CN211884998U - Marking pen for positioning and developing in radiotherapy - Google Patents
Marking pen for positioning and developing in radiotherapy Download PDFInfo
- Publication number
- CN211884998U CN211884998U CN201921558261.XU CN201921558261U CN211884998U CN 211884998 U CN211884998 U CN 211884998U CN 201921558261 U CN201921558261 U CN 201921558261U CN 211884998 U CN211884998 U CN 211884998U
- Authority
- CN
- China
- Prior art keywords
- pen
- radiotherapy
- shell
- refill
- soft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Radiation-Therapy Devices (AREA)
Abstract
The utility model relates to a radiotherapy location development marker pen, including a shell and the refill of setting in its inside, its characterized in that: the pen shell is dark brown and can shield light, the upper end of the pen shell is opened, and radiotherapy positioning developing solution is contained in the pen shell; the pen core is soaked in the radiotherapy positioning developing solution and comprises a pen core tube, a connecting pipe sleeve and a soft pen point, a sealing cover is fixedly arranged on the outer wall of the pen core tube, the sealing cover is in threaded connection with the upper end of the pen shell in a sealing mode and can be detached, the connecting pipe sleeve is installed at the front end of the pen core tube, and the soft pen point is installed at the front end of the connecting pipe sleeve. The utility model discloses a radiotherapy location development marker pen structure is ingenious, can make radiotherapy location development liquid paint evenly to live time is long.
Description
Technical Field
The utility model belongs to the technical field of the radiation therapy technique and specifically relates to a radiotherapy location developing solution and development marker pen.
Background
At present, malignant tumors become a main factor threatening the health and life of people, and bring heavy economic and social burdens to the nation, the society, families and individuals. Radiation therapy is one of the main means for treating malignant tumors, and most tumor patients need to receive radiation therapy for different purposes at different stages of the disease course. The ideal goal of tumor radiotherapy is to deliver a sufficiently large therapeutic dose to the target tumor volume while minimizing the exposure dose to surrounding normal tissues, especially vital and sensitive organs. To achieve this goal, accurate localization of the tumor is critical.
Body surface labeling is a commonly used technique in radiation therapy localization. At present, no standard and systematic radiotherapy positioning marking pen exists in clinical work, most of marking liquid with fuchsin as a main raw material is used, and a bamboo stick is dipped in the marking liquid for operation. However, the marking liquid contains chemical products, has toxicity, is harmful to human skin, is easy to cause skin allergy, and can only keep the skin mark for 3-5 days. Some medical institutions use common marking pens, but the lines of the marking pens for operating and drawing on the body surface are easy to bend and bend, the marking pens are not easy to use, and can only be kept for 3-5 days, so that the marking pens bring about no small trouble to medical staff. In addition, marking solutions and common mark pens which take fuchsin as a main raw material have the problem of easy decolorization, and particularly, under the condition that weather is hot or a patient easily sweats, the marking solutions can be decolorized and disappear within 1-2 days (see the attached figure 1 in the specification), and the positioning line position needs to be determined by repositioning, so that the treatment time of the patient is delayed.
Disclosure of Invention
The utility model aims to overcome the defects in the prior art and provide a radiotherapy positioning developing solution and a developing marking pen.
The first purpose of the utility model is realized through the following technical scheme:
the radiotherapy positioning developing solution is characterized by being prepared according to the following steps:
(1) taking xanthan gum powder and purified water, adding 0.35-0.5 g of xanthan gum powder into per 100ml of purified water, adding the xanthan gum powder into the purified water at room temperature, and fully stirring and dissolving to obtain primary colloid;
(2) taking gardenia blue pigment powder and the primary colloid prepared in the step (1), adding the gardenia blue pigment powder into the primary colloid according to the proportion of adding 3-5 g of the gardenia blue pigment powder into every 10ml of the primary colloid, and fully stirring and dissolving to obtain an intermediate colloid;
(3) adding 98% genipin powder into absolute ethyl alcohol according to the proportion that 1-2 g of 98% genipin powder is added into 10ml of absolute ethyl alcohol, and fully stirring and dissolving to obtain a genipin ethanol solution;
(4) and (3) adding the genipin ethanol solution into the intermediate colloid according to the proportion that 10-12 ml of the genipin ethanol solution is added into every 10ml of the intermediate colloid by taking the intermediate colloid prepared in the step (2) and the genipin ethanol solution prepared in the step (3), and stirring continuously during the adding process to fully mix the intermediate colloid and the genipin ethanol solution to form a uniform solution, namely the radiotherapy positioning developing solution.
As a further improvement of the radiotherapy localization developing solution, in the step (1), 0.4g of xanthan gum powder is added per 100ml of purified water.
As a further improvement of the radiotherapy positioning developing solution, in the step (2), 3g of gardenia blue pigment powder is added in each 10ml of primary colloid.
As a further improvement of the radiotherapy positioning developing solution, in the step (3), 2g of 98% genipin powder is added in each 10ml of absolute ethyl alcohol.
As a further improvement of the radiotherapy positioning developing solution, in the step (4), 10ml of genipin ethanol solution is added into every 10ml of intermediate colloid.
The second objective of the present invention is achieved by the following technical solution:
radiotherapy location development marker pen, including pen shell and the refill of setting in its inside, its characterized in that: the pen core is fully soaked with the radiotherapy positioning developing solution.
As a further improvement of the radiotherapy positioning developing marking pen, the pen shell is dark brown and is provided with an opening at the upper end, and the radiotherapy positioning developing solution is contained in the pen shell; the pen core is soaked in the radiotherapy positioning developing solution and comprises a pen core tube, a connecting pipe sleeve and a soft pen point, a sealing cover is fixedly arranged on the outer wall of the pen core tube, the sealing cover is in threaded connection with the upper end of the pen shell in a sealing mode and can be detached, the connecting pipe sleeve is installed at the front end of the pen core tube, and the soft pen point is installed at the front end of the connecting pipe sleeve.
As a further improvement of the radiotherapy positioning developing marking pen, an external thread is arranged on the outer wall of the opening at the upper end of the pen shell, an internal thread matched with the external thread is arranged on the inner wall of the sealing cover, and the sealing cover is in threaded connection with the upper end of the pen shell.
As a further improvement of the radiotherapy positioning developing marking pen, the pen shell is made of PVC material, and a hanging nose is integrally arranged on the outer wall of the upper part of the pen shell; the pencil core tube is made of PVC materials, and the pencil core tube and the sealing cover are integrally arranged.
As a further improvement of the radiotherapy positioning developing marker pen, the soft pen point is made of wolf hair, and the width of the soft pen point is 1.5-2 mm.
Compared with the prior art, the utility model, have following advantage:
1) the utility model discloses a radiation therapy location developer scribbles behind the skin, and three minutes back developer is basically totally dry and adhesion on the skin surface, and genipin can continue to react with top skin to reach very good coloring effect, because the time that the operation needs is very short, so do not influence the follow-up operation of radiotherapy location, can not prolong radiotherapy positioning time, moreover can normally operate under the unsmooth condition of body surface, reach the effect of bamboo let setting-out basically. The skin mark may be maintained for 10-15 days.
2) The marking pen for positioning and developing radiotherapy of the utility model has an ingenious structure, can ensure that the positioning and developing solution for radiotherapy is smeared evenly, and has long service life.
Drawings
Fig. 1 is a schematic diagram showing the comparison of the coloring effect of the radiotherapy positioning developing solution, the mark pen and the magenta marker solution applied to the skin at different time points according to embodiment 1 of the present invention.
Fig. 2 is a schematic structural diagram of a marking pen for positioning and visualization in radiotherapy according to embodiment 2 of the present invention.
Description of reference numerals: 1-pen shell, 1 a-hanging nose, 2-pen core, 2.1-pen core tube, 2.2-sealing cover, 2.3-connecting pipe sleeve and 2.4-soft pen point.
Detailed Description
The invention is further described with reference to the following specific drawings and examples.
Example 1
the radiotherapy positioning developing solution is characterized by being prepared according to the following steps:
(1) taking xanthan gum powder and purified water, adding 0.4g of xanthan gum powder into per 100ml of purified water, adding the xanthan gum powder into the purified water at room temperature, and fully stirring and dissolving to obtain primary colloid;
(2) taking gardenia blue pigment powder and the primary colloid prepared in the step (1), adding the gardenia blue pigment powder into the primary colloid according to the proportion of adding 3g of the gardenia blue pigment powder into each 10ml of the primary colloid, and fully stirring and dissolving to obtain an intermediate colloid;
(3) adding 98% genipin powder into absolute ethyl alcohol according to the proportion that 2g of 98% genipin powder is added into 10ml of absolute ethyl alcohol, and fully stirring and dissolving to obtain a genipin ethanol solution;
(4) and (3) adding the genipin ethanol solution into the intermediate colloid according to the proportion that 10ml of the genipin ethanol solution is added into every 10ml of the intermediate colloid by taking the intermediate colloid prepared in the step (2) and the genipin ethanol solution prepared in the step (3), and stirring continuously during the adding process to fully mix the genipin ethanol solution and the intermediate colloid to form a uniform solution, namely the radiotherapy positioning developing solution.
In the utility model, 98% genipin powder can be changed into genipin powder with other content percentages, such as 95% genipin powder, and the usage amount needs to be slightly increased.
The skin is composed of epidermis, dermis and subcutaneous tissue, and the epidermis is composed of basement membrane, basal layer and stratum corneum. Because of the skin's metabolic effects, basal cells differentiate and proliferate to form new keratinocytes, and aged keratinocytes are exfoliated, and this metabolic cycle is usually 2-4 weeks. With the shedding of aged keratinocytes, the blue color generated by the genipin contacting the skin gradually fades, so that the color development time of the genipin on the skin is 2-4 weeks, but the color development time is generally about 10-15 days due to the actions of sweat, washing, rubbing and the like.
The genipin skin staining mechanism is as follows: after the genipin contacts the skin, the genipin and the protein on the keratinocyte cell membrane on the outer layer of the skin are subjected to cross-linking reaction to form a blue substance, namely gardenia blue pigment. Generally, genipin develops color 2-4 hours after contacting the skin, is light blue at the beginning, then gradually darkens to navy blue or bluish black, and gradually fades after 10-15 days. The genipin has not been used for radiotherapy positioning at present because the longer the reaction time with the skin, the better the coloring effect. The radiotherapy positioning developing solution of the utility model uses genipin as the main raw material, and the genipin is reasonably proportioned with xanthan gum powder, gardenia blue pigment powder, absolute ethyl alcohol and other substances, and the genipin is used as the main raw material, so that the reaction speed can be accelerated and the coloring effect can be improved by increasing the concentration of the genipin. The xanthan gum is dissolved in the purified water to form xanthan gum colloid, and because the xanthan gum colloid has adhesiveness, when absolute ethyl alcohol in the developing solution volatilizes and takes away water in the developing solution, the developing solution can be adhered to the surface of the skin, so that genipin and the skin continuously react, and the coloring effect is improved. The absolute ethyl alcohol is not only an excellent solvent for genipin, but also an important raw material for quick drying of a developing solution. The gardenia blue pigment has no toxicity and is indigo, so that the locus of the drawn positioning line can be conveniently displayed. Make the utility model discloses a radiotherapy location developer can shorten the colouring time greatly, scribbles skin after, three minutes back developer is basically totally dry, and the developer of adhesion on skin surface can continue to react with the skin top layer, because operating time is very short, so do not influence the follow-up operation of radiotherapy location, can not prolong radiotherapy location time, moreover can normally operate under the unsmooth condition of body surface, reach the effect of bamboo let setting-out basically. The skin mark may be maintained for 10-15 days or even longer.
The radiotherapy positioning developing solution, the mark pen and the magenta marker solution in the embodiment 1 of the present invention are respectively coated on the skin surface of the abdomen (normally bathing after 8 hours, and bathing once a day, the bathing liquid is normally used), and the contrast conditions of the coloring effects at different time points are shown in fig. 1. As can be seen from FIG. 1, the marks of the mark pen fade substantially to be invisible after 4-5 days, the magenta marking solution fades substantially to be invisible after 6-7 days, and the radiotherapy positioning developing solution of the present invention is still clearly visible after 15 days.
Example 2
As shown in fig. 2, embodiment 2 discloses a marking pen for radiotherapy positioning visualization, which comprises a pen shell 1 and a pen core 2 arranged inside the pen shell, wherein the pen core 2 is fully soaked with the radiotherapy positioning visualization liquid prepared in embodiment 1.
As shown in fig. 2, in this embodiment 2, the pen case 1 is dark brown, the upper end of the pen case 1 is open, and the above radiotherapy positioning developing solution is contained in the pen case 1; the pen core 2 is soaked in the radiotherapy positioning developing solution, the pen core 2 comprises a pen core tube 2.1, a connecting pipe sleeve 2.3 and a soft pen point 2.4, a sealing cover 2.2 is fixedly arranged on the outer wall of the pen core tube 2.1, the sealing cover 2.2 is in sealing threaded connection with the upper end of the pen shell 1 and can be detached, the connecting pipe sleeve 2.3 is installed at the front end of the pen core tube 2.1, and the soft pen point 2.4 is installed at the front end of the connecting pipe sleeve 2.3.
When the positioning marking is needed, the medical staff holds the refill tube 2.1 by hands, reversely screws the refill tube to disconnect the sealing cover 2.2 from the upper end of the pen shell 1, and takes out the refill 2, thereby carrying out marking operation.
In this embodiment 2, be equipped with the external screw thread on the outer wall of 1 upper end opening part of shell, be equipped with on the inner wall of sealed lid 2.2 with the internal thread that the external screw thread matches. So set up, can conveniently install the sealing washer additional in the sealed lid 2.2 for the leakproofness after being connected between sealed lid 2.2 and the pen shell 1 is good.
As shown in fig. 2, in this embodiment 2, the pen casing 1 is made of PVC, and a hanging nose 1a is integrally disposed on an outer wall of an upper portion of the pen casing 1; the pen core tube 2.1 is made of PVC materials, and the pen core tube 2.1 and the sealing cover 2.2 are integrally arranged; the connecting pipe sleeve 2.3 is made of metal, the soft pen point 2.4 is made of wolf hair, and the width of the soft pen point 2.4 is 1.5-2 mm. By the arrangement, the pen shell 1 and the pen core tube 2.1 made of PVC materials are beneficial to reducing the product cost; the connecting pipe sleeve 2.3 made of metal materials is convenient to connect the refill tube 2.1 and the soft pen point 2.4; the wolf hair writing brush tip with the width of 1.5-2 mm has good flexibility, and can enable the radiotherapy positioning developing solution to be uniformly coated. In this embodiment, the pen casing 1 is a test tube, the length is preferably 10cm, the diameter is preferably 2cm, and the diameter of the tail end of the pen core tube 2.1 is preferably 0.5cm, so as to facilitate holding.
The above description is only for the preferred embodiment of the present invention, and the above specific embodiments are not intended to limit the present invention. Within the scope of the technical idea of the present invention, various modifications and alterations can be made, and any person skilled in the art can make modifications, amendments or equivalent replacements according to the above description, all belonging to the protection scope of the present invention.
Claims (4)
1. Radiotherapy location development marker pen, including pen shell (1) and setting at inside refill (2), its characterized in that: the pen shell (1) is dark brown, the upper end of the pen shell (1) is open, and radiotherapy positioning developing solution is contained in the pen shell (1); refill (2) soak in radiotherapy location developer, refill (2) including refill pipe (2.1), connection pipe box (2.3) and soft nib (2.4), fixed sealed lid (2.2) that is equipped with on refill pipe (2.1) outer wall, sealed lid (2.2) sealed threaded connection be in but the pen shell (1) upper end is shirked, refill pipe (2.1) front end installation connection pipe box (2.3), soft nib (2.4) of connection pipe box (2.3) front end installation.
2. The radiation therapy positioning visualization marker pen as recited in claim 1, wherein: the pen cap is characterized in that an external thread is arranged on the outer wall of an opening at the upper end of the pen cap (1), an internal thread matched with the external thread is arranged on the inner wall of the sealing cap (2.2), and the sealing cap (2.2) is in threaded connection with the upper end of the pen cap (1).
3. The radiation therapy positioning visualization marker pen as recited in claim 1, wherein: the pen shell (1) is made of PVC materials, and a hanging nose (1a) is integrally arranged on the outer wall of the upper part of the pen shell (1); the pencil core tube (2.1) is made of PVC materials, and the pencil core tube (2.1) and the sealing cover (2.2) are integrally arranged.
4. The radiation therapy positioning visualization marker pen as recited in claim 1, wherein: the soft pen point (2.4) is made of wolf hair, and the width of the soft pen point (2.4) is 1.5-2 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921558261.XU CN211884998U (en) | 2019-09-19 | 2019-09-19 | Marking pen for positioning and developing in radiotherapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921558261.XU CN211884998U (en) | 2019-09-19 | 2019-09-19 | Marking pen for positioning and developing in radiotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211884998U true CN211884998U (en) | 2020-11-10 |
Family
ID=73285626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921558261.XU Active CN211884998U (en) | 2019-09-19 | 2019-09-19 | Marking pen for positioning and developing in radiotherapy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211884998U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023095002A (en) * | 2021-12-24 | 2023-07-06 | 知子 秋田 | Skin marker for radiation therapy |
-
2019
- 2019-09-19 CN CN201921558261.XU patent/CN211884998U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023095002A (en) * | 2021-12-24 | 2023-07-06 | 知子 秋田 | Skin marker for radiation therapy |
| JP7353660B2 (en) | 2021-12-24 | 2023-10-02 | 知子 秋田 | Radiation therapy skin marker |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN211884998U (en) | Marking pen for positioning and developing in radiotherapy | |
| HUNT et al. | Cultured human melanocytes respond to MSH peptides and ACTH | |
| Fatima et al. | Selenium nanoparticles by moderating oxidative stress promote differentiation of mesenchymal stem cells to osteoblasts | |
| CN110559562A (en) | Positioning developing solution and developing marking pen for radiotherapy | |
| CN109528511A (en) | A kind of compound hair dye of artificial melanin and its application method | |
| CN105997555B (en) | It is a kind of that the dyeing pomade and preparation method thereof to fade can be washed with warm water | |
| CN112641645B (en) | Safe and nontoxic dyeing and scalding agent, preparation method and application | |
| CN101969917A (en) | Anti-wrinkle composition and external skin composition | |
| CN110192996A (en) | A kind of viola mandshurica moisturizer and preparation method thereof and the moisturizing moisturizing sleep mask containing the moisturizer | |
| TWI766379B (en) | Composition, application thereof in preparation of skin product for overnight person skin caring, and skin care product for overnight person skin | |
| KR20190042805A (en) | Composition of High Functional Tattoo Pigment | |
| CN108670879B (en) | Melanin hair dye and preparation method thereof | |
| CN204815378U (en) | Novel special medical mark of radiotherapy is applied ointment or plaster | |
| CN212593540U (en) | Positioning developing mark application | |
| Green | Morphological color change in the fiddler crab, Uca pugnax (SI Smith) | |
| CN112539986B (en) | Ferrous sulfate reagent and kit for melanin dyeing | |
| Beischel et al. | Ring oxidized retinals form unusual bacteriorhodopsin analogue pigments | |
| JP6718742B2 (en) | Hair dye | |
| CN100537548C (en) | Method of producing 3- methyl group - quinoline -2- carboxylic acid | |
| CN111282165A (en) | Radiotherapy positioning developing solution and positioning developing mark application | |
| TWI326600B (en) | Use of genipin as skin marker pigment | |
| CN104804343B (en) | A kind of Thermo-sensitive PVA hydrogel label film comprising water-solubility rare-earth material | |
| CN104307038B (en) | Gelatin-containing protein composite scaffold and preparation method thereof | |
| CN106943306B (en) | A kind of nanometer platinum colloid for cosmetics | |
| CN206231100U (en) | A kind of skin ink bow pen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |