CN110278711B - 作为RORγ调节剂的三环砜 - Google Patents
作为RORγ调节剂的三环砜 Download PDFInfo
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- CN110278711B CN110278711B CN201780082664.9A CN201780082664A CN110278711B CN 110278711 B CN110278711 B CN 110278711B CN 201780082664 A CN201780082664 A CN 201780082664A CN 110278711 B CN110278711 B CN 110278711B
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- fluorophenyl
- sulfonyl
- cyclopenta
- perfluoroprop
- naphth
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
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- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662419607P | 2016-11-09 | 2016-11-09 | |
| US62/419,607 | 2016-11-09 | ||
| PCT/US2017/060501 WO2018089402A1 (en) | 2016-11-09 | 2017-11-08 | Tricyclic sulfones as ror gamma modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110278711A CN110278711A (zh) | 2019-09-24 |
| CN110278711B true CN110278711B (zh) | 2023-12-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201780082664.9A Active CN110278711B (zh) | 2016-11-09 | 2017-11-08 | 作为RORγ调节剂的三环砜 |
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| Country | Link |
|---|---|
| US (1) | US10435369B2 (https=) |
| EP (1) | EP3541786B1 (https=) |
| JP (1) | JP7182553B2 (https=) |
| KR (1) | KR102599437B1 (https=) |
| CN (1) | CN110278711B (https=) |
| AR (1) | AR110152A1 (https=) |
| AU (1) | AU2017356911A1 (https=) |
| CA (1) | CA3042877A1 (https=) |
| EA (1) | EA201991128A1 (https=) |
| ES (1) | ES2820535T3 (https=) |
| IL (1) | IL266474A (https=) |
| MX (1) | MX2019005384A (https=) |
| TW (1) | TW201821404A (https=) |
| WO (1) | WO2018089402A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7542538B2 (ja) | 2018-09-18 | 2024-08-30 | ニカング セラピューティクス, インコーポレイテッド | Srcホモロジー-2ホスファターゼ阻害剤としての縮合三環式環誘導体 |
| CN114981245A (zh) * | 2020-01-24 | 2022-08-30 | 百时美施贵宝公司 | 作为RORγ调节剂的三环砜 |
| WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007084595A2 (en) * | 2006-01-20 | 2007-07-26 | Schering Corporation | Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors |
| WO2009008980A2 (en) * | 2007-07-05 | 2009-01-15 | Schering Corporation | Tetrahydropyranochromene gamma secretase inhibitors |
| WO2009011851A1 (en) * | 2007-07-17 | 2009-01-22 | Schering Corporation | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors |
| WO2015103507A1 (en) * | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Cyclohexyl sulfone rorϒ modulators |
| WO2015103510A1 (en) * | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Heterocyclic sulfone as ror-gamma modulators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2925313A4 (en) | 2012-11-29 | 2016-05-11 | Merck Sharp & Dohme | SPIROCYCLIC SULPHONES AS GAMMA SECRETASE INHIBITORS |
| WO2015103509A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators |
| WO2015103508A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | CARBOCYCLIC SULFONE RORγ MODULATORS |
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2017
- 2017-11-08 US US15/806,554 patent/US10435369B2/en active Active
- 2017-11-08 TW TW106138534A patent/TW201821404A/zh unknown
- 2017-11-08 EP EP17801248.0A patent/EP3541786B1/en active Active
- 2017-11-08 AU AU2017356911A patent/AU2017356911A1/en not_active Abandoned
- 2017-11-08 CA CA3042877A patent/CA3042877A1/en not_active Abandoned
- 2017-11-08 KR KR1020197016091A patent/KR102599437B1/ko active Active
- 2017-11-08 WO PCT/US2017/060501 patent/WO2018089402A1/en not_active Ceased
- 2017-11-08 EA EA201991128A patent/EA201991128A1/ru unknown
- 2017-11-08 AR ARP170103104A patent/AR110152A1/es unknown
- 2017-11-08 MX MX2019005384A patent/MX2019005384A/es unknown
- 2017-11-08 ES ES17801248T patent/ES2820535T3/es active Active
- 2017-11-08 CN CN201780082664.9A patent/CN110278711B/zh active Active
- 2017-11-08 JP JP2019545893A patent/JP7182553B2/ja active Active
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2019
- 2019-05-06 IL IL266474A patent/IL266474A/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007084595A2 (en) * | 2006-01-20 | 2007-07-26 | Schering Corporation | Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors |
| WO2009008980A2 (en) * | 2007-07-05 | 2009-01-15 | Schering Corporation | Tetrahydropyranochromene gamma secretase inhibitors |
| WO2009011851A1 (en) * | 2007-07-17 | 2009-01-22 | Schering Corporation | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors |
| WO2015103507A1 (en) * | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Cyclohexyl sulfone rorϒ modulators |
| WO2015103510A1 (en) * | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Heterocyclic sulfone as ror-gamma modulators |
Non-Patent Citations (8)
| Title |
|---|
| Aromatization of Tetrahydrocyclopropa[a]naphthalenes:an Alternative Synthesis of 1H-Cyclopropa[a]naphthalene;Paul Müller et al.;《Helvetica Chimica Acta》;19891231;第72卷(第7期);第1627-1638页 * |
| Cyclization of Ylidenemalononitriles. X. Synthesis of Benzazapropellane Derivatives from α-Cyano-β-chloroalkylcinnamonitriles;E. Campaigne et al.;《Journal of Heterocyclic Chemistry》;19771231;第14卷(第8期);第1337-1345页 * |
| Decomposition Products of Pyrazolines formed from 3-Alkylthioinden-1-ones and Diazomethane;Katherine Buggle et al.;《Journal of the Chemical Society Perkin Transactions I》;19750101(第6期);第572-575页 * |
| Intramolecular Capture of a Cyclobutylthionium Ion for the Synthesis of New Strained Heterocycles and Carbocycles: A Rapid Assembly of the BCD Ring Sequence of Penitrems;Guido Alberti et al.;《Synlett》;20060824(第14期);第2241-2245页 * |
| Ring-expansion of 3-Arylinden-1-ones with Lithium Methylsulphinylmethanide;Katherine Buggle et al.;《Journal of the Chemical Society Perkin Transactions I》;19830101;第2075-2076页 * |
| SAR of tricyclic sulfones as γ-secretase inhibitors;Xu Ruo et al.;《Science China Chemistry》;20111011;第54卷(第11期);第1688-1701页 * |
| Synthesis of New Heterocycles through a Cation-Driven Tandem Ring-Enlargement-Annulation Reaction;Angela M. Bernard et al.;《Organic Letters》;20020627;第4卷(第15期);第2565-2567页 * |
| Synthesis of Tribenzotriquinacene by Stereocontrolled Cyclization of Phenyl-Substituted Cs-Diindans(4bo1,9,9aa,lO-Tetrahydroindeno[1,2-a]indenes);Dietmar Kuck et al.;《Chemische Berichte》;19941231;第151-164页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020512300A (ja) | 2020-04-23 |
| ES2820535T3 (es) | 2021-04-21 |
| AR110152A1 (es) | 2019-02-27 |
| TW201821404A (zh) | 2018-06-16 |
| WO2018089402A1 (en) | 2018-05-17 |
| JP7182553B2 (ja) | 2022-12-02 |
| AU2017356911A1 (en) | 2019-06-20 |
| EP3541786A1 (en) | 2019-09-25 |
| KR102599437B1 (ko) | 2023-11-07 |
| EA201991128A1 (ru) | 2019-10-31 |
| US20180127368A1 (en) | 2018-05-10 |
| CN110278711A (zh) | 2019-09-24 |
| CA3042877A1 (en) | 2018-05-17 |
| KR20190084270A (ko) | 2019-07-16 |
| IL266474A (en) | 2019-07-31 |
| MX2019005384A (es) | 2019-08-12 |
| EP3541786B1 (en) | 2020-08-05 |
| US10435369B2 (en) | 2019-10-08 |
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