CN110338419A - 一种富含黄酮的降糖川木瓜含片的制备方法 - Google Patents
一种富含黄酮的降糖川木瓜含片的制备方法 Download PDFInfo
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Abstract
本发明涉及一种富含黄酮的降糖川木瓜含片的制备方法。该降血糖片剂由川木瓜、百香果、玫瑰花茶、清钱柳、荷叶、桃、柠檬、苹果、草莓、木糖醇、β‑环状糊精、预胶化淀粉研制而成，配方各组分的含量如下：15‑20%川木瓜，10%百香果，3‑6%玫瑰花茶，3‑6%清钱柳，3‑6%荷叶，5‑10%桃，5‑10%柠檬，5‑10%苹果，5‑10%草莓，15%β‑环糊精，用木糖醇补齐至100%。本发明产品创新之处在于提取多种原料黄酮成分添加入含片，精选多种天然产物并优化配比，活性成分协同作用，共同促进胰岛素分泌，同时具有抗氧化、降血糖和降血脂功能。以川木瓜黄酮及清钱柳为主料，以富含多酚类化合物水果为辅料，具有降糖功能强，口感好，毒副作用小，作用靶点多等特点。
Description
技术领域
本发明属于保健食品加工领域，涉及一种富含黄酮的降糖川木瓜含片的制备方法。
背景技术
糖尿病是仅次于肿瘤和心血管疾病的第三大疾病。由于不健康的生活习惯与各种压力，年轻人患糖尿病逐渐增多，糖尿病严重影响生活质量。药物治疗致毒副作用如胃肠道反应、水肿、心肝肾功能损害等。由于天然产物具有多途径、多靶点、副作用小的特点，国内外医药工作者已把治疗糖尿病的目标从化学药物转向从天然产物中筛选降血糖的活性成分，充分发挥天然活性成分在治疗糖尿病及其并发症上的独特优势。
川木瓜为皱皮木瓜的主要品种，属蔷薇科植物贴梗海棠的干燥近成熟果实，多生于四川、云贵、广西，有食用价值和药用价值。川木瓜主要含有三萜类、黄酮类、有机酸类化合物、精油和皂苷、糖类、氨基酸等多种成分，具有保肝、降糖、抗氧化、抗炎、抗肿瘤等其他功能。川木瓜中富含黄酮类化合物，黄酮类化合物在胰岛素敏感性组织中通过各种细胞内信号途径来调节碳水化合物的消化、胰岛素分泌、胰岛素信号通路和葡萄糖摄取，从而呈现良好的降糖和改善胰岛素抵抗的作用。可以改善胰岛β细胞，抑制α-葡糖苷酶活性，并且有类胰岛素的作用。因此，本发明利用川木瓜本身的食用药用价值，以川木瓜黄酮为主要原料，并辅助其他天然活性成分研制出专用于中老年人的降血糖片剂。
发明内容
本发明的本发明的目的在于为解决当今治疗糖尿病的化学药物具有毒副作用，研发困难，糖尿病患日益增高等问题，开发一种多用途、多靶点、副作用小的纯天然降血糖川木瓜复合含片。
本发明包括如下步骤：
购买优质新鲜川木瓜、桃、柠檬、苹果、草莓、百香果适量，其中除去果核、梗等，清洗干净后冷冻干燥48h，粉碎处理；购买β-环状糊精、预胶化淀粉、木糖醇，分别粉碎；购买干燥玫瑰花茶、清钱柳、荷叶适量，分别粉碎处理。超声提取川木瓜、玫瑰花茶、清钱柳、荷叶其中黄酮，条件为料液比1：15，60% 乙醇在50℃下，超声60min，超声功率400w，旋转蒸发至体积1/5时冷冻干燥得到提取物。各种原料分别过40目筛，称取如下原料15-20%川木瓜， 10%百香果，3-6%玫瑰花茶，3-6% 清钱柳，3-6%荷叶， 5-10%桃，5-10%柠檬，5-10%苹果，5-10%草莓，15%β-环糊精，用木糖醇补齐至100%。充分混合均匀得原料，将原料置于专用模具压制成片即得到成品。
本发明解决了川木瓜资源浪费问题，研制出了一款具有降糖功能的复合川木瓜含片，并且口感较好，易于被接受。
实施例1
购买优质新鲜川木瓜、桃、柠檬、苹果、百香果适量，其中除去果核、梗等，清洗干净后冷冻干燥48h，粉碎处理；购买β-环状糊精、预胶化淀粉、木糖醇，分别粉碎；购买干燥玫瑰花茶适量，粉碎处理。超声提取川木瓜、玫瑰花茶中黄酮，条件为料液比1：15，60% 乙醇在50℃下，超声60min，超声功率400w，旋转蒸发至体积1/5时冷冻干燥得到提取物。各种原料分别过40目筛，称取过筛后的川木瓜15g、桃8g、柠檬8g、苹果10g、百香果8g、玫瑰花茶3g、β-环状糊精6g、预胶化淀粉6g、木糖醇15g，充分混合均匀得原料，将原料置于专用模具压制成片即得到成品。
实施例2
购买优质新鲜川木瓜、柠檬、苹果、草莓、百香果适量，其中除去果核、梗等，清洗干净后冷冻干燥48h，粉碎处理；购买β-环状糊精、预胶化淀粉、木糖醇，分别粉碎；购买干燥清钱柳、荷叶适量，分别粉碎处理。超声提取川木瓜、清钱柳、荷叶其中黄酮，条件为料液比1：15，60% 乙醇在50℃下，超声60min，超声功率400w，旋转蒸发至体积1/5时冷冻干燥得到提取物。各种原料分别过40目筛，称取过筛后的川木瓜20g、柠檬6g、苹果10g、草莓6g、百香果6g、清钱柳5g、荷叶5g、β-环状糊精15g、预胶化淀粉7g、木糖醇8g，充分混合均匀得原料，将原料置于专用模具压制成片即得到成品。
实施例3
购买优质新鲜川木瓜、桃、柠檬、苹果、草莓适量，其中除去果核、梗等，清洗干净后冷冻干燥48h，粉碎处理；购买β-环状糊精、预胶化淀粉、木糖醇，分别粉碎；购买干燥玫瑰花茶、荷叶适量，分别粉碎处理。超声提取川木瓜、玫瑰花茶、清钱柳、荷叶其中黄酮，条件为料液比1：15，60% 乙醇在50℃下，超声60min，超声功率400w，旋转蒸发至体积1/5时冷冻干燥得到提取物。各种原料分别过40目筛，称取过筛后的川木瓜15g、桃10g、柠檬5g、苹果5g、草莓5g、玫瑰花茶3g、荷叶3g、β-环状糊精10g、预胶化淀粉7g、木糖醇20g，充分混合均匀得原料，将原料置于专用模具压制成片即得到成品。
以上所述为本发明较佳实施实例，仅为示范之用，并不用于限定本发明的实质技术内容范围。以上实施例未具体注明实验条件，通常按常规条件或规定处理。
Claims (4)
1.一种富含黄酮的降糖川木瓜含片的制备方法，其特征在于此含片以川木瓜黄酮为主要原料，百香果、玫瑰花茶、清钱柳、荷叶、桃、柠檬、苹果、草莓、木糖醇、β-环状糊精、预胶化淀粉组合配方研制而成。
2.按照权利要求1所述一种富含黄酮的降糖川木瓜含片的制备方法，其特征在于各组分的百分比如下：15-20%川木瓜， 10%百香果，3-6%玫瑰花茶，3-6% 清钱柳，3-6%荷叶， 5-10%桃，5-10%柠檬，5-10%苹果，5-10%草莓，15%β-环糊精，用木糖醇补齐至100%。
3.一种富含黄酮的降糖川木瓜含片的制备方法包括如下步骤：
（1）购买优质新鲜川木瓜、桃、柠檬、苹果、草莓、百香果，除去果核、梗等，清洗干净后冷冻干燥48h，粉碎处理；购买β-环状糊精、预胶化淀粉、木糖醇，分别粉碎；购买干燥玫瑰花茶、清钱柳、荷叶，分别粉碎处理（2）超声提取川木瓜、玫瑰花茶、清钱柳、荷叶其中黄酮，条件为料液比1：15，60% 乙醇在50℃下，超声60min，超声功率400w，旋转蒸发至体积1/5时冷冻干燥得到提取物（3）各种原料分别过40目筛，称取如下原料：15-20%川木瓜， 10%百香果，3-6%玫瑰花茶，3-6% 清钱柳，3-6%荷叶， 5-10%桃，5-10%柠檬，5-10%苹果，5-10%草莓，15%β-环糊精，用木糖醇补齐至100%（4）充分混合均匀得原料，将原料置于专用模具压制成片即得到成品。
4.按权利要求3所述的一种富含黄酮的降糖川木瓜含片的制备方法，其产品特征在于成品片剂规格为直径1～2cm，厚0.2～0.4cm，重2～4g。
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