CN110302394A - 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 - Google Patents
药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 Download PDFInfo
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- CN110302394A CN110302394A CN201910638349.0A CN201910638349A CN110302394A CN 110302394 A CN110302394 A CN 110302394A CN 201910638349 A CN201910638349 A CN 201910638349A CN 110302394 A CN110302394 A CN 110302394A
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-242347 | 2013-11-22 | ||
| JP2013242347 | 2013-11-22 | ||
| JP2014-096935 | 2014-05-08 | ||
| JP2014096935 | 2014-05-08 | ||
| CN201480063806.3A CN105899192B (zh) | 2013-11-22 | 2014-11-21 | 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480063806.3A Division CN105899192B (zh) | 2013-11-22 | 2014-11-21 | 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110302394A true CN110302394A (zh) | 2019-10-08 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910638349.0A Pending CN110302394A (zh) | 2013-11-22 | 2014-11-21 | 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 |
| CN201480063806.3A Expired - Fee Related CN105899192B (zh) | 2013-11-22 | 2014-11-21 | 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480063806.3A Expired - Fee Related CN105899192B (zh) | 2013-11-22 | 2014-11-21 | 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9937263B2 (enExample) |
| EP (1) | EP3072506B1 (enExample) |
| JP (3) | JP6086566B2 (enExample) |
| CN (2) | CN110302394A (enExample) |
| CA (1) | CA2931056C (enExample) |
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| CN110302394A (zh) * | 2013-11-22 | 2019-10-08 | 国立大学法人东京大学 | 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 |
| JP6797415B2 (ja) * | 2015-07-02 | 2020-12-09 | 国立大学法人 東京大学 | 薬剤送達用キャリア及びこれを含む組成物 |
| WO2018025657A1 (ja) * | 2016-07-30 | 2018-02-08 | 日本化薬株式会社 | 新規な高分子誘導体、及びそれらを用いた新規な高分子誘導体イメージングプローブ |
| US11433089B2 (en) * | 2016-09-23 | 2022-09-06 | National University Corporation Tokyo Medical And Dental University | Blood-brain barrier permeable heteroduplex nucleic acid |
| EP3564375A4 (en) * | 2016-12-27 | 2020-12-16 | The University Of Tokyo | ARNM FUNCTIONALIZATION PROCESS |
| WO2018207864A1 (ja) * | 2017-05-11 | 2018-11-15 | 公益財団法人川崎市産業振興財団 | 脳への薬剤送達用のキャリアおよびこれを含んでなる組成物 |
| JPWO2019009434A1 (ja) * | 2017-07-06 | 2020-07-02 | 学校法人京都薬科大学 | 薬物送達用高分子ミセル |
| JP2019069933A (ja) | 2017-10-05 | 2019-05-09 | 公益財団法人川崎市産業振興財団 | 体内における薬物動態を制御する組成物 |
| JP7333079B2 (ja) | 2018-03-19 | 2023-08-24 | 国立大学法人 東京医科歯科大学 | 毒性が軽減した核酸 |
| US20210346290A1 (en) * | 2018-06-13 | 2021-11-11 | Kawasaki Institute Of Industrial Promotion | POLYION COMPLEX MICELLE THAT INCLUDES ANTISENSE OLIGONUCLEOTIDE AND BLOCK COPOLYMER OF PEG BLOCK AND CATIONIC POLYMER, SAID BLOCK COPOLYMER HAVING NUMBER-AVERAGE MOLECULAR WEIGHT OF 3-10 kDa |
| WO2020116635A1 (ja) * | 2018-12-07 | 2020-06-11 | 国立大学法人 東京大学 | 輸送担体を用いた環状化合物の送達 |
| JP7600101B2 (ja) | 2019-04-26 | 2024-12-16 | 公益財団法人川崎市産業振興財団 | 抗体の抗原結合性断片を脳へ送達するための方法および組成物 |
| WO2020230793A1 (ja) * | 2019-05-13 | 2020-11-19 | 国立大学法人東京大学 | 血中からの中空ナノ粒子の脳への移行制御技術 |
| US12433956B2 (en) * | 2020-03-26 | 2025-10-07 | Kawasaki Institute Of Industrial Promotion | Method of administering a nanoparticle |
| WO2021207382A1 (en) * | 2020-04-08 | 2021-10-14 | The Johns Hopkins University | D-glucose and its analogs as tracers to assess the glucose transporter function |
| EP4342497A1 (en) | 2021-05-10 | 2024-03-27 | Kawasaki Institute of Industrial Promotion | Antibody having reduced binding affinity for antigen |
| EP4404976A1 (en) * | 2021-09-25 | 2024-07-31 | Nutaria Ltd. | Targeted encapsulation strategies for treatment modalities |
| JPWO2023210233A1 (enExample) * | 2022-04-27 | 2023-11-02 | ||
| WO2025221757A1 (en) * | 2024-04-15 | 2025-10-23 | Board Of Regents, The University Of Texas System | Carbohydrate-polymer conjugates for tunable protein binding on the blood brain barrier and methods of use |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050170394A1 (en) * | 2004-01-30 | 2005-08-04 | Xenoport, Inc. | GLUT1 transporters expressed in blood brain barrier cells |
| EP2382994A1 (en) * | 2010-04-26 | 2011-11-02 | Maurizio Victor Cattaneo | Ligand targeted nanocapsules for the delivery of RNAi and other agents |
Family Cites Families (5)
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| CA2632828C (en) | 2005-12-12 | 2012-07-10 | F. Hoffmann-La Roche Ag | Antibodies against amyloid beta with glycosylation in the variable region |
| JP2011506432A (ja) * | 2007-12-10 | 2011-03-03 | エピターゲット・アーエス | 非ラメラ形成脂質を含む音響感受性薬物送達粒子 |
| UA104742C2 (uk) * | 2008-12-19 | 2014-03-11 | Эли Лилли Энд Компани | Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази |
| EP3417934B1 (en) * | 2010-05-21 | 2023-12-27 | Japan Science And Technology Agency | Substance-encapsulating vesicle and process for producing the same |
| CN110302394A (zh) * | 2013-11-22 | 2019-10-08 | 国立大学法人东京大学 | 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050170394A1 (en) * | 2004-01-30 | 2005-08-04 | Xenoport, Inc. | GLUT1 transporters expressed in blood brain barrier cells |
| EP2382994A1 (en) * | 2010-04-26 | 2011-11-02 | Maurizio Victor Cattaneo | Ligand targeted nanocapsules for the delivery of RNAi and other agents |
Non-Patent Citations (1)
| Title |
|---|
| FULAN XIE, ET AL.: "Investigation of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers for brain targeting", 《INTERNATIONAL JOURNAL OF NANOMEDICINE》 * |
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| WO2015075942A1 (ja) | 2015-05-28 |
| CN105899192A (zh) | 2016-08-24 |
| US20160287714A1 (en) | 2016-10-06 |
| CA2931056C (en) | 2023-02-28 |
| US9937263B2 (en) | 2018-04-10 |
| JP2019194220A (ja) | 2019-11-07 |
| EP3072506A1 (en) | 2016-09-28 |
| CN105899192B (zh) | 2019-08-13 |
| EP3072506B1 (en) | 2022-04-20 |
| JP2017105802A (ja) | 2017-06-15 |
| JP6086566B2 (ja) | 2017-03-01 |
| EP3072506A4 (en) | 2017-10-11 |
| JP6782415B2 (ja) | 2020-11-11 |
| CA2931056A1 (en) | 2015-05-28 |
| JPWO2015075942A1 (ja) | 2017-03-16 |
| US10912838B2 (en) | 2021-02-09 |
| US20180185501A1 (en) | 2018-07-05 |
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