CN114015284A - Ink for special positioning pen for radiotherapy for preventing wet skin and preparation method thereof - Google Patents
Ink for special positioning pen for radiotherapy for preventing wet skin and preparation method thereof Download PDFInfo
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- CN114015284A CN114015284A CN202111369486.2A CN202111369486A CN114015284A CN 114015284 A CN114015284 A CN 114015284A CN 202111369486 A CN202111369486 A CN 202111369486A CN 114015284 A CN114015284 A CN 114015284A
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/16—Writing inks
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/16—Writing inks
- C09D11/17—Writing inks characterised by colouring agents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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Abstract
The ink for the special positioning pen for radiotherapy for preventing wet skin comprises, by mass, 5-8 parts of single-component essential oil, 5-10 parts of lemon stock solution, 1-2 parts of indian henna powder, 0.5-1 part of vitamin, 3-5 parts of sea buckthorn oil and 80-90 parts of genipa americana fruit juice. The invention adopts the seabuckthorn oil as the effect of preventing the wet skin, which is obviously better than gentian violet, kangfuxin, seabuckthorn flavone and sulfadiazine silver, and can effectively prevent the wet skin. The ink prepared by the invention has strong coloring capability and durable coloring, can be clearly marked only once, can not fade in a short time, has LD50 of more than 5000mg/kg for NIH mice, belongs to an actual nontoxic product, and can not cause harm to human bodies in the using process.
Description
Technical Field
The invention relates to ink for a special positioning pen for radiotherapy for preventing wet skin and a preparation method thereof, and belongs to the technical field of ink formulas.
Background
At present, radiotherapy is one of the three major therapeutic means of cancer, and is to irradiate tumor cells with various kinds of radiation of different energies, such as X-ray, gamma-ray, electron ray, etc., and due to the biological action of the radiation, it can kill and destroy cancer tissues to the maximum extent, shrink them, destroy the chromosomes of the cells, stop the growth of the cells, and achieve the therapeutic purpose in the way of inhibiting and killing cancer cells, however, the protection of the radiation during radiotherapy is very important because the cancer cells are killed and normal cells in human body are also killed.
When a doctor carries out radiotherapy on a patient, the protection mode of the radiotherapy is that colored-stroke radioactive rays are used for the radiation position of the patient, so that the accuracy of the radiotherapy is guaranteed, the radiotherapy doctor must draw lines on a fixed model or the body surface of the patient, more cross shapes are particularly adopted, the currently adopted method is common water pens and small dyed wood sticks, the pen points of the water pens are small, the long lines of 2.5 centimeters are drawn, the lines are not clear, the ink coloring capacity is poor, the durability is poor, multiple times of drawing are needed, errors exist, the accuracy of the radiotherapy is influenced, and more potential safety hazards are brought to the radiotherapy. The prior art CN201910099546X records ink for a special positioning pen for radiotherapy, and the ink comprises the following substances: the ink for the positioning pen for the radiotherapy is strong in coloring capacity, durable in coloring and free of fading in a short time, is safe, environment-friendly and non-toxic, and is suitable for being used by the positioning pen special for the radiotherapy.
The skin reaction of radiotherapy at present is mainly divided into dry and wet. For dry skin, following radiation therapy, the dry skin responds by manifesting as skin itching, erythema, pigmentation and desquamation, no exudate and generally no infection. For wet skin, after radiotherapy, the reaction of the wet skin is manifested as eczema and blisters on the skin in the irradiated area, which may cause erosion and ulceration in severe cases, and infection is likely to occur in the underarm, groin, armpit and perineum. Once an infection occurs, not only is unnecessary pain brought to the patient, but treatment may be delayed. Whether the prevention and treatment of the skin reaction problem caused by radiotherapy are timely or not is related to whether the quality of life of the patient can be improved after the patient is cured. In CN201910099546X, gentian violet is adopted as a component for preventing wet skin caused by radiotherapy, and the applicant finds that the ink for the positioning pen special for radiotherapy is not ideal in preventing the wet skin through actual clinical use.
Aiming at the problems in the patent, the invention develops the ink for the special positioning pen for radiotherapy, which can better prevent the wet skin.
Disclosure of Invention
In order to solve the technical problems, the invention provides the ink for the special positioning pen for radiotherapy for preventing wet skin, and seabuckthorn oil is adopted as the ink for preventing the wet skin, which is obviously better than gentian violet.
The invention aims to provide ink for a special radiotherapy positioning pen for preventing wet skin, which comprises the following components, by mass, 5-8 parts of single-component essential oil, 5-10 parts of lemon stock solution, 1-2 parts of India henna powder, 0.5-1 part of vitamins, 3-5 parts of sea buckthorn oil and 80-90 parts of American genipa fruit juice.
Furthermore, the single essential oil is prepared by mixing 50-80 parts of sweet almond oil, 1-3 parts of lavender essential oil and 2-5 parts of tea tree essential oil according to parts by weight.
Further, the lemon stock solution is juice obtained by squeezing and filtering the lemon.
Further, the vitamins are vitamin C and vitamin E according to the mass ratio of 1-2: 2-3, and mixing.
Further, the seabuckthorn oil is prepared by the following method: cleaning and drying seabuckthorn, and crushing to obtain seabuckthorn powder; placing fructus Hippophae powder in supercritical extraction device, and adopting CO2Extracting with supercritical fluid; and performing reduced pressure separation treatment after extraction to obtain the seabuckthorn oil.
Furthermore, the sea-buckthorn can be one or more of sea-buckthorn leaves, sea-buckthorn fruits and sea-buckthorn seeds.
Further, the extraction temperature is 45-60 ℃, the extraction pressure is 15-25 Mpa, and CO is2The flow rate is 150-200 kg/h.
Further, the temperature of the decompression separation treatment is 40-50 ℃, and the pressure is 5-6 Mpa.
The second purpose of the invention is to provide a preparation method of the ink for the special positioning pen for radiotherapy for preventing wet skin, which comprises the following steps: the ink for the special positioning pen for radiotherapy for preventing the wet skin is prepared by sequentially adding the raw materials in parts by mass into a reaction kettle, reacting for 1-2 hours at the temperature of 30-40 ℃ and the rotating speed of 200-300 rpm, and performing ultrasonic dispersion on the reaction kettle.
Further, the time of ultrasonic dispersion is 2-3 hours.
The invention has the beneficial effects that:
the invention adopts the seabuckthorn oil as the effect of preventing the wet skin, which is obviously better than gentian violet, kangfuxin, seabuckthorn flavone and sulfadiazine silver, and can effectively prevent the wet skin. The ink prepared by the invention has strong coloring capability and durable coloring, can be clearly marked only once, can not fade in a short time, has LD50 of more than 5000mg/kg for NIH mice, belongs to an actual nontoxic product, and can not cause harm to human bodies in the using process.
Detailed Description
The present invention is further described below in conjunction with specific examples to enable those skilled in the art to better understand the present invention and to practice it, but the examples are not intended to limit the present invention.
Example 1:
a preparation method of ink for a special positioning pen for radiotherapy comprises the following steps:
the ink for the special positioning pen for radiotherapy comprises the following components: the fruit juice beverage comprises, by mass, 8 parts of single-component essential oil, 10 parts of lemon stock solution, 2 parts of Indian henna powder, 1 part of vitamins, 5 parts of sea buckthorn oil and 90 parts of American genipa fruit juice.
A preparation method of ink for a special positioning pen for radiotherapy comprises the following steps: adding 8 parts by mass of single-component essential oil, 10 parts by mass of lemon stock solution, 2 parts by mass of India henna powder, 1 part by mass of vitamins, 5 parts by mass of sea buckthorn oil and 90 parts by mass of American genipap juice into a reaction kettle in sequence, reacting for 2 hours at the temperature of 40 ℃ and the rotating speed of 300rpm, and then placing the mixture into an ultrasonic machine for ultrasonic dispersion for 3 hours to obtain the ink for the special positioning pen for radiotherapy.
Wherein, the single-component essential oil is as follows: adding 80 parts by mass of sweet almond oil, 3 parts by mass of lavender essential oil and 5 parts by mass of tea tree essential oil into a mixer, and uniformly mixing to obtain a substance, wherein the solution is the single-component essential oil.
Wherein, the lemon stock solution is as follows: the collected fresh lemons were peeled and then squeezed using a squeezer, and the resulting juice was suction filtered to give a translucent liquid, which was the lemon stock.
Wherein, the vitamins are: the vitamin C and the vitamin E extracted from natural plants are mixed according to the mass ratio of 2: 3 in the ratio of 3.
Wherein the seabuckthorn oil is: cleaning fructus Hippophae, drying, and pulverizing to obtain fructus Hippophae powder; placing fructus Hippophae powder in supercritical extraction device, and adopting CO2Supercritical fluid at 50 deg.C and 20Mpa CO2Extracting at a flow rate of 180 kg/h; performing vacuum separation treatment at 45 deg.C and 5Mpa to obtain oleum Hippophae; or other commercially available oleum Hippophae extracts with purity greater than 80%.
Wherein the genipap juice is: juice extracted from the pulp of genipap americana is used.
Example 2:
a preparation method of ink for a special positioning pen for radiotherapy comprises the following steps:
the ink for the special positioning pen for radiotherapy comprises the following components: the fruit juice beverage comprises, by mass, 5 parts of single-component essential oil, 5 parts of lemon stock solution, 1 part of Indian henna powder, 0.5 part of vitamins, 3 parts of sea buckthorn oil and 80 parts of American genipa fruit juice.
A preparation method of ink for a special positioning pen for radiotherapy comprises the following steps: adding 5 parts by mass of single-component essential oil, 5 parts by mass of lemon stock solution, 1 part by mass of India henna powder, 0.5 part by mass of vitamins, 3 parts by mass of sea buckthorn oil and 80 parts by mass of American genipa fruit juice into a reaction kettle in sequence, reacting for 1 hour at the temperature of 30 ℃ and the rotating speed of 200rpm, and then placing the mixture into an ultrasonic machine for ultrasonic dispersion for 2 hours to obtain the ink for the special positioning pen for radiotherapy.
Wherein, the single-component essential oil is as follows: adding 50 parts by mass of sweet almond oil, 1 part by mass of lavender essential oil and 2 parts by mass of tea tree essential oil into a mixer, and uniformly mixing to obtain a substance, wherein the solution is the single-component essential oil.
Wherein, the lemon stock solution is as follows: the collected fresh lemons were peeled and then squeezed using a squeezer, and the resulting juice was suction filtered to give a translucent liquid, which was the lemon stock.
Wherein, the vitamins are: vitamin C and vitamin E extracted from natural plants are mixed according to the mass ratio of 1: 2, and mixing the mixture to prepare the obtained substance.
Wherein the seabuckthorn oil is: cleaning fructus Hippophae, drying, and pulverizing to obtain fructus Hippophae powder; placing fructus Hippophae powder in supercritical extraction device, and adopting CO2Supercritical fluid at 50 deg.C and 20Mpa CO2Extracting at a flow rate of 180 kg/h; performing vacuum separation treatment at 45 deg.C and 5Mpa to obtain oleum Hippophae; or other commercially available oleum Hippophae extracts with purity greater than 80%.
Wherein the genipap juice is: juice extracted from the pulp of genipap americana is used.
Example 3:
a preparation method of ink for a special positioning pen for radiotherapy comprises the following steps:
the ink for the special positioning pen for radiotherapy comprises the following components: the fruit juice beverage comprises, by mass, 6 parts of single-component essential oil, 10 parts of lemon stock solution, 1 part of Indian henna powder, 0.5 part of vitamins, 4 parts of sea buckthorn oil and 80 parts of American genipa fruit juice.
A preparation method of ink for a special positioning pen for radiotherapy comprises the following steps: adding 6 parts by mass of single-component essential oil, 10 parts by mass of lemon stock solution, 1 part by mass of India henna powder, 0.5 part by mass of vitamins, 4 parts by mass of sea buckthorn oil and 80 parts by mass of American genipa fruit juice into a reaction kettle in sequence, reacting for 1 hour at the temperature of 35 ℃ and the rotating speed of 300rpm, and then placing the mixture into an ultrasonic machine for ultrasonic dispersion for 3 hours to obtain the ink for the special positioning pen for radiotherapy.
Wherein, the single-component essential oil is as follows: adding 60 parts by mass of sweet almond oil, 3 parts by mass of lavender essential oil and 3 parts by mass of tea tree essential oil into a mixer, and uniformly mixing to obtain a substance, wherein the solution is the single-component essential oil.
Wherein, the lemon stock solution is as follows: the collected fresh lemons were peeled and then squeezed using a squeezer, and the resulting juice was suction filtered to give a translucent liquid, which was the lemon stock.
Wherein, the vitamins are: vitamin C and vitamin E extracted from natural plants are mixed according to the mass ratio of 1: 3 in the ratio of 3.
Wherein the seabuckthorn oil is: cleaning fructus Hippophae, drying, and pulverizing to obtain fructus Hippophae powder; placing fructus Hippophae powder in supercritical extraction device, and adopting CO2Supercritical fluid at 50 deg.C and 20Mpa CO2Extracting at a flow rate of 180 kg/h; performing vacuum separation treatment at 45 deg.C and 5Mpa to obtain oleum Hippophae; or other commercially available oleum Hippophae extracts with purity greater than 80%.
Wherein the genipap juice is: juice extracted from the pulp of genipap americana is used.
Example 4:
a preparation method of ink for a special positioning pen for radiotherapy comprises the following steps:
the ink for the special positioning pen for radiotherapy comprises the following components: the fruit juice comprises, by mass, 5 parts of single-component essential oil, 8 parts of lemon stock solution, 1 part of Indian henna powder, 0.8 part of vitamins, 5 parts of sea buckthorn oil and 85 parts of American genipa fruit juice.
A preparation method of ink for a special positioning pen for radiotherapy comprises the following steps: adding 5 parts by mass of single-component essential oil, 8 parts by mass of lemon stock solution, 1 part by mass of India henna powder, 0.8 part by mass of vitamins, 5 parts by mass of sea buckthorn oil and 85 parts by mass of American genipa fruit juice into a reaction kettle in sequence, reacting for 1 hour at the temperature of 35 ℃ and the rotating speed of 250rpm, and then placing the mixture into an ultrasonic machine for ultrasonic dispersion for 3 hours to obtain the ink for the special positioning pen for radiotherapy.
Wherein, the single-component essential oil is as follows: adding 50 parts by mass of sweet almond oil, 2 parts by mass of lavender essential oil and 5 parts by mass of tea tree essential oil into a mixer, and uniformly mixing to obtain a substance, wherein the solution is the single-component essential oil.
Wherein, the lemon stock solution is as follows: the collected fresh lemons were peeled and then squeezed using a squeezer, and the resulting juice was suction filtered to give a translucent liquid, which was the lemon stock.
Wherein, the vitamins are: vitamin C and vitamin E extracted from natural plants are mixed according to the mass ratio of 1: 2, and mixing the mixture to prepare the obtained substance.
Wherein the seabuckthorn oil is: cleaning fructus Hippophae, drying, and pulverizing to obtain fructus Hippophae powder; placing fructus Hippophae powder in supercritical extraction device, and adopting CO2Supercritical fluid at 50 deg.C and 20Mpa CO2Extracting at a flow rate of 180 kg/h; performing vacuum separation treatment at 45 deg.C and 5Mpa to obtain oleum Hippophae; or other commercially available oleum Hippophae extracts with purity greater than 80%.
Wherein the genipap juice is: juice extracted from the pulp of genipap americana is used.
Comparative example 1:
a preparation method of ink for a special positioning pen for radiotherapy comprises the following steps:
the ink for the special positioning pen for radiotherapy comprises the following components: the fruit juice comprises, by mass, 8 parts of single-component essential oil, 10 parts of lemon stock solution, 2 parts of Indian henna powder, 1 part of vitamins, 5 parts of gentian violet and 90 parts of American genipa fruit juice.
A preparation method of ink for a special positioning pen for radiotherapy comprises the following steps: adding 8 parts by mass of single-component essential oil, 10 parts by mass of lemon stock solution, 2 parts by mass of India henna powder, 1 part by mass of vitamins, 5 parts by mass of gentian violet and 90 parts by mass of American genipa fruit juice into a reaction kettle in sequence, reacting for 2 hours at the temperature of 40 ℃ and the rotating speed of 300rpm, and then placing the reaction kettle in an ultrasonic machine for ultrasonic dispersion for 3 hours to obtain the ink for the special positioning pen for radiotherapy.
Wherein, the single-component essential oil is as follows: adding 80 parts by mass of sweet almond oil, 3 parts by mass of lavender essential oil and 5 parts by mass of tea tree essential oil into a mixer, and uniformly mixing to obtain a substance, wherein the solution is the single-component essential oil.
Wherein, the lemon stock solution is as follows: the collected fresh lemons were peeled and then squeezed using a squeezer, and the resulting juice was suction filtered to give a translucent liquid, which was the lemon stock.
Wherein, the vitamins are: the vitamin C and the vitamin E extracted from natural plants are mixed according to the mass ratio of 2: 3 in the ratio of 3.
Wherein, the gentian violet is: is extracted from gentian plant, rather than artificially synthesized.
Wherein the genipap juice is: juice extracted from the pulp of genipap americana is used.
Comparative example 2:
a preparation method of ink for a special positioning pen for radiotherapy comprises the following steps:
the ink for the special positioning pen for radiotherapy comprises the following components: the fruit juice comprises, by mass, 8 parts of single-component essential oil, 10 parts of lemon stock solution, 2 parts of Indian henna powder, 1 part of vitamins, 5 parts of kangfuxin and 90 parts of American genipa fruit juice.
A preparation method of ink for a special positioning pen for radiotherapy comprises the following steps: adding 8 parts by mass of single-component essential oil, 10 parts by mass of lemon stock solution, 2 parts by mass of India henna powder, 1 part by mass of vitamins, 5 parts by mass of kangfuxin and 90 parts by mass of American genipap juice into a reaction kettle in sequence, reacting for 2 hours at the temperature of 40 ℃ and the rotating speed of 300rpm, and then placing the reaction kettle in an ultrasonic machine for ultrasonic dispersion for 3 hours to obtain the ink for the special positioning pen for radiotherapy.
Wherein, the single-component essential oil is as follows: adding 80 parts by mass of sweet almond oil, 3 parts by mass of lavender essential oil and 5 parts by mass of tea tree essential oil into a mixer, and uniformly mixing to obtain a substance, wherein the solution is the single-component essential oil.
Wherein, the lemon stock solution is as follows: the collected fresh lemons were peeled and then squeezed using a squeezer, and the resulting juice was suction filtered to give a translucent liquid, which was the lemon stock.
Wherein, the vitamins are: the vitamin C and the vitamin E extracted from natural plants are mixed according to the mass ratio of 2: 3 in the ratio of 3.
Wherein, the rehabilitation new is as follows: consists of periplaneta americana extract.
Wherein the genipap juice is: juice extracted from the pulp of genipap americana is used.
Comparative example 3:
a preparation method of ink for a special positioning pen for radiotherapy comprises the following steps:
the ink for the special positioning pen for radiotherapy comprises the following components: the fruit juice beverage comprises, by mass, 8 parts of single-component essential oil, 10 parts of lemon stock solution, 2 parts of Indian henna powder, 1 part of vitamins, 5 parts of seabuckthorn flavone and 90 parts of American genipap juice.
A preparation method of ink for a special positioning pen for radiotherapy comprises the following steps: adding 8 parts by mass of single-component essential oil, 10 parts by mass of lemon stock solution, 2 parts by mass of India henna powder, 1 part by mass of vitamins, 5 parts by mass of seabuckthorn flavone and 90 parts by mass of American genipap juice into a reaction kettle in sequence, reacting for 2 hours at the temperature of 40 ℃ and the rotating speed of 300rpm, and then placing the reaction kettle in an ultrasonic machine for ultrasonic dispersion for 3 hours to obtain the ink for the special positioning pen for radiotherapy.
Wherein, the single-component essential oil is as follows: adding 80 parts by mass of sweet almond oil, 3 parts by mass of lavender essential oil and 5 parts by mass of tea tree essential oil into a mixer, and uniformly mixing to obtain a substance, wherein the solution is the single-component essential oil.
Wherein, the lemon stock solution is as follows: the collected fresh lemons were peeled and then squeezed using a squeezer, and the resulting juice was suction filtered to give a translucent liquid, which was the lemon stock.
Wherein, the vitamins are: the vitamin C and the vitamin E extracted from natural plants are mixed according to the mass ratio of 2: 3 in the ratio of 3.
Wherein, the seabuckthorn flavone is: preparing seabuckthorn fruits into seabuckthorn juice, degreasing the seabuckthorn juice by using petroleum ether, and then obtaining a seabuckthorn flavone extract according to the treatment method of the seabuckthorn oil in the embodiment 1; compared with oleum Hippophae, the product has no fat and other components, and retains effective components such as flavonoids, flavonols, isoflavones, flavanones, and tea ketones.
Wherein the genipap juice is: juice extracted from the pulp of genipap americana is used.
Comparative example 4:
a preparation method of ink for a special positioning pen for radiotherapy comprises the following steps:
the ink for the special positioning pen for radiotherapy comprises the following components: the fruit juice beverage comprises, by mass, 8 parts of single-component essential oil, 10 parts of lemon stock solution, 2 parts of Indian henna powder, 1 part of vitamins, 5 parts of silver sulfadiazine and 90 parts of American genipa fruit juice.
A preparation method of ink for a special positioning pen for radiotherapy comprises the following steps: adding 8 parts by mass of single-component essential oil, 10 parts by mass of lemon stock solution, 2 parts by mass of India henna powder, 1 part by mass of vitamins, 5 parts by mass of silver sulfadiazine and 90 parts by mass of American genipa fruit juice into a reaction kettle in sequence, reacting for 2 hours at the temperature of 40 ℃ and the rotating speed of 300rpm, and then placing the reaction kettle in an ultrasonic machine for ultrasonic dispersion for 3 hours to obtain the ink for the special positioning pen for radiotherapy.
Wherein, the single-component essential oil is as follows: adding 80 parts by mass of sweet almond oil, 3 parts by mass of lavender essential oil and 5 parts by mass of tea tree essential oil into a mixer, and uniformly mixing to obtain a substance, wherein the solution is the single-component essential oil.
Wherein, the lemon stock solution is as follows: the collected fresh lemons were peeled and then squeezed using a squeezer, and the resulting juice was suction filtered to give a translucent liquid, which was the lemon stock.
Wherein, the vitamins are: the vitamin C and the vitamin E extracted from natural plants are mixed according to the mass ratio of 2: 3 in the ratio of 3.
Wherein, the silver sulfadiazine is as follows: artificially synthesizing the substance.
Wherein the genipap juice is: juice extracted from the pulp of genipap americana is used.
Test example:
(1) acute oral toxicity test of ink
According to the test according to 3.4 of the first minute manual of the technical Specification for Disinfection (third edition) (Fuzz No. 1999, 448); animals (40 common-grade NIH mice in each group, half of males and females, weight of 18-22 g) are fasted for 12 hours by supplying water, distilled water is used as a solvent, the tested substance is the sample prepared in the embodiment 1 and 2, the set dose is 5500mg/kg, and the tested substance is filled into the animals once by a stomach filling needle according to 0.2ml/20g of weight; immediately observing and recording the poisoning expression, death number and death time of the animals after administration, wherein the observation is carried out twice a day for two weeks; and (3) carrying out toxicity grading according to an acute toxicity grading standard, wherein the experimental result is as follows: in the observation period, the tested mice have no obvious symptoms and no death.
TABLE 1 test results of acute oral toxicity of test substances on NIH mice
The result shows that the acute menstruation LD50 of the NIH mouse of the ink prepared by the invention is more than 5000mg/kg, and the ink belongs to an actual non-toxic product and cannot cause harm to human bodies in the using process.
(2) Test for preventive Effect on Wet skin
30 tumor patients needing radiotherapy treatment in tumor hospitals in N markets are selected, and the patients are required to have the prior medical history of eczema, wet dermatitis and the like. Divided into experimental groups 1-2 and control groups 1-4. The experimental groups 1 to 2 were specifically positioned using the ink protocols of example 1 and example 2, respectively, and the control groups 1 to 4 were specifically positioned using the ink protocols of comparative example 1, comparative example 2, comparative example 3, and comparative example 4, respectively, to evaluate the preventive effect on wet skin.
TABLE 2 preventive effect on Wet skin
| The number of the treated people | Number of people falling off | Number of wet skin patients | |
| Experimental group 1 | 5 | 0 | 0 |
| Experimental group 2 | 5 | 1 | 0 |
| Control group 1 | 5 | 1 | 2 |
| Control group 2 | 5 | 0 | 1 |
| Control group 3 | 5 | 1 | 1 |
| Control group 4 | 5 | 0 | 2 |
As can be seen from Table 2, the number of wet skin occurrences was significantly lower in the experimental groups 1-2 than in the control groups 1-4, compared to the control group. The invention adopts the seabuckthorn oil as the effect of preventing the wet skin, which is obviously better than gentian violet, kangfuxin, seabuckthorn flavone and sulfadiazine silver. The invention achieves unexpected technical effects.
The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention is not limited thereto. The equivalent substitution or change made by the technical personnel in the technical field on the basis of the invention is all within the protection scope of the invention. The protection scope of the invention is subject to the claims.
Claims (10)
1. The ink for the special positioning pen for radiotherapy for preventing wet skin is characterized by comprising the following components, by mass, 5-8 parts of single-component essential oil, 5-10 parts of lemon stock solution, 1-2 parts of Indian henna powder, 0.5-1 part of vitamins, 3-5 parts of sea buckthorn oil and 80-90 parts of American genipap juice.
2. The ink for the special positioning pen for radiation therapy for preventing wet skin as claimed in claim 1, wherein the single essential oil is prepared by mixing 50-80 parts by weight of sweet almond oil, 1-3 parts by weight of lavender essential oil and 2-5 parts by weight of tea tree essential oil.
3. The ink for the special positioning pen for radiation therapy for preventing wet skin according to claim 1, wherein the lemon stock solution is juice obtained by squeezing and suction-filtering lemons.
4. The special positioning pen ink for radiation therapy for preventing wet skin as claimed in claim 1, wherein the vitamin is vitamin C and vitamin E in a mass ratio of 1-2: 2-3, and mixing.
5. The ink for the special positioning pen for radiation therapy for preventing wet skin according to claim 1, wherein the seabuckthorn oil is prepared by the following method: cleaning and drying seabuckthorn, and crushing to obtain seabuckthorn powder; placing fructus Hippophae powder in supercritical extraction device, and adopting CO2Extracting with supercritical fluid; and performing reduced pressure separation treatment after extraction to obtain the seabuckthorn oil.
6. The ink for the special positioning pen for radiation therapy for preventing wet skin according to claim 5, wherein the sea buckthorn is one or more of sea buckthorn leaves, sea buckthorn fruits and sea buckthorn seeds.
7. The ink for the special positioning pen for radiation therapy for preventing wet skin as claimed in claim 5, wherein the extraction temperature is 45-60 ℃, the extraction pressure is 15-25 Mpa, and CO is2The flow rate is 150-200 kg/h.
8. The ink for the special positioning pen for radiation therapy for preventing wet skin according to claim 5, wherein the temperature of the decompression separation treatment is 40 to 50 ℃, and the pressure is 5 to 6 MPa.
9. The method for preparing the ink for the special positioning pen for radiation therapy for preventing wet skin according to any one of claims 1 to 8, which is characterized by comprising the following steps: the ink for the special positioning pen for radiotherapy for preventing the wet skin is prepared by sequentially adding the raw materials in parts by mass into a reaction kettle, reacting for 1-2 hours at the temperature of 30-40 ℃ and the rotating speed of 200-300 rpm, and performing ultrasonic dispersion on the reaction kettle.
10. The method of claim 9, wherein the ultrasonic dispersion is carried out for a period of 2 to 3 hours.
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| CN202111369486.2A CN114015284B (en) | 2021-11-15 | 2021-11-15 | Ink for special positioning pen for radiotherapy for preventing wet skin and preparation method thereof |
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| CN202111369486.2A CN114015284B (en) | 2021-11-15 | 2021-11-15 | Ink for special positioning pen for radiotherapy for preventing wet skin and preparation method thereof |
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| CN114015284A true CN114015284A (en) | 2022-02-08 |
| CN114015284B CN114015284B (en) | 2022-11-25 |
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Denomination of invention: A radiation therapy specific positioning pen ink for preventing wet skin and its preparation method Effective date of registration: 20230529 Granted publication date: 20221125 Pledgee: Suzhou high tech Industrial Development Zone sub branch of Bank of Communications Co.,Ltd. Pledgor: JIANGSU YIBEI MEDICAL TECHNOLOGY Co.,Ltd. Registration number: Y2023980042061 |
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