CN106535956B - Duration blood purification device - Google Patents

Duration blood purification device Download PDF

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Publication number
CN106535956B
CN106535956B CN201580035633.9A CN201580035633A CN106535956B CN 106535956 B CN106535956 B CN 106535956B CN 201580035633 A CN201580035633 A CN 201580035633A CN 106535956 B CN106535956 B CN 106535956B
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fluid infusion
dialyzate
liquid level
waste liquid
liquid
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CN106535956A (en
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山口泰广
西川勇作
吉田真
吉田真一
松本幸男
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JMS Co Ltd
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Japan Lifeline Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis

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  • Heart & Thoracic Surgery (AREA)
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Abstract

The purpose of the present invention is to provide can make the duration blood purification device that fluid infusion pump stops in stage of at least blood back room full of fluid infusion when the flow path pressed from both sides from fluid infusion bottle to fluid infusion in fluid infusion pump work is closed.The duration blood purification device of the present invention has blood extracorporeal circulation circuit, dialysate circuit, fluid infusion flow path, waste liquid flow path, capacity formula metering units and control unit, there is fluid infusion bottle in fluid infusion flow arrangement, fluid infusion folder and fluid infusion pump, fluid infusion flow path between fluid infusion folder and fluid infusion pump is connected with configured with fluid infusion metering solenoid valve, upside fluid infusion liquid level sensor, the fluid infusion branch flow passage of fluid infusion measuring container and downside fluid infusion liquid level sensor, control unit output alarm in the case that state of the fluid infusion liquid level positioned at the position than downside fluid infusion liquid level sensor on the lower continue for certain time in fluid infusion pump work generates signal and pump stop signal.

Description

Duration blood purification device
Technical field
The present invention relates to the duration blood purification of the hemodiafiltration therapy for implementing last longer dresses It sets.
Background technology
From the viewpoint of the drastically variation for the isohydria for preventing patient, the blood of haemodialysis and blood filtering is used in combination Dialysis filtration therapy continues the long time (such as 24 hours or more) and is implemented.
In the duration blood purification device for implementing above-mentioned hemodiafiltration therapy, to dialyzate, fluid infusion And the flow of waste liquid be managed this case it is of crucial importance.Therefore, it is necessary to measure respective flow over time, and The rotating speed of liquid-feeding pump is modified etc. in the case of generating difference with respective setting flow and controls flow, so that with above-mentioned It is consistent to set flow.
In the past, proposed there is the capacity for having and capable of accurately measuring dialysate flow, fluid infusion flow and waste liquid flow The duration blood purification of formula metering units is with device (with reference to following patent documents 1 and patent document 2).
Figure 10 is the capacity formula metering shown in existing duration blood purification device for measuring fluid infusion flow The flow graph of unit.
In the figure, 80 be fluid infusion flow path, and 81 be fluid infusion bottle, and 82 be fluid infusion folder, and 83 be fluid infusion pump, and 84 be to roll folder (roller clamp), 85 be fluid infusion branch flow passage, and 86 be fluid infusion metering solenoid valve, and 87 be upside fluid infusion liquid level sensor, 88 be fluid infusion measuring container, and 89 be downside fluid infusion liquid level sensor, and 90 be blood extracorporeal circulation circuit, and 93 be blood back room, and 94 are Bubble detecting sensor, 95 be bubble folder.
As shown in Figure 10, in fluid infusion flow path 80 configured with fluid infusion bottle 81, rolling folder 84, fluid infusion folder 82 and fluid infusion pump 83.
Fluid infusion flow path 80 is the flow path for feeding fluid infusion by the purified blood of blood purification (illustration omitted) for court, with The blood back room 93 for being connected to blood extracorporeal circulation circuit 90 connects.Blood extracorporeal circulation circuit in the downstream side of the blood back room 93 90 press from both sides 95 configured with air bubble sensor 94 and bubble.
On the other hand, the fluid infusion flow path 80 between fluid infusion folder 82 and fluid infusion pump 83 is connected with fluid infusion branch flow passage 85, The fluid infusion branch flow passage 85 as measure the capacity formula metering units of fluid infusion flow configured with fluid infusion metering solenoid valve 86, Upside fluid infusion liquid level sensor 87, the fluid infusion measuring container 88 positioned at the position lower than fluid infusion bottle 81 and downside fluid infusion liquid level pass Sensor 89.
In the duration blood purification device for having capacity formula metering units shown in Fig. 10, by making fluid infusion pump So that fluid infusion metering solenoid valve 86 is become "Off" state in the state of 83 rotations and fluid infusion folder 82 made to become " opening " state, The fluid infusion in fluid infusion bottle 81 can be made to flow into blood back room 93 via fluid infusion flow path 80.
In the duration blood purification device, with separating predetermined time interval (i.e. intermittently) as follows Measure fluid infusion flow.
That is, by making the fluid infusion metering solenoid valve 86 for being in "Off" state originally become " opening " state, make fluid infusion Fluid infusion in bottle 81 flows into blood back room 93 via fluid infusion flow path 80, and also flows into fluid infusion meter via fluid infusion branch flow passage 85 Measure container 88.
Moreover, rising in the liquid level for flowing into the fluid infusion of fluid infusion measuring container 88 and being detected by upside fluid infusion liquid level sensor 87 After arriving, so that fluid infusion folder 82 is become "Off" state, as a result, flow out the fluid infusion in fluid infusion measuring container 88.The fluid infusion flowed out Blood back room 93 is flowed into via fluid infusion branch flow passage 85 and fluid infusion flow path 80.
Later, decline in the liquid level for the fluid infusion flowed out from fluid infusion measuring container 88 and examined by downside fluid infusion liquid level sensor 89 After measuring, make fluid infusion metering solenoid valve 86 that the decline of liquid level be made to stop (at this point, the liquid level position of fluid infusion as "Off" state In in fluid infusion branch flow passage 85), and fluid infusion folder 82 is made to become " opening " state (being back to the state before the measurement of flow), by This, makes the fluid infusion in fluid infusion bottle 81 flow into blood back room 93 via fluid infusion flow path 80.
Moreover, being detected certainly by upside fluid infusion liquid level sensor 87 according to the liquid level for the fluid infusion flowed out from fluid infusion measuring container 88 To playing until being detected by downside fluid infusion liquid level sensor 89 discharge of required time and fluid infusion during this period, Measure the fluid infusion flow of fluid infusion pump 83.
Patent document 1:No. 3180309 bulletins of Japanese Patent Publication No.
Patent document 2:Japanese Unexamined Patent Publication 2007-135908 bulletins
In the duration blood purification device for having capacity formula metering units as shown in Figure 10, consideration is forgotten to beat It is opened in the case where replacing the rolling folder 84 closed when fluid infusion bottle 81 (fluid infusion bag) or by not constituting the blood purification device Clip (pliers) oppress from fluid infusion bottle 81 to fluid infusion folder 82 fluid infusion flow path 80 the case where.In addition, it is also considered that mended being inserted in The endoporus of the puncture needle (spike needle) of liquid bottle 81 (fluid infusion bag) generates the case where blocking.
In this case, from fluid infusion bottle 81 to fluid infusion, the fluid infusion flow path 80 of folder 82 is closed.
If moreover, fluid infusion pump 83 continues work in the state that the fluid infusion flow path 80 of the folder 82 from fluid infusion bottle 81 to fluid infusion is closed Make (rotation), then (is in fluid infusion measuring container 88 and fluid infusion branch in the measurement of fluid infusion flow in fluid infusion branch flow passage 85 In flow path 85) fluid infusion attracted by fluid infusion pump 83, and be sent into towards in fluid infusion measuring container 88 from fluid infusion metering with solenoid valve 86 Air, in turn or even the fluid infusion in the fluid infusion flow path 80 in 83 downstream sides of fluid infusion pump and in blood back room 93 is all discharged (to blood Extracorporeal circulating circuit 90 conveys), blood back room 93 becomes the empty state being filled entirely with air.
In addition, the attraction generated by fluid infusion pump 83 is usually above the fluid infusion metering solenoid valve 86 in "Off" state Airtight power, therefore, even if being also possible to occur when fluid infusion metering is in "Off" state with solenoid valve 86 as described above Situation.
If blood back room 93 becomes empty state like this, bubble detecting sensor 94 detects the state, receives it The control unit (not shown) of detection signal makes fluid infusion pump 83 stop.Dialysis treatment is interrupted as a result,.
However, (making in the case where stopping fluid infusion pump 83 based on the detection signal from bubble detecting sensor 94 In the case that blood back room 93 becomes empty state), need to carry out towards filling fluid infusion in the blood back room 93, in fluid infusion flow path 80 into The such cumbersome operation of row exhaust, and a degree of time is needed until starting again at dialysis treatment.
Accordingly, it is desirable to provide it is a kind of have fluid infusion pump 83 can be made to stop before blood back room 93 becomes empty state be The duration blood purification device of system.
Even if in addition, for being imported in the dialysate circuit of dialyzate to blood purification, if in the dialysis positive work of liquid pump The flow path pressed from both sides from dialyzate bottle (dialyzate bag) to dialyzate when making is closed, then it is assumed that air can be mixed into the mould of blood purification Block holder (module holder).
Invention content
The present invention is completed based on situation as above.
The purpose of the present invention is to provide a kind of duration blood purification device, which has with device Standby capacity formula metering units, wherein when the flow path pressed from both sides from fluid infusion bottle to fluid infusion in the state of making fluid infusion pump work is closed, Fluid infusion pump can be made to stop in the stage of the flow path (at least blood back room) full of fluid infusion in the downstream side that fluid infusion pumps.
Another object of the present invention, which also resides in, provides a kind of duration blood purification device, wherein when making dialyzate It, can be in the flow path in the downstream side of dialysis liquid pump when the flow path pressed from both sides from dialyzate bottle to dialyzate in the state of pump work is closed The stage of (at least dialyzate injection hole of blood purification) full of dialyzate makes dialysis liquid pump stop.
(1) duration blood purification device of the invention exports blood from the vein or artery of patient, and will purification Blood recovery afterwards to patient vein,
Above-mentioned duration blood purification device is characterized in that,
Have：Blood extracorporeal circulation circuit, above-mentioned blood extracorporeal circulation circuit are from the vein of patient or artery to quiet The circulation loop of arteries and veins, and configured with the blood purification being made of filter for blood dialysis；Dialysate circuit, above-mentioned dialysis liquid stream Road is used to import dialyzate to above-mentioned blood purification；Fluid infusion flow path, above-mentioned fluid infusion flow path is used for court will be by above-mentioned blood purification The fluid infusion that device purifies or includes body fluid components by the purified blood supply of above-mentioned blood purification；Waste liquid flow path, it is above-mentioned useless Liquid stream road is used to the waste liquid after blood purification being discharged；Capacity formula metering units for intermittently measuring fluid infusion flow；And The control unit of the capacity formula metering units is controlled,
There are blood pump and above-mentioned blood purification in above-mentioned blood extracorporeal circulation loop configuration,
It is configured in order dialyzate bottle, dialyzate folder and dialysis liquid pump, above-mentioned dialysis liquid stream in above-mentioned dialysate circuit Road is connected to the dialyzate injection hole of above-mentioned blood purification in the downstream side of the allocation position of above-mentioned dialysis liquid pump,
It is configured in order fluid infusion bottle, fluid infusion folder and fluid infusion pump in above-mentioned fluid infusion flow path, above-mentioned fluid infusion flow path is in above-mentioned benefit The downstream side of the allocation position of liquid pump is connected to above-mentioned blood extracorporeal circulation circuit,
Above-mentioned fluid infusion flow path between above-mentioned fluid infusion folder and above-mentioned fluid infusion pump is connected with fluid infusion branch flow passage, in the fluid infusion Branch flow passage is as measuring, the capacity formula metering units of fluid infusion flow are configured in order fluid infusion metering solenoid valve, upside is mended Liquid liquid level sensor, fluid infusion measuring container and downside fluid infusion liquid level sensor positioned at the position lower than above-mentioned fluid infusion bottle,
It is configured in order outlet, waste liquid folder and waste drains pump in above-mentioned waste liquid flow path, above-mentioned waste liquid flow path is above-mentioned useless The upstream side of the allocation position of liquid pump is connected to the dialyzate tap of above-mentioned blood purification,
Above-mentioned control unit separate predetermined time interval control above-mentioned fluid infusion metering solenoid valve and above-mentioned fluid infusion folder Opening and closing is mended based on being calculated from the detection information of above-mentioned upside fluid infusion liquid level sensor and above-mentioned downside fluid infusion liquid level sensor Flow quantity, also,
When the liquid level of the fluid infusion when making above-mentioned fluid infusion pump work is located at compared to above-mentioned downside fluid infusion liquid level sensor on the lower Position state continue for certain time in the case of, output alarm generate signal.
(2) it in the duration blood purification device of the present invention, is preferably formed into：Above-mentioned control unit is repeated as follows Control：
By make in the state of making above-mentioned fluid infusion pump rotation above-mentioned fluid infusion metering solenoid valve and above-mentioned fluid infusion press from both sides at For " opening " state, makes the fluid infusion in above-mentioned fluid infusion bottle via fluid infusion flow path and conveyed to above-mentioned blood extracorporeal circulation circuit, and Above-mentioned fluid infusion measuring container is flowed into via fluid infusion branch flow passage,
Rise in the liquid level for flowing into the fluid infusion of above-mentioned fluid infusion measuring container and is detected by above-mentioned upside fluid infusion liquid level sensor After arriving, above-mentioned fluid infusion folder is made to become "Off" state, makes fluid infusion in above-mentioned fluid infusion measuring container from the fluid infusion measuring container stream Go out and conveyed via above-mentioned fluid infusion branch flow passage and above-mentioned fluid infusion flow path and to above-mentioned blood extracorporeal circulation circuit,
Decline in the liquid level for the fluid infusion flowed out from above-mentioned fluid infusion measuring container and is examined by above-mentioned downside fluid infusion liquid level sensor After measuring, above-mentioned fluid infusion folder is made to become " opening " state, so that the liquid level of fluid infusion is risen so that the liquid level of the fluid infusion is located at and compare Above-mentioned downside fluid infusion liquid level sensor position against the top then makes above-mentioned fluid infusion metering solenoid valve become "Off" state, And convey the fluid infusion in above-mentioned fluid infusion bottle to above-mentioned blood extracorporeal circulation circuit via above-mentioned fluid infusion flow path,
So that above-mentioned fluid infusion metering solenoid valve is become " opening " state with separating predetermined time interval；
In addition, above-mentioned control unit according to the liquid level of the fluid infusion flowed out from above-mentioned fluid infusion measuring container from by above-mentioned upside fluid infusion Liquid level sensor has detected the required delivery time (t1) until being detected by above-mentioned downside fluid infusion liquid level sensor And the discharge (V1) of fluid infusion during this period, measure fluid infusion flow (L1) using formula L1=V1/t1.
(3) it in the duration blood purification device of above-mentioned (2), is preferably formed into：Above-mentioned control unit is from above-mentioned benefit The liquid level of the fluid infusion of liquid measuring container outflow declines after being detected by above-mentioned downside fluid infusion liquid level sensor, and above-mentioned fluid infusion is made to press from both sides And above-mentioned fluid infusion metering maintains " opening " state with solenoid valve, until the fluid infusion liquid level rise and by above-mentioned downside fluid infusion Until liquid level sensor detects again.
(4) it in the duration blood purification device of the present invention, is preferably formed into：Above-mentioned control unit, which is worked as, makes above-mentioned benefit The liquid level of fluid infusion continue for one positioned at the state compared to the position of above-mentioned downside fluid infusion liquid level sensor on the lower when liquid pump works In the case of fixing time, output alarm generates signal, and exports the stop signal of above-mentioned fluid infusion pump.
(5) duration blood purification device of the invention exports blood from the vein or artery of patient, and will purification Blood recovery afterwards to patient vein,
Above-mentioned duration blood purification device is characterized in that,
Have：Blood extracorporeal circulation circuit, above-mentioned blood extracorporeal circulation circuit are from the vein of patient or artery to quiet The circulation loop of arteries and veins, and configured with the blood purification being made of filter for blood dialysis；Dialysate circuit, above-mentioned dialysis liquid stream Road is used to import dialyzate to above-mentioned blood purification；Fluid infusion flow path, above-mentioned fluid infusion flow path is used for court will be by above-mentioned blood purification The fluid infusion that device purifies or includes body fluid components by the purified blood supply of above-mentioned blood purification；Waste liquid flow path, it is above-mentioned useless Liquid stream road is used to the waste liquid after blood purification being discharged；Capacity formula metering units for intermittently measuring dialysate flow；With And the control unit of the capacity formula metering units is controlled,
There are blood pump and above-mentioned blood purification in above-mentioned blood extracorporeal circulation loop configuration,
It is configured in order dialyzate bottle, dialyzate folder and dialysis liquid pump, above-mentioned dialysis liquid stream in above-mentioned dialysate circuit Road is connected to the dialyzate injection hole of above-mentioned blood purification in the downstream side of the allocation position of above-mentioned dialysis liquid pump,
Above-mentioned dialysate circuit between above-mentioned dialyzate folder and above-mentioned dialysis liquid pump is connected with dialyzate branch flow passage, In the dialyzate branch flow passage dialyzate metering is configured in order as measuring the capacity formula metering units of dialysate flow With solenoid valve, upside dialyzate liquid level sensor, positioned at the position lower than above-mentioned dialyzate bottle dialyzate measuring container and Downside dialyzate liquid level sensor,
It is configured in order fluid infusion bottle, fluid infusion folder and fluid infusion pump in above-mentioned fluid infusion flow path, above-mentioned fluid infusion flow path is in above-mentioned benefit The downstream side of the allocation position of liquid pump is connected to above-mentioned blood extracorporeal circulation circuit,
It is configured in order outlet, waste liquid folder and waste drains pump in above-mentioned waste liquid flow path, above-mentioned waste liquid flow path is above-mentioned useless The upstream side of the allocation position of liquid pump is connected to the dialyzate tap of above-mentioned blood purification,
Above-mentioned control unit separates predetermined time interval and controls above-mentioned dialyzate metering electricity consumption magnet valve and above-mentioned dialyzate The opening and closing of folder, based on the detection letter from above-mentioned upside dialyzate liquid level sensor and above-mentioned downside dialyzate liquid level sensor Breath calculates dialysate flow, also,
Above-mentioned downside dialyzate liquid level sensor is compared when the liquid level of the dialyzate when making above-mentioned dialyzate pump work is located at In the case that the state of position on the lower continue for certain time, output alarm generates signal.
(6) it in the duration blood purification device of above-mentioned (5), is preferably formed into：
Above-mentioned control unit is repeated control as follows：
By making above-mentioned dialyzate measure electricity consumption magnet valve and above-mentioned dialysis in the state of so that above-mentioned dialysis liquid pump is rotated Liquid folder becomes " opening " state, make the dialyzate in above-mentioned dialyzate bottle via above-mentioned dialysate circuit and to above-mentioned blood purification The dialyzate injection hole of device conveys, and flows into above-mentioned dialyzate measuring container via dialyzate branch flow passage,
In the liquid level rising for flowing into the dialyzate of above-mentioned dialyzate measuring container by above-mentioned upside dialyzate level sensing After device detects, so that above-mentioned dialyzate folder is become "Off" state, keep the dialyzate in above-mentioned dialyzate measuring container saturating from this Analyse the outflow of liquid measuring container and via above-mentioned dialyzate branch flow passage and above-mentioned dialysate circuit and to above-mentioned blood purification Dialyzate injection hole conveying,
Decline in the liquid level of the dialyzate gone out from above-mentioned dialyzate metering container flow and is passed by above-mentioned downside dialyzate liquid level After sensor detects, so that above-mentioned dialyzate folder is become " opening " state, the liquid level of dialyzate is made to rise so that the dialyzate Liquid level is located at the position against the top compared to above-mentioned downside dialyzate liquid level sensor, then makes above-mentioned dialyzate metering electricity consumption magnet valve As "Off" state, and by the dialyzate in above-mentioned dialyzate bottle via above-mentioned dialysate circuit and to above-mentioned blood purification Dialyzate injection hole conveying,
So that above-mentioned dialyzate metering electricity consumption magnet valve is become " opening " state with separating predetermined time interval；
In addition, above-mentioned control unit according to the liquid level of dialyzate gone out from above-mentioned dialyzate metering container flow from by above-mentioned upside Dialyzate liquid level sensor has detected the required outflow until being detected by above-mentioned downside dialyzate liquid level sensor The discharge (V2) of time (t2) and dialyzate during this period, dialysate flow is measured using formula L2=V2/t2 (L2)。
(7) it in the duration blood purification device of above-mentioned (6), is preferably formed into：Above-mentioned control unit is from above-mentioned The liquid level of the dialyzate of analysis liquid measuring container outflow declines after being detected by above-mentioned downside dialyzate liquid level sensor, makes above-mentioned Dialyzate press from both sides and above-mentioned dialyzate metering electricity consumption magnet valve maintain " openings " state, until the dialyzate liquid level rising and by Until above-mentioned downside dialyzate liquid level sensor detects again.
(8) it in the duration blood purification device of any one of above-mentioned (5)~(7), is preferably formed into：Above-mentioned control Portion is located at compared to above-mentioned downside dialyzate liquid level sensor on the lower when the liquid level of the dialyzate when making above-mentioned dialyzate pump work Position state continue for certain time in the case of, output alarm generates signal, and exports the stopping of above-mentioned dialysis liquid pump Signal.
(9) it in the duration blood purification device of the present invention, is preferably formed into：
Have the capacity formula metering units for intermittently measuring waste liquid flow and controls the capacity formula metering units Control unit,
Above-mentioned waste liquid flow path between above-mentioned waste liquid folder and above-mentioned waste drains pump is connected with waste liquid branch flow passage, in the waste liquid Branch flow passage is as measuring, the capacity formula metering units of waste liquid flow are configured in order waste liquid metering solenoid valve, upside is given up Liquid liquid level sensor, the waste liquid measuring container positioned at the low position of the dialyzate tap than above-mentioned blood purification and downside Waste liquid liquid level sensor,
Above-mentioned control unit is repeated control as follows：
By making above-mentioned waste liquid metering solenoid valve as " opening " state in the state of so that above-mentioned waste drains pump is rotated, simultaneously So that above-mentioned waste liquid folder is become "Off" state, waste liquid made to flow into above-mentioned waste liquid measuring container,
Rise in the liquid level for flowing into the waste liquid of above-mentioned waste liquid measuring container and is detected by above-mentioned upside waste liquid liquid level sensor After arriving, so that above-mentioned waste liquid folder is become " opening " state, thus make the waste liquid in above-mentioned waste liquid measuring container via above-mentioned waste liquid point Zhi Liulu and above-mentioned waste liquid flow path are discharged from above-mentioned outlet,
So that above-mentioned waste liquid folder is become "Off" state with separating predetermined time interval；
In addition, above-mentioned control unit also according to the liquid level from the waste liquid for flowing into above-mentioned waste liquid measuring container by above-mentioned downside waste liquid Liquid level sensor has detected the required inlet time (t3) until being detected by above-mentioned upside waste liquid liquid level sensor And the influx (V3) of waste liquid during this period, measure waste liquid flow (L3) using formula L3=V3/t3.
(10) it in the duration blood purification device described in above-mentioned (4) or (8), is preferably formed into：In above-mentioned control When the stop signal of portion's output alarm generation signal and pump, stop above-mentioned blood pump.
(11) it in the duration blood purification device of the present invention, is preferably formed into：Above-mentioned control unit control is above-mentioned Liquid pump, above-mentioned fluid infusion pump and the respective rotating speed of above-mentioned waste drains pump are analysed, so that with separating predetermined time interval calculated Dialysate flow, fluid infusion flow and waste liquid flow are consistent with respective setting value.
(12) duration blood purification device of the invention exports blood from the vein or artery of patient, and will purification Blood recovery afterwards to patient vein,
Above-mentioned duration blood purification device is characterized in that,
Have：Blood extracorporeal circulation circuit, above-mentioned blood extracorporeal circulation circuit are from the vein of patient or artery to quiet The circulation loop of arteries and veins, and configured with the blood purification being made of transfusion filters；Fluid infusion flow path, above-mentioned fluid infusion flow path are used for court It to be purified by above-mentioned blood purification or the fluid infusion for including body fluid components is fed by the purified blood of above-mentioned blood purification； Waste liquid flow path, above-mentioned waste liquid flow path are used to the waste liquid after blood purification being discharged；Capacity for intermittently measuring fluid infusion flow Formula metering units；And the control unit of the capacity formula metering units is controlled,
There are blood pump and above-mentioned blood purification in above-mentioned blood extracorporeal circulation loop configuration,
It is configured in order fluid infusion bottle, fluid infusion folder and fluid infusion pump in above-mentioned fluid infusion flow path, above-mentioned fluid infusion flow path is in above-mentioned benefit The downstream side of the allocation position of liquid pump is connected to above-mentioned blood extracorporeal circulation circuit,
Above-mentioned fluid infusion flow path between above-mentioned fluid infusion folder and above-mentioned fluid infusion pump is connected with fluid infusion branch flow passage, in the fluid infusion Branch flow passage is as measuring, the capacity formula metering units of fluid infusion flow are configured in order fluid infusion metering solenoid valve, upside is mended Liquid liquid level sensor, fluid infusion measuring container and downside fluid infusion liquid level sensor positioned at the position lower than above-mentioned fluid infusion bottle,
It is configured in order outlet, waste liquid folder and waste drains pump in above-mentioned waste liquid flow path, above-mentioned waste liquid flow path is above-mentioned useless The upstream side of the allocation position of liquid pump is connected to above-mentioned blood purification,
Above-mentioned control unit separate predetermined time interval control above-mentioned fluid infusion metering solenoid valve and above-mentioned fluid infusion folder Opening and closing is mended based on being calculated from the detection information of above-mentioned upside fluid infusion liquid level sensor and above-mentioned downside fluid infusion liquid level sensor Flow quantity, also,
When making above-mentioned fluid infusion pump work, the liquid level of fluid infusion is located at compared to above-mentioned downside fluid infusion liquid level sensor on the lower In the case that the state of position continue for certain time, output alarm generates signal.
(13) duration blood purification device of the invention exports blood from the vein or artery of patient, and will purification Blood recovery afterwards to patient vein,
Above-mentioned duration blood purification device is characterized in that,
Have：Blood extracorporeal circulation circuit, above-mentioned blood extracorporeal circulation circuit are from the vein of patient or artery to quiet The circulation loop of arteries and veins, and configured with the blood purification being made of haemodialyser；Dialysate circuit, above-mentioned dialysate circuit are used In to above-mentioned blood purification import dialyzate；Waste liquid flow path, above-mentioned waste liquid flow path are used to the waste liquid after blood purification being discharged； Capacity formula metering units for intermittently measuring dialysate flow；And the control unit of the capacity formula metering units is controlled,
There are blood pump and above-mentioned blood purification in above-mentioned blood extracorporeal circulation loop configuration,
It is configured in order dialyzate bottle, dialyzate folder and dialysis liquid pump, above-mentioned dialysis liquid stream in above-mentioned dialysate circuit Road is connected to the dialyzate injection hole of above-mentioned blood purification in the downstream side of the allocation position of above-mentioned dialysis liquid pump,
Above-mentioned dialysate circuit between above-mentioned dialyzate folder and above-mentioned dialysis liquid pump is connected with dialyzate branch flow passage, In the dialyzate branch flow passage dialyzate metering is configured in order as measuring the capacity formula metering units of dialysate flow With solenoid valve, upside dialyzate liquid level sensor, positioned at the position lower than above-mentioned dialyzate bottle dialyzate measuring container and Downside dialyzate liquid level sensor,
It is configured in order outlet, waste liquid folder and waste drains pump in above-mentioned waste liquid flow path, above-mentioned waste liquid flow path is above-mentioned useless The upstream side of the allocation position of liquid pump is connected to the dialyzate tap of above-mentioned blood purification,
Above-mentioned control unit separates predetermined time interval and controls above-mentioned dialyzate metering electricity consumption magnet valve and above-mentioned dialyzate The opening and closing of folder, based on the detection letter from above-mentioned upside dialyzate liquid level sensor and above-mentioned downside dialyzate liquid level sensor Breath calculates dialysate flow, also,
Above-mentioned downside dialyzate liquid level sensor is compared when the liquid level of the dialyzate when making above-mentioned dialyzate pump work is located at In the case that the state of position on the lower continue for certain time, output alarm generates signal.
According to the duration blood purification device of above-mentioned (1)~(4), (12), when in the state of making fluid infusion pump work When the flow path pressed from both sides from fluid infusion bottle to fluid infusion is closed, fluid infusion can be full of in the flow path (at least blood back room) in the downstream side that fluid infusion pumps Stage make fluid infusion pump stop.As a result, after closed state is eliminated, dialysis treatment can be started again in a short time.
According to the duration blood purification device of above-mentioned (5)~(8), (13), when in the state for making dialyzate pump work Under the flow path that is pressed from both sides from dialyzate bottle to dialyzate when being closed, (at least blood is net for flow path that can be in the downstream side of dialysis liquid pump Change device dialyzate injection hole) full of dialyzate stage make dialysis liquid pump stop.Air will not be due to such closing as a result, It is mixed into the module carrier of blood purification, after closed is eliminated state, dialysis treatment can be started again in a short time.
According to the duration blood purification device of above-mentioned (9), additionally it is possible to accurately measure waste liquid flow.
According to the duration blood purification device of above-mentioned (10), additionally it is possible to prevent above-mentioned fluid infusion pump or above-mentioned dialyzate The solidification of blood when pump stops.
According to the duration blood purification device of above-mentioned (11), additionally it is possible to accurately control dialyzate, fluid infusion and give up The flow of liquid.
Description of the drawings
Fig. 1 is the flow graph of the duration blood purification device involved by an embodiment of the invention.
Fig. 2 is to show control unit in duration blood purification device shown in Fig. 1 and be used to measure fluid infusion flow The block diagram of connection relation between capacity formula metering units.
Fig. 3 A are the flows for the action (step-A1~A7) for showing the capacity formula metering units for measuring fluid infusion flow Figure.
Fig. 3 B are the flows for the action (step-A8~A16) for showing the capacity formula metering units for measuring fluid infusion flow Figure.
The monitoring and the control unit based on monitoring result that Fig. 4 is the liquid level for showing that downside fluid infusion liquid level sensor is carried out The flow chart of action.
Fig. 5 is to show control unit in duration blood purification device shown in Fig. 1 and be used to measure dialysate flow Capacity formula metering units between connection relation block diagram.
Fig. 6 A are the stream for the action (step-C1~C7) for showing the capacity formula metering units for measuring dialysate flow Cheng Tu.
Fig. 6 B are the stream for the action (step-C8~C16) for showing the capacity formula metering units for measuring dialysate flow Cheng Tu.
The monitoring and the control unit based on monitoring result that Fig. 7 is the liquid level for showing that downside dialyzate liquid level sensor is carried out Action flow chart.
Fig. 8 is to show control unit in duration blood purification device shown in Fig. 1 and be used to measure waste liquid flow The block diagram of connection relation between capacity formula metering units.
Fig. 9 is the flow chart for the action for showing the capacity formula metering units for measuring waste liquid fluid flow.
Figure 10 is the capacity formula metering shown in existing duration blood purification device for measuring fluid infusion flow The flow graph of the outline structure of unit.
Specific implementation mode
Hereinafter, being illustrated with device to the duration blood purification of the present invention.
Duration blood purification device 100 shown in FIG. 1 is to export blood and will be net from the vein or artery of patient Blood recovery after change to the vein of patient duration blood purification device.
＜ overall structures ＞
The duration blood purification device 100 of present embodiment has：Blood extracorporeal circulation circuit 10, the blood are external Circulation loop 10 is from the vein of patient or artery to the circulation loop of vein, and configured with being made of filter for blood dialysis Blood purification 12；Dialysate circuit 20, for importing dialyzate to blood purification 12；Fluid infusion flow path 30, for by 12 purified blood of blood purification feeds the fluid infusion for including body fluid components；Waste liquid flow path 40, being used for will be after blood purification Waste liquid is discharged；Capacity formula metering units, the flow for intermittently measuring dialyzate, fluid infusion and waste liquid independently of each other；With And control unit, control capability formula metering units.
In the blood extracorporeal circulation circuit 10 for constituting blood purification device 100, from the side court of the blood of export patient By the side of blood recovery, it is configured in order blood pump 11 (roller pump), blood purification 12, blood back room 13, air bubble sensor 14 and bubble folder 15.16 be syringe pump, is injected to the blood recycled in blood extracorporeal circulation circuit 10 using the syringe pump 16 Anticoagulant.
In the dialysate circuit 20 for constituting blood purification device 100, it is configured in order dialyzate bottle 21, dialyzate folder 22, dialysis liquid pump 23 (roller pump) and heater 24, the dialysate circuit 20 is in the downstream of the allocation position of dialysis liquid pump 23 Side is connected to the dialyzate injection hole of blood purification 12.
In addition, the dialysate circuit 20 between dialyzate folder 22 and dialysis liquid pump 23 is connected with dialyzate branch flow passage 25, in the dialyzate branch flow passage 25 dialyzate is configured in order as the capacity formula metering units for measuring dialysate flow Metering solenoid valve 26, upside dialyzate liquid level sensor 27, the dialyzate positioned at the position lower than dialyzate bottle 21 measure and hold Device 28 and downside dialyzate liquid level sensor 29.
It is configured in order fluid infusion bottle 31, fluid infusion folder 32 in the fluid infusion flow path 30 for constituting blood purification device 100 and mends Liquid pump 33 (roller pump), the fluid infusion flow path 30 are connected to the blood of blood purification 12 in the downstream side of the allocation position of fluid infusion pump 33 The blood extracorporeal circulation circuit 10 (blood back room 13) of liquid discharge side.
In addition, the fluid infusion flow path 30 between fluid infusion folder 32 and fluid infusion pump 33 is connected with fluid infusion branch flow passage 35, in the benefit Liquid branch flow passage 35 as measure the capacity formula metering units of fluid infusion flow be configured in order fluid infusion metering solenoid valve 36, Upside fluid infusion liquid level sensor 37, the fluid infusion measuring container 38 positioned at the position lower than fluid infusion bottle 31 and downside fluid infusion liquid level pass Sensor 39.
It is configured in order outlet 41, waste liquid folder 42 in the waste liquid flow path 40 for constituting blood purification device 100 and gives up Liquid pump 43 (roller pump), the waste liquid flow path 40 are connected to the saturating of blood purification 12 in the upstream side of the allocation position of waste drains pump 43 Analyse liquid tap.
In addition, the waste liquid flow path 40 between waste liquid folder 42 and waste drains pump 43 is connected with waste liquid branch flow passage 45, it is useless at this Liquid branch flow passage 45 as measure the capacity formula metering units of waste liquid flow be configured in order waste liquid metering solenoid valve 46, Upside waste liquid liquid level sensor 47, positioned at lower than the dialyzate tap of blood purification 12 and the position higher than outlet 41 Waste liquid measuring container 48 and downside waste liquid liquid level sensor 49.
The control unit 50 (not shown in Fig. 1) for constituting blood purification device 100 separates predetermined time interval control thoroughly The opening and closing for analysing liquid metering solenoid valve 26 and dialyzate folder 22 is based on coming from upside dialyzate liquid level sensor 27 and downside The detection information of dialyzate liquid level sensor 29 calculates dialysate flow.
In addition, the control unit 50 also separates predetermined time interval control fluid infusion metering solenoid valve 36 and fluid infusion folder 32 Opening and closing, based on from the detection information of upside fluid infusion liquid level sensor 37 and downside fluid infusion liquid level sensor 39 calculate fluid infusion Flow.
In addition, the control unit 50 also separates predetermined time interval control waste liquid metering solenoid valve 46 and waste liquid folder 42 Opening and closing, based on from the detection information of upside waste liquid liquid level sensor 47 and downside waste liquid liquid level sensor 49 calculate waste liquid Flow.
Also, the control unit 50 is located at when the liquid level of the dialyzate when making dialysis liquid pump 23 work than downside dialyzate liquid level The state of sensor 29 (that is, downside dialyzate liquid level sensor 29 detects air) more on the lower continue for the feelings of certain time Under condition, exports alarm to alarm device 60 and generate signal, and stop signal is exported to dialysis liquid pump 23.
Also, the control unit 50 is located at when the liquid level of the fluid infusion when making fluid infusion 33 work of pump than downside fluid infusion liquid level sensor In the case that the state of 39 (that is, downside fluid infusion liquid level sensor 39 detects air) more on the lower continue for certain time, to Alarm device 60 exports alarm and generates signal, and to 33 output stop signal of fluid infusion pump.
＜ fluid infusion flow path systems ＞
Present embodiment blood purification in device 100, controlled with the dialysis that device 100 carries out using blood purification It treats in (hemodiafiltration therapy), (i.e. intermittently) measure fluid infusion flow with separating predetermined time interval.Here, as " predetermined time interval " (measuring interval of fluid infusion flow), it is different according to the difference of fluid infusion flow etc., but for example, 1~20 Minute.
Hereinafter, being illustrated to the determination step of fluid infusion flow using Fig. 1~Fig. 3 A and Fig. 3 B.
Here, the connection relation between the capacity formula metering units Fig. 2 shows control unit and for measuring fluid infusion flow, should Control unit 50 shown in figure and fluid infusion folder 32, fluid infusion metering solenoid valve 36, upside fluid infusion liquid level sensor 37, downside fluid infusion liquid Level sensor 39, fluid infusion pump 33 and alarm device 60 connect.
First, control unit 50 makes fluid infusion pump 33 with rotary speed working (the step of Fig. 3 A-of the setting flow based on fluid infusion A1), and fluid infusion metering solenoid valve 36 and fluid infusion is made to press from both sides 32 as " opening " state (step-A2).
Here, as the setting flow of fluid infusion, it is set as 10~3000mL/hr, is preferably set to 500~1000mL/hr.
The fluid infusion in fluid infusion bottle 31 is via fluid infusion flow path 30 and by blood extracorporeal circulation circuit 10 (blood back room 13) as a result, Conveying, and by the difference of height between fluid infusion bottle 31 (the step of fluid infusion measuring container 38 is flowed into via fluid infusion branch flow passage 35 Suddenly-A3).
Control unit 50 judges whether the liquid level for flowing into the fluid infusion of fluid infusion measuring container 38 rises and passed by upside fluid infusion liquid level Sensor 37 detects (horizontal position for reaching upside fluid infusion liquid level sensor 37) (step-A4), be judged as being detected In the case of, so that fluid infusion folder 32 is cut off the supply (step-A5) for the fluid infusion for carrying out self-mending liquid bottle 31 as "Off" state, makes benefit Fluid infusion outflow (step-A6) in liquid measuring container 38.The fluid infusion flowed out from fluid infusion measuring container 38 is via fluid infusion branch flow passage 35 and fluid infusion flow path 30 and by blood extracorporeal circulation circuit 10 (blood back room 13) convey.
In addition, in step-A4, it is judged as the liquid level of fluid infusion not by upside fluid infusion liquid level sensor 37 in control unit 50 In the case of detecting, return to step-A3 continues inflow of the fluid infusion towards fluid infusion measuring container 38.
Next, control unit 50 judge the liquid level in step-A6 from the fluid infusion that fluid infusion measuring container 38 flows out whether under It drops and (step-A7) is detected by downside fluid infusion liquid level sensor 39, if being judged as being detected (at this point, control unit 50 obtains It is required until being detected by downside fluid infusion liquid level sensor 39 from being detected by upside fluid infusion liquid level sensor 37 Delivery time (t1)), then so that fluid infusion folder 32 is become " opening " state (the step of Fig. 3 B-A8), fluid infusion is made to again flow into fluid infusion meter It measures in container 38 (step-A9).
In addition, in step-A7, do not passed by downside fluid infusion liquid level in the liquid level for the fluid infusion that control unit 50 is judged as declining In the case that sensor 39 detects, return to step-A6 continues outflow (delivery time of the fluid infusion from fluid infusion measuring container 38 (t1) measurement).
Next, whether control unit 50 judges the liquid level for flowing into the fluid infusion of fluid infusion measuring container 38 in step-A9 by under Side fluid infusion liquid level sensor 39 detects (horizontal position for reaching downside fluid infusion liquid level sensor 39) (step-A10), if sentencing Break to be detected, then makes fluid infusion metering solenoid valve 36 as "Off" state and keep fluid infusion in fluid infusion measuring container 38 (step-A11), and the fluid infusion in fluid infusion bottle 31 (is walked via fluid infusion flow path 30 to the conveying of blood extracorporeal circulation circuit 10 Suddenly-A12).
In addition, in step-A10, do not passed by downside fluid infusion liquid level in the liquid level for the fluid infusion that control unit 50 is judged as rising In the case that sensor 39 detects, return to step-A9 continues inflow of the fluid infusion towards fluid infusion measuring container 38.That is, fluid infusion Folder 32 and fluid infusion metering maintain " opening " state with solenoid valve 36, until the liquid level of fluid infusion rises and passed by downside fluid infusion liquid level Until sensor 39 detects again.As a result, after the measurement of delivery time (t1), the fluid infusion measuring container 38 in dialysis treatment Fluid infusion is inside maintained, fluid infusion branch flow passage 35 is reliably full of by fluid infusion.
In addition, making fluid infusion flow into fluid infusion measuring container 38 by so that fluid infusion folder 32 is become " opening " state (step-A8) Interior (step-A9), the liquid level of fluid infusion will reach the level of downside fluid infusion liquid level sensor 39 usually within the shorter time Position, accordingly it is also possible to step-A10 not executed, to pass through after a certain period of time from making fluid infusion folder 32 become " opening " state The mode that fluid infusion metering becomes "Off" state with solenoid valve 36 is set to be controlled.
Next, control unit 50 judges whether have passed through the defined time from the measurement for starting previous fluid infusion flow (such as 1 minute) (step-A13) makes fluid infusion metering solenoid valve if control unit 50 is judged as have passed through the defined time 36 become " opening " state (step-A14).
In addition, in step-A13, in the case where control unit 50 was judged as without the defined time, step is returned to Suddenly-A12, and the operation for continuing to make the fluid infusion in fluid infusion bottle 31 to be conveyed to blood extracorporeal circulation circuit 10.
Next, control unit 50 determines whether to terminate the state for the dialysis treatment that blood purification is carried out with device 100 (step-A15) makes fluid infusion pump 33 stop (step-A16) in the case where being judged as YES the state of end.
In addition, in step-A15, in the case where it is not to terminate the state of dialysis treatment to be judged as, return to step- A3 makes the fluid infusion in fluid infusion bottle 31 be conveyed to blood extracorporeal circulation circuit 10 and also flows into fluid infusion measuring container 38.
Moreover, in step-A5~step-A8, according to the liquid level for the fluid infusion flowed out from fluid infusion measuring container 38 from quilt Upside fluid infusion liquid level sensor 37 has detected required above-mentioned until being detected by downside fluid infusion liquid level sensor 39 The discharge (V1) of delivery time (t1) and fluid infusion during this period, fluid infusion flow is calculated using formula L1=V1/t1 (L1)。
The rotating speed of fluid infusion pump 33 is set to increase in the case where fluid infusion flow (L1) calculated in this way is lower than setting flow, So that the rotating speed of fluid infusion pump 33 is declined in the case that fluid infusion flow (L1) calculated in this way is higher than setting flow, thus makes continuously The fluid infusion flow (L1) of measurement is consistent with setting flow.
The control unit 50 for constituting blood purification device 100 is measuring fluid infusion with separating predetermined time interval as described above Flow and concurrently make with this fluid infusion pump 33 work when, the liquid of fluid infusion is continuously obtained from downside fluid infusion liquid level sensor 39 Position is the information positioned at the top of the downside fluid infusion liquid level sensor 39 or lower section, is located at downside fluid infusion liquid in the liquid level of fluid infusion In the case that the state of the lower section of level sensor 39 continue for certain time, it is determined as the fluid infusion of the folder 32 from fluid infusion bottle 31 to fluid infusion Flow path 30 is closed, and exporting alarm to alarm device 60 generates signal, and to 33 output stop signal of fluid infusion pump.
Hereinafter, being illustrated to the step using Fig. 4.
Under the state (the step of Fig. 4-B1) for making 33 work of fluid infusion pump, control unit 50 utilizes downside fluid infusion level sensing Device 39 is detected the fluid infusion or air that are present in the allocation position (horizontal position) of the downside fluid infusion liquid level sensor 39 (step-B2).
Here, when detecting air using downside fluid infusion liquid level sensor 39, the liquid level of fluid infusion is in downside fluid infusion liquid The lower section of level sensor 39, in the case where detecting fluid infusion, the liquid level of fluid infusion is in the upper of downside fluid infusion liquid level sensor 39 Side.
In this way, the liquid level that downside fluid infusion liquid level sensor 39 detects fluid infusion always is to be located at downside fluid infusion liquid level sensor 39 Allocation position (horizontal position) top or lower section.
Therefore, control unit 50 for example continuously judged whether to be detected by downside fluid infusion liquid level sensor 39 with 1 second interval Air (step-B3) further judges to detect whether the state of air continues in the case where being judged as detecting air Certain time (step-B4) exports alarm to alarm device 60 and generates in the case where being judged as continue for certain time Signal, and to 33 output stop signal (step-B5) of fluid infusion pump.
Here, " certain time " in step-B4 refers to it can be determined that pressing from both sides 32 fluid infusion stream from fluid infusion bottle 31 to fluid infusion Road 30 is in the time for the state being closed, and is that air is not made to be reached with the attraction of the fluid infusion carried out by fluid infusion pump 33 The time in the downstream side (at least blood back room 13) of fluid infusion pump 33, the time is according to from downside fluid infusion liquid level sensor 39 to fluid infusion The difference of length of the flow path of pump 33 and different, but usually 2~30 seconds, preferably 3~10 seconds, if showing preferred one A example is then 5 seconds.
In the case where the time is too short, existing leads to generate 33 stopping of the alarm caused by malfunction and fluid infusion pump Misgivings.On the other hand, it in the case of the overlong time, is closed in the fluid infusion flow path 30 of the folder 32 from fluid infusion bottle 31 to fluid infusion When, the stopping delay of fluid infusion pump 33 when stopping can not be formed as that the flow path in the downstream side of fluid infusion pump 33 is made to be full of fluid infusion sometimes State.
In addition, by downside fluid infusion liquid level sensor 39 and air (detecting fluid infusion) ought be not detected in step-B3 In the case of or in step-B4 the time of the air feelings shorter than certain time are detected by downside fluid infusion liquid level sensor 39 Under condition, return to step-B2, and continue the detection of the fluid infusion or air that are executed by downside fluid infusion liquid level sensor 39.
Furthermore it is possible to make fluid infusion pump 33 stop according to the stop signal that control unit 50 is exported in step-B5 and make blood Liquid pump 11 stops, but can continue to carry out the work (cycle of blood) of blood pump 11.By continuing blood pump 11 Work, the solidification of blood when can prevent fluid infusion pump 33 from stopping.
As described above, present embodiment blood purification in device 100, which is characterized in that it is net that the blood will be constituted Change uses the downside fluid infusion liquid level sensor 39 of device 100 as the detection for measuring fluid infusion flow (determining the delivery time (t1)) Whether unit is used and as the fluid infusion flow path 30 for detecting from fluid infusion bottle 31 to fluid infusion folder 32 in being closed The unit of state is used.
＜ dialysate circuit systems ＞
Present embodiment blood purification in device 100, controlled with the dialysis that device 100 carries out using blood purification In treatment, dialysate flow (i.e. intermittently) is measured with also separating predetermined time interval.
Here, as " predetermined time interval " (measuring interval of dialysate flow), the measuring interval with fluid infusion flow It is identical.
Hereinafter, being illustrated to the determination step of dialysate flow using Fig. 1, Fig. 5, Fig. 6 A and Fig. 6 B.Here, Fig. 5 Connection relation between control unit and capacity formula metering units for measuring dialysate flow is shown, control unit shown in the figure 50 measure electricity consumption magnet valve 26, upside dialyzate liquid level sensor 27, downside dialyzate level sensing with dialyzate folder 22, dialyzate Device 29, dialysis liquid pump 23 and alarm device 60 connect.
First, control unit 50 makes the work (step of Fig. 6 A of dialysis liquid pump 23 with the rotating speed of the setting flow based on dialyzate Suddenly-C1), and dialyzate metering electricity consumption magnet valve 26 and dialyzate folder 22 is made to become " opening " state (step-C2).
Here, as the setting flow of dialyzate, it is set as 10~4000mL/hr, is preferably set to 500~1000mL/hr.
The dialyzate in dialyzate bottle 21 is noted via dialysate circuit 20 to the dialyzate of blood purification 12 as a result, Enter hole conveying, and dialyzate metering is flowed into via dialyzate branch flow passage 25 by the difference of height between dialyzate bottle 21 Container 28 (step-C3).
Control unit 50 judge the liquid level for flowing into the dialyzate of dialyzate measuring container 28 whether rise and by upside dialyzate Liquid level sensor 27 detects (horizontal position for reaching upside dialyzate liquid level sensor 27) (step-C4), is being judged as examining In the case of measuring liquid level, dialyzate folder 22 is made to cut off the supply of the dialyzate from dialyzate bottle 21 as "Off" state (step-C5), and the dialyzate in dialyzate measuring container 28 is made to flow out (step-C6).It is flowed from dialyzate measuring container 28 The dialyzate gone out is injected via dialyzate branch flow passage 25 and dialysate circuit 20 to the dialyzate of blood purification 12 Hole conveys.
In addition, in step-C4, it is judged as the liquid level of dialyzate not by upside dialyzate level sensing in control unit 50 In the case that device 27 detects, return to step-C3 continues inflow of the dialyzate towards dialyzate measuring container 28.
Next, control unit 50 judges that the liquid level of the dialyzate flowed out from dialyzate measuring container 28 in step-C6 is No decline and (step-C7) is detected by downside dialyzate liquid level sensor 29, if being judged as detecting liquid level (at this point, control Portion 50 obtains and is detected up to by downside dialyzate liquid level sensor 29 from being detected by upside dialyzate liquid level sensor 27 Until required delivery time (t2).), then so that dialyzate folder 22 is become " opening " state (the step of Fig. 6 B-C8), makes Analysis liquid again flows into dialyzate measuring container 28 (step-C9).
In addition, in step-C7, it is judged as the liquid level of the dialyzate declined not by downside dialyzate in control unit 50 In the case that liquid level sensor 29 detects, return to step-C6, and continue dialyzate from dialyzate measuring container 28 It flows out (measurement of time (t2)).
Next, control unit 50 judges that the liquid level of the dialyzate flowed into dialyzate measuring container 28 in step-C9 is It is no that (horizontal position for reaching downside dialyzate liquid level sensor 29) (step-is detected by downside dialyzate liquid level sensor 29 C10), if being judged as detecting liquid level, dialyzate metering electricity consumption magnet valve 26 is made to be measured in dialyzate as "Off" state Container 28 keeps dialyzate (step-C11), and by the dialyzate in dialyzate bottle 21 via dialysate circuit 20 and to blood The dialyzate injection hole conveying (step-C12) of clarifier 12.
In addition, in step-C10, it is judged as the liquid level of the dialyzate risen not by downside dialyzate in control unit 50 In the case that liquid level sensor 29 detects, return to step-C9, and continue dialyzate towards dialyzate measuring container 28 It flows into.That is, dialyzate folder 22 and dialyzate metering electricity consumption magnet valve 26 maintain " opening " state, until on the liquid level of dialyzate Rise and until being detected again by downside dialyzate liquid level sensor 29.As a result, after the measurement of delivery time (t2), dialysing Dialyzate is maintained in dialyzate measuring container 28 in treatment, and dialyzate branch flow passage 25 is reliably full of by dialyzate.
In addition, making dialyzate flow into dialyzate metering by so that dialyzate folder 22 is become " opening " state (step-C8) In container 28 (step-C9), the liquid level of dialyzate will reach downside dialyzate level sensing usually within the shorter time The horizontal position of device 29, accordingly it is also possible to do not execute step-C10, and with from making dialyzate folder 22 become " opening " state It rises and is controlled by the mode for making dialyzate metering electricity consumption magnet valve 26 become "Off" state after a certain period of time.
Next, control unit 50 judges whether have passed through the defined time from the measurement for starting previous dialysate flow (such as 1 minute) (step-C13) makes dialyzate measure electricity consumption magnetic if control unit 50 is judged as have passed through the defined time Valve 26 becomes " opening " state (step-C14).
In addition, in step-C13, it is judged as in control unit 50 and in the case of without the defined time, returns to step Suddenly-C12 continues to make the dialyzate in dialyzate bottle 21 to be conveyed to the dialyzate injection hole of blood purification 12.
Next, control unit 50 determines whether to terminate the state for the dialysis treatment that blood purification is carried out with device 100 (step-C15) makes dialysis liquid pump 23 stop (step-C16) in the case where being judged as YES the state of end.
In addition, in step-C15, in the case where it is not to terminate the state of dialysis treatment to be judged as, return to step- C3 makes the dialyzate in dialyzate bottle 21 be conveyed to the dialyzate injection hole of blood purification 12 and also flow into dialysate meter Measure container 28.
Moreover, in step-C5~step-C8, according to the liquid level of the dialyzate flowed out from dialyzate measuring container 28 It is required until being detected by downside dialyzate liquid level sensor 29 from being detected by upside dialyzate liquid level sensor 27 The discharge (V2) of above-mentioned delivery time (t2) for wanting and dialyzate during this period, is calculated using formula L2=V2/t2 Dialysate flow (L2).
Make on the rotating speed of dialysis liquid pump 23 in the case where dialysate flow (L2) calculated in this way is lower than setting flow It rises, so that the rotating speed of dialysis liquid pump 23 is declined in the case where dialysate flow (L2) calculated in this way is higher than setting flow, by This keeps the dialysate flow (L2) continuously measured consistent with setting flow.
The control unit 50 for constituting blood purification device 100 is measuring dialysis with separating predetermined time interval as described above Flow quantity and when dialysis liquid pump 23 concurrently being made to work with this, continuously obtains saturating from downside dialyzate liquid level sensor 29 The liquid level of analysis liquid is the information positioned at the top of the downside dialyzate liquid level sensor 29 or lower section, in the liquid level position of dialyzate In the case that the state of the position compared to downside dialyzate liquid level sensor 29 on the lower continue for certain time, filled to alarm It sets 60 conveying alarms and generates signal, and stop signal is exported to dialysis liquid pump 23.
Hereinafter, being illustrated to the step using Fig. 7.
Under the state (the step of Fig. 7-D1) for making dialysis liquid pump 23 work, control unit 50 utilizes downside dialyzate liquid level Sensor 29 to be present in the allocation position (horizontal position) of downside dialyzate liquid level sensor 29 dialyzate or air into Row detection (step-D2).
Here, when detecting air using downside dialyzate liquid level sensor 29, it is saturating that the liquid level of dialyzate is in downside The lower section of liquid liquid level sensor 29 is analysed, in the case where detecting dialyzate, the liquid level of dialyzate is in downside dialyzate liquid level The top of sensor 29.
In this way, the liquid level that downside dialyzate liquid level sensor 29 detects dialyzate always is to be located at downside dialyzate liquid level to pass The top or lower section of the allocation position (horizontal position) of sensor 29.
Therefore, control unit 50 for example continuously judged whether to be detected by downside dialyzate liquid level sensor 29 with 1 second interval To air (step-D3), in the case where being judged as detecting air, further judge to detect whether the state of air holds (step-D4) is continued certain time, in the case where being judged as continue for certain time, alarm production is exported to alarm device 60 Raw signal, and stop signal (step-D5) is exported to dialysis liquid pump 23.
Here, refer to it can be determined that being pressed from both sides from dialyzate bottle 21 to dialyzate as " certain time " in step-D4 22 dialysate circuit 20 is in the time for the state being closed, and is not make air saturating with being carried out by dialysis liquid pump 23 It analyses the attraction of liquid and reaches time in the downstream side (at least dialyzate injection hole of blood purification 12) of the dialysis liquid pump 23, it should Time according to from downside dialyzate liquid level sensor 29 to the difference of length of the flow path of dialysis liquid pump 23 and it is different, but usually 2~30 seconds, preferably 3~10 seconds are 5 seconds if showing a preferred example.
In the case where the time is too short, existing leads to generate the alarm caused by malfunction and the stopping of liquid pump 23 of dialysing Misgivings.On the other hand, in the case of the overlong time, in the dialysate circuit 20 of the folder 22 from dialyzate bottle 21 to dialyzate When being closed, the stopping delay of dialysis liquid pump 23 can not be formed as the stream for making the downstream side of dialysis liquid pump 23 sometimes when stopping Road is full of the state of dialyzate.
In addition, when by downside dialyzate liquid level sensor 29 and air being not detected (detecting dialysis in step-D3 Liquid) in the case of or detect in step-D4 the time of air than a timing by downside dialyzate liquid level sensor 29 Between it is short in the case of, return to step-D2, and continue the dialyzate executed by downside dialyzate liquid level sensor 29 or The detection of air.
Furthermore it is possible to make dialysis liquid pump 23 stop according to the stop signal that control unit 50 is exported in step-D5 and make Blood pump 11 stops, but can continue to carry out the work (cycle of blood) of blood pump 11.By continuing blood pump 11 work, the solidification of blood when can prevent dialysis liquid pump 23 from stopping.
As described above, present embodiment blood purification in device 100, which is characterized in that blood purification will be constituted Use the downside dialyzate liquid level sensor 29 of device 100 as the inspection for measuring dialysate flow (determining the delivery time (t2)) Unit is surveyed to be used and whether be in as the dialysate circuit 20 for detecting the folder 22 from dialyzate bottle 21 to dialyzate The unit for the state being closed is used.
＜ waste liquid flow path systems ＞
Present embodiment blood purification in device 100, controlled with the dialysis that device 100 carries out using blood purification In treatment, waste liquid flow (i.e. intermittently) is measured with also separating predetermined time interval.
Here, as " predetermined time interval " (measuring interval of waste liquid flow), the measuring interval phase with fluid infusion flow Together.
Hereinafter, being illustrated to the determination step of dialysate flow using Fig. 1, Fig. 8 and Fig. 9.
Here, Fig. 8 shows the connection relation between control unit and capacity formula metering units for measuring waste liquid flow, should Control unit 50 shown in figure and waste liquid folder 42, waste liquid metering solenoid valve 46, upside waste liquid liquid level sensor 47, downside waste liquid liquid Level sensor 49, waste drains pump 43 and alarm device 60 connect.
First, control unit 50 makes waste drains pump 43 rotate (the step of Fig. 9-E1) with the rotating speed of the setting flow based on waste liquid, And waste liquid metering solenoid valve 46 is made to become " opening " state, so that waste liquid folder 42 is become "Off" state (step-E2).
The waste liquid of the dialyzate tap from blood purification 12 is via waste liquid flow path 40 and waste liquid affluent-dividing as a result, Road 45 and flow into waste liquid measuring container 48 (step-E3).
Control unit 50 judges whether the liquid level for flowing into the waste liquid of waste liquid measuring container 48 rises and passed by downside waste liquid liquid level Sensor 49 and upside waste liquid liquid level sensor 47 detect (obtain from being detected by downside waste liquid liquid level sensor 49 up to Required inlet time (t3) until being detected by upside waste liquid liquid level sensor 47) (step-E4).
Moreover, in the case where being judged as detecting liquid level, so that waste liquid folder 42 is become " opening " state (step-E5), make (step-E6) is discharged from outlet 41 via waste liquid branch flow passage and waste liquid flow path in waste liquid in waste liquid measuring container 48.
In addition, in step-E4, in the case where control unit 50 is judged as not detecting liquid level, return to step-E3, after The continuous inflow for carrying out waste liquid from the dialyzate tap of blood purification 12 towards waste liquid measuring container 48.
Next, control unit 50 judges whether have passed through the defined time from the measurement for starting previous waste liquid flow (such as 1 minute) (step-E7) makes waste liquid folder 42 become "Off" state (step if being judged as have passed through the defined time Suddenly-E8).
In addition, in step-E7, in the case where control unit 50 was judged as without the defined time, return to step- E6 makes waste liquid be discharged from outlet 41.
Next, control unit 50 determines whether to terminate the state for the dialysis treatment that blood purification is carried out with device 100 (step-E9) makes waste drains pump 43 stop (step-E10) in the case where being judged as YES the state of end.
In addition, in step-E9, in the case where it is not to terminate dialysis treatment to be judged as, return to step-E3 continues Carry out inflow of the waste liquid towards waste liquid measuring container 48.
Moreover, in step-E2~step-E5, according to the liquid level for the waste liquid for flowing into waste liquid measuring container 48 from by under When side waste liquid liquid level sensor 49 has detected the required inflow until being detected by upside waste liquid liquid level sensor 47 Between the influx (V3) of (t3) and waste liquid during this period, calculate waste liquid flow (L3) using formula L3=V3/t3.
The device 100 of blood purification according to the present embodiment, when in the state of making fluid infusion 33 work of pump from fluid infusion bottle When the 31 fluid infusion flow paths 30 for pressing from both sides 32 to fluid infusion are closed, detected by downside fluid infusion liquid level sensor 39 if control unit 50 is identified The state of air (liquid level of fluid infusion is located at the lower section of the allocation position of downside fluid infusion liquid level sensor 39) continue for certain time (such as 5 seconds), then by based on the situation and alarm that control unit 50 is exported generates signal and alarm device 60 is made to generate police Report, and so that fluid infusion pump 33 is stopped by the stop signal that the control unit 50 is exported, thereby, it is possible in the downstream side of fluid infusion pump 33 Stage of the flow path (at least blood back room 13) full of fluid infusion so that fluid infusion pump 33 is stopped immediately.As a result, in such closed state quilt After elimination, dialysis treatment can be started again in a short time.
In addition, blood purification device 100 according to the present embodiment, when in the state of so that dialysis liquid pump 23 is worked from When the dialysate circuit 20 of dialyzate bottle 21 to dialyzate folder 22 is closed, if control unit 50 is identified by downside dialyzate liquid level Sensor 29 detects air (liquid level of dialyzate is located at the lower section of the allocation position of downside dialyzate liquid level sensor 29) State continue for certain time (such as 5 seconds), then by based on the situation and alarm that control unit 50 is exported generates signal So that alarm device 60 is generated alarm, and so that dialysis liquid pump 23 is stopped immediately by the stop signal that the control unit 50 is exported, by This, can be full of dialyzate in the flow path (at least dialyzate injection hole of blood purification 12) in the downstream side of dialysis liquid pump 23 Stage makes dialysis liquid pump 23 stop.Air will not be mixed into the module carrier of blood purification 12 because of such closing as a result, After closed state is eliminated, dialysis treatment can be started again in a short time.
An embodiment of the duration blood purification device of the present invention is illustrated above, but the present invention is simultaneously It is not limited to this, can be made various changes.
For example, comparing downside fluid infusion liquid when the liquid level of the fluid infusion (dialyzate) when making fluid infusion pump (dialysis liquid pump) work is located at It, can also in the case that the state of the position of level sensor (downside dialyzate liquid level sensor) on the lower continue for certain time Only output alarm generates signal.In this case, stop fluid infusion pump (dialysis liquid pump) by noticing the operating personnel of alarm.
In addition, constituting the blood of the fluid infusion flow path 30 and blood purification 12 of the blood purification device 100 of present embodiment The connection of blood extracorporeal circulation circuit 10 (feeding fluid infusion to by 12 purified blood of blood purification) of liquid discharge side, but also may be used Being connected with fluid infusion flow path 30 with the blood extracorporeal circulation circuit 10 in the blood introduction side of blood purification 12 (can also be to by blood Blood before liquid purifier 12 purifies feeds fluid infusion).
In addition, it can also be the blood filtering having as blood purification that the duration blood purification of the present invention, which uses device, Device, but without dialysate circuit, dialyzate branch flow passage and be configured at these flow paths inscape duration blood Filtering device.
Also, it can also be the haemodialysis having as blood purification that the duration blood purification of the present invention, which uses device, Device, but without fluid infusion flow path, fluid infusion branch flow passage and be configured at these flow paths inscape maintenance hemodialysis Device.
Reference sign
100：Duration blood purification device；10：Blood extracorporeal circulation circuit；11：Blood pump；12：Blood purification； 13：Blood back room；14：Air bubble sensor；15：Bubble presss from both sides；16：Syringe pump；20：Dialysate circuit；21：Dialyzate bottle；22：Dialysis Liquid presss from both sides；23：Dialysis liquid pump；24：Heater；25：Dialyzate branch flow passage；26：Dialyzate measures electricity consumption magnet valve, and (capacity formula is measured Unit)；27：Upside dialyzate liquid level sensor (capacity formula metering units)；28：(metering of capacity formula is single for dialyzate measuring container Member)；29：Downside dialyzate liquid level sensor (capacity formula metering units)；30：Fluid infusion flow path；31：Fluid infusion bottle；32：Fluid infusion is pressed from both sides； 33：Fluid infusion pumps；35：Fluid infusion branch flow passage；36：Fluid infusion metering solenoid valve (capacity formula metering units)；37：Upside fluid infusion liquid level Sensor (capacity formula metering units)；38：Fluid infusion measuring container (capacity formula metering units)；39：Downside fluid infusion liquid level sensor (capacity formula metering units)；40：Waste liquid flow path；41：Outlet；42：Waste liquid presss from both sides；43：Waste drains pump；45：Waste liquid branch flow passage； 46：Waste liquid metering solenoid valve (capacity formula metering units)；47：Upside waste liquid liquid level sensor (capacity formula metering units)；48： Waste liquid measuring container (capacity formula metering units)；49：Downside waste liquid liquid level sensor (capacity formula metering units)；50：Control unit； 60：Alarm device.

Claims (16)

1. a kind of duration blood purification device, blood is exported from the vein or artery of patient, and by purified blood It is fed back to the vein of patient,
The duration blood purification device is characterized in that,
Have：Blood extracorporeal circulation circuit (10), the blood extracorporeal circulation circuit (10) are the vein or artery from patient To the circulation loop of vein, and configured with the blood purification (12) being made of filter for blood dialysis；Dialysate circuit (20), The dialysate circuit (20) is used to import dialyzate to the blood purification (12)；Fluid infusion flow path (30), the fluid infusion stream Road (30), which is used for court, will be purified by the blood purification (12) or be mended by the purified blood of the blood purification (12) To the fluid infusion comprising body fluid components；Waste liquid flow path (40), the waste liquid flow path (40) are used to the waste liquid after blood purification being discharged； Capacity formula metering units for intermittently measuring fluid infusion flow；And the control unit of the capacity formula metering units is controlled,
It is configured with blood pump (11) and the blood purification (12) in the blood extracorporeal circulation circuit (10),
It is configured in order dialyzate bottle (21), dialyzate folder (22) and dialysis liquid pump (23) in the dialysate circuit (20), The dialysate circuit (20) is connected to the blood purification in the downstream side of the allocation position of the dialysis liquid pump (23) (12) dialyzate injection hole,
It is configured in order fluid infusion bottle (31), fluid infusion folder (32) and fluid infusion in the fluid infusion flow path (30) and pumps (33), the fluid infusion The downstream side that flow path (30) pumps the allocation position of (33) in the fluid infusion is connected to the blood extracorporeal circulation circuit (10),
The fluid infusion flow path (30) between fluid infusion folder (32) and fluid infusion pump (33) is connected with fluid infusion branch flow passage (35), it is configured in order based on fluid infusion as the capacity formula metering units by measuring fluid infusion flow in the fluid infusion branch flow passage (35) Amount solenoid valve (36), upside fluid infusion liquid level sensor (37), the fluid infusion metering for being located at the position lower than the fluid infusion bottle (31) Container (38) and downside fluid infusion liquid level sensor (39),
It is configured in order outlet (41), waste liquid folder (42) and waste drains pump (43), the waste liquid in the waste liquid flow path (40) Flow path (40) is connected to the dialyzate row of the blood purification (12) in the upstream side of the allocation position of the waste drains pump (43) Portal,
The control unit separates predetermined time interval and controls the fluid infusion metering solenoid valve (36) and fluid infusion folder (32) opening and closing, based on from the upside fluid infusion liquid level sensor (37) and the downside fluid infusion liquid level sensor (39) Detection information calculates fluid infusion flow, also,
It is leaned on compared to the downside fluid infusion liquid level sensor (39) when the liquid level of the fluid infusion when making the fluid infusion pump (33) work is located at In the case that the state of the position of lower section continue for certain time, output alarm generates signal.
2. duration blood purification device according to claim 1, which is characterized in that
The control unit is repeated control as follows：
By making the fluid infusion metering solenoid valve (36) and the fluid infusion in the state of so that the fluid infusion pump (33) is rotated Pressing from both sides (32) becomes " opening " state, keeps the fluid infusion in the fluid infusion bottle (31) external to the blood via fluid infusion flow path (30) Circulation loop (10) conveys, and flows into the fluid infusion measuring container (38) via fluid infusion branch flow passage (35),
In the liquid level rising for flowing into the fluid infusion of the fluid infusion measuring container (38) by the upside fluid infusion liquid level sensor (37) After detecting, fluid infusion folder (32) is made to become "Off" state, makes fluid infusion in the fluid infusion measuring container (38) from the benefit Liquid measuring container (38) flows out and via the fluid infusion branch flow passage (35) and the fluid infusion flow path (30) and to the blood Extracorporeal circulating circuit (10) conveys,
The fluid infusion flowed out from the fluid infusion measuring container (38) liquid level decline and by the downside fluid infusion liquid level sensor (39) after detecting, so that the fluid infusion folder (32) is become " opening " state, the liquid level of fluid infusion is made to rise so that the liquid of the fluid infusion Face is located at the position against the top compared to the downside fluid infusion liquid level sensor (39), then makes the fluid infusion metering solenoid valve (36) become "Off" state, and by the fluid infusion in the fluid infusion bottle (31) via the fluid infusion flow path (30) and to the blood Extracorporeal circulating circuit (10) conveys,
So that the fluid infusion metering solenoid valve (36) is become " opening " state with separating predetermined time interval；
In addition, the control unit according to the liquid level of the fluid infusion flowed out from the fluid infusion measuring container (38) from by the upside fluid infusion Liquid level sensor (37) has detected the required outflow until being detected by the downside fluid infusion liquid level sensor (39) The time t1 and discharge V1 of fluid infusion during this period, fluid infusion flow L1 is measured using formula L1=V1/t1.
3. duration blood purification device according to claim 2, which is characterized in that
The control unit the fluid infusion flowed out from the fluid infusion measuring container (38) liquid level decline and by the downside fluid infusion liquid After level sensor (39) detects, the fluid infusion folder (32) and fluid infusion metering is made to be maintained " opening " with solenoid valve (36) State, until the liquid level rising of the fluid infusion is detected again by the downside fluid infusion liquid level sensor (39).
4. duration blood purification device described in any one of claim 1 to 3, which is characterized in that
The control unit is passed when the liquid level of the fluid infusion when making the fluid infusion pump (33) work is located at compared to the downside fluid infusion liquid level In the case that the state of the position of sensor (39) on the lower continue for certain time, output alarm generates signal, and described in output Fluid infusion pumps the stop signal of (33).
5. duration blood purification device described in any one of claim 1 to 3, which is characterized in that
Have the capacity formula metering units for intermittently measuring waste liquid flow and controls the control of the capacity formula metering units Portion,
The waste liquid flow path (40) between waste liquid folder (42) and the waste drains pump (43) is connected with waste liquid branch flow passage (45), it is configured in order based on waste liquid as the capacity formula metering units by measuring waste liquid flow in the waste liquid branch flow passage (45) It measures with solenoid valve (46), upside waste liquid liquid level sensor (47), positioned at the dialyzate tap than the blood purification (12) The waste liquid measuring container (48) and downside waste liquid liquid level sensor (49) of low position,
The control unit is repeated control as follows：
By making the waste liquid metering solenoid valve (46) become " opening " shape in the state of so that the waste drains pump (43) is rotated State simultaneously makes the waste liquid folder (42) become "Off" state, and waste liquid is made to flow into the waste liquid measuring container (48),
In the liquid level rising for flowing into the waste liquid of the waste liquid measuring container (48) by the upside waste liquid liquid level sensor (47) After detecting, so that the waste liquid folder (42) is become " opening " state, thus pass through the waste liquid in the waste liquid measuring container (48) It is discharged from the outlet (41) by the waste liquid branch flow passage (45) and the waste liquid flow path (40),
So that the waste liquid folder (42) is become "Off" state with separating predetermined time interval；
In addition, the control unit also according to the liquid level from the waste liquid for flowing into the waste liquid measuring container (48) by the downside waste liquid Liquid level sensor (49) has detected the required inflow until being detected by the upside waste liquid liquid level sensor (47) The influx V3 of time t3 and waste liquid during this period, waste liquid flow L3 is measured using formula L3=V3/t3.
6. duration blood purification device according to claim 4, which is characterized in that export alarm in the control unit When the stop signal of generation signal and pump, stop the blood pump (11).
7. duration blood purification device described in any one of claim 1 to 3, which is characterized in that
The control unit controls the dialysis liquid pump (23), fluid infusion pump (33) and respective turn of the waste drains pump (43) Speed so that with separating predetermined time interval calculated dialysate flow, fluid infusion flow and waste liquid flow with it is respective Setting value is consistent.
8. a kind of duration blood purification device, blood is exported from the vein or artery of patient, and by purified blood It is fed back to the vein of patient,
The duration blood purification device is characterized in that,
Have：Blood extracorporeal circulation circuit (10), the blood extracorporeal circulation circuit (10) are the vein or artery from patient To the circulation loop of vein, and configured with the blood purification (12) being made of filter for blood dialysis；Dialysate circuit (20), The dialysate circuit (20) is used to import dialyzate to the blood purification (12)；Fluid infusion flow path (30), the fluid infusion stream Road (30), which is used for court, will be purified by the blood purification (12) or be mended by the purified blood of the blood purification (12) To the fluid infusion comprising body fluid components；Waste liquid flow path (40), the waste liquid flow path (40) are used to the waste liquid after blood purification being discharged； Capacity formula metering units for intermittently measuring dialysate flow；And the control unit of the capacity formula metering units is controlled,
It is configured with blood pump (11) and the blood purification (12) in the blood extracorporeal circulation circuit (10),
It is configured in order dialyzate bottle (21), dialyzate folder (22) and dialysis liquid pump (23) in the dialysate circuit (20), The dialysate circuit (20) is connected to the blood purification in the downstream side of the allocation position of the dialysis liquid pump (23) (12) dialyzate injection hole,
The dialysate circuit (20) between dialyzate folder (22) and the dialysis liquid pump (23) is connected with dialyzate Branch flow passage (25), the dialyzate branch flow passage (25) as the capacity formula metering units for measuring dialysate flow successively Configured with dialyzate metering electricity consumption magnet valve (26), upside dialyzate liquid level sensor (27), it is located at than the dialyzate bottle (21) The dialyzate measuring container (28) and downside dialyzate liquid level sensor (29) of low position,
It is configured in order fluid infusion bottle (31), fluid infusion folder (32) and fluid infusion in the fluid infusion flow path (30) and pumps (33), the fluid infusion The downstream side that flow path (30) pumps the allocation position of (33) in the fluid infusion is connected to the blood extracorporeal circulation circuit (10),
It is configured in order outlet (41), waste liquid folder (42) and waste drains pump (43), the waste liquid in the waste liquid flow path (40) Flow path (40) is connected to the dialyzate row of the blood purification (12) in the upstream side of the allocation position of the waste drains pump (43) Portal,
The control unit separates predetermined time interval and controls the dialyzate metering electricity consumption magnet valve (26) and the dialyzate The opening and closing for pressing from both sides (22), based on from the upside dialyzate liquid level sensor (27) and the downside dialyzate liquid level sensor (29) detection information calculates dialysate flow, also,
The downside dialyzate liquid level sensor is compared when the liquid level of the dialyzate when making the dialysis liquid pump (23) work is located at (29) in the case that the state of position on the lower continue for certain time, output alarm generates signal.
9. duration blood purification device according to claim 8, which is characterized in that
The control unit is repeated control as follows：
By making the dialyzate measure electricity consumption magnet valve (26) and described in the state of so that the dialysis liquid pump (23) is rotated Dialyzate, which presss from both sides (22), becomes " opening " state, makes the dialyzate in the dialyzate bottle (21) via the dialysate circuit (20) And conveyed to the dialyzate injection hole of the blood purification (12), and flowed into described via dialyzate branch flow passage (25) Liquid measuring container (28) is analysed,
In the liquid level rising for flowing into the dialyzate of the dialyzate measuring container (28) by the upside dialyzate level sensing After device (27) detects, so that the dialyzate folder (22) is become "Off" state, make in the dialyzate measuring container (28) Dialyzate flows out from the dialyzate measuring container (28) and via the dialyzate branch flow passage (25) and the dialysis liquid stream Road (20) and to the dialyzate injection hole of the blood purification (12) convey,
Decline in the liquid level of the dialyzate flowed out from the dialyzate measuring container (28) and is passed by the downside dialyzate liquid level After sensor (29) detects, so that the dialyzate folder (22) is become " opening " state, the liquid level of dialyzate is made to rise so that this The liquid level of dialyzate is located at the position against the top compared to the downside dialyzate liquid level sensor (29), then makes the dialyzate Metering becomes "Off" state with solenoid valve (26), and by the dialyzate in the dialyzate bottle (21) via the dialysis liquid stream Road (20) and to the dialyzate injection hole of the blood purification (12) convey,
So that the dialyzate metering electricity consumption magnet valve (26) is become " opening " state with separating predetermined time interval；
In addition, the control unit according to the liquid level of the dialyzate flowed out from the dialyzate measuring container (28) from by the upside Needed for dialyzate liquid level sensor (27) has detected until being detected by the downside dialyzate liquid level sensor (29) The discharge V2 of the delivery time t2 that wants and dialyzate during this period, dialysis liquid stream is measured using formula L2=V2/t2 Measure L2.
10. duration blood purification device according to claim 9, which is characterized in that
The control unit is saturating by the downside in the liquid level decline of the dialyzate flowed out from the dialyzate measuring container (28) After analysis liquid liquid level sensor (29) detects, the dialyzate folder (22) and dialyzate metering electricity consumption magnet valve (26) is made to tie up It holds in " opening " state, until the liquid level of the dialyzate rises and detected again by the downside dialyzate liquid level sensor (29) Until.
11. duration blood purification device according to any one of claims 8 to 10, which is characterized in that
The control unit compares the downside dialyzate when the liquid level of the dialyzate when making the dialysis liquid pump (23) work is located at In the case that the state of the position of liquid level sensor (29) on the lower continue for certain time, output alarm generates signal, and defeated Go out the stop signal of the dialysis liquid pump (23).
12. duration blood purification device according to any one of claims 8 to 10, which is characterized in that
Have the capacity formula metering units for intermittently measuring waste liquid flow and controls the control of the capacity formula metering units Portion,
The waste liquid flow path (40) between waste liquid folder (42) and the waste drains pump (43) is connected with waste liquid branch flow passage (45), it is configured in order based on waste liquid as the capacity formula metering units by measuring waste liquid flow in the waste liquid branch flow passage (45) It measures with solenoid valve (46), upside waste liquid liquid level sensor (47), positioned at the dialyzate tap than the blood purification (12) The waste liquid measuring container (48) and downside waste liquid liquid level sensor (49) of low position,
The control unit is repeated control as follows：
By making the waste liquid metering solenoid valve (46) become " opening " shape in the state of so that the waste drains pump (43) is rotated State simultaneously makes the waste liquid folder (42) become "Off" state, and waste liquid is made to flow into the waste liquid measuring container (48),
In the liquid level rising for flowing into the waste liquid of the waste liquid measuring container (48) by the upside waste liquid liquid level sensor (47) After detecting, so that the waste liquid folder (42) is become " opening " state, thus pass through the waste liquid in the waste liquid measuring container (48) It is discharged from the outlet (41) by the waste liquid branch flow passage (45) and the waste liquid flow path (40),
So that the waste liquid folder (42) is become "Off" state with separating predetermined time interval；
In addition, the control unit also according to the liquid level from the waste liquid for flowing into the waste liquid measuring container (48) by the downside waste liquid Liquid level sensor (49) has detected the required inflow until being detected by the upside waste liquid liquid level sensor (47) The influx V3 of time t3 and waste liquid during this period, waste liquid flow L3 is measured using formula L3=V3/t3.
13. duration blood purification device according to claim 11, which is characterized in that
When control unit output alarm generates the stop signal of signal and pump, stop the blood pump (11).
14. duration blood purification device according to any one of claims 8 to 10, which is characterized in that
The control unit controls the dialysis liquid pump (23), fluid infusion pump (33) and respective turn of the waste drains pump (43) Speed so that with separating predetermined time interval calculated dialysate flow, fluid infusion flow and waste liquid flow with it is respective Setting value is consistent.
15. a kind of duration blood purification device, blood is exported from the vein or artery of patient, and by purified blood It is fed back to the vein of patient,
The duration blood purification device is characterized in that,
Have：Blood extracorporeal circulation circuit, the blood extracorporeal circulation circuit are from the vein of patient or artery to vein Circulation loop, and configured with the blood purification being made of transfusion filters；Fluid infusion flow path, the fluid infusion flow path are used for towards will be by The blood purification purification or the fluid infusion for including body fluid components by the purified blood supply of the blood purification；Waste liquid Flow path, the waste liquid flow path are used to the waste liquid after blood purification being discharged；Based on the capacity formula for intermittently measuring fluid infusion flow Measure unit；And the control unit of the capacity formula metering units is controlled,
There are blood pump and the blood purification in the blood extracorporeal circulation loop configuration,
Fluid infusion bottle, fluid infusion folder and fluid infusion pump, the fluid infusion flow path are configured in order in the fluid infusion flow path to pump in the fluid infusion The downstream side of allocation position be connected to the blood extracorporeal circulation circuit,
The fluid infusion flow path between fluid infusion folder and fluid infusion pump is connected with fluid infusion branch flow passage, in the fluid infusion branch Flow path is configured in order fluid infusion metering solenoid valve, upside fluid infusion liquid as measuring the capacity formula metering units of fluid infusion flow Level sensor, fluid infusion measuring container and downside fluid infusion liquid level sensor positioned at the position lower than the fluid infusion bottle,
It is configured in order outlet, waste liquid folder and waste drains pump in the waste liquid flow path, the waste liquid flow path is in the waste drains pump The upstream side of allocation position be connected to the blood purification,
The control unit separates the opening and closing that predetermined time interval controls the fluid infusion metering solenoid valve and fluid infusion folder, Based on from the detection information of the upside fluid infusion liquid level sensor and downside fluid infusion liquid level sensor calculating fluid infusion stream Amount, also,
When making the fluid infusion pump work, the liquid level of fluid infusion, which is located at, compares the position of the downside fluid infusion liquid level sensor on the lower State continue for certain time in the case of, output alarm generate signal.
16. a kind of duration blood purification device, blood is exported from the vein or artery of patient, and by purified blood It is fed back to the vein of patient,
The duration blood purification device is characterized in that,
Have：Blood extracorporeal circulation circuit, the blood extracorporeal circulation circuit are from the vein of patient or artery to vein Circulation loop, and configured with the blood purification being made of haemodialyser；Dialysate circuit, the dialysate circuit be used for The blood purification imports dialyzate；Waste liquid flow path, the waste liquid flow path are used to the waste liquid after blood purification being discharged；For Intermittently measure the capacity formula metering units of dialysate flow；And the control unit of the capacity formula metering units is controlled,
There are blood pump and the blood purification in the blood extracorporeal circulation loop configuration,
Dialyzate bottle, dialyzate folder and dialysis liquid pump, the dialysate circuit are configured in order in the dialysate circuit to exist The downstream side of the allocation position of the dialysis liquid pump is connected to the dialyzate injection hole of the blood purification,
The dialysate circuit between dialyzate folder and the dialysis liquid pump is connected with dialyzate branch flow passage, at this Dialyzate branch flow passage is configured in order dialyzate metering electricity consumption as measuring the capacity formula metering units of dialysate flow Magnet valve, upside dialyzate liquid level sensor, the dialyzate measuring container positioned at the position lower than the dialyzate bottle and downside Dialyzate liquid level sensor,
It is configured in order outlet, waste liquid folder and waste drains pump in the waste liquid flow path, the waste liquid flow path is in the waste drains pump The upstream side of allocation position be connected to the dialyzate tap of the blood purification,
The control unit separates predetermined time interval and controls dialyzate metering electricity consumption magnet valve and dialyzate folder Opening and closing, based on the detection information meter from the upside dialyzate liquid level sensor and the downside dialyzate liquid level sensor Dialysate flow is calculated, also,
When the liquid level of the dialyzate when making the dialyzate pump work is located at compared to the downside dialyzate liquid level sensor on the lower In the case that the state of the position of side continue for certain time, output alarm generates signal.
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