CN110280200A - A kind of filtering type reaction vessel for Peptide systhesis - Google Patents
A kind of filtering type reaction vessel for Peptide systhesis Download PDFInfo
- Publication number
- CN110280200A CN110280200A CN201910729227.2A CN201910729227A CN110280200A CN 110280200 A CN110280200 A CN 110280200A CN 201910729227 A CN201910729227 A CN 201910729227A CN 110280200 A CN110280200 A CN 110280200A
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- autoclave body
- reaction kettle
- liquid
- filtering
- filter
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 74
- 238000001914 filtration Methods 0.000 title claims abstract description 28
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 41
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000007787 solid Substances 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 9
- 238000004321 preservation Methods 0.000 claims abstract description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 240000007643 Phytolacca americana Species 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 2
- 238000003466 welding Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 229920001184 polypeptide Polymers 0.000 abstract description 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 4
- 238000000034 method Methods 0.000 description 6
- 239000012467 final product Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000011343 solid material Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- 238000004880 explosion Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000013067 intermediate product Substances 0.000 description 2
- 239000011344 liquid material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
- B01D29/03—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements self-supporting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
- B01D35/02—Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0013—Controlling the temperature of the process
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0073—Sealings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00094—Jackets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/0015—Controlling the temperature by thermal insulation means
- B01J2219/00155—Controlling the temperature by thermal insulation means using insulating materials or refractories
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00162—Controlling or regulating processes controlling the pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00182—Controlling or regulating processes controlling the level of reactants in the reactor vessel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The invention discloses a kind of filtering type reaction vessels for Peptide systhesis, including reaction kettle autoclave body, kettle cover, agitating device, filter device, bottom valve, the reaction kettle autoclave body includes inner cylinder, chuck layer, insulating layer, the chuck layer is equipped with inlet and outlet pipeline, and heat preservation material is filled in the insulating layer；The kettle cover is located at the top of reaction kettle autoclave body, the kettle cover is equipped with solid feed inlet, liquid inlet opening, nitrogen mouth, liquid level mouth, thermometer wrap nozzle, hand hole, visor hole, relief valve port, stirring port, charging device is circumscribed on the solid feed inlet, the liquid inlet opening and nitrogen mouth are respectively connected with pipeline, it is circumscribed with liquidometer on the liquid level mouth, is circumscribed with thermometer on the thermometer wrap nozzle.The polypeptides reactive container of this programme has the function of reaction kettle and filtering function simultaneously, and function is more perfect, high degree of automation, and easy to operate, furthermore its production process is safer, more environmentally friendly.
Description
Technical field
The present invention relates to polypeptide preparation technical field more particularly to a kind of filtering type reaction vessels for Peptide systhesis.
Background technique
Reaction kettle is widely used in the industries such as petroleum, chemical industry, rubber, pesticide, dyestuff, medicine, food, is to be mainly used to
At the consersion unit of the chemical enginnering process such as vulcanization, nitrification, hydrogenation, polymerization, condensation；Reaction kettle structure is generally by autoclave body, transmission
The composition such as device, agitating device, heating device, cooling device, sealing device；In polypeptide production process, reaction needs multistep
It completes, intermediate product and final product are solidliquid mixture, need to be repeated reaction, separation of solid and liquid and washing.
Existing equipment configuration is that glassware reaction kettle adds filter, and intermediate product and final product are needed by filter
It is separated by solid-liquid separation, solid product transports back reaction kettle by manually taking out after separation, then is washed, reacted, filtered, repeatedly anti-
Multiple operation, existing equipment configuration have the disadvantage in that
1, the laboratory glassware stage is rested on, equipment maximum volume is limited, is not suitable for industrialized production；
2, reaction kettle and filter process can not be completed in closed equipment or pipeline, artificial direct contacting material, uneasy
Entirely；
3, solids exit needs to open filter plant, and residual solvent understands uncontrollable discharge, not environmentally；
4, large labor intensity, can not accomplish automated production, and utilization rate of equipment and installations is low.
Therefore it needs to improve existing equipment.
Summary of the invention
The purpose of the present invention is to solve disadvantage existing in the prior art, and propose a kind of for Peptide systhesis
Filtering type reaction vessel.
To achieve the goals above, present invention employs following technical solutions:
A kind of filtering type reaction vessel for Peptide systhesis, including reaction kettle autoclave body, kettle cover, agitating device, filtering dress
It sets, bottom valve, the reaction kettle autoclave body includes inner cylinder, chuck layer, insulating layer, and the chuck layer is equipped with inlet and outlet pipeline, the guarantor
Filled with heat preservation material in warm layer；
The kettle cover is located at the top of reaction kettle autoclave body, and the kettle cover is equipped with solid feed inlet, liquid inlet opening, nitrogen
Mouth, liquid level mouth, thermometer wrap nozzle, hand hole, visor hole, relief valve port, stirring port are circumscribed on the solid feed inlet and feed intake
Device, the liquid inlet opening and nitrogen mouth are respectively connected with pipeline, and liquidometer, the thermometer wrap are circumscribed on the liquid level mouth
Thermometer is circumscribed on nozzle；
The agitating device includes agitating shaft, stirring blade, mechanical seal, decelerating motor, and the agitating shaft passes through kettle cover
On poke hole be passed through in reaction kettle autoclave body, the stirring blade use bipolar blade, the mechanical seal use packaging type machine
Tool band bearing and collecting tank, the decelerating motor use frequency conversion explosion proof motor, and the agitating device is fixed by mounting plate
In on kettle cover；
The filter device is located at the bottom of reaction kettle autoclave body, and the filter device includes filter plate, connects liquid plate, goes out liquid
Mouthful, the filter plate includes outer press ring in filter screen, filter screen and filtering sieve bottom support frame, and the liquid plate that connects is located at filtering
The lower section of plate, the liquid outlet, which is located at, to be connect on the bottom wall of liquid plate；
The bottom valve is located at the center position of filter device bottom, and the bottom valve includes spool, fixed valve base, valve body peace
Fill seat, spool fixed ring, seal joint, discharge port, valve body, cylinder block, cylinder frame, cylinder.
Preferably, the side of the reaction kettle autoclave body is equipped with observation visor.
Preferably, the reaction kettle autoclave body is equipped with Butterworth Hatch.
Preferably, the cylinder selects stainless steel circular cylinder.
Preferably, the filter screen uses the stainless steel mesh grid of 48 μ of precision, in the filter screen and filter screen external pressure with
And filtering sieve bottom support frame is welded as a whole.
Preferably, the filter plate is fixed on reaction kettle autoclave body by upper lower flange.
Compared with the prior art, the beneficial effects of the present invention are:
1, perfect in shape and function；This reaction kettle not only has the function of reaction kettle, but also has filtering function, it can be achieved that reaction, washing, mistake
The operation repeatedly of filter, it is not necessary that the auxiliary devices such as filter are separately configured；
2, high degree of automation；This reaction kettle compared with prior art, can be discharged by pneumatically upper exhibition valve control, in conjunction with
TCU temperature control system and nitrogen envelope, exhaust system, additionally it is possible to the key parameters such as A.T.C, pressure, easy to operate, intelligence
Degree height can be changed；
3, safe and environment-friendly reliable；This reaction kettle is made of metal or enamel material, is equipped with pressure-regulating valve, can be automatic
Reacting kettle inner pressure is controlled, securely and reliably；All reaction process are completed in closed equipment and pipeline, and operator is without connecing
Material is touched, production process is safer, more environmentally friendly.
In conclusion the polypeptides reactive container of this programme has the function of reaction kettle and filtering function simultaneously, function is more complete
Kind, high degree of automation is easy to operate, and furthermore its production process is safer, more environmentally friendly.
Detailed description of the invention
Fig. 1 is a kind of reaction kettle autoclave body front view of the filtering type reaction vessel for Peptide systhesis proposed by the present invention；
Fig. 2 is a kind of reaction kettle autoclave body cross-sectional view of the filtering type reaction vessel for Peptide systhesis proposed by the present invention；
Fig. 3 is the structural schematic diagram of bottom valve in the present invention.
In figure: 1 reaction kettle autoclave body, 2 kettle covers, 3 agitating devices, 4 filter devices, 5 bottom valves, 6 inner cylinders, 7 chuck layers, 8 heat preservations
Layer, 9 solid feed inlets, 10 liquid level mouths, 11 thermometer wrap nozzles, 12 agitating shafts, 13 stirring blades, 14 mechanical seals, 15 are slowed down
Motor, 16 filter plates, 17 connect liquid plate, 18 liquid outlets, 19 spools, 20 fixed valve bases, 21 valve body mounting bases, 22 spool fixed rings,
23 seal joints, 24 discharge ports, 25 valve bodies, 26 cylinder blocks, 27 cylinder frames, 28 cylinders.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
In the description of the present invention, it is to be understood that, term " on ", "lower", "front", "rear", "left", "right", "top",
The orientation or positional relationship of the instructions such as "bottom", "inner", "outside" is to be based on the orientation or positional relationship shown in the drawings, merely to just
In description the present invention and simplify description, rather than the device or element of indication or suggestion meaning must have a particular orientation, with
Specific orientation construction and operation, therefore be not considered as limiting the invention.
Referring to Fig.1-3, a kind of filtering type reaction vessel for Peptide systhesis, including reaction kettle autoclave body 1, kettle cover 2, stirring
Device 3, filter device 4, bottom valve 5, which is characterized in that reaction kettle autoclave body 1 includes inner cylinder 6, chuck layer 7, insulating layer 8, chuck layer 7
Equipped with inlet and outlet pipeline, it can be passed through heat-conducting medium, thus realize the function of adjusting reaction kettle temperature in the kettle, filling in insulating layer 8
There is heat preservation material.
Kettle cover 2 is located at the top of reaction kettle autoclave body 1, kettle cover 2 be equipped with solid feed inlet 9, liquid inlet opening, nitrogen mouth,
Liquid level mouth 10, thermometer wrap nozzle, hand hole, visor hole, relief valve port, stirring port are circumscribed with the dress that feeds intake on solid feed inlet 9
It sets, for putting into solid material, liquid inlet opening and nitrogen mouth are respectively connected with pipeline, and liquidometer is circumscribed on liquid level mouth 10, use
Level condition in measurement kettle, and feed back in system, it is circumscribed with thermometer on thermometer wrap nozzle 11, for measuring in kettle
The temperature of object, hand hole has booster for cleaning autoclave body, and convenient for operation, visor hole is for illuminating and observing in kettle
Response situation.
Agitating device 3 includes agitating shaft 12, stirring blade 13, mechanical seal 14, decelerating motor 15, and agitating shaft 12 passes through kettle
Poke hole on lid 2 is passed through in reaction kettle autoclave body 1, and stirring blade 13 uses bipolar blade, and mechanical seal 14 uses packaging type machine
Tool band bearing and collecting tank, decelerating motor 15 use frequency conversion explosion proof motor, and agitating device 3 is fixed on kettle cover by mounting plate
On 2.
Filter device 4 is located at the bottom of reaction kettle autoclave body 1, and filter device 4 includes filter plate 16, connects liquid plate 17, liquid outlet
18, filter plate 16 includes outer press ring in filter screen, filter screen and filtering sieve bottom support frame, connects liquid plate 17 and is located at filter plate 16
Lower section, liquid outlet 18, which is located at, to be connect on the bottom wall of liquid plate 17, for by filtered liquid guide flow to liquid outlet 18.
Bottom valve 5 is located at the center position of 4 bottom of filter device, and bottom valve 5 includes spool 19, fixed valve base 20, valve body peace
Seat 21, spool fixed ring 22, seal joint 23, discharge port 24, valve body 25, cylinder block 26, gas frame 27, cylinder 28 are filled, gas is passed through
Cylinder 28 carries out folding control to bottom valve 55.
The side of reaction kettle autoclave body 1 is equipped with observation visor, convenient for the response situation and liquid in observing response kettle autoclave body 1 at any time
Position situation, the case where grasping entire reaction process in time convenient for operator.
Reaction kettle autoclave body 1 is equipped with Butterworth Hatch, can carry out on-line cleaning to reaction kettle autoclave body 1.
Cylinder 28 selects stainless steel circular cylinder.
Filter screen uses the stainless steel mesh grid of 48 μ of precision, external pressure and filtering sieve bottom branch in filter screen and filter screen
Support is welded as a whole.
Filter plate 16 is fixed on reaction kettle autoclave body 1 by upper lower flange.
The working principle of the invention is: liquid material enters reaction kettle autoclave body 1 by pipeline, starts decelerating motor 15, stirs
It mixes start-up operation, solid is added by glove box in whipping process or liquid is added dropwise, start to react, when reaction passes through outside
TCU controls the temperature of reaction kettle autoclave body 1, and after reaction, liquid material is discharged by liquid outlet 18, and solid material can be trapped in
On filter plate 16, as needed, solvents upon solids material is added and is washed, or secondary response again, final product is to be filtered to be finished
Afterwards, bottom valve 5 is opened, solid material is closed to be transferred in container, into next process.
It is equipped with blow-down pipe and vacuum tube at the top of reaction kettle autoclave body 1, can control the pressure of reaction kettle autoclave body 1 by regulating valve
Power, reaction kettle autoclave body 1 are equipped with nitrogen pipeline, and the nitrogen amount in reaction kettle autoclave body 1 is entered by nitrogen adjustment valve control.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. a kind of filtering type reaction vessel for Peptide systhesis, including reaction kettle autoclave body (1), kettle cover (2), agitating device (3),
Filter device (4), bottom valve (5), which is characterized in that the reaction kettle autoclave body (1) includes inner cylinder (6), chuck layer (7), insulating layer
(8), the chuck layer (7) is equipped with inlet and outlet pipeline, and heat preservation material is filled in the insulating layer (8)；
The kettle cover (2) is located at the top of reaction kettle autoclave body (1), the kettle cover (2) be equipped with solid feed inlet (9), liquid into
Material mouth, nitrogen mouth, liquid level mouth (10), thermometer wrap nozzle, hand hole, visor hole, relief valve port, stirring port, the solid charging
It is circumscribed with charging device on mouthful (9), the liquid inlet opening and nitrogen mouth are respectively connected with pipeline, external on the liquid level mouth (10)
There is liquidometer, is circumscribed with thermometer on the thermometer wrap nozzle (11)；
The agitating device (3) includes agitating shaft (12), stirring blade (13), mechanical seal (14), decelerating motor (15), described
Agitating shaft (12) is passed through in reaction kettle autoclave body (1) by the poke hole on kettle cover (2), and the stirring blade (13) uses bipolar leaf
Piece, the mechanical seal (14) use frequency conversion using integrated mechanical sealing band bearing and collecting tank, the decelerating motor (15)
Fire-proof motor, the agitating device (3) are fixed on kettle cover (2) by mounting plate；
The filter device (4) is located at the bottom of reaction kettle autoclave body (1), and the filter device (4) includes filter plate (16), connects liquid
Plate (17), liquid outlet (18), the filter plate (16) include outer press ring in filter screen, filter screen and filtering sieve bottom support
Frame, the lower section for connecing liquid plate (17) and being located at filter plate (16), the liquid outlet (18), which is located at, to be connect on the bottom wall of liquid plate (17)；
The bottom valve (5) is located at the center position of filter device (4) bottom, and the bottom valve (5) includes spool (19), fixed valve
Seat (20), valve body mounting base (21), spool fixed ring (22), seal joint (23), discharge port (24), valve body (25), cylinder block
(26), cylinder frame (27), cylinder (28).
2. a kind of filtering type reaction vessel for Peptide systhesis according to claim 1, which is characterized in that the reaction
The side of kettle autoclave body (1) is equipped with observation visor.
3. a kind of filtering type reaction vessel for Peptide systhesis according to claim 1, which is characterized in that the reaction
Kettle autoclave body (1) is equipped with Butterworth Hatch.
4. a kind of filtering type reaction vessel for Peptide systhesis according to claim 1, which is characterized in that the cylinder
(28) stainless steel circular cylinder is selected.
5. a kind of filtering type reaction vessel for Peptide systhesis according to claim 1, which is characterized in that the filtering
Net uses the stainless steel mesh grid of 48 μ of precision, external pressure and filtering sieve bottom support frame welding in the filter screen and filter screen
It is integrated.
6. a kind of filtering type reaction vessel for Peptide systhesis according to claim 1, which is characterized in that the filtering
Plate (16) is fixed on reaction kettle autoclave body (1) by upper lower flange.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910729227.2A CN110280200A (en) | 2019-08-08 | 2019-08-08 | A kind of filtering type reaction vessel for Peptide systhesis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910729227.2A CN110280200A (en) | 2019-08-08 | 2019-08-08 | A kind of filtering type reaction vessel for Peptide systhesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110280200A true CN110280200A (en) | 2019-09-27 |
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ID=68025007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910729227.2A Pending CN110280200A (en) | 2019-08-08 | 2019-08-08 | A kind of filtering type reaction vessel for Peptide systhesis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112028973A (en) * | 2020-08-06 | 2020-12-04 | 山东辰龙药业有限公司 | Resin-carbetocin cracking device |
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| CN202951321U (en) * | 2012-12-05 | 2013-05-29 | 陈建伟 | Automatic vacuum feeding, washing discharging, vacuum filtering and washing device |
| CN104948816A (en) * | 2015-06-29 | 2015-09-30 | 洛阳栾川钼业集团股份有限公司 | Electromagnetic pneumatic valve |
| CN205833148U (en) * | 2016-06-03 | 2016-12-28 | 江西邦浦医药化工有限公司 | A kind of filter pressing reactor |
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