CN112641645B - Safe and nontoxic dyeing and scalding agent, preparation method and application - Google Patents

Abstract

A safe and nontoxic dyeing and scalding agent, a preparation method and application thereof, belonging to the field of special cosmetics. The dyeing and ironing agent is a black plain dyeing and ironing agent integrating dyeing and ironing, and comprises an agent A1, an agent A2, an agent B and an agent C. Wherein the A1 agent is thioglycolic acid, thioglycolates or cysteine reducing agent solution; the A2 agent comprises cystine or its derivatives, buffer solution and melanin precursor; the agent B is sodium bromate or hydrogen peroxide type oxidant solution; the preparation C comprises melanin precursor, buffer solution and oxidant. The invention uses melanin precursor substance to dye hair, and avoids using phenylenediamine substance with high carcinogenic sensitization risk. The invention combines the hair dyeing process with the hair perming process, realizes the combination of dyeing and perming, and does not need to dye the hair for secondary damage after perming. The invention uses the melanin to be attached to the surface of the hair, and the melanin has good ultraviolet shielding effect, can protect the keratin of the hair from yellowing and brittleness due to the ultraviolet effect, and can protect the damaged hair.

Description

Safe and nontoxic dyeing and scalding agent, preparation method and application

Technical Field

The invention belongs to the field of special cosmetics, and particularly relates to a synthetic melanin dyeing and ironing agent integrating dyeing and ironing and application thereof.

Background

Most people begin at age 35 and hair pigment cells begin to decline, gradually developing white hair. The population structure of the current society gradually ages, the demand for green and healthy hair dyes is higher and higher, however, all the hair dyes in the market contain phenylenediamine substances, and the substances have higher risk of carcinogenic sensitization. The world health organization under the international agency for research on cancer states that the hairdresser's risk of developing cancer may increase due to frequent exposure to hair dyes and other chemicals.

Polydopamine is one of natural melanin and has excellent biocompatibility. The polydopamine is selected to replace phenylenediamine as a black precursor of the hair dye, so that the risk of carcinogenesis and sensitization can be avoided, and the polydopamine has good ultraviolet absorption capacity, can better resist ultraviolet rays, prevents the hair keratin from being damaged by ultraviolet irradiation, and enables the hair to become yellow and brittle. Polydopamine, as a macromolecule, does not penetrate the skin barrier and thus potentially damages the human body. Therefore, the polydopamine has very wide prospect as the hair dyeing material.

The pursuit of beauty and fashion has never been stopped by human beings, and ancient Egypt had cosmetics as early as 4000 years ago. In the cosmetics of that time, hair dyeing oil and the like are used for hairdressing. With the rapid development of the times, the science and technology and the productivity are rapidly improved, and the requirements of beauty and fashion products and people are also developed along with the development of the productivity. People often choose to hair dye and perm simultaneously in the process of hairdressing. However, the burden of hair is great, and the hair is brittle and broken due to weak hair and easy damage to the scalp. The time interval between the first scalding and the second dyeing is usually several days, so that not only is the time wasted, but also secondary damage is still caused to the hair and the scalp. At present, no dyeing and ironing agent capable of being simultaneously used is available in the market.

Chinese patent publication No. CN 109528511 a mentions that the use of an alkali solution of 5, 6-dihydroxyindole and 5, 6-dihydroxyindole acid can be used to dye hair, thereby avoiding the use of phenylenediamine to dye hair. However, the strong alkaline environment can destroy hair scale keratin, and the hair scale keratin can be dyed into brown color and cannot be dyed into dark black color, and the color adhesion is low. The use of CuSO is mentioned in Mimicking Natural Human Hair amplification with Synthetic Melanin, ACS Central Science 20206 (7),1179-₄+H₂O₂The Fenton-like system promotes the synthesis of melanin to dye hair, but has the defects of light hair dyeing color, single color, metal ion content and the like. However, no dyeing and permanent agent for simultaneously dyeing and permanent wave is available in the market at present. The invention adopts melanin precursor, combines the hair dyeing step with the hair perming step, successfully improves the color fastness, shortens the dyeing time, deepens the color chromaticity, simultaneously achieves the purpose of combining dyeing and perming, reduces the secondary damage of the hair by dyeing and perming, simultaneously can also play a role in protecting the hair, and is more suitable for the market demands of pursuing fashion and beauty, efficiency and health at present.

Disclosure of Invention

The invention aims to provide a melanin dyeing and ironing agent integrating dyeing and ironing and application thereof, which avoids using substances with potential carcinogenic sensitization risks such as phenylenediamine and the like, combines perming and dyeing, can be carried out simultaneously, improves the efficiency, improves the fastness of combination of melanin and hair, and shortens the hair dyeing time.

In order to solve the problems, the invention adopts the following technical scheme:

a safe and nontoxic dyeing and ironing agent is a black plain dyeing and ironing agent integrating dyeing and ironing, and comprises an agent A1, an agent A2, an agent B and an agent C. Wherein the A1 agent is thioglycolic acid, thioglycolates or cysteine reducing agent solution; the A2 agent comprises cystine or its derivatives, buffer solution and melanin precursor; the agent B is sodium bromate or hydrogen peroxide type oxidant solution; the preparation C comprises melanin precursor, buffer solution and oxidant.

The A1 agent is a reducing agent solution of ammonium thioglycolate.

The content of cystine or its derivatives in the A2 preparation is 0.1-2mg/mL, and the content of melanin precursor is 0.5-5 mg/mL. The cystine or its derivative is one or more of cystine, homocystine, polypeptide or protein containing cystine, preferably cystine; the melanin precursor is one or more of dopamine, dopa, 5, 6-dihydroxyindole acid, dopaquinone, 5, 6-diquinoyl indole and 5, 6-diquinoyl indole acid, preferably dopamine.

The agent B is a sodium bromate type oxidant solution.

The concentration of the sodium bromate or the hydrogen peroxide type oxidant in the agent B is 8-12 wt%.

The content of melanin precursor in the agent C is 3-10mg/mL, and the content of oxidant is 10-100 mmoL/L; the melanin precursor is one or a combination of more than two of dopamine, dopa, 5, 6-dihydroxyindole acid, dopaquinone, 5, 6-diquinoyl indole and 5, 6-diquinoyl indole acid, preferably dopamine; the oxidant in the agent C is one or the combination of more than two of sodium periodate, ammonium persulfate, hydrogen peroxide solution of copper sulfate and laccase.

The activity of the laccase in the C agent is 0.1-1.0 u/mL.

The buffer solution in the agent A2 and the agent C is one of a Tris buffer solution with pH of 7-9.5, a PBS buffer solution, a carbonate buffer solution or an acetic acid-sodium acetate buffer solution with pH of 4-6.5, preferably a Tris buffer solution with pH of 8.5; wherein when the oxidant of the agent C is laccase, the buffer solution in the agent C is preferably acetic acid-sodium acetate buffer solution with pH of 4-6.5.

The A1 agent can be added with oleyl polyether and other substances, and the pH is further adjusted to 8-10 by ethanolamine, ammonium bicarbonate and other substances.

The agent A1 and the agent C can be additionally added with a surfactant and a thickening agent, wherein the surfactant is cocamidopropyl betaine, and the thickening agent is pluronic F127 or xanthan gum.

The agent B can be additionally added with a hair conditioning agent, wherein the hair conditioning agent is laurylamine oxide.

The preparation method of the A2 agent comprises the following steps: adding cystine or its derivative into buffer solution, stirring to dissolve, adding melanin precursor, and stirring to completely dissolve melanin precursor. The preparation method of the agent C comprises the following steps: adding an oxidant into the buffer solution, stirring until the oxidant is dissolved, adding a melanin precursor substance, and stirring until the melanin precursor substance is completely dissolved.

The application method of the dyeing and ironing combined melanin dyeing and ironing agent comprises the following steps:

(1) compounding the A1 agent with the A2 agent to ensure that the concentration of thioglycolic acid, thioglycolates or cysteine reducing agents reaches 6 to 10 weight percent; after being compounded, the mixture is coated on the hair at the temperature of 20-40 ℃, and the hair can be randomly shaped;

(2) after 10-30min, uniformly smearing the hair with the agent B;

(3) washing hair with clear water after 10-30 min;

(4) and (3) coating the agent C on hair, and keeping the temperature at 30-50 ℃ for 10-90min to finish hair dyeing and perming.

The invention has the beneficial effects that:

1) the invention uses melanin precursor substance to dye hair, and avoids using phenylenediamine substance with high carcinogenic sensitization risk.

2) The invention combines the hair dyeing process with the hair perming process, realizes the combination of dyeing and perming, and does not need to dye the hair for secondary damage after perming.

3) The invention uses the melanin to be attached to the surface of the hair, and the melanin has good ultraviolet shielding effect, can protect the keratin of the hair from yellowing and brittleness due to the ultraviolet effect, and can protect the damaged hair.

4) The invention improves the hair dyeing speed and increases the washing fastness by combining the hair dyeing process with the hair perming process.

Detailed Description

The present invention will be further described with reference to the following examples. The following examples are given solely for the purpose of illustration and are not intended to limit the scope of the invention, which is to be construed as broadly as the appended claims.

Example 1

Preparation of a1 agent: ammonium thioglycolate, oleyl polyether, cocamidopropyl betaine were added and ethanolamine was added to adjust the pH to 9. The concentration of ammonium thioglycolate in the A1 agent is 16 wt%, the concentration of oleyl polyether in the A1 agent is 1 wt%, and the content of cocamidopropyl betaine in the A1 agent is 0.5 wt%.

Preparation of a2 agent: cystine was added to Tris buffer at pH 8.5 and stirred until dissolved. Adding dopamine hydrochloride, stirring, and mixing with A1 agent in a ratio of 1: 1 after being compounded. The content of cystine in A2 preparation is 0.5mg/mL, and the content of dopamine hydrochloride is 1 mg/mL.

Preparation of agent B: sodium bromate is added, and a proper amount of lauryl amine oxide as a hair conditioner is added. The content of sodium bromate in the agent B is 8 wt%, and the content of laurylamine oxide is 0.5 wt%.

Preparation of agent C: the thickener pluronic F127 and the surfactant cocamidopropyl betaine were added to the Tris buffer solution at pH 8.5 and stirred until dissolved. Adding CuSO₄、H₂O₂Stirring until dissolved. Adding dopamine hydrochloride to dissolve in the buffer solution, and stirring until dissolving. The content of dopamine hydrochloride in the C agent is 5mg/mL, and the CuSO₄The content of (A) is 10mmoL/L, H₂O₂The content of (a) is 50 mmoL/L. The content of cocamidopropyl betaine was 0.5 wt%, and the content of pluronic F127 was 25 wt%.

In hair-waving, the A1 and A2 agents were mixed and applied to hair at room temperature, and the hair was curled with a curling iron. After 15min, the agent B is uniformly applied on the hair, after 15min, a curling bar is removed, the hair is washed by clear water, the agent C is uniformly applied on the hair, and the hair is kept for 30min at room temperature and then cleaned, so that the dyeing and scalding are finished.

Example 2:

the specific procedure was as in example 1, wherein the cystine content in the A2 dose was changed to 0.2 mg/mL.

Example 3:

the specific procedure was as in example 1, wherein the dopamine hydrochloride content in the A2 dose was changed to 2 mg/mL.

Example 4:

the procedure was as in example 1, wherein the dopamine hydrochloride content in the C dose was changed to 8 mg/mL.

Example 5:

the specific implementation procedure is the same as that of example 1, but the oxidant CuSO in the agent C is₄、H₂O₂By conversion to NaIO₄NaIO in agent C₄The content of (a) is 50 mmoL/L.

Example 6:

the specific procedure was performed as in example 5, wherein the cystine content in the A2 dose was changed to 0.2 mg/mL.

Example 7:

the specific procedure was as in example 5, wherein the dopamine hydrochloride content in the A2 dose was changed to 2 mg/mL.

Example 8:

the procedure was carried out as in example 5, wherein the dopamine hydrochloride content in the C dose was changed to 8 mg/mL.

Example 9:

the specific implementation procedure is the same as that of example 1, but the oxidant CuSO in the agent C is₄、H₂O₂The ammonium persulfate is replaced, and the content of the ammonium persulfate in the agent C is 50 mmoL/L.

Example 10:

the specific procedure was carried out as in example 9, wherein the cystine content in the A2 dose was changed to 0.2 mg/mL.

Example 11:

the specific procedure was as in example 9, wherein the dopamine hydrochloride content in the A2 dose was changed to 2 mg/mL.

Example 12:

the procedure was as in example 9, wherein the dopamine hydrochloride content in the C dose was changed to 8 mg/mL.

Example 13:

adding 0.5u/mL laccase and stirring until the laccase is dissolved.

The specific implementation flow is the same as that of example 1, but the buffer solution in the agent C is changed into acetic acid-sodium acetate with pH of 6, the corresponding oxidant is changed into laccase, and the activity of the laccase is 0.5 u/mL.

Example 14:

the specific procedure was carried out as in example 12, wherein the cystine content in the A2 dose was changed to 0.2 mg/mL.

Example 15:

the specific procedure was performed as in example 12, wherein the dopamine hydrochloride content in the A2 dose was changed to 2 mg/mL.

Example 16:

the procedure was carried out as in example 12, wherein the dopamine hydrochloride content in the C dose was changed to 8 mg/mL.

Comparative example 1:

adding the thickening agent and the surfactant into a Tris buffer solution with the pH value of 8.5, and stirring until the thickening agent and the surfactant are dissolved. 5mg/mL dopamine hydrochloride is added and dissolved in the buffer solution, and the mixture is stirred until the dopamine hydrochloride is dissolved. 50mmol/L H was added₂O₂And 10mmol/L CuSO₄Stirring to dissolve, and uniformly applying on hair.

Comparative example 2:

the procedure was as in comparative example 1, wherein the oxidizing agent was changed to 50mmoL/L NaIO₄。

Comparative example 3:

the procedure was carried out in the same manner as in comparative example 1, wherein the oxidizing agent was changed to 50mmoL/L ammonium persulfate.

Comparative example 4:

the hair was washed and dried.

TABLE 1 colour comparison of examples with comparative examples

	L*	a*	b*	ΔE
					Example 1	-45.948	-3.285	-17.573	49.304
Example 5	-46.747	-2.031	-17.470	49.946
					Example 9	-49.615	-1.293	-18.424	52.941
Comparative example 1	-36.420	-3.150	-13.747	39.056
					Comparative example 2	-30.010	1.483	-6.268	30.694
Comparative example 3	-29.563	2.361	-7.888	30.688
					Comparative example 4a	0	0	0	0

^aData are reported as the values of L, a, b of comparative example 4 as zero

As is apparent from table 1, the examples of the present application, which incorporate the melanin precursor substance on the hair surface, have better color fastness and darker color than the comparative examples, which directly deposit melanin on the hair surface, thus proving that more melanin is deposited on the hair in the examples; and the hair dye of this application can realize dyeing and scalding the unification, accomplishes the molding when having hair dyed, can reduce the time that the consumer dyed and scalds the hair by a wide margin, improves consumer experience level.

Example 9 is reddish brown and comparative example 3 is brownish yellow, and example 9 has more obvious curling compared with comparative example 3, which shows that under the same condition, the hair treated by the melanin precursor substance is easier to deposit melanin, so that the hair is darker in color and higher in color fastness to washing, and the hair can be shaped to achieve the purpose of dyeing and ironing.

Example 5 is a brownish black color and comparative example 2 is a brownish yellow color, and example 9 has a more pronounced curl than comparative example 3, indicating that under the same conditions, hair treated with a melanin precursor substance more readily deposits melanin, resulting in a darker color and a higher wash fastness, and can be styled to achieve the goal of a combination of dyeing and ironing.

Example 1 is black and comparative example 1 is brown-black, and example 9 has more distinct curl than comparative example 3, which shows that under the same conditions, hair treated with melanin precursor substance is easier to deposit melanin, so that the hair has darker color and higher color fastness to washing, and the hair can be shaped to achieve the purpose of dyeing and ironing.

Claims (9)

1. A safe and nontoxic dyeing and ironing agent is characterized in that the dyeing and ironing agent is a black plain dyeing and ironing agent integrating dyeing and ironing, and comprises an agent A1, an agent A2, an agent B and an agent C; wherein the agent A1 is thioglycolic acid or thioglycolate reducing agent solution; the A2 agent comprises cystine or its derivatives, buffer solution and melanin precursor; the agent B is sodium bromate or hydrogen peroxide type oxidant solution; the agent C comprises melanin precursor, buffer solution and oxidant;

the agent A1 and the agent C also contain a surfactant and a thickening agent; the agent B also contains a hair conditioner;

the content of melanin precursor in the agent C is 3-10mg/mL, and the content of oxidant is 10-100 mmoL/L; the melanin precursor is one or a combination of more than two of dopamine, dopa, 5, 6-dihydroxyindole acid, dopaquinone, 5, 6-diquinoyl indole and 5, 6-diquinoyl indole acid; the oxidant is one or the combination of more than two of sodium periodate, ammonium persulfate, hydrogen peroxide solution of copper sulfate and laccase;

the preparation method of the A2 agent comprises the following steps: adding cystine or its derivative into buffer solution, stirring to dissolve, adding melanin precursor, and stirring until the melanin precursor is completely dissolved; the preparation method of the agent C comprises the following steps: adding an oxidant into the buffer solution, stirring until the oxidant is dissolved, adding a melanin precursor substance, and stirring until the melanin precursor substance is completely dissolved;

the application method of the dyeing and ironing agent comprises the following steps:

(1) compounding the A1 agent and the A2 agent to ensure that the concentration of thioglycolic acid or thioglycolate reducing agent reaches 6-10 wt%; after being compounded, the mixture is coated on the hair at the temperature of 20-40 ℃, and the hair can be randomly shaped;

(2) after 10-30min, uniformly smearing the hair with the agent B;

(3) washing hair with clear water after 10-30 min;

(4) and (3) coating the agent C on hair, and keeping the temperature at 30-50 ℃ for 10-90min to finish hair dyeing and perming.

2. A safe and non-toxic dye/permanent wave agent as claimed in claim 1, wherein the agent a1 is a reducing agent solution of ammonium thioglycolate type.

3. A safe and non-toxic dye/permanent wave agent as claimed in claim 1, wherein the amount of cystine or its derivatives in the a2 agent is 0.1-2mg/mL, and the amount of melanin precursor is 0.5-5 mg/mL; the cystine or the derivatives thereof is one or the combination of more than two of cystine, homocystine, polypeptide or protein containing cystine; the melanin precursor is one or more of dopamine, dopa, 5, 6-dihydroxyindole acid, dopaquinone, 5, 6-diquinoyl indole and 5, 6-diquinoyl indole acid.

4. A safe and non-toxic dye/permanent wave agent as claimed in claim 1, wherein the concentration of the sodium bromate or hydrogen peroxide type oxidant in the agent B is 8-12 wt%.

5. A safe and non-toxic dye/permanent wave agent according to claim 1, wherein the laccase activity in the agent C is 0.1-1.0 u/mL.

6. A safe and non-toxic permanent wave agent as claimed in claim 1, wherein the buffer solution in the agent a2 and the agent C is one of Tris buffer solution, PBS buffer solution, carbonate buffer solution with pH 7-9.5, or acetic acid-sodium acetate buffer solution with pH 4-6.5; wherein when the oxidant of the agent C is laccase, the buffer solution in the agent C is acetic acid-sodium acetate buffer solution with pH of 4-6.5.

7. A safe and non-toxic hair dye and permanent wave agent as claimed in claim 1, wherein the buffer solution in the agent a2 and the agent C is Tris buffer solution with pH 8.5.

8. The method for preparing a safe and non-toxic dyeing and scalding agent according to any one of claims 1 to 7, wherein the A2 agent is prepared as follows: adding cystine or its derivative into buffer solution, stirring to dissolve, adding melanin precursor, and stirring until the melanin precursor is completely dissolved; the preparation method of the agent C comprises the following steps: adding an oxidant into the buffer solution, stirring until the oxidant is dissolved, adding a melanin precursor substance, and stirring until the melanin precursor substance is completely dissolved.

9. The use of a safe and non-toxic dye/permanent agent as claimed in any one of claims 1 to 7, wherein the dye/permanent agent is used by a method comprising:

(1) compounding the A1 agent and the A2 agent to ensure that the concentration of thioglycolic acid or thioglycolate reducing agent reaches 6-10 wt%; after being compounded, the mixture is coated on the hair at the temperature of 20-40 ℃, and the hair can be randomly shaped;

(2) after 10-30min, uniformly smearing the hair with the agent B;

(3) washing hair with clear water after 10-30 min;

(4) and (3) coating the agent C on hair, and keeping the temperature at 30-50 ℃ for 10-90min to finish hair dyeing and perming.