CN110313898A - A kind of evaluation method of Shu Min substance used for cosmetic - Google Patents
A kind of evaluation method of Shu Min substance used for cosmetic Download PDFInfo
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- CN110313898A CN110313898A CN201910601033.4A CN201910601033A CN110313898A CN 110313898 A CN110313898 A CN 110313898A CN 201910601033 A CN201910601033 A CN 201910601033A CN 110313898 A CN110313898 A CN 110313898A
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- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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Abstract
The invention discloses a kind of methods for evaluating Shu Min substance used for cosmetic using sensitive detection agent, include the following steps: 1) to prepare the facial mask for detecting sensitive skin, the facial mask includes face mask substrate material and facial mask liquid, contains cosmetic base and sensitive detection agent in the facial mask liquid；2) in above-mentioned steps 1) facial mask liquid in add Shu Min substance, preparation addition Shu Min substance facial mask；3) respectively in facial application above-mentioned steps 1) and step 2) prepared by facial mask, perceptible stimulus evaluates whether the Shu Min substance has Shu Min active according to stimuli responsive situation of the skin to sensitive detection agent.Evaluation method of the invention is easy to operate, requires operator lower, experimental result more objective reality, has the advantages of easy to operate, experimental result objective reality, high sensitivity.
Description
This application claims Chinese earlier application, application number 201910199966.5, the priority of applying date 2019-03-15.
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of evaluation method of Shu Min substance used for cosmetic.
Background technique
Sensitive refers in particular to a kind of high reactiveness that skin occurs under physiology or pathological conditions, takes place mostly in face
Portion, clinical manifestation are that scorching hot, shouting pain, itch and tight feeling etc. easily occurs in skin when being stimulated by factors such as physics, chemistry, spirit
Subjective symptom, companion or not companion's objective signs such as erythema, the scales of skin that peel off, telangiectasis.The possible triggering factors master of sensitive
Have: (1) physical factor: such as season alternation, temperature change, solarization；(2) chemical factor: such as cosmetics, cleaning supplies, disinfection
The externally applied drug of the irritations such as product, Tretinoin, environmental contaminants (such as haze, dust, tail gas)；(3) mental element: such as anxiety, suppression
It is strongly fragrant etc..Sensitive has higher incidence in countries in the world, wherein and Asia women incidence is 40%~55.98%,
China's women incidence is about 36.1%.In recent years, on the one hand with environmental pollution, the increase of stress, so that sensibility
Dermatosis incidence constantly increases；On the other hand with the improvement of people ' s living standards and to the raising that sensitive recognizes, quick
The perception rate and attention rate for feeling skin are gradually increasing.Has effects that antiallergic sense as a result, the cosmetics of anti-irritant are increasingly subject to people
Attention, and have effects that antiallergic sense, the substance of anti-irritant also receives the favor of numerous research staff in cosmetic field.
Currently, being directed to sensitive skin exploitation and having filtered out a variety of anti-sensitive materials that can be applied to cosmetics
(Shu Min substance), while the active appraisal experiment also with a variety of Shu Min substances for numerous different emphasis, including it is external
Experiment, zoopery, human experimentation, cell experiment and patch modelling etc., specific aim, which has, promotes barrier function, neural town
Point that be quiet, inhibiting inflammatory reaction.However, the current country is still in infancy Shu Min object Quality Research used for cosmetic, it is existing
Evaluation method usually require to complete under particular circumstances, very high, and experimental result and human body are required to operator
Often there is larger difference using result, Shu Min substance can not be truly reflected to the anti-sensitizing effect of sensitive skin.Also, it adopts
The antiallergic activity used time with In vivo model measurement substance is longer, spends more.Therefore, urgent need will be established a kind of quickly comments in vitro
The method of valence Shu Min substance used for cosmetic.
Summary of the invention
In order to overcome above-mentioned deficiency, the present invention is intended to provide a kind of simple and easy to do, high sensitivity, result objective reality
Method for screening Shu Min substance used for cosmetic.
The principle of the present invention are as follows:
(1) it prepares a kind of for detecting the facial mask of sensitive skin
Wherein, the facial mask includes facial mask cloth and facial mask liquid, and the facial mask liquid contains cosmetic base and sensitive detection agent
Composition.
Wherein, the sensitive detection agent is Phenoxyethanol, lactic acid, capsaicine, lauryl sodium sulfate and hydroxybenzoic acid
Any one in ester.
Wherein, the cosmetic base comprises the following raw materials by weight percent:
1,3 butanediols 3%
Xanthan gum 0.2%
Glycerol 2%
NaCl 1%
The water of surplus.
Wherein, the preparation method of the facial mask, comprising the following steps:
1) after dispersing xanthan gum with 1,3-BDO plus water is warming up to 80~85 DEG C, and stirring and dissolving is uniform, heat preservation
15min obtains mixed liquor；
2) mixed liquor that the step 1) obtains is cooled to after 40~45 DEG C and sequentially adds sensitive detection agent, glycerol and
NaCl stirs 15~25 minutes, after being cooled to 30~35 DEG C, obtains facial mask liquid；
3) facial mask liquid that the step 2) obtains is stored in face mask substrate material, obtains facial mask.
Wherein, the face mask substrate material is non-woven fabrics, silk fabric, biological fiber, any one in nanofiber.
The preparation process of facial mask be specially by facial mask liquid it is filling to containing fold face mask substrate material facial mask bag in get face
The band liquid measure of facial mask liquid is 17.5~22.5g on film base material.
Prepared facial mask adds sensitive detection agent in the facial mask liquid of specified mix, and consumer is led in this facial mask of application
Perceptible stimulus position and stimulation time are crossed, with this for detecting sensitive skin, method particularly includes: the facial mask of preparation is spread on into face
Portion, perception is with the presence or absence of stimulation；It stimulates if it exists, records stimulation location and stimulation time, skin sensitivity degree is evaluated with this.
Wherein, the stimulation includes shouting pain, itch, burns, is tight, any one or more feeling in tingling, itch.
(2) it is added in the facial mask liquid of the facial mask for detecting sensitive skin of above-mentioned preparation a kind of doubtful living with Shu Min
Property Shu Min substance after, facial mask is made, respectively application be not added with above-mentioned Shu Min substance facial mask and be added to above-mentioned Shu Min substance
Facial mask, evaluate the responsiveness of the stimulation of two kinds of facial masks whether the Shu Min substance has Shu Min according to human facial skin
Activity screens Shu Min substance used for cosmetic with this.
Based on above description, as the first aspect of the present invention, evaluated the present invention provides a kind of using sensitive detection agent
The method of Shu Min substance used for cosmetic.
Preferably, the method is by skin before and after detection addition Shu Min substance to the stimuli responsive feelings of sensitive detection agent
Condition evaluates whether the Shu Min substance has Shu Min active.
Preferably, the sensitive detection agent is prepared to facial mask, skin is detected by the way that facial mask is spread on human skin
Stimuli responsive situation of the skin to sensitive detection agent.
Preferably, described method includes following steps:
1) facial mask for detecting sensitive skin is prepared, the facial mask includes face mask substrate material and facial mask liquid, the facial mask liquid
In contain cosmetic base and sensitive detection agent；
2) in above-mentioned steps 1) facial mask liquid in add Shu Min substance, prepare the facial mask containing the Shu Min substance；
3) application above-mentioned steps 1 respectively) and step 2) prepared by facial mask, perceptible stimulus, according to skin to sensitive detection
The stimuli responsive situation of agent evaluates whether the Shu Min substance has Shu Min active.
Preferably, the sensitive detection agent is Phenoxyethanol, lactic acid, capsaicine, lauryl sodium sulfate and hydroxyl
Any one or a few in benzoic ether.
Preferably, the cosmetic base comprises the following raw materials by weight percent:
The water of surplus.
Preferably, the stimulation includes any one or more sense in calcination, shouting pain, tight, tingling, itch
Feel.
Preferably, wherein, the preparation of the facial mask of step 1) the following steps are included:
1) after dispersing xanthan gum with 1,3-BDO plus water is warming up to 80~85 DEG C, and stirring and dissolving is uniform, heat preservation
15min obtains mixed liquor；
2) mixed liquor that the step 1) obtains is cooled to after 40~45 DEG C and sequentially adds sensitive detection agent, glycerol and
NaCl stirs 15~25 minutes, after being cooled to 30~35 DEG C, obtains facial mask liquid；
3) facial mask liquid that the step 2) obtains is stored in face mask substrate material to get facial mask.
Preferably, wherein, the preparation of the facial mask of step 2) the following steps are included:
1) after dispersing xanthan gum with 1,3-BDO plus water is warming up to 80~85 DEG C, and stirring and dissolving is uniform, heat preservation
15min obtains mixed liquor；
2) mixed liquor that the step 1) obtains is cooled to after 40~45 DEG C and sequentially adds sensitive detection agent, glycerol,
NaCl and Shu Min substance stirs 15~25 minutes, after being cooled to 30~35 DEG C, obtains facial mask liquid；
3) facial mask liquid that the step 2) obtains is stored in face mask substrate material to get facial mask.
Preferably, the face mask substrate material is non-woven fabrics, silk fabric, biological fiber, any one in nanofiber.
As a second aspect of the invention, the present invention provides a kind of side that Shu Min substance used for cosmetic is evaluated using facial mask
Method.
Preferably, described method includes following steps:
1) facial mask for detecting sensitive skin is prepared, the facial mask includes face mask substrate material and facial mask liquid, the facial mask liquid
In contain cosmetic base and sensitive detection agent；
2) in above-mentioned steps 1) facial mask liquid in add Shu Min substance, prepare the facial mask containing the Shu Min substance；
3) application above-mentioned steps 1 respectively) and step 2) prepared by facial mask, perceptible stimulus, according to skin to sensitive detection
The stimuli responsive situation of agent evaluates whether the Shu Min substance has Shu Min active.
Preferably, the sensitive detection agent is Phenoxyethanol, lactic acid, capsaicine, lauryl sodium sulfate and hydroxyl
Any one or a few in benzoic ether.
Preferably, the cosmetic base comprises the following raw materials by weight percent:
The water of surplus.
Preferably, the stimulation includes any one or more sense in calcination, shouting pain, tight, tingling, itch
Feel.
Preferably, wherein, the preparation of the facial mask of step 1) the following steps are included:
1) after dispersing xanthan gum with 1,3-BDO plus water is warming up to 80~85 DEG C, and stirring and dissolving is uniform, heat preservation
15min obtains mixed liquor；
2) mixed liquor that the step 1) obtains is cooled to after 40~45 DEG C and sequentially adds sensitive detection agent, glycerol and
NaCl stirs 15~25 minutes, after being cooled to 30~35 DEG C, obtains facial mask liquid；
3) facial mask liquid that the step 2) obtains is stored in face mask substrate material to get facial mask.
Preferably, wherein, the preparation of the facial mask of step 2) the following steps are included:
1) after dispersing xanthan gum with 1,3-BDO plus water is warming up to 80~85 DEG C, and stirring and dissolving is uniform, heat preservation
15min obtains mixed liquor；
2) mixed liquor that the step 1) obtains is cooled to after 40~45 DEG C and sequentially adds sensitive detection agent, glycerol,
NaCl and Shu Min substance stirs 15~25 minutes, after being cooled to 30~35 DEG C, obtains facial mask liquid；
3) facial mask liquid that the step 2) obtains is stored in face mask substrate material to get facial mask.
Preferably, the face mask substrate material is non-woven fabrics, silk fabric, biological fiber, any one in nanofiber.
As the third aspect of the present invention, the present invention provides a kind of facial mask, includes sensitive detection agent in the facial mask and relaxes
Quick substance.
Preferably, the facial mask includes face mask substrate material and facial mask liquid, sensitive detection agent is contained in the facial mask liquid and is relaxed
Quick substance.
Preferably, the sensitive detection agent contained in the facial mask liquid is Phenoxyethanol, lactic acid, capsaicine, dodecane
Any one or a few in base sodium sulphate and hydroxybenzoate.
Preferably, when sensitive detection agent is Phenoxyethanol, the weight hundred of the Phenoxyethanol contained in the facial mask liquid
Divide than being 0.01~1.0%.
Preferably, the weight percent of the lactic acid contained in the facial mask liquid is 4.0 when sensitive detection agent is lactic acid
~6.0%.
Preferably, when sensitive detection agent is capsaicine, the weight percent of the capsaicine contained in the facial mask liquid
It is 0.01~0.03%.
Preferably, when sensitive detection agent is dodecyl sodium sulfate, the dodecyl sulphur that contains in the facial mask liquid
The weight percent of sour sodium is 5.0~8.0%.
Preferably, when sensitive detection agent is hydroxybenzoate, the hydroxybenzoate that contains in the facial mask liquid
Weight percent be 0.1~0.3%.
Preferably, also containing cosmetic base in the facial mask liquid.
Preferably, the cosmetic base comprises the following raw materials by weight percent:
The water of surplus.
Preferably, the face mask substrate material is non-woven fabrics, silk fabric, biological fiber, any one in nanofiber.
As the fourth aspect of the present invention, the present invention provides a kind of sensitive detection agent conduct evaluation Shu Min substance used for cosmetic
Whether there is the active new application of Shu Min.
Preferably, the sensitivity detection agent is for screening Shu Min substance used for cosmetic.
Preferably, the sensitivity detection agent is for verifying the Shu Min activity of Shu Min substance used for cosmetic.
Preferably, the sensitivity detection agent is for comparing the Shu Min activity of two or more cosmetics Shu Min substance
Compared with.
Preferably, being evaluated by skin before and after detection addition Shu Min substance the stimuli responsive situation of sensitive detection agent
Whether the Shu Min substance has Shu Min active.
Preferably, the sensitive detection agent is prepared to facial mask, skin is detected by the way that facial mask is spread on human skin
Stimuli responsive situation of the skin to sensitive detection agent.
Preferably, whether evaluation Shu Min substance has the active method of Shu Min, include the following steps:
1) facial mask for detecting sensitive skin is prepared, the facial mask includes face mask substrate material and facial mask liquid, the facial mask liquid
In contain cosmetic base and sensitive detection agent；
2) in above-mentioned steps 1) facial mask liquid in add Shu Min substance, prepare the facial mask containing the Shu Min substance；
3) application above-mentioned steps 1 respectively) and step 2) prepared by facial mask, perceptible stimulus, according to skin to sensitive detection
The stimuli responsive situation of agent evaluates whether the Shu Min substance has Shu Min active.
Preferably, the sensitive detection agent is Phenoxyethanol, lactic acid, capsaicine, lauryl sodium sulfate and hydroxyl
Any one or a few in benzoic ether.
Preferably, the cosmetic base comprises the following raw materials by weight percent:
The water of surplus.
Preferably, the stimulation includes any one or more sense in calcination, shouting pain, tight, tingling, itch
Feel.
It is to be appreciated that invention of the invention includes the meaning of following three aspects: (1) for screening used for cosmetic relax
Quick substance, i.e., method of the invention, which can be used in screening, has the active substance of Shu Min, thus for low stimulation, high temperature and cosmetics
The new active raw material of Shu Min (2) that can play of preparation screening verified for carrying out the Shu Min activity of Shu Min substance, i.e. this hair
Bright method can verify the anti-sensitive active of a certain known Shu Min substance, specifically, can verify its active size,
Verifying it is to play antiallergic sense particular by alleviation shouting pain or itch or calcination or tight or tingling to live
Property；(3) for being compared to the Shu Min activity of different Shu Min substances, i.e., method of the invention can be used to a variety of Shu Min objects
The anti-sensitive active of matter compares, and is cosmetics to more fully understand the anti-sensitive active of variety classes Shu Min substance
The additive amount of middle Shu Min substance provides technological guidance.
The utility model has the advantages that
(1) present invention screens Shu Min substance used for cosmetic, this method for the first time using sensitive detection agent in the form of facial mask
It is easy to operate, operator is required it is lower, subject can be obtained in application facial mask whether with Shu Min effect conclusion,
It is more mild effective compared to other test methods.
(2) present invention carries out the screening and verifying of Shu Min substance, gained experiment knot by the way that facial mask directly to be spread on to face
Fruit is more intuitive, closer to human body truth, can more really and objectively relax for screening Shu Min substance, and known to verifying
The activity of quick substance.
Sensitivity detection agent used in facial mask of the invention has the characteristics that as described below:
Phenoxyethanol: Phenoxyethanol (PE) is the common ingredient made up in production process as anticorrosion and bactericidal agent, but simultaneously
Phenoxyethanol is also the stimulant to skin.Selection cosmetics often are offseted to have for expense person with raw material Phenoxyethanol and preferably be connect
It is spent.In terms of safety, in strict accordance with " cosmetics safety technical specification " related request, controlled concentration limits the use of range 1%, with
Guarantee safety of the invention.In the present invention, using Phenoxyethanol as the additive amount preferably 0.01 of sensitive detection agent~
1.0%.
Lactic acid: lactic acid has good biocompatibility, has effects that wrinkle, skin care, blast, and can also be effectively
The pH for adjusting cosmetics, makes it closer to human body, is therefore widely used in skin care item to improve dry skin and cutin
Change phenomenon.But lactic acid has certain irritation, is one of the typical stimulus for detecting skin sensitivity.In the present invention, with cream
Additive amount preferably 4.0~6.0% of the acid as sensitive detection agent.
Capsaicine: capsaicine is the high-quality natural pigment being present in pimiento, has bright-coloured color, good heat steady
Qualitative, safety and reliability can be used as natural pigment addition in cosmetics, while capsaicine has the work of activating vessels
With can make of pink and healthy-looking glossy.Although capsaicine is not in cosmetics register, the common raw material being not belonging in cosmetics,
But because it is with stronger irritation, by one of the common typical stimulus as detection skin sensitivity.In the present invention, capsicum
Element only does test and uses, using capsaicine as the additive amount preferably 0.01~0.03% of sensitive detection agent.
Dodecyl sodium sulfate: dodecyl sodium sulfate (SDS) is common surfactant in cosmetics, with good
Good emulsification, infiltration and dispersion performance.However, the SDS of high concentration can rapidly result in the damage of cell membrane, cell occurs bright
Aobvious rupture is made into haemolysis, and therefore, SDS is common standard stimulus source in existing stimulation test.In the present invention, with
Additive amount preferably 5.0~8.0% of the SDS as sensitive detection agent.
Hydroxybenzoate: hydroxybenzoate, mainly as sterilization antiseptic, can destroy micro- life in cosmetics
The cell membrane of object makes intracellular protein denaturation, the antibacterial action with wide spectrum.But hydroxyl is excessively used in cosmetics
Benzoic ether can cause contact dermatitis and allergic dermatitis, and regulation hydroxybenzoic acid esters make in " cosmetics health specification "
Maximum concentration be 0.4%, in the present invention, using hydroxybenzoate as sensitivity detection agent additive amount preferably 0.1~
0.3%.
Detailed description of the invention
Fig. 1 is the result on trial of the facial mask of embodiment 1-11.
Fig. 2 is using the shouting pain demographics figure after A, B, C facial mask.
Fig. 3 is using the statistical chart for generating different degrees of shouting pain after A, B, C facial mask.
Fig. 4 is using the different degrees of tight statistical chart of generation after A, B, C facial mask.
Specific embodiment
Below with reference to embodiment, the content of the present invention will be explained in more detail.It should be appreciated that implementation of the invention is not limited to
In the following examples, the accommodation in any form and/or change made to the present invention fall within the scope of the present invention.
In the present invention, if not refering in particular to, all parts, percentage are unit of weight, and all equipment and raw material etc. are equal
It is commercially available or the industry is common.If the method that embodiment uses is technology generally in the art without specializing.
Facial mask
For facial mask, the understanding of broad sense should be done, can be the facial mask for capableing of directly application with carrier, or smear
The liquid or slurry of formula.It is by the way that facial mask liquid is adsorbed on conduct when facial mask is to be capable of the form of direct application with carrier
It is formed on the face mask substrate material of carrier, facial mask liquid is adsorbed on the general technology that the method on face mask substrate material is this field, in this hair
In bright, preferably the size of face mask substrate material is 300~350cm2, in single piece facial mask substrate the band liquid measure of facial mask liquid be 17.5~
22.5g, the band liquid measure of facial mask are 0.05~0.075g/cm2.The place of application of facial mask is not limited only to face, can apply in people
Body other positions, such as neck, arm etc..
Shu Min substance
Shu Min substance is to refer to make an addition in cosmetics to have antiallergic sense, the active substance of anti-irritant, such as plant
The substances such as extract, polysaccharide, polyphenol, flavones, alkaloid.Commonly used in the art any have effects that anti-sensitive active or antiallergic sense
Substance can be used as Shu Min substance be applied to the present invention in.
Embodiment 1 is a kind of for detecting the facial mask of sensitive skin
The preparation of facial mask liquid: the component of facial mask liquid is as shown in the table, and xanthan gum adds water liter after first being dispersed with 1,3-BDO
For temperature to 80-85 DEG C, stirring and dissolving is uniform, keeps the temperature 15min.B phase is sequentially added after being cooled to 40-45 DEG C, is stirred 15-25 minutes,
After turn to stir at low speed be cooled to 30-35 DEG C after discharge.
The preparation of facial mask: facial mask liquid is filling into containing the facial mask bag for folding face mask substrate material, wherein facial mask base used
Material is non-woven fabrics, and the area of face mask substrate material is 350 square centimeters, and the amount of pouring into of facial mask liquid is 17.5g.
The facial mask liquid of table 1 using Phenoxyethanol as sensitive detection agent forms
Embodiment 2 is a kind of for detecting the facial mask of sensitive skin
The component of facial mask liquid is as shown in the table, and the preparation of facial mask liquid and facial mask is the same as described in embodiment 1.The facial mask is marked as
Facial mask A.
The facial mask liquid of table 2 using Phenoxyethanol as sensitive detection agent forms
Embodiment 3 is a kind of for detecting the facial mask of sensitive skin
The component of facial mask liquid is as shown in the table, wherein face mask substrate material used is non-woven fabrics, and the area of face mask substrate material is
300 square centimeters, the amount of pouring into of facial mask liquid is 22.5g, remaining is the same as described in embodiment 1.
The facial mask liquid of table 3 using Phenoxyethanol as sensitive detection agent forms
Embodiment 4 is a kind of for detecting the facial mask of sensitive skin
The component of facial mask liquid is as shown in the table, and the preparation of facial mask liquid and facial mask is the same as described in embodiment 1.
The facial mask liquid of table 4 using lactic acid as sensitive detection agent forms
Embodiment 5 is a kind of for detecting the facial mask of sensitive skin
The component of facial mask liquid is as shown in the table, and the preparation of facial mask liquid and facial mask is the same as described in embodiment 1.
The facial mask liquid of table 5 using lactic acid as sensitive detection agent forms
Embodiment 6 is a kind of for detecting the facial mask of sensitive skin
The component of facial mask liquid is as shown in the table, and the preparation of facial mask liquid and facial mask is the same as described in embodiment 1.
The facial mask liquid of table 6 using lactic acid as sensitive detection agent forms
Embodiment 7 is a kind of for detecting the facial mask of sensitive skin
The component of facial mask liquid is as shown in the table, and the preparation of facial mask liquid and facial mask is the same as described in embodiment 1.
The facial mask liquid of table 7 using capsaicine as sensitive detection agent forms
Embodiment 8 is a kind of for detecting the facial mask of sensitive skin
The component of facial mask liquid is as shown in the table, and the preparation of facial mask liquid and facial mask is the same as described in embodiment 1.
The facial mask liquid of table 8 using SDS as sensitive detection agent forms
Embodiment 9 is a kind of for detecting the facial mask of sensitive skin
The component of facial mask liquid is as shown in the table, and the preparation of facial mask liquid and facial mask is the same as described in embodiment 1.
The facial mask liquid of table 9 using hydroxybenzoate as sensitive detection agent forms
Embodiment 10 is a kind of for detecting the facial mask of sensitive skin
The component of facial mask liquid is as shown in the table, and the preparation of facial mask liquid and facial mask is the same as described in embodiment 1.
The facial mask liquid of table 10 using Phenoxyethanol and lactic acid as sensitive detection agent forms
Embodiment 11 is a kind of for detecting the facial mask of sensitive skin
The component of facial mask liquid is as shown in the table, and the preparation of facial mask liquid and facial mask is the same as described in embodiment 1.
The facial mask liquid of table 11 using Phenoxyethanol and lactic acid as sensitive detection agent forms
The proof test of facial mask prepared by 12 embodiment 1~11 of embodiment
To carrying out using test for the facial mask of embodiment 1-11, while to contain only cosmetic base without sensitive detection agent
Facial mask as a control group (component of control group facial mask liquid are as follows: 1,3 butanediol 3.0%, xanthan gum 0.2%, glycerol 2.0%,
NaCl 1.0%, water 93.8%).
Select age bracket 25 years old to 40 years old health volunteer 7, all subject's skin of face health are smooth, no erythema,
The fash such as furfur, without other dermatopathies or systemic disease.Before test, every subject signs informed consent form, after face cleaning
According to usually facial mask being used to get used to tested facial mask, and self-assessment is carried out.Every subject uses a kind of facial mask daily,
Face does not use other any skin-protection products during test, and excessive sunlight exposure is avoided during test.Experimental result is such as
Shown in Fig. 1.
It can be seen that subject to the excitement of 0.5% lactic acid, 1.0% lactic acid not as good as 0.5% benzene oxygen from the result of Fig. 1
Ethyl alcohol and 1.0% Phenoxyethanol are obvious, illustrate that Phenoxyethanol has stronger irritation compared to lactic acid, are screening sensitive skins
The good selection of crowd.The reactivity of 1.0% Phenoxyethanol is 100%, with lower tingling sensation and burning sensation, tested
Within the scope of person is sustainable, for more preferred embodiment.
It finds simultaneously, 6.0% lactic acid, 8.0% dodecyl sodium sulfate and 0.1% hydroxybenzoate can be used as quick
Sense stimulant is for distinguishing and screening sensitive group；The reactivity of 0.01% capsaicine is 100%, but more sensitive to skin
Irritation is larger for crowd, can also be used as sensitive stimulant, but needs its additive amount of strict control.
The sensitive detection agent of two kinds of addition simultaneously in facial mask liquid, such as thorn caused by lactic acid and Phenoxyethanol is added simultaneously
Swash larger, tingling sensation and burning sensation are more obvious, also faster, but may generate insufferable shouting pain to sensitive group.
Inventor simultaneously to containing 4.0% lactic acid, 5.0% lactic acid, 0.03% capsaicine, 5% dodecyl sodium sulfate,
The facial mask of 7% dodecyl sodium sulfate, 0.2% hydroxybenzoate and 0.3% hydroxybenzoate is tried out, and is obtained
Same effect illustrates that the facial mask of the sensitive detection agent containing concentrations above may be incorporated for screening sensitive skin.
Above-mentioned experiment shows containing 0.01%~1.0% Phenoxyethanol or 4.0%~6.0% lactic acid or 0.01%~
The facial mask of 0.03% capsaicine or 5.0%~8.0% neopelex or 0.1~0.3% hydroxybenzoate is equal
It can be used in screening sensitive skin, this method has the advantages that safe and reliable, effective, comprehensive.
A kind of facial mask for adding Shu Min substance of embodiment 13
(facial mask prepared by embodiment 2 is labeled as facial mask A) on the basis of the facial mask of above-described embodiment 2, in facial mask
The facial mask that Shu Min effect object 4- tert. butyl cyclohexanol prepares a kind of substance containing Shu Min, the component of the facial mask liquid of the facial mask are added in liquid
As shown in the table, that the preparation method is the same as that of Example 1 is described for facial mask liquid and facial mask.The facial mask is marked as facial mask B.
A kind of facial mask liquid component for adding Shu Min substance of table 12
The Shu Min substance 4- tert. butyl cyclohexanol selected in the present embodiment, which is recorded in, " has used cosmetic material Names Catalogue
(2015) version " in, it was reported that 4- tert. butyl cyclohexanol has the function of preferably soothing the skin sensitivity [Roeding J, Maurin
V, Lu Jie, etal.4- tert. butyl cyclohexanol: " adjuster of releiving " [J] China cosmetic (industry) of sensitive skin, 2010
(5):79-81.]。
A kind of facial mask for adding Shu Min substance of embodiment 14
On the basis of the facial mask of embodiment 2, Chinese herbal medicine is added in facial mask liquid and releives composition as Shu Min effect object
Chinese herbal medicine composition of releiving prepares the facial mask of substance containing Shu Min a kind of, and the component of the facial mask liquid of the facial mask is as shown in the table, facial mask
That the preparation method is the same as that of Example 1 is described for liquid and facial mask.The facial mask is marked as facial mask C.
A kind of facial mask liquid component for adding Shu Min substance of table 13
The Shu Min substance Chinese herbal medicine selected in the present embodiment composition of releiving includes: kuh-seng, radix saposhnikoviae, puncture vine and northern trifoliate orange Dulcis,
Known above-mentioned four kinds of Chinese herbal medicines, which all have, soothes the skin effect, the combination of this Four Plants of this experimental selection, mixed according to special ratios
Close, verify obtained Chinese herbal medicine releive composition skin releive aspect effect.
Kuh-seng: have the effects that heat-clearing, eliminating dampness as China's traditional Chinese medicine.Matrine contained by it to Escherichia coli, becomes
Shape bacillus, staphylococcus aureus and beta streptococcus have obvious inhibiting effect, in the antipruritic tincture of Liu Jingping compound and Shao Zhanjie
There is kuh-seng in anti-inflammatory anti-itch lotion, it is certain to illustrate that it has effects that in skin itching-stopping prescription face, is related to hardship below with reference to document
Join the application in terms of skin diseases:
[the antipruritic tincture of Liu Jingping compound treats neurodermatitis 90 [J] external treatment with Chinese medicine magazines, 2001,10 (5)]
[Shao Zhanjie anti-inflammatory anti-itch lotion for treatment acute contact dermatitis [J] external treatment with Chinese medicine magazine, 2002,11 (4): 53-
53.]
[Zhang Feng, Xue Jiqiang, Yang Xuesong kuh-seng controlled outside skin disease in application lift the Gansu corner [J] Chinese medicine, 2007,20
(7):56-57.]
Radix saposhnikoviae: having the various actives substances such as polysaccharide, flavones, sterol in radix saposhnikoviae, has antibacterial, anti-inflammatory, throe, antiallergic etc.
Effect.Radix saposhnikoviae is commonly used to pruitus caused by treatment measles without adequate eruption, rubeola, eczema, scabies etc..Caused by a variety of causes
Pruritus, radix saposhnikoviae are drug of first choice, are related to effect and its application of radix saposhnikoviae below with reference to document:
[progress [J] the China medicine company of Wang Linli, Song Zhiyong radix saposhnikoviae, 2006,15 (10): 63-64.]
[clinical application of Sun Xiaohong, Shao Shihe, Li Hongtao, et al. radix saposhnikoviae and research [J] Beihua University journal: natural
Scientific version, 2004 (2): 138-141.]
Puncture vine: there is the laudatory title of " name medicine in grass ", mainly contain the compounds such as saponins, flavonoids, alkaloid, polysaccharide, separately
Outside also containing ingredients such as sterols, amino acids, terpene, fatty acid, inorganic salts.Puncture vine water extract has analgesia, anti-inflammatory effect,
It can inhibit the growth of staphylococcus aureus, Escherichia coli.Treatment anaphylactia is applied alone in tribulus terrestris, can significantly inhibit histamine institute
Guinea-pig isolated trachea, the ileum smooth muscle of cause are shunk, and prompt it that may play antiallergy by acting on Anaphylactic mediator (histamine)
The effect of acting on, being related to puncture vine below with reference to document and its application:
[Li Guangzong, Zhang Guangzhong, Wang Qian, et al. puncture vine dermatology application the Beijing [J] traditional Chinese medicine, 2008,27
(1):48-50.]
Northern trifoliate orange Dulcis: Chinese medicine thinks that north product chess has effects that heat-clearing, and bark root skin and leaf also have the function of activating blood and relaxing tendons,
Northern trifoliate orange Dulcis triterpene rich in, Flavonoid substances, pharmacologically have the function of calm and anti peroxidation of lipid.The research such as Sue
Show that north product chess extract can inhibit by inhibiting MAPK signal transduction in TNF-α/IFN-γ induction HaCaT cell
The generation of chemotactic factor (CF) TARC and MDC；By adjusting immunoglobulin (Ig) E and immunoglobulin G 2a (IgG2a) in serum
The mRNA expression of Th1 and Th2 associated media improves atopic dermatitis to adjust responsing reaction in horizontal and skin injury,
The effect of being related to northern trifoliate orange Dulcis below with reference to document and its application:
[Xu Lianmin, Liang Qiaoli trifoliate orange Dulcis platymiscium chemical component and pharmacological activity [J] modern medicines and clinic, 2001,16
(5):190-193.]
[Effects of Hovenia dulcis Thunb.extract and methyl vanillate on
atopic dermatitis-like skin lesions and TNF-α/IFN-γinduced chemokines
production in HaCaT cells[J].Journal of Pharmacy&Pharmacology,2016,68(11):
1465-1479.]
In the present embodiment, using Chinese herbal medicine releive composition the preparation method comprises the following steps: kuh-seng dry root, radix saposhnikoviae is dry
Stem, puncture vine dry flower, northern trifoliate orange Dulcis dry fruit are mixed according to weight ratio 3:2:1:1, are crushed, using decocting method heating and refluxing extraction
3 times, water consumption is followed successively by the 10 of medicinal material weight, 5,5 times, and 3 extraction times are followed successively by 2h, 1h, 1h, after No. 3 extracting solution merging
Centrifugation, extracting centrifugal liquid is concentrated under reduced pressure into 5 times of medicinal material weight, and it is spare to obtain Chinese herbal medicine composition of releiving.
The in-service evaluation of the facial mask of 15 embodiment 2,13,14 of embodiment
Select age bracket 25 years old to 40 years old health volunteer 18, wherein male subject 2, owns by female subject 16
Subject's skin of face health is smooth, the fash such as no erythema, furfur, without other dermatopathies or systemic disease.Before test, often
Position subject signs informed consent form, according to usually facial mask being used to get used to tested facial mask (A, B, C) after face cleaning, and carry out from
I evaluates.Every subject uses a kind of facial mask daily, and face does not use other any skin-protection products during test, and is trying
Excessive sunlight exposure is avoided during testing.
Subject perceives skin in application facial mask and calcination, shouting pain, tight, tingling, the feeling of itch occurs, and records out
The position now stimulated and stimulation time evaluate Shu Min effect of Shu Min raw material with this, specific as follows:
1, whether there is sense of discomfort, including shouting pain, calcination, tight, tingling, itch；
2, the degree of sense of discomfort, including insentience, indistinctly feel, slightly feeling, medium feeling, strong feel；
3, the appearance position of sense of discomfort, including forehead, cheek, wing of nose two sides, eye circumference.
After Fig. 2 is application facial mask A~C, the demographics of shouting pain are generated.Figure it is seen that for A facial mask, tested
There are 10 people not generate tingling sensation in person, there are 8 people to produce tingling sensation, illustrates that the A facial mask containing Phenoxyethanol can be used
In screening sensitive skin crowd；(B and C facial mask) has 11 people not have B facial mask after Shu Min raw material is added on the basis of A facial mask
There is generation tingling sensation, 7 people produce tingling sensation, for C facial mask, there are 12 people not generate tingling sensation, 6 people produce thorn
Pain is felt.It was found that the number for generating shouting pain is reduced, illustrates that the Shu Min raw material of addition can alleviate the stimulation of Phenoxyethanol, have one
Fixed Shu Min effect, wherein releive Shu Min effect of composition of Chinese herbal medicine is better than 4- tert. butyl cyclohexanol.
Fig. 3 be using A~C facial mask after, generate the statistics of different degrees of shouting pain, it can be seen that selection C facial mask without tingling sensation
It is most, medium tingling sensation caused by B facial mask is most, and strong tingling sensation caused by A facial mask is most, caused by illustrating B facial mask
Tingling sensation is strong compared with C group.
Fig. 4 be using A~C facial mask after, generate tight statistics in various degree, it can be seen that use nothing after A, B, C facial mask
The people of tight feeling is most, illustrates that tight feeling caused by A, B, C facial mask is weaker, and wherein A facial mask can cause slight tight.
According to above the conclusion, B facial mask causes the number of shouting pain more compared with C facial mask (T is examined without conspicuousness), mildness compared with
C facial mask is poor (T is examined without conspicuousness), wherein causes the shouting pain of cheek, the wing of nose more compared with the number of C facial mask.
Above-mentioned data can be seen that Chinese herbal medicine releives composition (corresponding C facial mask, content 0.1%) compared to 4- tert-butyl ring
Hexanol (corresponding B facial mask, content 0.1%) has better Shu Min activity, i.e., it is different that method of the invention can be applied to comparison
The Shu Min activity of Shu Min substance, to make evaluation to the anti-sensitive active of different Shu Min substances.
A kind of facial mask for adding Radix et Caulis Opuntiae Dillenii extract of embodiment 16
(facial mask prepared by embodiment 6 is labeled as facial mask D) on the basis of the facial mask of above-described embodiment 6, in facial mask
Radix et Caulis Opuntiae Dillenii extract is added in liquid, the component of the facial mask liquid of the facial mask is as shown in the table, and the preparation method of facial mask liquid and facial mask is same
Described in embodiment 1.The facial mask is marked as facial mask E.
A kind of facial mask liquid component for adding Shu Min substance of table 19
Radix et Caulis Opuntiae Dillenii extract's the preparation method is as follows: takes fresh cactus, is cleaned, removed the peel, is cut into small pieces, with crushing
3 times of weight of cactus are added after machine mashing obtains slurries for deionized water heating extraction 1 hour, and slurries are filtered, are centrifuged to obtain
Supernatant by supernatant concentration, is freeze-dried up to Radix et Caulis Opuntiae Dillenii extract.
The in-service evaluation of the facial mask of 17 embodiment 6,16 of embodiment
Human body application experiment is carried out to facial mask prepared by embodiment 6 and embodiment 16, selects age bracket at 25 years old to 40 years old
Health volunteer 20, wherein male subject 4, female subject 16.The screening requirement of subject and experimentation are the same as implementation
Described in example 15.
1, the demographics of sensitive stimulation are generated
It can be seen from the results above that adding the D facial mask of sensitive detection agent lactic acid can be effectively used for screening sensitive skin
Skin crowd has 14 people to produce stimulate the reaction to D facial mask in subject；And the E facial mask of application addition Radix et Caulis Opuntiae Dillenii extract
Afterwards, feel that the number of stimulation is substantially reduced, illustrate that the stimulation of lactic acid can be effectively relieved in Radix et Caulis Opuntiae Dillenii extract, i.e. cactus mentions
Take object that there is Shu Min activity.
2, stimulus type counts
| Shouting pain | It is tight | Tingling | Calcination | Itch | |
| D facial mask | 12 | 2 | 3 | 9 | 5 |
| E facial mask | 5 | 2 | 2 | 4 | 2 |
It can be seen from the results above that it is the most obvious using lactic acid as shouting pain caused by sensitive detection agent and calcination, and add
After adding Radix et Caulis Opuntiae Dillenii extract, it can significantly alleviate shouting pain, and alleviation calcination and itch, result above are said to a certain extent
Bright, Radix et Caulis Opuntiae Dillenii extract can be used as the Shu Min substance for being mainly used to alleviate shouting pain.Cactus is rich in polysaccharide, polyphenol, flavonoids
Substance, it may be possible to which substance of this kind plays main anti-sensitization.
In conclusion method of the invention, which is used not only for screening, has the active substance of Shu Min, and can be used in
The Shu Min activity of existing Shu Min substance is evaluated, can also specifically have which kind of Shu Min activity to visit to Shu Min substance
Study carefully, provides technological guidance for low stimulation, the preparation of high temperature and cosmetics.Method of the invention by being in facial application facial mask
It could be assumed that it is more true and reliable compared to other zooperies, cell experiment, it more can accurately reflect human body real conditions,
And method of the invention is simple to operation, is not necessarily to additional instruments equipment.
The foregoing is only a preferred embodiment of the present invention, rather than the embodiment of present invention whole.Above-mentioned implementation
Example is not intended to restrict the invention, and for those skilled in the art, the invention may be variously modified and varied.It is all
Within the scope of the spirit and principles in the present invention, any modification, equivalent replacement, improvement and so on should be included in guarantor of the invention
Within the scope of shield.
Claims (11)
1. a kind of method for evaluating Shu Min substance used for cosmetic using sensitive detection agent, which is characterized in that the method passes through inspection
Skin evaluates the stimuli responsive situation of sensitive detection agent whether the Shu Min substance has Shu Min before and after surveying addition Shu Min substance
Activity.
2. the method according to claim 1, wherein the sensitive detection agent is prepared to facial mask, pass through by
Facial mask spreads on human skin to detect skin to the stimuli responsive situation of sensitive detection agent.
3. according to the method described in claim 2, it is characterized in that, described method includes following steps:
1) facial mask for detecting sensitive skin is prepared, the facial mask includes face mask substrate material and facial mask liquid, is contained in the facial mask liquid
There are cosmetic base and sensitive detection agent；
2) in above-mentioned steps 1) facial mask liquid in add Shu Min substance, prepare the facial mask containing Shu Min substance；
3) respectively application above-mentioned steps 1) and step 2) prepared by facial mask, perceptible stimulus, according to skin to sensitive detection agent
Stimuli responsive situation evaluates whether the Shu Min substance has Shu Min active.
4. according to the method described in claim 3, it is characterized in that, the sensitive detection agent is Phenoxyethanol, lactic acid, capsicum
Any one or a few in element, lauryl sodium sulfate and hydroxybenzoate.
5. according to the method described in claim 3, it is characterized in that, the cosmetic base by following weight percent original
Material composition:
6. according to the method described in claim 3, it is characterized in that, the stimulation includes calcination, shouting pain, tight, tingling, scabies
Any one or more feeling in itching.
7. according to the method described in claim 5, it is characterized in that, wherein, step 1) for detecting the facial mask of sensitive skin
Preparation the following steps are included:
(1) after dispersing xanthan gum with 1,3-BDO plus water is warming up to 80~85 DEG C, and stirring and dissolving is uniform, keeps the temperature 15min, obtains
Mixed liquor；
(2) mixed liquor that the step (1) obtains is cooled to after 40~45 DEG C and sequentially adds sensitive detection agent, glycerol and
NaCl stirs 15~25 minutes, after being cooled to 30~35 DEG C, obtains facial mask liquid；
(3) facial mask liquid that the step (2) obtains is stored in face mask substrate material to get the facial mask for detecting sensitive skin；
Wherein, the facial mask containing Shu Min substance of step 2) preparation the following steps are included:
(1) after dispersing xanthan gum with 1,3-BDO plus water is warming up to 80~85 DEG C, and stirring and dissolving is uniform, keeps the temperature 15min, obtains
Mixed liquor；
(2) mixed liquor that the step (1) obtains is cooled to after 40~45 DEG C and sequentially adds sensitive detection agent, glycerol,
NaCl and Shu Min substance stirs 15~25 minutes, after being cooled to 30~35 DEG C, obtains facial mask liquid；
(3) facial mask liquid that the step (2) obtains is stored in face mask substrate material to get the facial mask containing Shu Min substance.
8. the method according to the description of claim 7 is characterized in that the face mask substrate material is non-woven fabrics, silk fabric, biology fibre
Dimension, any one in nanofiber.
9. whether sensitive detection agent has the active new application of Shu Min as evaluation Shu Min substance used for cosmetic, which is characterized in that
Evaluate the stimuli responsive situation of sensitive detection agent whether the Shu Min substance has by skin before and after detection addition Shu Min substance
There is Shu Min active, wherein the sensitive detection agent is prepared to facial mask, detects skin by the way that facial mask is spread on human skin
To the stimuli responsive situation of sensitive detection agent.
10. purposes according to claim 9, which is characterized in that the sensitive detection agent is Phenoxyethanol, lactic acid, peppery
Any one or a few in green pepper element, lauryl sodium sulfate and hydroxybenzoate.
11. purposes according to claim 10, which is characterized in that when sensitive detection agent is Phenoxyethanol, the facial mask
Facial mask liquid in the weight percent of Phenoxyethanol that contains be 0.01~1.0%；Or, when sensitive detection agent is lactic acid, institute
The weight percent for stating the lactic acid contained in the facial mask liquid of facial mask is 4.0~6.0%；Or, when sensitive detection agent is capsaicine,
The weight percent of the capsaicine contained in the facial mask liquid of the facial mask is 0.01~0.03%；Or, when sensitive detection agent is ten
When dialkyl sulfonates, the weight percent of the dodecyl sodium sulfate contained in the facial mask liquid of the facial mask is 5.0~
8.0%；Or, when sensitive detection agent is hydroxybenzoate, the hydroxybenzoate that contains in the facial mask liquid of the facial mask
Weight percent is 0.1~0.3%.
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| PCT/CN2020/085326 WO2021000631A1 (en) | 2019-03-15 | 2020-04-17 | Evaluation method for allergy-soothing substance for cosmetics |
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| WO2021000631A1 (en) * | 2019-03-15 | 2021-01-07 | 上海中翊日化有限公司 | Evaluation method for allergy-soothing substance for cosmetics |
| CN113203835A (en) * | 2021-04-30 | 2021-08-03 | 广州山海生物科技有限公司 | Method for evaluating soothing effect of cosmetic raw material |
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| CN113702586A (en) * | 2021-08-26 | 2021-11-26 | 广州美域医学检验有限公司 | Cosmetic soothing and repairing test method and application thereof |
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| 中国香料香精化妆品工业协会编译: "《1999化妆品成分评审概要》", 30 April 2000, 中国轻工业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021000631A1 (en) * | 2019-03-15 | 2021-01-07 | 上海中翊日化有限公司 | Evaluation method for allergy-soothing substance for cosmetics |
| CN113203835A (en) * | 2021-04-30 | 2021-08-03 | 广州山海生物科技有限公司 | Method for evaluating soothing effect of cosmetic raw material |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109953746A (en) | 2019-07-02 |
| WO2021000631A1 (en) | 2021-01-07 |
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