社ノエビア | Topical skin preparation |
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