KR20180087763A - Feminine cleanser composition comprising fenugreek extract - Google Patents

Abstract

The present invention relates to a feminine cleanser composition containing a fenugreek extract or a mixture composed of the fenugreek extract and a composite medicinal herb extract. According to the present invention, the feminine cleanser composition ensures excellent antibacterial and/or antifungal activities.

Description

FEMININE CLEANSER COMPOSITION COMPRISING FENUGREEK EXTRACT < RTI ID = 0.0 >

The present invention relates to a female detergent composition comprising a mixture of a fenugreek extract or a fenugreek extract and a herbal extract.

The quality of the woman is the connection between the vulva and the uterus, which is the most humid and warm place in the female body. Therefore, bacteria and fungi, which are the main causes of vaginitis, are suitable for habitat, so the diseases are likely to occur. Under normal conditions, many lactic acid bacteria live in the vagina, making the inside of the vagina mildly acidic and inhibiting the growth of pathogens and molds. However, it is difficult to prevent the growth of pathogens or fungi by using long-term antibiotics, long-term use of pills, use of tampons or loops or pregnancy or childbirth, When the balance inside the vagina breaks down due to hormonal balance changes, vaginitis may occur due to the proliferation of opportunistic pathogens that normally inhibit growth under normal conditions in the vagina.

Vaginitis has been reported as bacterial vaginosis, Candida vaginitis, Trichomonas vaginitis and Atrophic vaginitis. The most common disease is bacterial vaginosis, caused by Gardnerella vaginalis . Candida albicans , common with bacterial vaginosis, is caused by the fungus Candida albicans .

In order to prevent such female diseases, a cleaning agent (vaginal cleanser) and a vulva cleanser are often used. As a local cleaning agent commonly used to prevent vaginitis, a product obtained by sulfonating fatty acids or distilled lauryl alcohol and synthesizing emollients, thickeners, nutrients, foaming agents and organic disinfectants Are being sold. However, the chemical quality detergent has a limitation in that the detergent effect is lowered and the germs are removed instead of removing the germs, and the odor and unpleasant odor removing effect are inhibited. Even if many methods as described above are developed, there is a problem that recurrence occurs well.

In addition, polyene-based drugs such as nystatin, amphotericin B, azole-based drugs such as ketoconazole, miconazole, , And triazole drugs such as itraconazole and fluconazole. However, when the amount of the antibiotics is insufficient, the germs do not die, This results in greater difficulty in subsequent treatment.

Although various drugs have been proposed as methods for treating vaginal cleansing and abnormal symptoms, it is still not enough to present a non-irritating detergent, a cleanser or a drug in consideration that the site of use is the most sensitive mucosal site for external substances . Thus, there is a need to develop new technologies to meet the ongoing need for cleaners using natural extracts without irritation and side effects.

Korean Patent Publication No. 10-2003-004587 Korean Patent Publication No. 10-2006- 002369

It is an object of the present invention to provide a female detergent composition which is non-toxic and which comprises a natural extract which is safe for the human body.

In order to accomplish the above object, one aspect of the present invention provides a female detergent composition comprising a fenugreek extract. Specifically, the extracts of Omija, Gumi Extract, Ginseng Extract, Gum Extract, Puerariae Radix Extract, Bacillus sp. Extract, Kwakwako Extract, Licorice Extract, Ganoderma Extract, Ganoderma Extract, The extract may be further comprised of at least one extract selected from the group consisting of Hwangbuk extract and Hwasung extract. In the present invention, the term "herb medicine" is generically referred to as "medicinal herb" in the present invention, for example, Omija, Bongryeong, Red ginseng, Zucchinaceae, White ginseng, Gwacheonjae, Licorice, Gosam,

In the present invention, " Trigonella foenum - graecum , Fenugreek) is a soybean plant that is hulled. Fenugreek is a word for "hay of Greece" and is a name given to the smell of dried hay. The major components of these fenugreek include alkaloids and proteins such as gentianine, choline, carpaine, and the like. It is warm and poisonous and has been used to treat bladder and kidney diseases in Africa, the Middle East, and India, and has also been used to treat people with cold or swollen diarrhea. Today, it has been shown to be effective in balancing blood sugar and insulin in the body and effective in weight control.

In the present invention, " Schizandrae Fructus ) "is a deciduous broad-leafed vine, with leaves alternating with ovate or obovate, with sharp tips, sharp teeth, and slightly hairs on the back side. The flower is reddish white, bloomed in June-July, and it is migratory. Fruit is used for food, hangs in the shape of a spike at the end of the branch, and ripens red from August to September. The main ingredients are schizandrin, schizandran, γ-schizandrin, ethamigrenal, gomisin and essential oils such as citral, nesquiqualene (), 담 (祛) function, uterine contraction, antimicrobial action, hypotensive effect (祛), 해 (祛) , Coronary action, and transaminase lowering action are known.

In the present invention, " Poria cocos " is a sclerot growing from a pine root, having a ball shape or an oval shape of 5 to 7 cm in diameter, and brown or dirty black with a piece of bark on the ground. It is said that Byeongryong is used as a stabilizer for Chiara, and it not only has the effect of stabilizing the heat, but also warms the body. It is effective for peptic ulcer, muscle cramps, thirst, dizziness, mental anxiety, and numbness. It is used for the treatment of kidney disease, cystitis, urethritis, etc. In addition, the contact dermatitis-inhibiting action effect is known.

In the present invention, the term " red ginseng " means a ginseng obtained by steaming or swelling ginseng or otherwise ginseng starch. Ginsenoside, a major ginseng saponin known as the main pharmacological component, has very different effects on saponins and other peculiar chemical structures found in other plants. Red ginseng has sedative and excitatory effects on the central nervous system. It protects the liver and acts on the endocrine system at the periphery, so that it acts indirectly on the reproductive effect, especially in anti-inflammatory and antitumor actions.

In the present invention, " Magnolia officinalis " is an evergreen broad-leaved tree belonging to the dicotyledonous plant, and is an evergreen broad-leaved tree belonging to the family Ranunculaceae, and lives in South Korea, Japan, Taiwan and southern China. As a medicinal herb, stem and egg shells have been used in the treatment of asthma and gastrointestinal disorders and contain ingredients such as magnolol, isomagnolol, honokiol, and machiol. Among them, honokiol belongs to polyphenol and is used as a useful substance showing antidepressant, thrombolytic inhibition, nerve stabilization and antibacterial activity.

In the present invention, " Puerariae radix " is a root of Pueraria lobata Ohwi according to Korean Pharmacopoeia, and is widely used as a food, beverage, and health food in the private sector. It is used for the purpose of releasing cold muscle, digestive diseases, and steel tube, and it helps the spleen and gastrointestinal muscles to rise. It is known.

In the present invention, the term " Bacillus " is a tubercle of the grown ( Bletilla striata Reichb. Fil.). The fresh raw meat contains 14.6% moisture, 30.48% starch and 1.5% glucose and contains essential oils and mucus. The roots contain bletilla mannan. Bacillus is known to be used for the treatment of complications of pulmonary tuberculosis and tuberculosis and pulmonary tuberculosis, as well as a hemostatic function for coagulating blood cells with good local hemostasis and forming an artificial thrombus

In the present invention, " Pogostemonis Herba "is widely grown in the Philippines, India and southern China. Pogostemon cabin Bentham, a perennial vegetation, is a dried plant, and contains pachouli alcohols, eugenol, cinnamic aldehyde, pagostol, pachouli pyridine, , And it is known to have a therapeutic effect on inflammatory bowel disease such as ulcerative colitis or Crohn's disease.

In the present invention, " Glycyrrhizae Radix " is a perennial herb belonging to Leguminosae, and is classified as European licorice ( Glycyrrhiza glabra L.), Manju licorice ( Glycyrrhiza uralensis F.) or other roots and leaves of the main stem (run 莖 莖) as it is or is removed. It is widely used in oriental medicine because of its excellent efficacy of pain relief and detoxification / detoxification. Sedative, anti-inflammatory and antibacterial effects.

In the present invention, " Sophora flavescens "is a perennial herb with rosemary roots and twigs. It is also known as the caterpillars of thieves, foxes, and snakes. The roots that are peeled off from the ginseng are well known as raw materials showing skin fungus inhibition, skin moisturizing, whitening, blood circulation improvement as well as preservative effect. Gosam is effective for jaundice, dysentery, dysentery, and genital itching caused by Hachohe fever (fever fever). The itch is caused by cleansing the affected part with water. It is used for skin itching, It has been known to be effective for symptoms that are sick.

In the present invention, " Eleutherococcus Senticosus ( Rupr . & Maxim. ) Maxim .) "is native to Mt. Odaesan, Mt. Jiri, Manchuria, Siberia, Hokkaido, etc. It stimulates the overall function of living organisms and promotes environmental adaptation and defense of living organisms. It is known.

In the present invention, " Persiccae Semen " is a mature seed of the peach tree Prunus persica Batsh. Belonging to the Rosaceae family. It contains fatty oil (40-50%), amygdalin, triolein, PR-A, PR-B (Shigeru et al., Shoyakugaku Zasshi 40, 2, 129, 1986) and is used for the treatment of anticoagulant blood, genomes, intestinal lubrication and stagnant blood. .

In the present invention, " Liriope Platyphylla "is a perennial plant that grows rhizomes and seeds. It is mainly distributed in low hills below 500 m in Korea, and the leaves are green throughout the year (Huh, MK, HW Huh, JS Choi, and BK Lee 2007. Genetic diversity and population structure of Liriope platyphylla (Liliaceae) in Korea. J. Life Sci. 17, 328-333.). MacMundong has been widely used in oriental medicine for curing diseases such as coughs and phlegm in Korea and China. Recently, it has been known to have an effect of treating diabetes, improving memory, inhibiting microorganisms, and suppressing inflammation.

In the present invention, " Panax ginseng " is a plant that grows in a deep mountain area, reaches a height of 60 cm, has a short rhizome, stands straight or diagonally, and develops like a bellflower root. It is widely cultivated in Korea and China. Ginseng is known to refresh the body and to help people with weakness, boredom, fatigue, anorexia, vomiting and diarrhea.

In the present invention, " Angelica gigas Nakai " is a perennial plant, which is known to be cultivated in mountainous areas and highland areas in the central part of Korea, and has been used for a long time as a medicinal material and food. Coumarin derivatives such as decursin and decursinol and α-pinene, β-eudesmol and the like as main components. It is known that the herbal medicine has an effect on the antimicrobial effect, the fatigue recovery and the blood, the anemia and the female lineage system by the pharmacological effect.

In the present invention, " Coptis chinensis ") is a perennial herb belonging to the ranuculaceae. It is known to contain alkaloid compounds such as berberine, coptisine and palmatine and components such as obacunone and obaculactone. Antimicrobial activity, blood pressure lowering effect , And relaxation of tracheal smooth muscle in the uterus

In the present invention, " Phellodendri Cortex " is a stem skin that has been peeled off from the leaves of the primrose ( Phellodendron amurense Rupr. The active ingredients of the yellowish white include peel ingredients such as berberine, palmatine, guanidine, jatrorr-hizine, phyellodendrine, candicine, menisperin alkaloid-based components such as me-nisperine, high-quality substances such as obakunone and obakulactone, and steroid-based substances. It has antimicrobial activity, blood pressure lowering effect, central nervous system inhibitory action, acetylcholine enhancing action and anti-inflammatory action, and is known to have antioxidant and anti-aging effect.

In the present invention, " Houttuynia cordata thunb.) is a prey of the Houttuynia cordata Thunb., a plant of Saururaceae, which lives in southeastern Asia and especially in Japan and Korea. It is pharmacologically known to have strong cardiac, diuretic, antibacterial, detoxifying and anti-cancer efficacy, and is used as a cosmetic and health functional food for detoxification and beauty in the private sector. It is known that there are many decanoyl acetaldehyde compounds and antioxidants, antioxidants, antifungal compounds and flavonoid compounds which are effective for diuretic, vasoconstriction and defecation.

The " extract " of the present invention is an extract of Holofa, Omija, Bepyeong, Red ginseng, Zucchini, Puerariae, White ginseng, Kwakwaki, Licorice, Gosam, A mixture of the above extracts, a mixture of the above-mentioned extracts, horopara, omija, gyeonggyeong, red ginseng, hwangbuk, Extracts of all the formulations which can be formed using the extract itself and extracts such as an extract obtained by extraction, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, a preparation or a purified product of the extract, .

The extract of the present invention can be extracted from natural, hybrid, or mutant plants of the respective plants, and can also be extracted from plant tissue cultures.

The method for extracting the extract of the present invention is not particularly limited and may be carried out according to a method commonly used in the art. Non-limiting examples of the extraction method include hydrothermal extraction, ultrasonic extraction, filtration, and reflux extraction. These may be performed alone or in combination with two or more methods.

The kind of the extraction solvent used in the present invention is not particularly limited, and any solvent known in the art can be used. Non-limiting examples of the extraction solvent include water, anhydrous or lower alcohol of C ₁ to C ₄ , a mixed solvent of water and lower alcohol, acetone, 1,3-butylene glycol, ethyl acetate, chloroform Or a mixture of two or more of them.

More specifically, water (or distilled water) may be used as an extraction solvent in the present invention. The above-mentioned solvent is used to at least one or more of the above-mentioned Holofa, Omija, Bepyeong, Red Ginseng, Hwangbuk, Gwacheon, Baekwon, Kwakwagyeol, Licorice, Gosam, And the solvent extract can be prepared. The dry extract obtained by vacuum distillation or spray drying the solvent extract can be prepared.

 In a specific example of the present invention, a fenugreek extract was prepared using water (or distilled water) (Example 1), and the fenugreek extract was prepared by mixing the fenugreek extract, (Example 2) were prepared, and the mixture was mixed with the fenugreek extract (Example 2).

In the present invention, the extract obtained by hot water extraction or cold extraction is filtered to remove suspended solid particles by filtration, for example, nylon or the like, or by freeze filtration, Spray drying and the like.

Specifically, the extracts of Holofa, Omija, Bepyeong, Red ginseng, Zucchinaceae, White ginseng, Gwacheonjae, Licorice, Gosam, 1 to 10/1 to 10/1 to 10/1 to 10/1 to 10/1 to 10/1 to 10/1 to 10/1 to 10/1 to 10/1 to 10/1 to 10/1 to 10/1, 10: 1 to 10: 1 to 10: 1 to 10: 1 to 10 by weight.

In Example 1 of the present invention, the fenugreek extract was prepared (Example 1), and the fenugreek extract was mixed with the fenugreek extract and the extracts of Omija, Bepyeong, Red ginseng, The mixture was prepared by mixing the extracts of ginseng, Angelica gigas, Angelica keiskei, Hwangbyeong and Hwasungcho at the same ratio on the weight ratio basis. The mixture was mixed with the fenugreek extract of Example 1 at a weight ratio of 5: 5. These mixing ratios can be modified and used as needed. In particular, the raw materials of all the extracts of the present invention are derived from natural materials and thus have no toxicity. They are classified as EWG (Environmental Working Group) grade 1 and have been proved to have excellent safety. Therefore, even if a specific extract is contained in excess, .

In the present invention, " female cleanser " is intended to prevent secretions, itching, smell, and the like, which are caused by infection by bacteria invading from the outside, and to reduce or eliminate unpleasantness. Such a cleansing agent may be effective in eliminating the causes of various women's diseases such as infertility, uterine myoma, and uterine cancer, which may be caused by cold infection, inflammation and itching as well as bacterial infection or inflammation.

The composition of the present invention can exhibit an effect of relieving the stimulation on the sensitive region while suppressing or killing harmful bacteria in the vagina.

It was confirmed in Example 1 of the present invention that the mixture of the fenugreek extract (Example 1) and the mixture of the fenugreek extract and the herb extract (Example 2) showed strong growth inhibition effect (Table 1). In addition, it was confirmed that the composition of the present invention inhibits the growth of Candida bacillus and Gardnerella vaginalis, though it has no significant effect on lactobacillus casei which is a lactic acid bacterium (Table 2). In particular, the above results show that the antimicrobial effect of the composition of the present invention has little effect on the beneficial lactic acid bacteria, while the inhibitory effect on the harmful bacteria is very high and the antibacterial effect is also selectable. In addition, it was confirmed that the female cleaner composition of the present invention comprising the natural extract of the present invention was safe without toxicity to the cells of the body (Table 3).

The female cleansing composition of the present invention can be used as a cleansing agent, a pharmaceutical agent, a cosmetic agent, a wet tissue, or the like.

The detergent may be formulated into a spray, a liquid, a gel, a powder, a solid soap, a foam, or the like, but is not limited thereto. In addition, the liquid formulation can be applied to a nonwoven fabric or pulp and applied as a wet tissue.

The cosmetic composition may be a conventional lotion, a lotion, a cream, an essence, an aerosol, a powder, an oil or a mist, but is not limited thereto. In addition, in the present invention, in addition to the herbal medicine extract described above, the female cleansing composition for cosmetics may contain various components commonly used in external preparations for skin, for example, a water-soluble component, a powder component , Oil, surfactant, moisturizing agent, viscosity controlling agent, preservative, antioxidant, fragrance, pigment and the like.

The pharmaceutical preparations may be formulated into tablets, pills, powders, granules, capsules and the like as solid preparations for oral administration. Examples of the formulations for parenteral administration include creams, ointments, lotions, dressings, And the like, but the present invention is not limited thereto.

Specifically, in the above-described female cleanser composition, the fenugreek extract may be contained in an amount of 0.005 to 30.0% by weight based on the total weight of the cosmetic composition. And more specifically from 0.01% to 20% by weight. There is an advantage that excellent antifungal or antimicrobial effect is exhibited within the above range, and there is an advantage that the formulation of the composition is stabilized.

Further, the natural extract of the present invention can be prepared into various health functional foods by adding a palatable food ingredient and can be manufactured in a general food form, and the additive ingredient can be appropriately selected and blended by those skilled in the art have.

The composition comprising the fenugreek extract of the present invention or a mixture of the fenugreek extract and the herbal extract is excellent in antibacterial activity and / or antifungal activity.

In addition, since the composition of the present invention is a substance derived from natural materials, it has no toxicity and does not cause side effects even when it is applied to human body, and thus it is highly utilized as a female cleansing agent. Particularly, all the raw materials used in the present invention are classified as EWG (Environmental Working Group) grade 1, and thus it has been proved that the raw materials are excellent in safety.

It should be understood that the effects of the present invention are not limited to the effects described above, but include all effects that can be deduced from the description of the invention or the composition of the invention set forth in the claims.

Hereinafter, the present invention will be described in detail by way of examples. However, the following examples are illustrative of the present invention, and the present invention is not limited by the following examples.

Example  One. Horopa  Preparation of extract

100 g of the dried weight of fenugreek was put into a flask and extracted with 1,000 g of an extraction solvent (distilled water) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare an extract.

Example  2. Horopa  Preparation of mixtures of extracts and herbal extracts

(100 g) of the dried weight of each of the extracts (distilled water) 1,000 (g) was added to the flask, g for 3 days. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare respective extracts. Each of the above extracts was mixed in the same ratio on a weight basis, and the mixture was mixed with the Fowley extract prepared in Example 1 at a weight ratio of 5: 5 to prepare a mixture of Fowley extract and herb extract.

Comparative Example  1. Our own women Cleaner

A commercially available in-house cleaner was used as a comparative example.

Experimental Example  1. Evaluation of antibacterial activity

In order to confirm the antibacterial activity of the natural extracting antimicrobial composition prepared in Examples 1 and 2, a disk diffusion method was used. Candida albicans , which is a fungus, and Gardnerella , a common bacterium, vaginalis ) was used.

100 [mu] L of pre-cultured Candida albicans and guinea-nella bajinalis were dispensed into each well of Sabouraud Dextrose Agar (Difco, USA) for disk diffusion assay, and the extract was applied to a sterilized paper disk at 5 mg / And the sample was placed on the medium. Itraconazole, an antifungal agent for Candida albicans, and Ampicillin, an antibiotic for Gardnerella vaginalis were used as a positive control, and they were placed on a paper disk at a concentration of 100 μg / disk and then placed on a medium I left it. The size (mm) of the growth inhibition zone (mm) after culturing the plate medium at 28 ° C for 48 hours was measured and shown in Table 1 below.

Candida albicans Guard Nella Trousers Positive control group 24 25 Example 1 29 31 Example 2 30 31 Comparative Example 1 29 27

As shown in Table 1, it was found that the compositions of Examples 1 and 2 exhibited strong growth inhibition effects. In particular, it was confirmed that Example 2, which is a mixture of the fenugreek extract and the herbal extract, showed remarkably excellent growth inhibition effect as compared with the positive control.

Experimental Example  2. Assessment of microbial growth inhibition

Effects of Lactobacillus casei and Lactobacillus casei on the growth of Candida albicans and Gardnerella vaginalis , which are known as lactic acid bacteria that grow in female vagina, Respectively.

Microbial growth was confirmed by increasing the turbidity in the medium and the IC ₅₀ (half maximal inhibitory concentration) value required for 50% inhibition of the antimicrobial activity and microorganisms was measured using the Broth Microdilution Susceptibility Tests Respectively.

Specifically, each strain was diluted with Sabouraud Dextrose medium to a cell density of 2 × 10 ⁵ cells / ml, and then treated by serial dilution in a 96-well plate. After incubation at 28 ° C for 24 hours, the absorbance was measured at a wavelength of 570 nm using a microplate reader (BIO-RAD) to determine IC ₅₀ values. The results are shown in Table 2 below.

sample density
(mg / ml) Survival rate (%) Lactobacillus casei Candida albicans Guard Nella Trousers Example 1 5 100 42.1 53.1 10 98 11.8 13.2 20 95 3.1 5.1 50 94 1.2 2.2 Example 2 5 100 22.1 31.2 10 97 5.3 9.6 20 96 1.7 3.2 50 92 0.8 1.1 Comparative Example 1 5 100 39.6 40.3 10 93 15.4 20.1 20 87 7.8 5.6 50 84 2.2 3.4

As shown in Table 2, Example 1 and Example 2 of the present invention do not have a large effect on lactobacillus casei, which is a lactic acid bacterium, but they inhibit the growth of Candida bacillus and Gardnerella var. . In particular, in the case of Comparative Example 1, the higher the concentration, the more the growth of Lactobacillus casei was, and the growth inhibitory effect on Candida albicans and Gardnerella vaginalis was somewhat higher than those of Examples 1 and 2 And it was found that the composition of the present invention is more effective as a female cleanser than the conventional products. In addition, the above results suggest that the antimicrobial effect of the composition of the present invention is up to selectivity.

Experimental Example  3. Assessment of cytotoxicity

Experiments were conducted to confirm the cytotoxicity of the above Example 1, Example 2 and Comparative Example 1. Human Diploid Fibroblast cells were diluted to a concentration of 5000 cells / μl in a 96-well plate, and 100 μl of each was inoculated and cultured for 24 hours. After the culture, all of the medium was removed, and 90 μl of serum-free medium was added to each well. Thereafter, 10 μl of each of the samples of Examples 1 and 2 and Comparative Example 1 diluted to a final concentration of 200 μg / μl was treated in each well and cultured.

After 24 hours of incubation, 20 μl of MTT reagent dissolved in phosphate buffered saline (PBS) at a concentration of 5 mg / ml was added and incubated for 4 hours. Thereafter, the media containing the MTT reagent and the samples of Example 1, Example 2 and Comparative Example 1 were all removed, 100 μl of acidisopropanol (0.04 N HCliniso-propanol) was added to each well, stirred for 30 minutes, And the absorbance at 570 nm was measured. The cell viability of the fibroblasts was measured and the results are shown in Table 3.

Cell survival rate (%) Example 1 101.3 Example 2 100.8 Comparative Example 1 98.4

As shown in Table 3, it was confirmed that the female cleaner composition of the present invention comprising the natural extract of the present invention was safe and toxic to the cells of the body.

Manufacturing example 1. Bonn  Liquid women containing the extract of the invention Cleaner  Composition manufacturing

A liquid female cleaner composition was prepared as shown in Table 4 below (unit: wt%).

Raw material name Content (% by weight) The extract of the present invention 20 Propylene glycol 5 1,2-hexanediol 5 Hydroxyethyl cellulose 4.25 Bp 4 Betaine 1.5 Piperazine-25-butes-26 One Phage-40-hydrogeneate One Disodium iodide 0.2 Dipotassium glycyrrhizate 0.2 Citric acid 0.2 Purified water To 100

Manufacturing example  2. A cream-form female containing the extract of the present invention Cleaner  Produce

A cream form cosmetic composition was prepared as shown in the following Table 5 (unit: wt%).

Composition Content (% by weight) The extract of the present invention 20 Dimethicone copolyol 10 Cyclomethicone 10 Urea 20 glycerin 20 Triethanolamine 0.02 antiseptic One Purified water To 100

It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. For example, each component described as a single entity may be distributed and implemented, and components described as being distributed may also be implemented in a combined form.

The scope of the present invention is defined by the appended claims, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included within the scope of the present invention.

Claims (6)

A female detergent composition comprising a fenugreek extract. The method according to claim 1, wherein the extract is selected from the group consisting of Schizandra chinensis extract, Schizandra chinensis extract, Ginkgo biloba extract, Red ginseng extract, Zygomycota extract, Puerariae radix extract, Bacillus subtilis extract, Wherein the extract further comprises one or more extracts selected from the group consisting of Rhodiola extract, HuangYin extract, HuangYong extract and Rhododendron sulphate extract. 3. The method according to claim 1 or 2,
The composition may have an antifungal effect on Candida albicans or an antifungal effect on Candida albicans or Gardnerella < RTI ID = 0.0 > vaginalis ). < / RTI > The female detergent composition according to claim 1, wherein the fenugreek extract is extracted from fenugreek seeds. The method according to claim 1,
Wherein the extract is selected from the group consisting of water, an anhydrous or lower alcohol of C ₁ to C ₄ , a mixed solvent of water and a lower alcohol, acetone, 1,3-butylene glycol, ethyl acetate and chloroform Gt; The method according to claim 1,
Wherein the fenugreek extract is present in an amount of from 0.005% to 30.0% by weight based on the total weight of the cosmetic composition.