CN210058221U - Solid phase reaction kettle - Google Patents
Solid phase reaction kettle Download PDFInfo
- Publication number
- CN210058221U CN210058221U CN201822096162.6U CN201822096162U CN210058221U CN 210058221 U CN210058221 U CN 210058221U CN 201822096162 U CN201822096162 U CN 201822096162U CN 210058221 U CN210058221 U CN 210058221U
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- kettle
- solid phase
- reaction kettle
- phase reaction
- cover
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- 238000003746 solid phase reaction Methods 0.000 title claims abstract description 25
- 238000006243 chemical reaction Methods 0.000 claims abstract description 33
- 238000003756 stirring Methods 0.000 claims abstract description 24
- 238000007789 sealing Methods 0.000 claims abstract description 9
- 239000011521 glass Substances 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 230000005540 biological transmission Effects 0.000 claims abstract description 5
- 239000000706 filtrate Substances 0.000 claims abstract description 5
- 238000001914 filtration Methods 0.000 claims abstract description 4
- 238000012544 monitoring process Methods 0.000 claims abstract description 4
- 229920001184 polypeptide Polymers 0.000 claims description 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 19
- 238000005070 sampling Methods 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 15
- 239000000523 sample Substances 0.000 claims description 10
- 238000004140 cleaning Methods 0.000 claims description 6
- 238000010532 solid phase synthesis reaction Methods 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 230000002572 peristaltic effect Effects 0.000 claims description 3
- 239000007790 solid phase Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 4
- 230000002349 favourable effect Effects 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000002156 mixing Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000010923 batch production Methods 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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Abstract
The utility model discloses a solid phase reaction kettle, reation kettle includes kettle cover, the cauldron body, lower kettle cover, go up the kettle cover and be dull and stereotyped structure, install the motor, the pivot of motor is passed through transmission and is linked to each other with the stirring rake. The kettle body is internally provided with a stirring paddle, a viewing mirror and a strip-shaped baffle respectively; the sight glass can enable the sight to cover the whole kettle body, so that the condition in the kettle can be observed conveniently; the strip baffle is favorable to preventing the formation of stirring vortex phenomenon, increases the mixed effect, is particularly favorable to the stirring of heterogeneous reaction to mix. The side wall of the kettle body is provided with a heat-insulating jacket, a temperature monitoring port and a feed liquid discharge port. The lower kettle cover is of a flat plate structure and is provided with a filtering sieve plate and a filtrate outlet. The diameter of the filter sieve plate is slightly larger than the inner diameter of the kettle body, and the kettle body, the filter sieve plate and the lower kettle cover are sealed through a T-shaped sealing ring. The lower kettle cover is fixedly connected with the kettle body through a quick-opening flange. The lower kettle cover is provided with a pneumatic or electric push rod, and the lower kettle cover can be automatically lifted and disassembled.
Description
Technical Field
The utility model relates to a solid phase reaction field, in particular to polypeptide solid phase synthesis reation kettle.
Background
In the field of polypeptide solid phase synthesis, glass reaction kettles are generally used for small-batch production, the content condition can be clearly seen, but a large amount of class A solvent is used, heat is generated in the reaction process, and the EHS requirement is not met. In large-scale production, stainless steel or plastic-lined reaction kettles are used in many cases. However, the reaction conditions in the whole kettle, including the change of the volume of the resin, the viscosity of the reaction liquid, the wall adhesion condition and the like, are not convenient to observe due to the opaque material, and the process research and control are not facilitated.
When the stirring speed of the conventional polypeptide solid-phase reaction kettle is low, a solid-liquid mixture is easy to layer, and when the stirring speed is high, a vortex is easy to form, so that the mixing effect is not ideal enough, and the reaction efficiency is influenced;
the filter plate of the existing polypeptide solid phase reaction kettle, the reaction kettle body and the lower flange are directly provided with a layer of sealing ring and are compressed through a plurality of bolts, so that the leakage is easy and the disassembly and the assembly are inconvenient.
In the production process, the reactants need to be frequently sampled and Kaiser Test and the like are carried out, and the sampling amount is very small each time. And the existing reaction kettle is not provided with a proper sampling port. And because the cauldron is long high, and the headspace is little, generally can only put into the rope etc. through the manual work from the top and dip in and get the sample, actual operation is extremely inconvenient.
SUMMERY OF THE UTILITY MODEL
For solving the problem that exists, the utility model provides a solid phase reaction kettle that visual, steerable stirring and material mixing degree, leakproofness are good, the sample of being convenient for. The characteristics are as follows:
a solid phase reaction kettle is characterized in that: comprises an upper kettle cover, a reaction kettle body and a lower kettle cover. The upper kettle cover is of a flat plate structure and is provided with a motor, a rotating shaft of the motor is connected with the stirring paddle through a transmission device, and the upper kettle cover is respectively provided with a material liquid port, a cleaning port, a gas port and a sampling port. The reaction kettle is internally and respectively provided with stirring paddles (not less than 1), a sight glass and a baffle plate, the side wall of the reaction kettle is provided with a heat-preservation jacket, a temperature probe port and a side discharge port, and the side wall of the reaction kettle is provided with a rotary supporting mechanism. The lower kettle cover is of a flat plate structure and is provided with a filter plate and a filtrate outlet.
Preferably, the sight glass be the bar, and be no less than 1, make the sight cover whole cauldron body, be convenient for observe the interior condition of cauldron.
Preferably, the strip-shaped baffle is not less than 2, so that the stirring vortex phenomenon is prevented, the mixing effect is increased, and the stirring and mixing of the heterogeneous reaction of the polypeptide solid phase synthesis are particularly facilitated.
Preferably, the baffle is provided with a material suction pipe and a graduated scale, so that the volume of the material liquid and the volume of the resin in the kettle can be visually checked. The problem that the sampling tube cannot be installed in a kettle in an inserted manner in real time due to the fact that the diameter of the sampling tube is small and the sampling tube is easy to bend by stirring of a solid-liquid mixture is solved; the problem of artifical because the operation space problem upper portion inserts the sampling tube sample degree of difficulty big is also solved.
Preferably, the sampling port is connected with the material suction pipe in a quick-plugging manner, and can be used for sampling through an injection cylinder type sampler and cleaning the sampling pipe. Or forming on-line circulation through a peristaltic pump and accessing UV on-line monitoring.
Preferably, the diameter of the filter sieve plate is slightly larger than the inner diameter of the kettle body, the filter sieve plate is connected, fixed and sealed with the reaction kettle body and the lower kettle cover through the quick-mounting flange and the T-shaped sealing ring, multi-point sealing is achieved, the use of redundant bolts is reduced, the sealing effect is guaranteed, and the filter sieve plate is easy to disassemble and assemble.
Preferably, lower kettle cover be equipped with pneumatic or electric putter, kettle cover under can the automatic lifting dismouting, solved lower kettle cover from great, kettle bottom operating space is little and artifical dismouting bolt difficulty scheduling problem.
Preferably, the discharge port on the side wall of the kettle body can be connected with a drying system through a pipeline to form reaction-filtration-drying integration.
Preferably, the reaction kettle is connected with a PLC control system, and can control the stirring device and/or the rotary supporting device and/or the filtering device and/or the push rod device and/or the feeding and discharging device, but not limited to the above.
Preferably, the reaction kettle body can control the rotary supporting device to incline directionally through the PLC control system, so that the solid in the kettle is washed for several times and discharged from the side discharge port until no residue is left.
Preferably, the reaction kettle can be used for solid phase reaction, and is particularly suitable for heterogeneous phase reaction such as polypeptide solid phase synthesis reaction.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is the utility model discloses reation kettle is used for connecting simultaneously sealed filter sieve, the reation kettle body, the T type sealing washer sketch map of lower kettle cover.
Detailed Description
The technical solutions in the embodiments of the present invention are described in detail below with reference to the accompanying drawings in the embodiments of the present invention. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. Other embodiments formed by similar replacement, modification or combination based on the present embodiment belong to the protection scope of the present invention.
The first embodiment is as follows:
referring to fig. 1-2, a solid phase reaction kettle comprises an upper kettle cover (1), a reaction kettle body (2) and a lower kettle cover (3). The upper kettle cover (1) is of a flat plate structure and is provided with a motor (4), a rotating shaft of the motor is connected with the stirring paddle through a transmission device, and the stirring device is connected with the upper kettle cover through double-end-face mechanical seal; the upper kettle cover is respectively provided with a sampling port (5), a material liquid port (6), a cleaning port (7), a gas port (8) and a sampler (9). Install stirring rake (10)2 respectively in the reation kettle body (2), 2 faces of sight glass (11), baffle (12)2, be equipped with on the baffle and inhale material pipe and scale mark, the sample connection with inhale the material pipe and be connected for inserting fast, accessible injection cylinder sampler (9) can take a sample to wash the sampling tube. The side wall is provided with a heat-insulating jacket (13), a temperature probe port and a side discharge port (14), and the side discharge port can be connected with a drying system through a pipeline. The side wall of the reaction kettle body (2) is provided with a rotary supporting mechanism (15). The lower kettle cover (3) is of a flat plate structure and is provided with a filter plate (16), a filtrate outlet (17) and an electric push rod (19); wherein, the diameter of the filter sieve plate is larger than the inner diameter of the kettle body by 5cm, and the filter sieve plate is connected, fixed and sealed with the reaction kettle body and the lower kettle cover through a quick-mounting flange and a T-shaped sealing ring (18). The reaction kettle is connected with the PLC control system, and can control the stirring device, the rotary supporting device, the filtering device, the push rod device and the feeding and discharging device, but is not limited to the above.
Example two:
referring to fig. 1-2, a solid phase reaction kettle comprises an upper kettle cover (1), a reaction kettle body (2) and a lower kettle cover (3). The upper kettle cover (1) is of a flat plate structure and is provided with a motor (4), a rotating shaft of the motor is connected with the stirring paddle through a transmission device, and the stirring device is connected with the upper kettle cover through double-end-face mechanical seal; the upper kettle cover is respectively provided with a sampling port (5), a material liquid port (6), a cleaning port (7), a gas port (8) and a sampling port (9). Install stirring rake (10)1 respectively in the reation kettle body (2), sight glass (11)3 faces, baffle (12)4, be equipped with on the baffle and inhale material pipe and scale mark, the sample connection with inhale the material pipe and be the formula of inserting soon and connect, form online circulation through the peristaltic pump, insert UV on-line monitoring. The side wall is provided with a heat-insulating jacket (13), a temperature probe port and a side discharge port (14). The side wall of the reaction kettle body (2) is provided with a rotary supporting mechanism (15). The lower kettle cover (3) is of a flat plate structure and is provided with a filter plate (16), a filtrate outlet (17) and a pneumatic push rod (19); wherein, the diameter of the filter sieve plate is 10cm larger than the inner diameter of the kettle body, and the filter sieve plate is connected, fixed and sealed with the reaction kettle body and the lower kettle cover through a quick-mounting flange and a T-shaped sealing ring (18). The reaction kettle is connected with the PLC control system, and can control the stirring device, the rotary supporting device, the push rod device and the feeding and discharging device, but is not limited to the above.
Claims (12)
1. The utility model provides a polypeptide solid phase reation kettle which characterized in that: comprises an upper kettle cover (1), a reaction kettle body (2) and a lower kettle cover (3); the upper kettle cover (1) is of a flat plate structure and is provided with a motor (4), a rotating shaft of the motor (4) is connected with the stirring paddle through a transmission device, and the upper kettle cover (1) is respectively provided with a sampling port (5), a material liquid port (6), a cleaning port (7), a gas port (8) and a sampler (9); at least 1 stirring paddle (10), a sight glass (11) and a baffle (12) are respectively arranged in the reaction kettle body (2), a heat-insulating jacket (13), a temperature probe port and a side discharge port (14) are arranged on the side wall of the reaction kettle body, and a rotary supporting mechanism (15) is arranged on the side wall of the reaction kettle body (2); the lower kettle cover (3) is of a flat plate structure and is provided with a filter plate (16) and a filtrate outlet (17).
2. The polypeptide solid phase reaction kettle of claim 1, wherein the sight glass is not less than 1 surface.
3. The polypeptide solid phase reaction kettle of claim 1, wherein the baffle is strip-shaped, and the number of the baffle is not less than 2.
4. The polypeptide solid phase reaction kettle of claim 1 or 3, wherein the baffle plate is provided with a material suction pipe and a graduated scale.
5. The polypeptide solid phase reaction kettle of claim 4, wherein the material suction pipe is connected with the sampling port in a quick-inserting manner, and can be used for sampling through an injection cylinder type sampler (9) and cleaning the sampling pipe; or forming on-line circulation through a peristaltic pump and accessing UV on-line monitoring.
6. The polypeptide solid phase reaction kettle of claim 1, wherein the diameter of the filter plate is slightly larger than the inner diameter of the kettle body, and the filter plate is connected, fixed and sealed with the reaction kettle body and the lower kettle cover through a quick-mounting flange and a T-shaped sealing ring (18).
7. The polypeptide solid phase reaction kettle of claim 1, wherein the lower kettle cover is provided with a pneumatic or electric push rod (19).
8. The polypeptide solid phase reaction kettle of claim 1, wherein a discharge port on the side wall of the kettle body is connected with a drying system through a pipeline.
9. The polypeptide solid phase reaction kettle of claim 1, wherein the solid phase reaction kettle is connected with a PLC control system.
10. The polypeptide solid phase reaction kettle of claim 9, wherein the PLC control system can control at least one of a stirring device, a rotating support device, a filtering device, a pushing device, a feeding device and a discharging device.
11. The polypeptide solid phase reaction kettle of claim 1, wherein the reaction kettle is used in a solid phase reaction.
12. The polypeptide solid phase reaction vessel of claim 1, wherein the solid phase reaction is a heterogeneous reaction including a polypeptide solid phase synthesis reaction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822096162.6U CN210058221U (en) | 2018-12-11 | 2018-12-11 | Solid phase reaction kettle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822096162.6U CN210058221U (en) | 2018-12-11 | 2018-12-11 | Solid phase reaction kettle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210058221U true CN210058221U (en) | 2020-02-14 |
Family
ID=69424219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201822096162.6U Active CN210058221U (en) | 2018-12-11 | 2018-12-11 | Solid phase reaction kettle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210058221U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112028973A (en) * | 2020-08-06 | 2020-12-04 | 山东辰龙药业有限公司 | Resin-carbetocin cracking device |
| CN115282908A (en) * | 2022-07-25 | 2022-11-04 | 恒丰泰精密机械股份有限公司 | Lithium battery multifunctional reaction stirring equipment |
-
2018
- 2018-12-11 CN CN201822096162.6U patent/CN210058221U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112028973A (en) * | 2020-08-06 | 2020-12-04 | 山东辰龙药业有限公司 | Resin-carbetocin cracking device |
| CN112028973B (en) * | 2020-08-06 | 2024-05-07 | 山东辰龙药业有限公司 | Resin-carbetocin pyrolysis device |
| CN115282908A (en) * | 2022-07-25 | 2022-11-04 | 恒丰泰精密机械股份有限公司 | Lithium battery multifunctional reaction stirring equipment |
| CN115282908B (en) * | 2022-07-25 | 2024-06-04 | 恒丰泰精密机械股份有限公司 | Multifunctional lithium-battery reaction stirring equipment |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210203 Address after: 518118 No. 14 Jinhui Road, Kengzi Street, Pingshan New District, Shenzhen City, Guangdong Province, No. 7 Building, Shenzhen Biomedical Innovation Industrial Park Patentee after: SHENZHEN JX BIO-PHARMACEUTICAL Co.,Ltd. Address before: 518118 8th floor, building 1, Biomedical Innovation Industrial Park, 14 Jinhui Road, Kengzi street, Pingshan New District, Shenzhen City, Guangdong Province Patentee before: Zhong Xianglong Patentee before: Li Xinyu Patentee before: Wang Hongxin |
|
| TR01 | Transfer of patent right |