CN110200978B - 甲状腺β-激动剂的应用 - Google Patents

甲状腺β-激动剂的应用 Download PDF

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Publication number
CN110200978B
CN110200978B CN201910397947.3A CN201910397947A CN110200978B CN 110200978 B CN110200978 B CN 110200978B CN 201910397947 A CN201910397947 A CN 201910397947A CN 110200978 B CN110200978 B CN 110200978B
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Chinese (zh)
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CN110200978A (zh
Inventor
B·连
R·汉利
M·迪纳曼
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Mortebos Treatment Co ltd
Viking Therapeutics Inc
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Mortebos Treatment Co ltd
Viking Therapeutics Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/665Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
CN201910397947.3A 2016-04-22 2017-04-24 甲状腺β-激动剂的应用 Active CN110200978B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910397947.3A CN110200978B (zh) 2016-04-22 2017-04-24 甲状腺β-激动剂的应用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662326431P 2016-04-22 2016-04-22
US62/326,431 2016-04-22
CN201910397947.3A CN110200978B (zh) 2016-04-22 2017-04-24 甲状腺β-激动剂的应用
CN201780038675.7A CN109641003A (zh) 2016-04-22 2017-04-24 甲状腺β-激动剂的应用
PCT/US2017/029102 WO2017185083A1 (en) 2016-04-22 2017-04-24 Use of thyroid beta-agonists

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780038675.7A Division CN109641003A (zh) 2016-04-22 2017-04-24 甲状腺β-激动剂的应用

Publications (2)

Publication Number Publication Date
CN110200978A CN110200978A (zh) 2019-09-06
CN110200978B true CN110200978B (zh) 2023-10-31

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Application Number Title Priority Date Filing Date
CN201910397947.3A Active CN110200978B (zh) 2016-04-22 2017-04-24 甲状腺β-激动剂的应用
CN201780038675.7A Pending CN109641003A (zh) 2016-04-22 2017-04-24 甲状腺β-激动剂的应用
CN202110804956.7A Pending CN113730421A (zh) 2016-04-22 2017-04-24 甲状腺β-激动剂的应用

Family Applications After (2)

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CN201780038675.7A Pending CN109641003A (zh) 2016-04-22 2017-04-24 甲状腺β-激动剂的应用
CN202110804956.7A Pending CN113730421A (zh) 2016-04-22 2017-04-24 甲状腺β-激动剂的应用

Country Status (10)

Country Link
US (1) US20190134069A1 (https=)
EP (1) EP3445372B1 (https=)
JP (1) JP2019515915A (https=)
KR (1) KR102407053B1 (https=)
CN (3) CN110200978B (https=)
AU (2) AU2017252122B2 (https=)
BR (1) BR112018071559B1 (https=)
CA (1) CA3021677C (https=)
MX (1) MX2018012904A (https=)
WO (1) WO2017185083A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3445373B1 (en) 2016-04-22 2024-08-21 Viking Therapeutics, Inc. Use of thyroid beta-agonists
US11752161B2 (en) 2020-03-27 2023-09-12 Gannex Pharma Co., Ltd. Pharmaceutical compositions, method of making and method of using thereof
JP2025520449A (ja) * 2022-06-15 2025-07-03 バイキング セラピューティクス,インコーポレーテッド X-ald治療のための甲状腺ベータ作動薬投与計画

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CA2543132A1 (en) * 2003-10-23 2005-05-19 Celgene Corporation Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
CN1886131A (zh) * 2003-10-30 2006-12-27 细胞基因公司 用于治疗黄斑变性的组合物和方法
CN101072555A (zh) * 2004-12-08 2007-11-14 西来昂诊疗公司 治疗与视黄醇有关的疾病的方法、分析和组合物
WO2011038207A1 (en) * 2009-09-25 2011-03-31 Metabasis Therapeutics, Inc. Phosphorus-containing thyroid hormone receptor agonists and methods of use
CN103153296A (zh) * 2010-08-16 2013-06-12 阿勒根公司 用α-2B肾上腺素能受体激动剂活化调节T细胞的方法

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US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
US5091552A (en) 1986-06-30 1992-02-25 Board Of Regents, The University Of Texas System Novel antitumor aldophosphamide analogs
ATE131825T1 (de) 1990-06-13 1996-01-15 Arnold Glazier Phosphorylierte prodrugs
US5157027A (en) 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
ATE199906T1 (de) 1993-06-29 2001-04-15 Mitsubishi Chem Corp Phosphonat-nukleotid ester-derivate
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
DK0999825T3 (da) 1997-07-29 2004-02-09 Alcon Lab Inc Oftalmiske sammensætninger indeholdende galactomannanpolymerer og borater
US6110973A (en) 1998-01-29 2000-08-29 Sepracor Methods for treating obesity and weight gain using optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
CA2534484A1 (en) 2003-08-07 2005-02-17 Allergan, Inc. Compositions for delivery of therapeutics into the eyes and methods for making and using same
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
CN1882327A (zh) 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
WO2006128058A2 (en) 2005-05-26 2006-11-30 Metabasis Therapeutics, Inc. Thyromimetics for the treatment of fatty liver diseases
EP1987827A1 (en) * 2006-02-20 2008-11-05 Takeda Pharmaceutical Company Limited Novel pharmaceutical
WO2014178892A1 (en) * 2013-05-03 2014-11-06 Scanlan Thomas S Use of sobetirome in the treatment of x-linked adrenolenoleukodystrophy
EP3259246B1 (en) * 2015-02-20 2023-03-22 Oregon Health & Science University Derivatives of sobetirome
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2543132A1 (en) * 2003-10-23 2005-05-19 Celgene Corporation Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
CN1886131A (zh) * 2003-10-30 2006-12-27 细胞基因公司 用于治疗黄斑变性的组合物和方法
CN101072555A (zh) * 2004-12-08 2007-11-14 西来昂诊疗公司 治疗与视黄醇有关的疾病的方法、分析和组合物
WO2011038207A1 (en) * 2009-09-25 2011-03-31 Metabasis Therapeutics, Inc. Phosphorus-containing thyroid hormone receptor agonists and methods of use
CN103153296A (zh) * 2010-08-16 2013-06-12 阿勒根公司 用α-2B肾上腺素能受体激动剂活化调节T细胞的方法

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* Cited by examiner, † Cited by third party
Title
67届美国糖尿病大会热点回顾;李宏亮等;《实用糖尿病杂志》;20081231;第5卷(第2期);第7-9页 *
Induction of the adrenoleukodystrophy-related gene (ABCD2) by thyromimetics;Emmanuelle C. Genin et al.;《J Steroid Biochem Mol Biol》;20090831;第116卷;摘要,第38页左栏第2-3段,第39页左栏第3段-第40页右栏第1段,图1-图4 *
Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index;Mark D. Erion et al.;《PNAS》;20070925;第104卷(第39期);第15490-15495页 *
过氧化物酶体增殖物激活受体γ与甲状腺相关性眼病;金康等;《国际病理科学与临床杂志》;20101231;第30卷(第06期);第531-535页 *

Also Published As

Publication number Publication date
AU2017252122A1 (en) 2018-11-15
EP3445372A4 (en) 2020-03-25
KR20190017748A (ko) 2019-02-20
AU2023202321A1 (en) 2023-05-11
CA3021677C (en) 2024-11-12
KR102407053B1 (ko) 2022-06-10
BR112018071559B1 (pt) 2024-02-06
CN113730421A (zh) 2021-12-03
WO2017185083A1 (en) 2017-10-26
CN110200978A (zh) 2019-09-06
US20190134069A1 (en) 2019-05-09
AU2023202321B2 (en) 2025-04-24
AU2017252122B2 (en) 2023-02-09
CA3021677A1 (en) 2017-10-26
CN109641003A (zh) 2019-04-16
EP3445372B1 (en) 2026-02-25
MX2018012904A (es) 2019-01-31
EP3445372A1 (en) 2019-02-27
JP2019515915A (ja) 2019-06-13
BR112018071559A2 (pt) 2019-05-14

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