CN105854105B - The pre- punching method of anti-coagulants for sampled plasma - Google Patents
The pre- punching method of anti-coagulants for sampled plasma Download PDFInfo
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- CN105854105B CN105854105B CN201610257181.5A CN201610257181A CN105854105B CN 105854105 B CN105854105 B CN 105854105B CN 201610257181 A CN201610257181 A CN 201610257181A CN 105854105 B CN105854105 B CN 105854105B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
Abstract
The invention discloses a kind of pre- punching methods of the anti-coagulants for sampled plasma.It is controlled blood pump and anticoagulant pump including the use of control device and is rotated with same rotational speed, anticoagulant pump turnning circle is counted using counting device, the characteristic value of anticoagulant pump pipeline is calculated using the mass change data of the second gravity measure device measurement anti-coagulants and using the second computing device.The present invention is detected by the blood plasma to each plasma donor with ratio of blood, personalized anti-coagulants usage amount is calculated, it realizes the minimum of anti-coagulants and uses purpose, simultaneously by carrying out real-time measurement to consumptive material characteristic value used in sampled plasma process, it eliminates because of the problem of anti-coagulants caused by different consumptive material differences is using increasing, improves the quality of acquisition blood plasma.
Description
The application is patent application: for the anti-coagulants control system of sampled plasma and the divisional application of method, former patent
The applying date of application are as follows: 2015-04-24；Application No. is 201510198723.1；Title are as follows: the anti-coagulants for sampled plasma
Control system and method.
Technical field
The invention belongs to sampled plasma technical field more particularly to a kind of pre- punching methods of anti-coagulants for sampled plasma.
Background technique
During Plasma Pheresis/Apheresis Plasma, in order to guarantee that the blood in consumptive material does not solidify, need according to a certain percentage by whole blood with
Anti-coagulants is mixed.Since part anti-coagulants can enter in plasma donor body with the also defeated of haemocyte, it may cause and offer slurry
The uncomfortable reaction of member, another part anti-coagulants enter in collected raw blood plasma, reduce the protein content of raw blood plasma, and
Influence the quality of terminal blood product.Blood plasma in blood of human body is different from the ratio of haemocyte, and difference between male is obvious, therefore,
Under the premise of guaranteeing that Plasma Pheresis/Apheresis Plasma process blood coagulation does not occur, the fewer the use of anti-coagulants the better.
In addition, the degree of wear is different in long-term use for the moving component of machine in sampled plasma, lead to changes in flow rate
It is different；For every suit consumptive material, characteristic value (pump is each to enclose the flow passed by) is influenced by many factors, comprising: pipe
The internal diameter on road, wall thickness squeeze rebound velocity, the pressure etc. in pipeline.It, will if controlled according to theoretical value anti-coagulants
Consume more actually unnecessary anti-coagulants.
Summary of the invention
Goal of the invention of the invention is: in order to solve in the prior art, when carrying out sampled plasma, anti-coagulants cannot be controlled accurately
The problem of processed, the invention proposes a kind of anti-coagulants control systems and method for sampled plasma.
The technical scheme is that a kind of anti-coagulants control system for sampled plasma, comprising:
Anticoagulant pump, for driving anti-coagulants to flow in pipeline；
Blood pump, for driving blood to flow in pipeline；
Detection device, for detecting blood plasma and red cell proportion in blood；
First computing device, for calculating the mixing ratio of anti-coagulants and whole blood according to the ratio of blood plasma and red blood cell；
Control device, for when being obtained by the flow-rate ratio of anticoagulant pump and blood pump according to the mixing of anti-coagulants and whole blood
Anticoagulant pump and blood pump rotating ratio control anticoagulant pump and blood pump rotation.
Further, further includes:
Flow measuring device, for calculating the flow-rate ratio for passing through anticoagulant pump and blood pump.
Further, further includes:
Counting device, for counting the turnning circle of anticoagulant pump and blood pump；
Second computing device for calculating the characteristic value of anticoagulant pump pipeline and the characteristic value of blood pump tubing, and calculates anti-
The flow-rate ratio of setting agent pump and blood pump.
Further, further includes:
First metering device, for measuring plasma purity；
First empty spy, the second empty spy and third sky are visited, all interior with the presence or absence of air for detecting pipeline；
Described first empty visit is set on anti-coagulants pipeline, and the described second empty spy and the spy of third sky are sequentially arranged in blood conduit
On.
Further, further includes:
Sensing device, the volume for measuring blood in Centrifuge Cup change；
4th empty visit is visited with the 5th sky, for detecting in pipeline with the presence or absence of air；
Described 4th empty visit is set on anti-coagulants pipeline, and the described 5th empty visit is set on blood conduit.
Further, further includes: the second metering device, for measuring anti-coagulants quality；Third metering device, for measuring
Plasma purity.
The invention also provides a kind of anti-coagulants control methods for sampled plasma, comprising the following steps:
A, anti-coagulants and blood are respectively driven using anticoagulant pump and blood pump to flow in pipeline, and is examined using detection device
Survey blood plasma and red cell proportion in blood；
B, the mixing ratio M of anti-coagulants and whole blood is calculated according to the ratio of blood plasma and red blood cell using the first computing device；
C, it is counted using counting device and is visited in detection pipeline without air to the second sky without sky in the first empty visit in detection pipeline
Anticoagulant pump turnning circle during gas, and utilize the characteristic value T of the second computing device calculating anticoagulant pump pipelinek；
D, it counts to visit in detection pipeline in third sky using counting device and counts blood plasma matter without air to the first metering device
Amount reaches blood pump turnning circle during pulp distinguished value, and the characteristic value of blood pump tubing is calculated using the second computing device
Tx；
E, the anticoagulant pump pipeline feature value T according to obtained in step CkWith blood pump tubing characteristic value obtained in step D
Tx, the rotating ratio of anticoagulant pump and blood pump is calculated using the second computing device, and anti-according to what is be calculated using control device
The rotation of the rotating ratio of setting agent pump and blood pump control anticoagulant pump and blood pump.
Further, the rotating ratio of anticoagulant pump and blood pump is calculated in the step E using the second computing device, specifically
Are as follows:
The revolving speed of anticoagulant pump is set as Vk, the revolving speed of blood pump is Vx, obtain the rotating ratio for calculating anticoagulant pump and blood pump
Expression formula are as follows:
The invention also provides a kind of applied to the anti-of the anti-coagulants control method for being used for sampled plasma described in claim 7
The solidifying pre- punching method of agent, comprising the following steps:
S1, it is rotated using control device control blood pump and anticoagulant pump with same rotational speed, anti-coagulants is poured in pipeline；
S2, it is visited in detection pipeline without air to the second sky without sky using counting device statistics in the first empty visit in detection pipeline
Anticoagulant pump turnning circle during gas.
The invention has the following advantages:
(1) it is detected by the blood plasma to each plasma donor with ratio of blood, personalized anti-coagulants is calculated
Usage amount realizes the minimum using purpose of anti-coagulants, is beneficial to plasma donor health, also improves the blood plasma matter of acquisition
Amount.
(2) it by carrying out real-time measurement to consumptive material characteristic value used in sampled plasma process, eliminates because of rotation section
Part long-time service leads to the problem of abrasion and anti-coagulants caused by the form variations of appearance improves anti-coagulants dosage using increasing
Control precision.
(3) it by being rushed in advance to anti-coagulants, direct measuring can be obtained through anticoagulant pump before carrying out adopting slurry
Flow avoids and carries out excessive measuring and calculating operation during adopting slurry, ensure that the accurate dosage of anti-coagulants.
Detailed description of the invention
Fig. 1 is the anti-coagulants control system schematic diagram for sampled plasma of the invention.
Fig. 2 is the anti-coagulants control method flow diagram for sampled plasma of the invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.
As shown in Figure 1, being the anti-coagulants control system schematic diagram for sampled plasma of the invention.One kind is adopted for blood plasma
The anti-coagulants control system of collection, comprising: anticoagulant pump, for driving anti-coagulants to flow in pipeline；Blood pump, for driving blood to exist
Flowing in pipeline；Detection device, for detecting blood plasma and red cell proportion in blood；First computing device, for according to blood plasma
The mixing ratio of anti-coagulants and whole blood is calculated with the ratio of red blood cell；Control device, for the mixing ratio according to anti-coagulants and whole blood
And the rotating ratio of the anticoagulant pump and blood pump obtained by the flow-rate ratio of anticoagulant pump and blood pump controls anticoagulant pump and blood pump
Rotation.
Anticoagulant pump and blood pump of the invention is all the common device during sampled plasma；Wherein, pacify on anticoagulant pump
Equipped with anti-coagulants pipeline, anticoagulant pump is for driving the anti-coagulants in pipeline to flow；Similarly, blood tube is installed on blood pump
Road, blood pump are used to drive the blood flow in pipeline.In the collection process of sampled plasma, anticoagulant pump and the same luck of blood pump
Row promotes anti-coagulants and blood in pipeline to mix and flows into centrifuge；Sampled plasma it is also defeated during, only blood pump transport
Row, anticoagulant pump are not run, and the red blood cell that blood pump drives obtain after centrifuge is centrifuged returns to human body.
Detection device of the invention is for detecting blood plasma and red cell proportion in blood.The realization of the function can be using logical
The photodetector crossed in centrifuge detects the light transmittance of blood, according to the blood light transmittance that detection obtains obtains red blood cell ratio
Hold, to obtain blood plasma and red cell proportion；The blood that can also be obtained after centrifuge is centrifuged using metering device measurement blood
It starches quality, then by calculating it can be concluded that Quality of Erythrocyte, according to the density of blood plasma and red blood cell and then obtains blood plasma and red thin
Born of the same parents' ratio；The red blood cell in pipeline can also be detected by the red blood cell detector on the plasma tube of Centrifuge Cup outlet, it is hot
Cell detection device detection pipeline memory illustrates that Centrifuge Cup has been filled with red blood cell in red blood cell, is held according to piping volume and Centrifuge Cup
Product calculates red blood cell volume, the plasma purity for recycling metering device measurement blood to obtain after centrifuge is centrifuged, by blood plasma matter
Amount is converted into volume and blood plasma and red cell proportion in blood can be obtained.
First computing device of the invention is used to calculate the mixing of anti-coagulants and whole blood according to the ratio of blood plasma and red blood cell
Than.The realization of the function obtains blood plasma after can performing mathematical calculations by the hematocrit value detected according to detection device
With the ratio of red blood cell, perform mathematical calculations to obtain anti-coagulants and whole blood further according to the ratio of the blood plasma and red blood cell that are calculated
Mixing ratio, anti-coagulants here refers to the capacity ratio that anti-coagulants is mixed with whole blood with the mixing ratio of whole blood.
Control device of the invention is used to when pass through according to the mixing of anti-coagulants and whole blood the stream of anticoagulant pump and blood pump
Rotation of the amount than rotating ratio the control anticoagulant pump and blood pump of obtained anticoagulant pump and blood pump.The function can choose monolithic
Machine, microprocessor (MCU) or central processing unit (CPU) etc. are realized；The rotating ratio of anticoagulant pump and blood pump can be by anti-coagulants
Mixing with whole blood is when calculated by the flow-rate ratio of anticoagulant pump and blood pump；Pass through the flow-rate ratio of anticoagulant pump and blood pump
Can be calculated by consumptive material specification, can also through the invention in the flow measuring method that is described below obtain.
Further, for the consumptive material difference of the modifying factor difference trade mark or lot number and caused by error, the invention also includes:
Flow measuring device, for calculating the flow-rate ratio for passing through anticoagulant pump and blood pump.It is driven according to anticoagulant pump anticoagulant
The accurate control of anti-coagulants usage amount in blood may be implemented in the ratio of the flow of the flow and blood pump drives blood of agent, eliminates
Because of existing for pipeline consumptive material various influence factors are influencing caused by anti-coagulants usage amount.
In order to calculate the flow-rate ratio by anticoagulant pump and blood pump, the present invention is illustrated with a kind of embodiment.
Flow measuring device of the invention includes: counting device, for counting the turnning circle of anticoagulant pump and blood pump；The
Two computing devices for calculating the characteristic value of anticoagulant pump pipeline and the characteristic value of blood pump tubing, and calculate anticoagulant pump and blood
The flow-rate ratio of pump；First metering device, for measuring plasma purity；First empty spy, the second empty spy and third sky are visited, all for examining
It whether there is air in test tube road；First empty visit is set on anti-coagulants pipeline, and the described second empty spy and the spy of third sky are sequentially arranged in
On blood conduit.
Counting device of the invention is used to count the operating circle number of anticoagulant pump and blood pump.The realization of the function can use
Common logic circuit.
First metering device of the invention is for counting the plasma purity that blood obtains after centrifuge is centrifuged.The function
Realization can use stent-type electronic scale；When in use, the plasma bags for being used to store blood plasma are placed on electronic scale bracket, electricity
Son claims in real time to count plasma purity.
Of the invention first is empty to be visited, and the second sky is visited and third sky is visited and all whether there is air in pipeline for detecting, and first
Sky, which is visited, to be set on anti-coagulants pipeline, and the described second empty spy and the spy of third sky are sequentially arranged on blood conduit.The realization of the function can
To use common air detection device, its working principle is that using ultrasonic wave with different propagation speed in liquids and gases
Degree is to judge whether be mixed with air in the blood in pipeline.
Second computing device of the invention is used to calculate the characteristic value of the characteristic value and blood pump tubing of anticoagulant pump pipeline, and
Calculate the rotating ratio of anticoagulant pump and blood pump.The realization of the function can be counted according to counting device detects pipeline in the first empty visit
Number is enclosed without anticoagulant pump operating in air event in interior no air to the second empty spy detection pipeline and passes through the anticoagulant of anticoagulant pump
The characteristic value of agent calculation of capacity anticoagulant pump pipeline, the anti-coagulants capacity by anticoagulant pump here can be according to anti-coagulants pipe
Road size and the first empty visit to the duct length between the second empty spy are calculated；Similarly, it can also be counted according to counting device
Blood pump operates during reaching setting value without air to the first metering device statistics plasma purity in third sky visits detection pipeline
It encloses number and calculates the characteristic value of blood pump tubing by the blood volume of blood pump, the blood volume by blood pump here can basis
Centrifuge Cup capacity is visited to the calculation of capacity of blood conduit between plasma bags plus third sky and is obtained, and third sky is visited between plasma bags
The capacity of blood conduit can be visited to the duct length between plasma bags according to blood conduit size and third sky and is calculated.This
In characteristic value be defined as anticoagulant pump or blood pump operating after a week by the flow of anticoagulant pump or blood pump.Further according to anti-coagulants
The characteristic value in pump line road and the characteristic value of blood pump tubing calculate the rotating ratio of anticoagulant pump and blood pump.
Preferably, in order to calculate the flow-rate ratio by anticoagulant pump and blood pump, another embodiment of the invention specifically:
Flow measuring device of the invention includes: counting device, for counting the turnning circle of anticoagulant pump and blood pump；The
Two computing devices for calculating the characteristic value of anticoagulant pump pipeline and the characteristic value of blood pump tubing, and calculate anticoagulant pump and blood
The flow-rate ratio of pump；Sensing device, the volume for measuring blood in Centrifuge Cup change；4th empty visit is visited with the 5th sky, for examining
It whether there is air in test tube road；4th empty visit is set on anti-coagulants pipeline, and the described 5th empty visit is set on blood conduit.
Counting device of the invention is used to count the operating circle number of anticoagulant pump and blood pump.The realization of the function can use
Common logic circuit.
Second computing device of the invention is used to calculate the characteristic value of the characteristic value and blood pump tubing of anticoagulant pump pipeline, and
Calculate the rotating ratio of anticoagulant pump and blood pump.Realizing for the function can be according to the anticoagulant pump operating circle number that counting device counts
And the characteristic value of the anti-coagulants calculation of capacity anticoagulant pump pipeline by anticoagulant pump, the anti-coagulants by anticoagulant pump here
Capacity can be calculated according to empty visit to the duct length between the 5th empty spy of anti-coagulants line size and the 4th；Similarly,
The characteristic value of blood pump tubing can be calculated according to the blood pump operating circle number that counting device counts and by the blood volume of blood pump, this
In the blood volume by blood pump can perform mathematical calculations to obtain according to the volume of red blood cell and blood plasma.Here characteristic value
Anticoagulant pump or blood pump operating are defined as after a week by anticoagulant pump or the flow of blood pump.Further according to the spy of anticoagulant pump pipeline
Value indicative and the characteristic value of blood pump tubing calculate the rotating ratio of anticoagulant pump and blood pump.
Sensing device of the invention is used to measure the volume variation of blood in Centrifuge Cup.The realization of the function can by from
Photodetector in scheming detects the light transmittance of blood, further according to the boundary of blood determination of light transmittance red blood cell and blood plasma
Line can respectively obtain the volume of red blood cell and blood plasma by the line of demarcation.
The empty spy of of the invention the 4th and the 5th empty spy all whether there is air for detecting in pipeline, the 4th empty spy is set to anti-
On solidifying agent pipeline, the described 5th empty visit is set on blood conduit.The realization of the function can use common air detection device,
Its working principle is that having different spread speeds to judge in the blood in pipeline in liquids and gases using ultrasonic wave
Whether air is mixed with.
Preferably, in order to calculate the flow-rate ratio by anticoagulant pump and blood pump, the third embodiment of the invention specifically:
Flow measuring device of the invention includes: counting device, for counting the turnning circle of anticoagulant pump and blood pump；The
Two computing devices for calculating the characteristic value of anticoagulant pump pipeline and the characteristic value of blood pump tubing, and calculate anticoagulant pump and blood
The flow-rate ratio of pump；Second metering device, for measuring anti-coagulants quality；Third metering device, for measuring plasma purity.
Counting device of the invention is used to count the operating circle number of anticoagulant pump and blood pump.The realization of the function can use
Common logic circuit.
Second metering device of the invention is used to measure the quality of anti-coagulants in anti-coagulants bag.The realization of the function can adopt
With stent-type electronic scale；When in use, the anti-coagulants bag for being stored with anti-coagulants is placed on electronic scale bracket, electronic scale is real-time
Anti-coagulants quality is counted.
Third metering device of the invention is for measuring the plasma purity that blood obtains after centrifuge is centrifuged.The function
Realization can use stent-type electronic scale；When in use, the plasma bags for being used to store blood plasma are placed on electronic scale bracket, electricity
Son claims in real time to count plasma purity.
Second computing device of the invention is used to calculate the characteristic value of the characteristic value and blood pump tubing of anticoagulant pump pipeline, and
Calculate the rotating ratio of anticoagulant pump and blood pump.The realization of the function can be counted according to counting device detects pipeline in the first empty visit
Number is enclosed without anticoagulant pump operating in air event in interior no air to the second empty spy detection pipeline and passes through the anticoagulant of anticoagulant pump
The characteristic value of agent calculation of capacity anticoagulant pump pipeline, the anti-coagulants capacity by anticoagulant pump here can be according to the second metering
The anti-coagulants qualitative data of device measurement is calculated；Similarly, it can also be counted to visit in third sky according to counting device and detected
Reach blood pump operating circle number during setting value without air to the first metering device statistics plasma purity in pipeline and passes through blood pump
Blood volume calculate the characteristic value of blood pump tubing, the blood volume by blood pump here can survey according to third metering device
Fixed plasma purity is calculated.Here characteristic value be defined as anticoagulant pump or blood pump operating after a week by anticoagulant pump or
The flow of blood pump.The characteristic value of characteristic value and blood pump tubing further according to anticoagulant pump pipeline calculates turn of anticoagulant pump and blood pump
Speed ratio.
The present invention is further appreciated that for the ease of those skilled in the art, and the targeted use of the present invention is described below
In the solidifying agent control method of the anti-coagulants control system of sampled plasma.
As shown in Fig. 2, being the anti-coagulants control method flow diagram for sampled plasma of the invention.One kind being used for blood
Starch the anti-coagulants control method of acquisition, comprising the following steps:
A, anti-coagulants and blood are respectively driven using anticoagulant pump and blood pump to flow in pipeline, and is examined using detection device
Survey blood plasma and red cell proportion in blood；
B, the mixing ratio M of anti-coagulants and whole blood is calculated according to the ratio of blood plasma and red blood cell using the first computing device；
C, it is counted using counting device and is visited in detection pipeline without air to the second sky without sky in the first empty visit in detection pipeline
Anticoagulant pump turnning circle during gas, and utilize the characteristic value T of the second computing device calculating anticoagulant pump pipelinek；
D, it counts to visit in detection pipeline in third sky using counting device and counts blood plasma matter without air to the first metering device
Amount reaches blood pump turnning circle during pulp distinguished value, and the characteristic value of blood pump tubing is calculated using the second computing device
Tx；
E, the anticoagulant pump pipeline feature value T according to obtained in step CkWith blood pump tubing characteristic value obtained in step D
Tx, the rotating ratio of anticoagulant pump and blood pump is calculated using the second computing device, and anti-according to what is be calculated using control device
The rotation of the rotating ratio of setting agent pump and blood pump control anticoagulant pump and blood pump.
In step, anticoagulant pump and blood pump are run simultaneously, respectively drive anti-coagulants and blood using anticoagulant pump and blood pump
Liquid flows in pipeline, and promotes anti-coagulants and blood in pipeline to mix and flow into centrifuge.Pass through the photoelectricity in centrifuge again
Detector detects the light transmittance of blood, obtains hematocrit value according to the blood light transmittance that detection obtains, to obtain blood plasma
With red cell proportion；Preferably, the plasma purity that can also be obtained after centrifuge is centrifuged using metering device measurement blood, then
By calculating it can be concluded that Quality of Erythrocyte, further according to the density of blood plasma and red blood cell and then obtains the ratio of blood plasma and red blood cell
Example；Preferably, the red blood cell in pipeline can also be detected by the red blood cell detector on the plasma tube of Centrifuge Cup outlet, when
Red blood cell detector detection pipeline memory illustrates that Centrifuge Cup has been filled with red blood cell in red blood cell, according to piping volume and Centrifuge Cup
Volume calculations red blood cell volume, the plasma purity for recycling metering device measurement blood to obtain after centrifuge is centrifuged, by blood plasma
Blood plasma and red cell proportion in blood can be obtained at volume in mass conversion.
In stepb, the blood plasma and red cell proportion detected using the first computing device according to detection device is carried out
The mixing ratio M of anti-coagulants and whole blood is obtained after mathematical operation.
In step C, anticoagulant pump driving anti-coagulants flows in pipeline, detects in pipeline in anti-coagulants in the first empty visit
It is detected using counting device statistics in the first empty visit in anti-coagulants without in air event in no air to the second empty spy detection pipeline
It is detected in pipeline without air to the second empty visit without anticoagulant pump turnning circle in air event in pipeline；Second is recycled to calculate dress
It sets according to the anticoagulant pump operating circle number of counting device statistics and by the anti-coagulants calculation of capacity anti-coagulants pump line of anticoagulant pump
The characteristic value in road operates circle number divided by anticoagulant pump using the anti-coagulants capacity by anticoagulant pump and obtains anticoagulant pump pipeline
Characteristic value Tk。
In step D, it is similar to step C, blood pump drives blood flows in pipeline, visits blood in detection pipeline in third sky
During reaching setting value to the first metering device statistics plasma purity without air in liquid, using counting device statistics in third sky
It visits in detection pipeline and reaches blood pump turning collar during pulp distinguished value without air to the first metering device statistics plasma purity
Number；The blood pump operating for recycling the second computing device to be counted according to counting device encloses number and calculates blood by the blood volume of blood pump
The characteristic value in pump line road is pumped, i.e., operates circle number divided by blood pump using the blood volume by blood pump and obtains the characteristic value of blood pump tubing
Tx。
In step E, using the second computing device according to the characteristic value T of anticoagulant pump pipelinekWith the feature of blood pump tubing
Value TxCalculate the rotating ratio of anticoagulant pump and blood pump.Here the rotating ratio obtained eliminates because of anti-coagulants caused by consumptive material loss
The problem of using increasing.
The present invention is further appreciated that for the ease of those skilled in the art, is come below with specific embodiment to this hair
The algorithm of the bright middle rotating ratio that anticoagulant pump and blood pump are calculated using the second computing device is illustrated.
The revolving speed of anticoagulant pump is set as Vk, the revolving speed of blood pump is Vx, obtain the rotating ratio for calculating anticoagulant pump and blood pump
Expression formula are as follows:
The invention also provides a kind of anti-coagulants applied to the anti-coagulants control method for sampled plasma of the invention
Pre- punching method, which comprises the following steps:
S1, it is rotated using control device control blood pump and anticoagulant pump with same rotational speed, anti-coagulants is poured in pipeline；
S2, it is visited in detection pipeline without air to the second sky without sky using counting device statistics in the first empty visit in detection pipeline
Anticoagulant pump turnning circle during gas.
The pre- punching method of anti-coagulants of anti-coagulants control method for sampled plasma of the invention is used to adopt in progress blood plasma
Before collection, accurately calculating to the anticoagulant agent flux by anticoagulant pump is realized.
The present invention is further appreciated that for the ease of those skilled in the art, is come below with specific embodiment to this hair
The pre- punching method of anti-coagulants of anti-coagulants control method in bright for sampled plasma is described further.
Since the pre- punching method of anti-coagulants of the invention is for before carrying out sampled plasma, at this time blood collection needles pipeline and
Saline needle pipeline is all in closed state；It is carried out before rushing in advance, is needed anti-coagulants using the pre- punching method of anti-coagulants of the invention
Syringe needle is inserted into the outlet of anti-coagulants bag, then starts anti-coagulants and rushes in advance.
Blood pump and anticoagulant pump are controlled first with control device to be rotated clockwise with same rotational speed, and anti-coagulants is rushed
Enter in pipeline；When in the first empty spy detection pipeline without air, start the turnning circle for counting anticoagulant pump using counting device；
When in the second empty spy detection pipeline without air, terminate the turnning circle for counting anticoagulant pump using counting device.By anticoagulant
The anti-coagulants capacity of agent pump can be calculated according to empty visit to the duct length between the second empty spy of anti-coagulants line size and first
It arrives, anticoagulant pump operating circle number further according to counting device statistics and what is obtained can be counted by the anti-coagulants capacity of anticoagulant pump
Calculate the exact flow rate of anticoagulant pump.
Those of ordinary skill in the art will understand that the embodiments described herein, which is to help reader, understands this hair
Bright principle, it should be understood that protection scope of the present invention is not limited to such specific embodiments and embodiments.This field
Those of ordinary skill disclosed the technical disclosures can make according to the present invention and various not depart from the other each of essence of the invention
The specific variations and combinations of kind, these variations and combinations are still within the scope of the present invention.
Claims (1)
1. a kind of pre- punching method of anti-coagulants for sampled plasma, which comprises the following steps:
S1, it is rotated using control device control blood pump and anticoagulant pump with same rotational speed, anti-coagulants is poured in pipeline；
S2, it is visited in detection pipeline without air to the second sky without air mistake using counting device statistics in the first empty visit in detection pipeline
Anticoagulant pump turnning circle in journey；
S3, it is visited in detection pipeline without air to the second sky without sky using the measurement of the second gravity measure device in the first empty visit in detection pipeline
During gas in anti-coagulants bag anti-coagulants mass change data；
S4, the anticoagulant pump turnning circle and the second gravity measure device counted using the second computing device according to counting device are measured
Anti-coagulants mass change data calculate the characteristic value of anticoagulant pump pipeline in anti-coagulants bag.
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| CN201510198723.1A CN104800905B (en) | 2015-01-16 | 2015-04-24 | Anticoagulant control system for sampled plasma |
| CN201610257181.5A CN105854105B (en) | 2015-04-24 | 2015-04-24 | The pre- punching method of anti-coagulants for sampled plasma |
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| US11386993B2 (en) | 2011-05-18 | 2022-07-12 | Fenwal, Inc. | Plasma collection with remote programming |
| CN107789693B (en) * | 2017-10-31 | 2019-07-23 | 四川南格尔生物科技有限公司 | A kind of sampled plasma system optimizing anti-coagulants dosage |
| US11412967B2 (en) | 2018-05-21 | 2022-08-16 | Fenwal, Inc. | Systems and methods for plasma collection |
| EP3954407B1 (en) | 2018-05-21 | 2023-07-12 | Fenwal, Inc. | Systems and methods for optimization of plasma collection volumes |
| CN110215217A (en) * | 2019-06-05 | 2019-09-10 | 四川南格尔生物科技有限公司 | A kind of sampled plasma system and method |
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| CN105854105A (en) | 2016-08-17 |
| CN104800905B (en) | 2016-12-28 |
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