CN110226975A - A kind of long lasting skin marking pen based on Geniposide coloring principle - Google Patents
A kind of long lasting skin marking pen based on Geniposide coloring principle Download PDFInfo
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- CN110226975A CN110226975A CN201910612920.1A CN201910612920A CN110226975A CN 110226975 A CN110226975 A CN 110226975A CN 201910612920 A CN201910612920 A CN 201910612920A CN 110226975 A CN110226975 A CN 110226975A
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- geniposide
- marking pen
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- skin marking
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3937—Visible markers
- A61B2090/395—Visible markers with marking agent for marking skin or other tissue
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses a kind of long lasting skin marking pens based on Geniposide coloring principle, including consisting of raw material: Geniposide 1%-6%, gentian violet 1%-3%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan gum 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.It joined Geniposide in the present invention, Geniposide is a kind of iridoid, Geniposide to form final color product by reacting with fibroin albumen, it can be by human skin dura mater outer layer permanent stain, to form blue-black temporary tatt, until skin regenerates after 2-3 weeks, therefore using the skin marking pen of the present invention rear duration up to 2-3 weeks, it may replace the invasive laser dotting mark mode of tradition, avoid patient's pain experience in label, secondly, color falls off after being marked using long lasting skin marking pen label to avoid common skin marking pen, influence treatment accuracy.
Description
Technical field
The present invention relates to ink technology related fields more particularly to a kind of long lasting skin notes based on Geniposide coloring principle
Number pen.
Background technique
Effect and status of the radiotherapy in oncotherapy become increasingly conspicuous, it has also become treat the main means of malignant tumour
One of.About 70% cancer patient needs to use radiotherapy during treating cancer.To guarantee each radiotherapy position
Repeatability, need patient body-surface accurate marker go out radiotherapy localization line for every time treat when laser positioning, i.e., radiotherapy label, mesh
Preceding common body surface marking mode has laser dotting, common skin marking pen label and common oil pen's label.
The mode of existing frequently-used body surface marking has the disadvantage in that
(1) laser dotting: refer to and stamp permanent label in patient skin surface with laser beam, and laser labelling is that one kind has
Wound label, leads to patient pain unbearably, meanwhile, laser dotting is possible to cause permanent scar, influences beauty；
(2) common skin marking pen: currently used skin marking pen is mainly using aldrich mixture as ink, still
Common skin marking pen label after be easy fade, and mark the duration it is short (about 3-5 days), but due to having a bath, rubbing one's body with a towel, clothes
It is smudgy to frequently result in radiotherapy label, or even loses completely for the factors such as friction；
(3) common oil pen: easy colour fading, coloration time are short after the common permanent pen label skin used now
(about 2-3 days), and the ink of common oil pen stimulates greatly human skin.
For this purpose, it is particularly significant to study a kind of noninvasive, long-acting coloring, mark mode not easy to fade.
Summary of the invention
The purpose of the present invention is to solve body surface marking mode in the prior art there are the shortcomings that, and propose a kind of base
In the long lasting skin marking pen of Geniposide coloring principle.
To achieve the goals above, present invention employs following technical solutions:
A kind of long lasting skin marking pen based on Geniposide coloring principle, including consisting of raw material: Geniposide 1%-
6%, gentian violet 1%-3%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan gum 0.3%-0.5%, polyvinyl pyrrole
Alkanone 2%-3%, water 60%-70%.
Preferably, including consisting of raw material: Geniposide 1%-2%, gentian violet 1%-2%, ethyl alcohol 20%-30%, third
Glycol 10%-20%, xanthan gum 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.
Preferably, including consisting of raw material: Geniposide 2%-3%, gentian violet 1%-2%, ethyl alcohol 20%-30%, third
Glycol 10%-20%, xanthan gum 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.
Preferably, including consisting of raw material: Geniposide 3%-4%, gentian violet 1%-2%, ethyl alcohol 20%-30%, third
Glycol 10%-20%, xanthan gum 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.
Preferably, including consisting of raw material: Geniposide 1%-2%, gentian violet 2%-3%, ethyl alcohol 20%-30%, third
Glycol 10%-20%, xanthan gum 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.
Preferably, including consisting of raw material: Geniposide 3%-4%, gentian violet 2%-3%, ethyl alcohol 20%-30%, third
Glycol 10%-20%, xanthan gum 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.
Preferably, the gentian violet is the main source of ink color, and the ethyl alcohol and propylene glycol are cosolvent, the Huang
Virgin rubber is thickener, and the polyvinylpyrrolidone is film forming agent.
Preferably, the preparation condition of the ink are as follows: uniformly mixed under the conditions of 2000-5000rpm/min.
Compared with the prior art, the beneficial effects of the present invention are:
It joined Geniposide in the present invention, Geniposide is a kind of iridoid, and life can be reacted with amino acid
Au bleu element.Biomedical material and material engineering, food and pigment additive, Chinese medicine Hepatoprotective cholagogue, anticancer and anti-inflammatory,
Biological detection and agricultural production volume increase etc. have a wide range of applications.The covering that general dyestuff multi-pass crosses intrinsic colour carries out
Dyeing, can also generate coloring matter by reaction.Common protein staining reagent, it is weaker with the binding force of protein,
Mainly by intermolecular active force, therefore, it is very easy to fade, and protein fibre is more difficult to dye, Geniposide by with fibroin egg
White reaction forms final color product, can be by human skin dura mater outer layer permanent stain, to be formed blue-black interim
It tatoos, it is desirable until skin regenerates after 2-3 weeks, therefore using the skin marking pen of the present invention rear duration up to 2-3 weeks
The generation invasive laser dotting mark mode of tradition avoids patient's pain experience in label, secondly, using long lasting skin marking pen mark
Color falls off after note can mark to avoid common skin marking pen, influences to treat accuracy.
Detailed description of the invention
Fig. 1 is a kind of pilot survey table of the long lasting skin marking pen based on Geniposide coloring principle proposed by the present invention
Figure；
Fig. 2 is that a kind of coloring effect of long lasting skin marking pen based on Geniposide coloring principle proposed by the present invention is shown
Figure.
Specific embodiment
Combined with specific embodiments below the present invention is made further to explain.
Embodiment one
The invention proposes a kind of long lasting skin marking pens based on Geniposide coloring principle, including consisting of raw material:
Geniposide 1%-2%, gentian violet 1%-2%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan gum 0.3%-0.5%,
Polyvinylpyrrolidone 2%-3%, water 60%-70% are uniformly mixed under the conditions of 2000-5000rpm/min, complete preparation,
Wherein gentian violet is the main source of ink color, and ethyl alcohol and propylene glycol are cosolvent, and xanthan gum is thickener, polyvinyl pyrrole
Alkanone is film forming agent.
Embodiment two
The invention proposes a kind of long lasting skin marking pens based on Geniposide coloring principle, including consisting of raw material:
Geniposide 2%-3%, gentian violet 1%-2%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan gum 0.3%-0.5%,
Polyvinylpyrrolidone 2%-3%, water 60%-70% are uniformly mixed under the conditions of 2000-5000rpm/min, complete preparation,
Wherein gentian violet is the main source of ink color, and ethyl alcohol and propylene glycol are cosolvent, and xanthan gum is thickener, polyvinyl pyrrole
Alkanone is film forming agent.
Embodiment three
The invention proposes a kind of long lasting skin marking pens based on Geniposide coloring principle, including consisting of raw material:
Geniposide 3%-4%, gentian violet 1%-2%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan gum 0.3%-0.5%,
Polyvinylpyrrolidone 2%-3%, water 60%-70% are uniformly mixed under the conditions of 2000-5000rpm/min, complete preparation,
Wherein gentian violet is the main source of ink color, and ethyl alcohol and propylene glycol are cosolvent, and xanthan gum is thickener, polyvinyl pyrrole
Alkanone is film forming agent.
Example IV
The invention proposes a kind of long lasting skin marking pens based on Geniposide coloring principle, including consisting of raw material:
Geniposide 1%-2%, gentian violet 2%-3%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan gum 0.3%-0.5%,
Polyvinylpyrrolidone 2%-3%, water 60%-70% are uniformly mixed under the conditions of 2000-5000rpm/min, complete preparation,
Wherein gentian violet is the main source of ink color, and ethyl alcohol and propylene glycol are cosolvent, and xanthan gum is thickener, polyvinyl pyrrole
Alkanone is film forming agent.
Embodiment five
The invention proposes a kind of long lasting skin marking pens based on Geniposide coloring principle, including consisting of raw material:
Geniposide 3%-4%, gentian violet 2%-3%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan gum 0.3%-0.5%,
Polyvinylpyrrolidone 2%-3%, water 60%-70% are uniformly mixed under the conditions of 2000-5000rpm/min, complete preparation,
Wherein gentian violet is the main source of ink color, and ethyl alcohol and propylene glycol are cosolvent, and xanthan gum is thickener, polyvinyl pyrrole
Alkanone is film forming agent.
The beneficial effect of the present invention will be further illustrated by the following test examples drug.
The body surface of human body is marked in ink prepared in embodiment one to five respectively, is then normally washed one's hair
Bath, test result is as shown in Fig. 1 table.
Therefore deduce that, this ink set have it is easy to operate, the ink coloration time of production is 2-3 weeks,
Color marker is clear, not fugitive color, and ink set is highly suitable for pigmenting of skin respectively at environmentally friendly.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change and any should all cover by the long lasting skin marking pen of Color base of Geniposide
Within protection scope of the present invention.
Claims (8)
1. a kind of long lasting skin marking pen based on Geniposide coloring principle, which is characterized in that including consisting of raw material: capital Buddhist nun
Flat 1%-6%, gentian violet 1%-3%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan gum 0.3%-0.5%, poly- second
Alkene pyrrolidone 2%-3%, water 60%-70%.
2. a kind of long lasting skin marking pen based on Geniposide coloring principle according to claim 1, which is characterized in that packet
Include consisting of raw material: Geniposide 1%-2%, gentian violet 1%-2%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan
Glue 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.
3. a kind of long lasting skin marking pen based on Geniposide coloring principle according to claim 1, which is characterized in that packet
Include consisting of raw material: Geniposide 2%-3%, gentian violet 1%-2%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan
Glue 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.
4. a kind of long lasting skin marking pen based on Geniposide coloring principle according to claim 1, which is characterized in that packet
Include consisting of raw material: Geniposide 3%-4%, gentian violet 1%-2%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan
Glue 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.
5. a kind of long lasting skin marking pen based on Geniposide coloring principle according to claim 1, which is characterized in that packet
Include consisting of raw material: Geniposide 1%-2%, gentian violet 2%-3%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan
Glue 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.
6. a kind of long lasting skin marking pen based on Geniposide coloring principle according to claim 1, which is characterized in that packet
Include consisting of raw material: Geniposide 3%-4%, gentian violet 2%-3%, ethyl alcohol 20%-30%, propylene glycol 10%-20%, xanthan
Glue 0.3%-0.5%, polyvinylpyrrolidone 2%-3%, water 60%-70%.
7. a kind of long lasting skin marking pen based on Geniposide coloring principle according to claim 1, which is characterized in that institute
The main source that gentian violet is ink color is stated, the ethyl alcohol and propylene glycol are cosolvent, and the xanthan gum is thickener, described
Polyvinylpyrrolidone is film forming agent.
8. a kind of long lasting skin marking pen based on Geniposide coloring principle according to claim 1, which is characterized in that institute
State the preparation condition of ink are as follows: uniformly mix under the conditions of 2000-5000rpm/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910612920.1A CN110226975A (en) | 2019-07-09 | 2019-07-09 | A kind of long lasting skin marking pen based on Geniposide coloring principle |
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|---|---|---|---|
| CN201910612920.1A CN110226975A (en) | 2019-07-09 | 2019-07-09 | A kind of long lasting skin marking pen based on Geniposide coloring principle |
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| CN110226975A true CN110226975A (en) | 2019-09-13 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109629025A (en) * | 2018-12-29 | 2019-04-16 | 恒天纤维集团有限公司 | A kind of coloured anti-bacterial Lyocell fiber and preparation method thereof |
| WO2021248243A1 (en) * | 2020-06-10 | 2021-12-16 | inkbox ink Inc. | Semi-permanent tattoos |
| CN114015284A (en) * | 2021-11-15 | 2022-02-08 | 江苏义倍医疗科技股份有限公司 | Ink for special positioning pen for radiotherapy for preventing wet skin and preparation method thereof |
| WO2022036113A1 (en) * | 2020-08-12 | 2022-02-17 | inkbox ink Inc. | Semi-permanent tattoos |
| WO2023023851A1 (en) * | 2021-08-25 | 2023-03-02 | Inkbox Ink Incorporated | Ink applicators |
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| TW200908991A (en) * | 2007-08-24 | 2009-03-01 | zhen-rong Zhang | Use of genipin as marker pigment for skin |
| WO2010054219A2 (en) * | 2008-11-07 | 2010-05-14 | Viscot Medical, Llc | Scrub-resistant ink and methods and apparatus for fabrication and use thereof |
| CN104888279A (en) * | 2015-03-16 | 2015-09-09 | 绍兴振德医用敷料有限公司 | Collagen/silk fibroin composite support and manufacturing method and application thereof |
| CN107109093A (en) * | 2015-01-07 | 2017-08-29 | 白金万年笔株式会社 | Surgical marker ink |
| CN108291095A (en) * | 2015-10-05 | 2018-07-17 | 威尔德香精有限公司 | natural colorant and its manufacturing method |
| CN109679407A (en) * | 2019-01-31 | 2019-04-26 | 江苏义倍医疗科技股份有限公司 | A kind of preparation method of the dedicated pen with means for holding it in right position ink of radiotherapy |
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2019
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Patent Citations (6)
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| TW200908991A (en) * | 2007-08-24 | 2009-03-01 | zhen-rong Zhang | Use of genipin as marker pigment for skin |
| WO2010054219A2 (en) * | 2008-11-07 | 2010-05-14 | Viscot Medical, Llc | Scrub-resistant ink and methods and apparatus for fabrication and use thereof |
| CN107109093A (en) * | 2015-01-07 | 2017-08-29 | 白金万年笔株式会社 | Surgical marker ink |
| CN104888279A (en) * | 2015-03-16 | 2015-09-09 | 绍兴振德医用敷料有限公司 | Collagen/silk fibroin composite support and manufacturing method and application thereof |
| CN108291095A (en) * | 2015-10-05 | 2018-07-17 | 威尔德香精有限公司 | natural colorant and its manufacturing method |
| CN109679407A (en) * | 2019-01-31 | 2019-04-26 | 江苏义倍医疗科技股份有限公司 | A kind of preparation method of the dedicated pen with means for holding it in right position ink of radiotherapy |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109629025A (en) * | 2018-12-29 | 2019-04-16 | 恒天纤维集团有限公司 | A kind of coloured anti-bacterial Lyocell fiber and preparation method thereof |
| CN109629025B (en) * | 2018-12-29 | 2021-06-25 | 恒天纤维集团有限公司 | Colored antibacterial Lyocell fiber and preparation method thereof |
| WO2021248243A1 (en) * | 2020-06-10 | 2021-12-16 | inkbox ink Inc. | Semi-permanent tattoos |
| WO2022036113A1 (en) * | 2020-08-12 | 2022-02-17 | inkbox ink Inc. | Semi-permanent tattoos |
| WO2023023851A1 (en) * | 2021-08-25 | 2023-03-02 | Inkbox Ink Incorporated | Ink applicators |
| CN114015284A (en) * | 2021-11-15 | 2022-02-08 | 江苏义倍医疗科技股份有限公司 | Ink for special positioning pen for radiotherapy for preventing wet skin and preparation method thereof |
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Application publication date: 20190913 |