CN210385857U

CN210385857U - Filtering type reaction vessel for polypeptide synthesis

Info

Publication number: CN210385857U
Application number: CN201921285193.4U
Authority: CN
Inventors: 向兵; 张燕霞; 王波; 陈志华
Original assignee: Shanghai Youyin Chemical Technology Co ltd
Current assignee: Shanghai Youyin Chemical Technology Co ltd
Priority date: 2019-08-08
Filing date: 2019-08-08
Publication date: 2020-04-24
Anticipated expiration: 2029-08-08

Abstract

The utility model discloses a filtering type reaction vessel for polypeptide synthesis, which comprises a reaction kettle body, a kettle cover, a stirring device, a filtering device and a bottom valve, wherein the reaction kettle body comprises an inner cylinder, a jacket layer and a heat preservation layer, the jacket layer is provided with an inlet and outlet pipeline, and the heat preservation layer is filled with heat preservation materials; the kettle cover is located above the kettle body of the reaction kettle, the kettle cover is provided with a solid feed inlet, a liquid feed inlet, a nitrogen port, a liquid level port, a thermometer sleeve port, a hand hole, a sight glass hole, a safety valve port and a stirring port, the solid feed inlet is externally connected with a feeding device, the liquid feed inlet and the nitrogen port are both connected with pipelines, the liquid level port is externally connected with a liquid level meter, and the thermometer sleeve port is externally connected with a thermometer. The polypeptide reaction vessel of this scheme has reation kettle function and filtering capability simultaneously, and the function is comparatively perfect, and its degree of automation is high, and is easy and simple to handle, and its production process is safer, more environmental protection in addition.

Description

Filtering type reaction vessel for polypeptide synthesis

Technical Field

The utility model relates to a polypeptide preparation technical field especially relates to a filtration formula reaction vessel for polypeptide synthesis.

Background

The reaction kettle is widely applied to industries such as petroleum, chemical industry, rubber, pesticide, dye, medicine, food and the like, and is reaction equipment mainly used for completing chemical process procedures such as vulcanization, nitration, hydrogenation, polymerization, condensation and the like; the reaction kettle structure generally comprises a kettle body, a transmission device, a stirring device, a heating device, a cooling device, a sealing device and the like; in the production process of the polypeptide, the reaction needs to be completed in multiple steps, the intermediate product and the final product are both solid-liquid mixtures, and the reaction, solid-liquid separation and washing need to be repeatedly carried out.

The existing equipment configuration is that a glass vessel reaction kettle is added with a filter, an intermediate product and a final product need to be subjected to solid-liquid separation through the filter, the separated solid product is taken out manually and transferred back to the reaction kettle, and then washing, reaction and filtration are carried out, repeated operation is carried out for many times, and the existing equipment configuration has the following defects:

1. staying in a laboratory glassware stage, the maximum volume of equipment is limited, and the equipment is not suitable for industrial production;

2. the reaction kettle and the filtering process cannot be finished in closed equipment or pipelines, and the materials are in direct contact with manpower, so that the method is unsafe;

3. solid discharging requires starting filtering equipment, and residual solvent can be discharged in an unorganized manner, so that the method is not environment-friendly;

4. the labor intensity is high, the automatic production cannot be realized, and the equipment utilization rate is low.

There is therefore a need for improvements to existing equipment.

SUMMERY OF THE UTILITY MODEL

The utility model aims at solving the defects in the prior art and providing a filtering type reaction vessel for polypeptide synthesis.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

a filtering type reaction vessel for polypeptide synthesis comprises a reaction kettle body, a kettle cover, a stirring device, a filtering device and a bottom valve, wherein the reaction kettle body comprises an inner cylinder, a jacket layer and a heat insulation layer, the jacket layer is provided with an inlet and outlet pipeline, and the heat insulation layer is filled with heat insulation materials;

the kettle cover is positioned above the kettle body of the reaction kettle, a solid feed inlet, a liquid feed inlet, a nitrogen port, a liquid level port, a thermometer sleeve port, a hand hole, a sight glass hole, a safety valve port and a stirring port are arranged on the kettle cover, a feeding device is externally connected to the solid feed inlet, the liquid feed inlet and the nitrogen port are both connected with pipelines, a liquid level meter is externally connected to the liquid level port, and a thermometer is externally connected to the thermometer sleeve port;

the stirring device comprises a stirring shaft, stirring blades, a mechanical seal and a speed reduction motor, wherein the stirring shaft is introduced into the reaction kettle body through a stirring hole on the kettle cover, the stirring blades adopt bipolar blades, the mechanical seal adopts a container type mechanical seal belt bearing and a liquid collecting tank, the speed reduction motor adopts a variable frequency explosion-proof motor, and the stirring device is fixed on the kettle cover through a mounting plate;

the filtering device is positioned at the bottom of the reaction kettle body and comprises a filtering plate, a liquid receiving plate and a liquid outlet, wherein the filtering plate comprises a filtering net, an inner and outer annular ring in the filtering net and a supporting frame at the bottom of the filtering net;

the bottom valve is located at the positive center of the bottom of the filtering device and comprises a valve core, a fixed valve seat, a valve body mounting seat, a valve core fixing ring, a sealing pressure ring, a discharge hole, a valve body, a cylinder seat, a cylinder frame and a cylinder.

Preferably, an observation sight glass is arranged on the side of the reaction kettle body.

Preferably, the reaction kettle body is provided with a cleaning port.

Preferably, the cylinder is a stainless steel circular cylinder.

Preferably, the filter screen is a stainless steel woven mesh with the precision of 48 mu, and the filter screen and the inner and outer pressure of the filter screen and the support frame at the bottom of the filter screen are welded into a whole.

Preferably, the filter plate is fixed on the reaction kettle body through an upper flange and a lower flange.

Compared with the prior art, the beneficial effects of the utility model reside in that:

1. the functions are complete; the reaction kettle has the functions of a reaction kettle and a filter, can realize repeated operation of reaction, washing and filtering, and does not need to be provided with auxiliary equipment such as a filter and the like independently;

2. the automation degree is high; compared with the prior art, the reaction kettle can control discharging through a pneumatic upward expansion valve, can automatically control key parameters such as temperature, pressure and the like by combining a TCU temperature control system and a nitrogen seal and tail gas system, and is simple and convenient to operate and high in intelligent degree;

3. the method is safe, environment-friendly and reliable; the reaction kettle is made of metal or enamel materials, and is provided with the pressure regulating valve, so that the pressure in the reaction kettle can be automatically controlled, and the reaction kettle is safe and reliable; all reaction processes are completed in closed equipment and pipelines, operators do not need to contact materials, and the production process is safer and more environment-friendly.

To sum up, the polypeptide reaction vessel of this scheme has reation kettle function and filtering capability simultaneously, and the function is comparatively perfect, and its degree of automation is high, and is easy and simple to handle, and its production process is safer, more environmental protection in addition.

Drawings

FIG. 1 is a front view of a reaction kettle body of a filtering reaction vessel for polypeptide synthesis according to the present invention;

FIG. 2 is a sectional view of a reaction kettle body of a filtering reaction vessel for polypeptide synthesis according to the present invention;

fig. 3 is a schematic structural diagram of the middle bottom valve of the present invention.

In the figure: 1 reaction kettle body, 2 kettle covers, 3 agitating units, 4 filtering devices, 5 bottom valves, 6 inner cylinders, 7 jacket layers, 8 heat preservation layers, 9 solid feed inlets, 10 liquid level ports, 11 thermometer sleeve ports, 12 stirring shafts, 13 stirring blades, 14 mechanical seals, 15 speed reduction motors, 16 filter plates, 17 liquid receiving plates, 18 liquid outlets, 19 valve cores, 20 fixed valve seats, 21 valve body installation seats, 22 valve core fixed rings, 23 sealed pressure rings, 24 discharge ports, 25 valve bodies, 26 cylinder seats, 27 cylinder frames and 28 cylinders.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

Referring to fig. 1-3, a filtration formula reaction vessel for polypeptide synthesis, includes the reation kettle cauldron body 1, kettle cover 2, agitating unit 3, filter equipment 4, bottom valve 5, its characterized in that, reation kettle cauldron body 1 includes inner tube 6, presss from both sides jacket layer 7, heat preservation 8, and jacket layer 7 is equipped with the import and export pipeline, can let in heat-conducting medium to realize the function of adjusting the temperature in the reation kettle cauldron, and heat preservation 8 intussuseption is filled with the heat preservation material.

Kettle cover 2 is located the top of the reation kettle cauldron body 1, be equipped with solid charge door 9 on kettle cover 2, liquid feed inlet, the nitrogen gas mouth, liquid level mouth 10, thermometer sleeve pipe mouth, the hand hole, the sight glass hole, the safety valve mouth, the stirring mouth, it has the feeding device to connect outward on the solid charge door 9, be used for throwing into solid material, liquid feed inlet and nitrogen gas mouth all are connected with the pipeline, it has the level gauge to connect outward on the liquid level mouth 10, be used for measuring the liquid level condition in the cauldron, and feed back to in the system, it has the thermometer to connect outward on thermometer sleeve pipe mouth 11, be used for measuring the temperature of the internal object of cauldron, the hand hole is used for cleaning the cauldron body, and have the booster, the operation of being convenient for, the sight glass hole is used.

Agitating unit 3 includes (mixing) shaft 12, stirring vane 13, mechanical seal 14, gear motor 15, and in (mixing) shaft 12 let in the reation kettle cauldron body 1 through the stirring hole on the kettle cover 2, stirring vane 13 adopted bipolar blade, and mechanical seal 14 adopts cartridge type mechanical seal area bearing and collecting tank, and gear motor 15 adopts frequency conversion explosion proof machine, and agitating unit 3 is fixed in on the kettle cover 2 through the mounting panel.

Filter equipment 4 is located the bottom of reation kettle cauldron body 1, and filter equipment 4 includes filter 16, connects liquid board 17, liquid outlet 18, and filter 16 contains filter screen, filter screen internal and external pressure ring and filter screen bottom sprag frame, connects liquid board 17 to be located the below of filter 16, and liquid outlet 18 is located the diapire that connects liquid board 17 for liquid water conservancy diversion to liquid outlet 18 after will filtering.

The bottom valve 5 is located at the right center of the bottom of the filtering device 4, the bottom valve 5 comprises a valve core 19, a fixed valve seat 20, a valve body installation seat 21, a valve core fixing ring 22, a sealing press ring 23, a discharge hole 24, a valve body 25, a cylinder seat 26, an air frame 27 and a cylinder 28, and the bottom valve 55 is controlled to be opened and closed through the cylinder 28.

The side of the reaction kettle body 1 is provided with an observation sight glass, so that the reaction condition and the liquid level condition in the reaction kettle body 1 can be observed conveniently at any time, and the operator can master the condition of the whole reaction process in time.

The reaction kettle body 1 is provided with a cleaning opening, and the reaction kettle body 1 can be cleaned on line.

The cylinder 28 is a stainless steel circular cylinder.

The filter screen adopts the stainless steel mesh grid of precision 48 mu, and the filter screen is as an organic whole with the internal and external pressure of filter screen and the welding of filter screen bottom support frame.

The filter plate 16 is fixed on the reaction kettle body 1 through an upper flange and a lower flange.

The utility model discloses a theory of operation is: liquid material passes through the pipeline and gets into reation kettle cauldron body 1, start gear motor 15, the stirring begins work, add solid or dropwise add liquid through the glove box among the stirring process, begin the reaction, the temperature through outside TCU control reation kettle cauldron body 1 during reaction, after the reaction, liquid material passes through liquid outlet 18 and discharges, solid material can be held back on filter 16, as required, add the solvent and wash solid material, or react once more, the final product is waited to filter the back that finishes, open bottom valve 5, solid material is airtight to be shifted to in the container, get into next process.

The top of the reaction kettle body 1 is provided with a vent pipe and a vacuum pipe, the pressure of the reaction kettle body 1 can be controlled by the regulating valve, the reaction kettle body 1 is provided with a nitrogen pipeline, and the nitrogen amount entering the reaction kettle body 1 is controlled by the nitrogen regulating valve.

The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.

Claims

1. A filter type reaction vessel for polypeptide synthesis comprises a reaction kettle body (1), a kettle cover (2), a stirring device (3), a filtering device (4) and a bottom valve (5), and is characterized in that the reaction kettle body (1) comprises an inner cylinder (6), a jacket layer (7) and a heat preservation layer (8), wherein the jacket layer (7) is provided with an inlet and outlet pipeline, and the heat preservation layer (8) is filled with heat preservation materials;

the kettle cover (2) is positioned above the kettle body (1) of the reaction kettle, a solid feeding port (9), a liquid feeding port, a nitrogen port, a liquid level port (10), a thermometer sleeve port, a hand hole, a sight glass hole, a safety valve port and a stirring port are arranged on the kettle cover (2), a feeding device is externally connected to the solid feeding port (9), the liquid feeding port and the nitrogen port are both connected with pipelines, a liquid level meter is externally connected to the liquid level port (10), and a thermometer is externally connected to the thermometer sleeve port (11);

the stirring device (3) comprises a stirring shaft (12), stirring blades (13), a mechanical seal (14) and a speed reducing motor (15), wherein the stirring shaft (12) is introduced into the reaction kettle body (1) through a stirring hole on the kettle cover (2), the stirring blades (13) adopt bipolar blades, the mechanical seal (14) adopts a container type mechanical seal belt bearing and a liquid collecting tank, the speed reducing motor (15) adopts a variable frequency explosion-proof motor, and the stirring device (3) is fixed on the kettle cover (2) through a mounting plate;

the filtering device (4) is positioned at the bottom of the reaction kettle body (1), the filtering device (4) comprises a filtering plate (16), a liquid receiving plate (17) and a liquid outlet (18), the filtering plate (16) comprises a filtering net, a filtering net inner and outer ring and a filtering net bottom supporting frame, the liquid receiving plate (17) is positioned below the filtering plate (16), and the liquid outlet (18) is positioned on the bottom wall of the liquid receiving plate (17);

the bottom valve (5) is located at the center of the bottom of the filtering device (4), and the bottom valve (5) comprises a valve core (19), a fixed valve seat (20), a valve body mounting seat (21), a valve core fixing ring (22), a sealing pressing ring (23), a discharging hole (24), a valve body (25), a cylinder seat (26), a cylinder frame (27) and a cylinder (28).

2. The filtering reaction vessel for polypeptide synthesis according to claim 1, wherein an observation sight glass is arranged at the side of the reaction kettle body (1).

3. The filter type reaction vessel for polypeptide synthesis according to claim 1, wherein the reaction kettle body (1) is provided with a cleaning port.

4. The filter-type reaction vessel for polypeptide synthesis according to claim 1, wherein the cylinder (28) is a stainless steel circular cylinder.

5. The filter type reaction vessel for polypeptide synthesis according to claim 1, wherein the filter screen is a stainless steel woven mesh with a precision of 48 μ, and the filter screen is welded with the inner and outer pressure of the filter screen and the support frame at the bottom of the filter screen.

6. The filtration-type reaction vessel for polypeptide synthesis according to claim 1, wherein the filter plate (16) is fixed to the reaction vessel body (1) by upper and lower flanges.