CN110250509A - 一种改善关节健康的组合物及其制备方法 - Google Patents
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Abstract
本发明公开了一种改善关节健康的组合物，由以下重量份原料制备：胶原蛋白肽100‑1000份，含Ⅱ型胶原蛋白软骨粉0.5‑5份，N‑乙酰葡萄糖胺5‑50份，绿贻贝粉50‑500份，维生素C 5‑50份。上述原料加入辅料混合制成常规食品保健品剂型。本发明的组合物既能缓解关节疼痛症状，促进关节润滑，更能促进关节软骨的修复再生，从根本上改善关节健康。本发明可以丰富市场上的关节保健产品，让消费者有更多的选择。
Description
技术领域
本发明涉及一种保健食品及其制备方法，特别涉及一种改善关节健康的组合物及其制备方法。
背景技术
骨关节炎为困扰中老年人群的一种常见退行性病变，据国内外调查发现60岁以上人群骨关节炎的患病概率达50％，75岁以上人群则高达80％。骨关节炎以关节软骨的丢失、软骨的增厚、骨赘的形成为其病理特征，疼痛与功能障碍为其主要临床症状。疾病终末期常需行关节置换术，但该术式为骨关节炎终末期的治疗手段。世界卫生组织已将2000～2010年定为“骨关节十年”，将2010～2020年定义为第二个“骨关节十年”，可见骨关节健康受到世界卫生组织的高度重视。
目前，药物治疗作为骨关节炎的一线疗法。目前用于骨关节炎的药物主要为非甾体类抗炎药，具有消炎和止痛作用，但只能治标不能治本。而且各种药物多存在易用性、安全性、不良反应、副作用等缺陷。
针对骨关节炎保健食品产品主要是氨基葡萄糖和硫酸软骨素，该类产品对缓解关节疼痛和关节润滑一定程度的改善作用，但消炎作用弱，还是不能从根本上解决关节问题。而且这类产品趋于雷同，功能上也是参差不齐。
发明内容
为了解决现有技术中的问题，本发明提供一种改善关节健康的组合物及其制备方法，解决现有市场上的关节保健产品趋于雷同，功效不显著，同质化严重的问题。
本发明的技术方案是：
一种改善关节健康的组合物，由以下重量份原料制备：胶原蛋白肽100-1000份，含Ⅱ型胶原蛋白软骨粉0.5-5份，N-乙酰葡萄糖胺5-50份。
所述原料还包括绿贻贝粉50-500份，维生素C 5-50份。
一种改善关节健康的组合物的制备方法，包括以下步骤：
(1)按照配方将原料混合，得到活性物料；
(2)将活性物料与辅料混合制成常规食品保健品剂型。
所述辅料包括调味剂、稀释剂、助悬剂、助流剂、抗结剂、崩解剂、粘合剂。
所述剂型包括固体饮料、饮料、压片糖果、凝胶糖果、果冻、软糖、粉剂、颗粒剂、口服液、硬胶囊、软胶囊。
本发明的有益效果为：
本发明从关节健康的三个维度出发：通过补充胶原蛋白肽，可以促进软骨的修复和再生；含Ⅱ型胶原蛋白软骨粉良好的抗炎止痛作用，缓解关节疼痛；N-乙酰葡萄糖胺，可以促进关节液中透明质酸的合成，帮助关节润滑。绿贻贝粉天然含有氨基葡萄糖成分和糖胺聚糖，对软骨细胞的更新和关节润滑都有良好的作用。维生素C可以促进骨胶原蛋白在体内的吸收合成，同时具有良好的抗氧化作用。本发明的组合物既能缓解关节疼痛症状，促进关节润滑，更能促进关节软骨的修复再生，从根本上改善关节健康。本发明可以丰富市场上的关节保健产品，让消费者有更多的选择。
本发明为改善关节健康的功能食品，通过多种原料的合理配伍组方，协同增效，具有补充关节营养，促进关节修复，促进关节润滑、抗炎止痛，对关节炎或关节运动受损者有良好的治疗和预防作用。
具体实施方式
下面对本发明作进一步的详细说明。
实施例1
按照以下配方称取原料：胶原蛋白肽1000份，含Ⅱ型胶原蛋白软骨粉0.5份，N-乙酰葡萄糖胺50份,混合，得到活性物料；将活性物料加入柠檬果粉、三氯蔗糖、阿拉伯胶，制成固体饮料剂型。
实施例2
按照以下配方称取原料：胶原蛋白肽100份，含Ⅱ型胶原蛋白软骨粉5份，N-乙酰葡萄糖胺5份,混合，得到活性物料；将活性物料加入水、蓝莓浓缩汁、柠檬酸、甜菊糖苷，制成液体饮料剂型。
实施例3
按照以下配方称取原料：胶原蛋白肽1000份，含Ⅱ型胶原蛋白软骨粉0.5份，N-乙酰葡萄糖胺50份,绿贻贝粉50份，维生素C 50份，混合，得到活性物料；将活性物料加入异麦芽酮糖醇、山梨糖醇、糊精、硬脂酸镁，制成压片糖果剂型。
实施例4
按照以下配方称取原料：胶原蛋白肽100份，含Ⅱ型胶原蛋白软骨粉5份，N-乙酰葡萄糖胺5份,绿贻贝粉500份，维生素C 5份，混合，得到活性物料；将活性物料加入水、果冻粉、赤藓糖醇、罗汉果苷、柠檬酸，制成凝胶果冻剂型。
试验例
一、功效试服实验：
1、实验方案：采用国际公认的VAS评分、WOMAC骨关节炎指数作为临床观察指标，进行评分，每2周1次，治疗4周，对所测数据进行统计学分析，观察各组患者治疗前后各项指标的变化及治疗前后疗效及组间疗效差别。
2、实验人员：选取膝骨关节炎患者60人。
3、实验周期：4周。
4、实验样品：实验组：按照上述优化配方：实施例1，制成改善关节健康的固体饮料饮品，每日1袋，冲服。对照组：市售氨糖硫酸软骨素产品：2g/次，每日2次。
5、实验结果：
治疗结果实验组、对照组治疗前后VAS、WOMAC指数评分，结果详见表1，表2。实验组第4周与第0周结果有显著差异(P＜0.05)；对照组第4周与第0周结果有显著差异(P＜0.05)。实验组和对照组第4周结果无显著性(P＞0.05)。结果表明：实验组与对照组都有明显的治疗效果。
表1两组治疗前后VAS评分对比情况(x±s，分值，n＝30)
表2两组治疗前后WOMAC指数对比情况(x±s，分值，n＝30)
疗效判定标准参考《中药新药治疗骨性关节炎的临床研究指导原则》。结果详见表3。结果表明：实验组的总体效果优于对照组，总有效率为86.7％。
表3两组临床疗效比较(例，n＝30)
以上所述仅为本发明的优选实施方式，凡是利用本发明说明书内容所作的若干改进或变形，或直接或间接运用在其他相关的技术领域，也应视为在本发明的专利保护范围内。
Claims (5)
1.一种改善关节健康的组合物，其特征在于，由以下重量份原料制备：胶原蛋白肽100-1000份，含Ⅱ型胶原蛋白软骨粉0.5-5份，N-乙酰葡萄糖胺5-50份。
2.根据权利要求1所述改善关节健康的组合物，其特征在于，所述原料还包括绿贻贝粉50-500份，维生素C5-50份。
3.一种权利要求1或2改善关节健康的组合物的制备方法，其特征在于，包括以下步骤：
(1)按照配方将原料混合，得到活性物料；
(2)将活性物料与辅料混合制成常规保健食品剂型。
4.根据权利要求3所述改善关节健康的组合物的制备方法，其特征在于，所述辅料包括调味剂、稀释剂、助悬剂、助流剂、抗结剂、崩解剂、粘合剂。
5.根据权利要求3所述改善关节健康的组合物的制备方法，其特征在于，所述剂型包括固体饮料、饮料、压片糖果、凝胶糖果、果冻、软糖、粉剂、颗粒剂、口服液、硬胶囊、软胶囊。
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