CN110215217A - A kind of sampled plasma system and method - Google Patents
A kind of sampled plasma system and method Download PDFInfo
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- CN110215217A CN110215217A CN201910494121.9A CN201910494121A CN110215217A CN 110215217 A CN110215217 A CN 110215217A CN 201910494121 A CN201910494121 A CN 201910494121A CN 110215217 A CN110215217 A CN 110215217A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150366—Blood collection bags, e.g. connected to the patient by a catheter comprising means for removing a small sample of collected blood from the bag
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F22/00—Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
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- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
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- General Health & Medical Sciences (AREA)
- Fluid Mechanics (AREA)
- General Physics & Mathematics (AREA)
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Abstract
The present invention provides a kind of sampled plasma system and method, the sampled plasma system includes blood pump (4), blood separator (5), blood plasma collecting bag (6), first weighing device (7), anti-coagulants bag (12) and anticoagulant pump (13), the blood separator (5) respectively with blood pump (4), blood plasma collecting bag (6) connection, and blood separator (5) is driven by centrifuge (9), the anticoagulant pump (13) respectively with blood pump (4), anti-coagulants bag (12) connection, the weight of first weighing device (7) monitoring blood plasma collecting bag (6).The present invention monitors the weight change of blood plasma collecting bag by the first weighing device, and the consumption of anti-coagulants is obtained according to anticoagulant pump, thus calculates the volume of the true plasma in blood plasma collecting bag, improves the accuracy of true plasma collection capacity；Centralized and unified control is carried out by setting controller, moreover it is possible to greatly improve sampled plasma working efficiency.
Description
Technical field
The present invention relates to sampled plasma technical fields, more particularly, to a kind of sampled plasma system and method.
Background technique
Collected whole blood blood usually imported into centrifugal plasma blood separator, utilizes blood by sampled plasma
Slurry seperator driving plasma blood separate cup is centrifuged；According to the density variation of ingredient each in blood, it is substantially separated
For plasma layer, tunica albuginea layer (blood platelet and leucocyte etc.) and red blood cell layer.
But existing sampled plasma system is at work, and due to containing anti-coagulants in collected blood, lead to
Cross the mixture that the blood plasma that sampled plasma system is finally collected into is actually blood plasma and anti-coagulants.Anti-coagulants therein is of course
The certain volume of blood plasma collecting bag is occupied, therefore, the volume of the true plasma in blood plasma collecting bag is actually less than blood plasma point
It disembarks pre-set sampled plasma amount, is less than the pre-set blood of blood separator so as to cause the actual amount of sampled plasma
Starch collection capacity.
Summary of the invention
The technical problem to be solved by the present invention is in view of the problems of the existing technology, providing a kind of sampled plasma system
And method, improve the accuracy of true plasma collection capacity.
The technical problem to be solved in the present invention is realized using following technical scheme: a kind of sampled plasma system, including blood
Pump, blood separator, blood plasma collecting bag, the first weighing device, anti-coagulants bag and anticoagulant pump, the blood separator difference
Be connected to blood pump, blood plasma collecting bag and blood separator driven by centrifuge, the anticoagulant pump respectively with blood pump, anticoagulant
The connection of agent bag, the weight of the first weighing device monitoring blood plasma collecting bag.
It preferably, further include the second weighing device, the weight of the second weighing device monitoring anti-coagulants bag.
It preferably, further include controller, second weighing device uses electronic scale, and the controller and second claim
Refitting forms electrical connection between setting.
It preferably, further include controller, first weighing device uses electronic scale, and the controller and first claim
Refitting forms electrical connection between setting.
Preferably, it is formed and is electrically connected between the controller and anticoagulant pump.
It preferably, further include HCT sensor, the HCT sensor is electrically connected with controller formation.
It preferably, further include ccd sensor, whole blood layered image in the described ccd sensor monitoring blood separator,
And real-time Transmission is to controller.
A kind of sampled plasma method is carried out using sampled plasma system as described above, is included the following steps:
S1 monitors the weight change of blood plasma collecting bag by the first weighing device；
S2 calculates the volume of the anti-coagulants in blood plasma collecting bag and the volume of true plasma；
S3, judges whether the volume of the true plasma in blood plasma collecting bag reaches predetermined set amount, adopts if so, terminating blood plasma
Collection；If not, continuing sampled plasma.
Preferably, the volume of the anti-coagulants in the blood plasma collecting bag is obtained by counting the rotating cycle of anticoagulant pump
?.
Preferably, the anticoagulant pump rotates according to a certain percentage with blood pump, anticoagulant in the blood plasma collecting bag
The volume of agent is obtained by counting the rotating cycle of blood pump.
Compared with prior art, the beneficial effects of the present invention are: monitoring plasma collection by the first weighing device of setting
The weight change of bag, and obtain according to anticoagulant pump the consumption of anti-coagulants, thus calculate the true plasma in blood plasma collecting bag
Volume；If the volume of the true plasma in blood plasma collecting bag reaches predetermined set amount, terminate sampled plasma；If blood plasma is received
The volume of true plasma in collection bag does not reach predetermined set amount, then continues sampled plasma, so as to effectively improve
The accuracy of true plasma collection capacity is conducive to improve sampled plasma working efficiency.
Detailed description of the invention
Fig. 1 is a kind of organigram of sampled plasma system of the present invention.
Fig. 2 is a kind of flow diagram of sampled plasma method of the present invention.
Marked in the figure: 1- blood catheter, 2-HCT sensor, 3- three-way connection, 4- blood pump, 5- blood separator, 6- blood plasma
Collecting bag, the first weighing device of 7-, 8-CCD sensor, 9- centrifuge, 10- controller, the second weighing device of 11-, 12- are anticoagulant
Agent bag, 13- anticoagulant pump.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawing and specific implementation
The present invention is described in detail for example.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not
For limiting the present invention.
Sampled plasma system as shown in Figure 1 mainly includes blood pump 4, blood separator 5, the title of blood plasma collecting bag 6, first
7, anti-coagulants bag 12 and anticoagulant pump 13 are set in refitting, and the blood separator 5 passes through pipe with blood pump 4, blood plasma collecting bag 6 respectively
Road connection communicates, the arrival end of the anticoagulant pump 13 is connected to anti-coagulants bag 12, outlet end pass through three-way connection 3 respectively with blood
Fluid catheter 1, blood pump 4 are connected to, and first weighing device 7 is used to monitor the weight of blood plasma collecting bag 6, according to the weight monitored
Amount variation, it can be learnt that into the amount of liquid of blood plasma collecting bag 6.
When carrying out sampled plasma operation using above-mentioned sampled plasma system, operating method is as shown in Fig. 2, specifically include
Following steps:
Step 1 is introduced whole blood by blood catheter 1, meanwhile, start anticoagulant pump 13, will be resisted by anticoagulant pump 13
Anti-coagulants in solidifying agent bag 12 is introduced at three-way connection 3 and is allowed to mix with whole blood.
Step 2 starts blood pump 4, the mixed liquor of whole blood, anti-coagulants is introduced in blood separator 5 by blood pump 4, described
Blood separator 5 driven by centrifuge 9.5 high speed rotation of blood separator is driven by centrifuge 9, so that whole blood is in blood
It is centrifugated, is automatically separated from inside to outside as plasma layer, tunica albuginea layer and red blood cell layer in separate cup 5.
Above-mentioned plasma layer is imported into blood plasma collecting bag 6 by step 3, monitors plasma collection by the first weighing device 7
The weight change of bag 6 can be calculated into true plasma, the anti-coagulants mixed liquor in blood plasma collecting bag 6 according to weight change
Total weight.During this period, it should be noted that: since to prevent the anti-coagulants in anticoagulated whole blood from staying in red for the osmotic pressure of red blood cell
In cell, it is therefore contemplated that anti-coagulants is mixed with plasma layer, and leaves blood separator 5 together, plasma collection is entered back into
In bag 6；It in other words, is actually the weight of true plasma Yu anti-coagulants mixed liquor by the weight change that the first weighing device 7 measures
Amount, rather than the weight of true plasma.
Step 4 calculates the volume of the anti-coagulants in blood plasma collecting bag 6.Its specific calculation method can use following 3 kinds
Method:
The second weighing device 11 is arranged in method 1, and the weight of anti-coagulants bag 12 is monitored by the second weighing device 11.Root
According to the weight change monitored, the consumption of anti-coagulants can be calculated, that is, enters the anti-coagulants in blood plasma collecting bag 6
Weight.Since the density of anti-coagulants is certain, according to formula ρ=m/V, the anti-coagulants in blood plasma collecting bag 6 can be calculated
Volume.
Method 2 obtains the volume of the anti-coagulants in blood plasma collecting bag 6 according to the rotating cycle of anticoagulant pump 13.Due to
For each revolution, the flow of output is fixed value to anticoagulant pump 13, therefore, by counting the rotating cycle of anticoagulant pump 13,
It can be concluded that the dosage of anti-coagulants, and then calculate the volume of the anti-coagulants in blood plasma collecting bag 6.
Method 3 obtains the volume of the anti-coagulants in blood plasma collecting bag 6 according to the rotating cycle of blood pump 4.Due to anti-coagulants
Pump 13 is rotated according to a certain percentage with blood pump 4, and usual ratio is 1:16, the ratio be also anticoagulated whole blood dosage with
Therefore the ratio of anti-coagulants dosage can be obtained anti-coagulants by counting the rotating cycle of blood pump 4, then by ratiometric conversion
Dosage, and then calculate the volume of the anti-coagulants in blood plasma collecting bag 6.
Step 5 calculates the volume of the true plasma in blood plasma collecting bag 6.The weight change that first weighing device 7 is measured
(weight of true plasma and anti-coagulants mixed liquor) subtracts the weight of anti-coagulants, the as weight of the true plasma in blood plasma collecting bag 6.
Since the density of true plasma is certain, according to formula ρ=m/V, the volume of the true plasma in blood plasma collecting bag 6 can be calculated.
Step 6, judges whether the volume of the true plasma in blood plasma collecting bag 6 reaches predetermined set amount.If reaching predetermined
Set amount can terminate sampled plasma operation.
If not reaching predetermined set amount, sampled plasma can be continued, repeatedly above-mentioned step 1 to step 6,
So circulation, until the volume of the true plasma in blood plasma collecting bag 6 reaches predetermined set amount.It is monitored by the first weighing device 7
The weight of blood plasma collecting bag 6 and the consumption that anti-coagulants is obtained by anticoagulant pump 13, thus calculate in blood plasma collecting bag 6
The volume of true plasma, so as to effectively improve the accuracy of true plasma collection capacity.
In order to further improve the accuracy of true plasma collection capacity, and Collecting operation efficiency is improved, described first claims
The 7, second weighing device 11 is set in refitting can be using electronic scale, also, makes blood pump 4, the first weighing device 7, centrifuge 9, second
Weighing device 11, anticoagulant pump 13 are electrically connected with the formation of controller 10 respectively, as shown in Figure 1.The controller 10 can be adopted
With the controller on blood plasma collecting machine, other other controllers with the same function can also be used.By controller 10 into
What row was concentrated is uniformly controlled, as shown in Fig. 2, the volume of the true plasma in blood plasma collecting bag 6 can be quickly and automatically calculated,
And judge whether the volume of the true plasma in blood plasma collecting bag 6 reaches predetermined set amount.
As shown in Figure 1, setting HCT sensor 2, the HCT sensor 2 and control can be increased on blood catheter 1
Electrical connection is formed between device 10；In addition, ccd sensor 8 can also be set at blood separator 5, the ccd sensor 8
The whole blood layered image in blood separator 5 and real-time Transmission are monitored to controller 10.Whole blood is being carried out by blood catheter 1
When acquisition, by the HCT value in HCT sensor 2 automatically monitoring acquisition whole blood and by the data transfer to controller 10, by controlling
Device 10 processed calculates the collection capacity and global cycle number of each acquisition circulation according to total sampled plasma amount and HCT value automatically, thus
The time that entire sampled plasma can effectively be shortened, improve Collecting operation efficiency.The controller 10 claims according to first
The variable of the 7, second weighing device 11 feedback is set in refitting, calculates the volume of the true plasma in blood plasma collecting bag 6, and with it is predetermined
Set amount is compared；If not up to predetermined set amount, acquisition circulation will be continued, until the pure blood in blood plasma collecting bag 6
The volume of slurry reaches predetermined set amount.
By ccd sensor 8, can by the whole blood layered image real-time Transmission in blood separator 5 to controller 10, when
When controller 10 judges that red blood cell therein has been filled with blood separator 5, the control centrifuge 9 of controller 10 is out of service, stops
Adopt slurry；It, can be by blood constituent remaining in blood separator 5 (tunica albuginea layer and red blood cell layer) when centrifuge 9 is out of service
Take out, restart next acquisition circulation, so as to be effectively prevented red blood cell overflow blood separator 5 and generation fill it is red.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, it is noted that all
Made any modifications, equivalent replacements, and improvements etc. within the spirit and principles in the present invention should be included in guarantor of the invention
Within the scope of shield.
Claims (10)
1. a kind of sampled plasma system, including blood pump (4), blood separator (5) and blood plasma collecting bag (6), the blood point
It is connected to respectively with blood pump (4), blood plasma collecting bag (6) from cup (5) and blood separator (5) is driven by centrifuge (9), feature
It is: further includes the first weighing device (7), anti-coagulants bag (12) and anticoagulant pump (13), the anticoagulant pump (13) is respectively
It is connected to blood pump (4), anti-coagulants bag (12), the weight of the first weighing device (7) monitoring blood plasma collecting bag (6).
2. a kind of sampled plasma system according to claim 1, it is characterised in that: it further include the second weighing device (11),
The weight of second weighing device (11) monitoring anti-coagulants bag (12).
3. a kind of sampled plasma system according to claim 2, it is characterised in that: it further include controller (10), it is described
Second weighing device (11) uses electronic scale, is formed and is electrically connected between the controller (10) and the second weighing device (11).
4. a kind of sampled plasma system according to claim 1, it is characterised in that: it further include controller (10), it is described
First weighing device (7) uses electronic scale, is formed and is electrically connected between the controller (10) and the first weighing device (7).
5. a kind of sampled plasma system according to claim 3 or 4, it is characterised in that: the controller (10) with
Electrical connection is formed between anticoagulant pump (13).
6. a kind of sampled plasma system according to claim 3 or 4, it is characterised in that: it further include HCT sensor (2),
The HCT sensor (2) is formed with controller (10) and is electrically connected.
7. a kind of sampled plasma system according to claim 3 or 4, it is characterised in that: it further include ccd sensor (8),
Whole blood layered image and real-time Transmission in ccd sensor (8) monitoring blood separator (5) give controller (10).
8. a kind of sampled plasma method, it is characterised in that: using as the described in any item sampled plasma systems of claim 1-7 into
Row, includes the following steps:
S1 passes through the weight change of the first weighing device (7) monitoring blood plasma collecting bag (6)；
S2 calculates the volume of the anti-coagulants in blood plasma collecting bag (6) and the volume of true plasma；
S3, judges whether the volume of the true plasma in blood plasma collecting bag (6) reaches predetermined set amount, adopts if so, terminating blood plasma
Collection；If not, continuing sampled plasma.
9. a kind of sampled plasma method according to claim 8, it is characterised in that: anti-in the blood plasma collecting bag (6)
The volume of solidifying agent is obtained by counting the rotating cycle of anticoagulant pump (13).
10. a kind of sampled plasma method according to claim 8, it is characterised in that: the anticoagulant pump (13) and blood
Pump (4) rotates according to a certain percentage, and the volume of the anti-coagulants in the blood plasma collecting bag (6) is by counting blood pump (4)
Rotating cycle obtains.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910494121.9A CN110215217A (en) | 2019-06-05 | 2019-06-05 | A kind of sampled plasma system and method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910494121.9A CN110215217A (en) | 2019-06-05 | 2019-06-05 | A kind of sampled plasma system and method |
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| CN201910494121.9A Pending CN110215217A (en) | 2019-06-05 | 2019-06-05 | A kind of sampled plasma system and method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529791A (en) * | 2020-05-08 | 2020-08-14 | 四川九八村信息科技有限公司 | Method for reducing leukocyte interfusion amount in collected plasma and plasma collecting system |
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| US20060287628A1 (en) * | 2005-06-17 | 2006-12-21 | Terumo Kabushiki Kaisha | Blood component collection apparatus and method |
| CN101968435A (en) * | 2010-10-30 | 2011-02-09 | 张红侠 | Blood cell analyzer |
| CN104800905A (en) * | 2015-01-16 | 2015-07-29 | 成都市佳颖医用制品有限公司 | Anticoagulant control system and anticoagulant control method for plasma collection |
| CN107789693A (en) * | 2017-10-31 | 2018-03-13 | 四川南格尔生物科技有限公司 | A kind of sampled plasma system for optimizing anti-coagulants dosage |
| CN108577863A (en) * | 2018-04-26 | 2018-09-28 | 江苏伯纳德生物科技发展有限公司 | A kind of full-automatic whole blood acquisition piece-rate system |
-
2019
- 2019-06-05 CN CN201910494121.9A patent/CN110215217A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060287628A1 (en) * | 2005-06-17 | 2006-12-21 | Terumo Kabushiki Kaisha | Blood component collection apparatus and method |
| CN101968435A (en) * | 2010-10-30 | 2011-02-09 | 张红侠 | Blood cell analyzer |
| CN104800905A (en) * | 2015-01-16 | 2015-07-29 | 成都市佳颖医用制品有限公司 | Anticoagulant control system and anticoagulant control method for plasma collection |
| CN107789693A (en) * | 2017-10-31 | 2018-03-13 | 四川南格尔生物科技有限公司 | A kind of sampled plasma system for optimizing anti-coagulants dosage |
| CN108577863A (en) * | 2018-04-26 | 2018-09-28 | 江苏伯纳德生物科技发展有限公司 | A kind of full-automatic whole blood acquisition piece-rate system |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529791A (en) * | 2020-05-08 | 2020-08-14 | 四川九八村信息科技有限公司 | Method for reducing leukocyte interfusion amount in collected plasma and plasma collecting system |
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Effective date of registration: 20220128 Address after: 610000 Chengdu Tianfu international biological city, Chengdu, Sichuan Province (618 Fenghuang Road, Shuangliu District) Applicant after: Sichuan Tianfu nanger biomedical Co.,Ltd. Address before: No.28 Kuixing Road, Dongxi Town, Jianyang City, Chengdu City, Sichuan Province Applicant before: SICHUAN NIGALE BIOTECHNOLOGY Co.,Ltd. |
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Application publication date: 20190910 |
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