CN110300755B - 茚满基氨基氮杂二氢苯并呋喃乙酸、用于治疗糖尿病的药物组合物 - Google Patents

茚满基氨基氮杂二氢苯并呋喃乙酸、用于治疗糖尿病的药物组合物 Download PDF

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CN110300755B
CN110300755B CN201880010175.7A CN201880010175A CN110300755B CN 110300755 B CN110300755 B CN 110300755B CN 201880010175 A CN201880010175 A CN 201880010175A CN 110300755 B CN110300755 B CN 110300755B
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dimethyl
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CN110300755A (zh
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M·埃克哈特
H·瓦格纳
S·彼得斯
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Boehringer Ingelheim International GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880010175.7A 2017-02-08 2018-02-02 茚满基氨基氮杂二氢苯并呋喃乙酸、用于治疗糖尿病的药物组合物 Active CN110300755B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17155191.4 2017-02-08
EP17155191 2017-02-08
PCT/EP2018/052620 WO2018146008A1 (en) 2017-02-08 2018-02-02 Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes

Publications (2)

Publication Number Publication Date
CN110300755A CN110300755A (zh) 2019-10-01
CN110300755B true CN110300755B (zh) 2022-10-04

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Country Status (5)

Country Link
US (1) US10550127B1 (enExample)
EP (1) EP3580222B1 (enExample)
JP (1) JP7049353B2 (enExample)
CN (1) CN110300755B (enExample)
WO (1) WO2018146008A1 (enExample)

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US10603317B2 (en) 2017-01-26 2020-03-31 Boehringer Ingelheim International Gmbh Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
CN110248929B (zh) 2017-01-26 2023-05-12 勃林格殷格翰国际有限公司 苄基氨基吡嗪基环丙烷甲酸、其药物组合物和用途
US10913720B2 (en) 2017-01-26 2021-02-09 Boehringer Ingelheim International Gmbh Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
CN110300755B (zh) 2017-02-08 2022-10-04 勃林格殷格翰国际有限公司 茚满基氨基氮杂二氢苯并呋喃乙酸、用于治疗糖尿病的药物组合物
CN111712494A (zh) 2018-02-13 2020-09-25 吉利德科学公司 Pd-1/pd-l1抑制剂
US12083118B2 (en) 2018-03-29 2024-09-10 Arbutus Biopharma Corporation Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same
EP4600247A3 (en) 2018-04-19 2025-11-19 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR20230159715A (ko) 2018-07-13 2023-11-21 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
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WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists
BR112022017039A2 (pt) 2020-02-28 2022-11-16 Kallyope Inc Agonistas de gpr40
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂

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Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010143733A1 (en) * 2009-06-09 2010-12-16 Takeda Pharmaceutical Company Limited Novel fused cyclic compound and use thereof
WO2012072691A1 (en) * 2010-12-01 2012-06-07 Boehringer Ingelheim International Gmbh Indanyloxydihydrobenzofuranylacetic acids
CN104321319A (zh) * 2012-03-26 2015-01-28 勃林格殷格翰国际有限公司 新的茚满基氧基二氢苯并呋喃乙酸衍生物及其用作gpr40 受体激动剂的用途
CN104822675A (zh) * 2012-11-28 2015-08-05 勃林格殷格翰国际有限公司 新的茚满基氧基二氢苯并呋喃乙酸
WO2015078802A1 (en) * 2013-11-28 2015-06-04 Boehringer Ingelheim International Gmbh New indanyloxyphenylcyclopropanecarboxylic acids
CN105001212A (zh) * 2014-04-16 2015-10-28 江苏柯菲平医药股份有限公司 稠环化合物及其制备方法和应用
WO2017042121A1 (en) * 2015-09-09 2017-03-16 Boehringer Ingelheim International Gmbh [{[2,3-dihydro-1h-inden-1-yl]amino}-2h,3h-furo[3,2-b]pyridin-3-yl]acetic acids, pharmaceutical compositions and uses thereof

Also Published As

Publication number Publication date
EP3580222B1 (en) 2021-04-07
US20200017515A1 (en) 2020-01-16
JP2020506205A (ja) 2020-02-27
JP7049353B2 (ja) 2022-04-06
CN110300755A (zh) 2019-10-01
WO2018146008A1 (en) 2018-08-16
EP3580222A1 (en) 2019-12-18
US10550127B1 (en) 2020-02-04

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