CN110193059A - 新型抗栓胶囊及其制备方法 - Google Patents
新型抗栓胶囊及其制备方法 Download PDFInfo
- Publication number
- CN110193059A CN110193059A CN201910590649.6A CN201910590649A CN110193059A CN 110193059 A CN110193059 A CN 110193059A CN 201910590649 A CN201910590649 A CN 201910590649A CN 110193059 A CN110193059 A CN 110193059A
- Authority
- CN
- China
- Prior art keywords
- parts
- preparation
- mixed
- wine
- resisting capsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Insects & Arthropods (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Husbandry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及中医药的技术领域,特别是涉及一种新型抗栓胶囊及其制备方法,其工艺更加先进,可以更好的发挥疗效,便于服用;包括以下重量份数的中药:当归尾170~210份、丹参170~210份、僵蚕(麸炒)60~130份、壁虎60~130份、土鳖虫170~210份、蜈蚣40~70份、水蛭170~210份、蜂房60~130份、地龙60~130份、马钱子(制)30~60份、人工麝香1~5份、蟾酥(酒制)1~3份、甘草60~130份、土茯苓170~210份、延胡索(醋制)60~130份、骨碎补(制)170~210份、乌稍蛇(酒制)170~210份、虻虫(去翅)40~70份、三棱60~130份;其制备方法,包括以下步骤:(1)第一次煎煮;(2)第二次煎煮;(3)浓缩;(4)原料粉碎;(5)混合;(6)干燥;(7)粉碎制粒;(8)总混;(9)装胶囊。
Description
技术领域
本发明涉及中医药的技术领域,特别是涉及一种新型抗栓胶囊及其制备方法。
背景技术
抗栓胶囊是一种治疗血栓性疾病的纯中药制剂,具有活血化瘀,抗栓通脉的功能,用于血栓闭塞性脉管炎瘀血阻络症。对脑血栓、心肌梗塞,血栓性静脉炎等亦有较好的辅助治疗作用,经多年应用得到了较好的临床效果,但是随着社会的发展,为了更好的发挥疗效,便于服用,需要对其处方、工艺、功能主治、服用剂量等方面进行改进。
发明内容
为解决上述技术问题,本发明提供一种工艺更加先进,可以更好的发挥疗效,便于服用的新型抗栓胶囊及其制备方法。
本发明的新型抗栓胶囊,包括以下重量份数的中药:
当归尾170~210份、丹参170~210份、僵蚕(麸炒)60~130份、壁虎60~130份、土鳖虫170~210份、蜈蚣40~70份、水蛭170~210份、蜂房60~130份、地龙60~130份、马钱子(制)30~60份、人工麝香1~5份、蟾酥(酒制)1~3份、甘草60~130份、土茯苓170~210份、延胡索(醋制)60~130份、骨碎补(制)170~210份、乌稍蛇(酒制)170~210份、虻虫(去翅)40~70份、三棱60~130份。
本发明的新型抗栓胶囊的制备方法,包括以下步骤:
(1)第一次煎煮:分别称取当归尾、丹参、马钱子(制)、甘草、土茯苓、延胡索(醋制)、骨碎补(制)和三棱八味中药,加入其总质量7~12倍质量的水中,煎煮1~4h,过滤,得到第一次煎煮滤液;
(2)第二次煎煮:将过滤出的八味中药加入其总质量7~12倍质量的水中,煎煮1~4h,过滤,得到第二次煎煮滤液;
(3)浓缩:将第一次煎煮滤液和第二次煎煮滤液合并,并将其浓缩得到浸膏;
(4)原料粉碎:将僵蚕(麸炒)、壁虎、土鳖虫、蜈蚣、水蛭、蜂房、地龙、乌稍蛇(酒制)和虻虫(去翅)九味药材进行粉碎至60~130目的细粉;
(5)混合:将上述步骤粉碎得到的细粉混入浸膏中,搅拌使其混合均匀;
(6)干燥:将混合后的软材进行干燥处理;
(7)粉碎制粒:将干燥后的干膏进行粉碎处理,得到药物颗粒;
(8)总混:将人工麝香和蟾酥(酒制)研细混匀,并将其混入粉碎后的药物颗粒中,混合均匀;
(9)装胶囊:将混合后的颗粒装入胶囊中,得到新型抗栓胶囊。
本发明的新型抗栓胶囊的制备方法,所述步骤(3)中得到的浸膏的相对密度为1.05~1.4g/cm3。
本发明的新型抗栓胶囊的制备方法,所述步骤(3)中的浓缩条件为40~90℃减压浓缩。
本发明的新型抗栓胶囊的制备方法,所述步骤(6)中的干燥温度为30~100℃。
与现有技术相比本发明的有益效果为:
1、本发明采用纯中药处方进行制备,疗效好,服用方便,毒副作用小;
2、本发明从处方中去除国家二级濒危保护动物药材穿山甲,更利于保护野生资源;
3、本发明中煎煮液为40~90℃减压浓缩,相比传统100℃常压浓缩,浓缩温度低,耗能低,浓缩时间短,热敏性成分损失小,有效成分回收率高;服用量减少,疗效更佳,便于服用;
4、本发明的新型抗栓胶囊扩大了疗效范围,对脑血栓、心肌梗塞,血栓性静脉炎等由有较好的辅助治疗作用变为治疗作用。本发明在制剂成型过程中不用辅料,产品更易吸收。
具体实施方式
下面结合实施例,对本发明的具体实施方式作进一步详细描述。以下实施例用于说明本发明,但不用来限制本发明的范围。
实施例1
分别称取以下重量份中药:当归尾200g、丹参200g、僵蚕(麸炒)100g、壁虎100g、土鳖虫200g、蜈蚣50g、水蛭200g、蜂房100g、地龙100g、马钱子(制)30g、人工麝香3g、蟾酥(酒制)1g、甘草100g、土茯苓200g、延胡索(醋制)100g、骨碎补(制)200g、乌稍蛇(酒制)200g、虻虫(去翅)50g、三棱80g。
分别称取当归尾、丹参、马钱子(制)、甘草、土茯苓、延胡索(醋制)、骨碎补(制)和三棱八味中药,加入其总质量8倍质量的水中,煎煮2h,过滤,得到第一次煎煮滤液,将过滤出的八味中药加入其总质量8倍质量的水中,煎煮1h,过滤,得到第二次煎煮滤液,将第一次煎煮滤液和第二次煎煮滤液合并,在65℃下进行减压浓缩,得到相对密度为1.2g/cm3的浸膏,将僵蚕(麸炒)、壁虎、土鳖虫、蜈蚣、水蛭、蜂房、地龙、乌稍蛇(酒制)和虻虫(去翅)九味药材进行粉碎至100目的细粉,将粉碎得到的细粉混入浸膏中,搅拌使其混合均匀,将混合后的软材在80℃下进行干燥处理,将干燥后的干膏进行粉碎处理,并过60目筛,得到药物颗粒,将人工麝香和蟾酥(酒制)研细混匀,并将其混入粉碎后的药物颗粒中,混合均匀,最后将混合后的颗粒装入胶囊中,得到新型抗栓胶囊。
实施例2
分别称取以下重量份中药:当归尾180g、丹参180g、僵蚕(麸炒)100g、壁虎100g、土鳖虫180g、蜈蚣50g、水蛭180g、蜂房100g、地龙100g、马钱子(制)60g、人工麝香1g、蟾酥(酒制)1g、甘草100g、土茯苓180g、延胡索(醋制)70g、骨碎补(制)200g、乌稍蛇(酒制)190g、虻虫(去翅)50g、三棱100g。
分别称取当归尾、丹参、马钱子(制)、甘草、土茯苓、延胡索(醋制)、骨碎补(制)和三棱八味中药,加入其总质量12倍质量的水中,煎煮3h,过滤,得到第一次煎煮滤液,将过滤出的八味中药加入其总质量12倍质量的水中,煎煮2.5h,过滤,得到第二次煎煮滤液,将第一次煎煮滤液和第二次煎煮滤液合并,在90℃下进行减压浓缩,得到相对密度为1.1g/cm3的浸膏,将僵蚕(麸炒)、壁虎、土鳖虫、蜈蚣、水蛭、蜂房、地龙、乌稍蛇(酒制)和虻虫(去翅)九味药材进行粉碎至120目的细粉,将粉碎得到的细粉混入浸膏中,搅拌使其混合均匀,将混合后的软材在100℃下进行干燥处理,将干燥后的干膏进行粉碎处理,并过100目筛,得到药物颗粒,将人工麝香和蟾酥(酒制)研细混匀,并将其混入粉碎后的药物颗粒中,混合均匀,最后将混合后的颗粒装入胶囊中,得到新型抗栓胶囊。
实施例3
分别称取以下重量份中药:当归尾170g、丹参170g、僵蚕(麸炒)100g、壁虎100g、土鳖虫170g、蜈蚣50g、水蛭170g、蜂房80g、地龙80g、马钱子(制)50g、人工麝香2g、蟾酥(酒制)3g、甘草80g、土茯苓200g、延胡索(醋制)90g、骨碎补(制)190g、乌稍蛇(酒制)190g、虻虫(去翅)40g、三棱90g。。
分别称取当归尾、丹参、马钱子(制)、甘草、土茯苓、延胡索(醋制)、骨碎补(制)和三棱八味中药,加入其总质量12倍质量的水中,煎煮12h,过滤,得到第一次煎煮滤液,将过滤出的八味中药加入其总质量12倍质量的水中,煎煮2h,过滤,得到第二次煎煮滤液,将第一次煎煮滤液和第二次煎煮滤液合并,在80℃下进行减压浓缩,得到相对密度为1.3g/cm3的浸膏,将僵蚕(麸炒)、壁虎、土鳖虫、蜈蚣、水蛭、蜂房、地龙、乌稍蛇(酒制)和虻虫(去翅)九味药材进行粉碎至80目的细粉,将粉碎得到的细粉混入浸膏中,搅拌使其混合均匀,将混合后的软材在90℃下进行干燥处理,将干燥后的干膏进行粉碎处理,并过80目筛,得到药物颗粒,将人工麝香和蟾酥(酒制)研细混匀,并将其混入粉碎后的药物颗粒中,混合均匀,最后将混合后的颗粒装入胶囊中,得到新型抗栓胶囊。
对所公开的实施例的上述说明,使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的,本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下,在其他实施例中实现。因此,本发明将不会被限制于本文所示的这些实施例,而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (5)
1.一种新型抗栓胶囊,其特征在于,包括以下重量份数的中药:
当归尾170~210份、丹参170~210份、僵蚕(麸炒)60~130份、壁虎60~130份、土鳖虫170~210份、蜈蚣40~70份、水蛭170~210份、蜂房60~130份、地龙60~130份、马钱子(制)30~60份、人工麝香1~5份、蟾酥(酒制)1~3份、甘草60~130份、土茯苓170~210份、延胡索(醋制)60~130份、骨碎补(制)170~210份、乌稍蛇(酒制)170~210份、虻虫(去翅)40~70份、三棱60~130份。
2.一种新型抗栓胶囊的制备方法,其特征在于,包括以下步骤:
(1)第一次煎煮:分别称取当归尾、丹参、马钱子(制)、甘草、土茯苓、延胡索(醋制)、骨碎补(制)和三棱八味中药,加入其总质量7~12倍质量的水中,煎煮1~4h,过滤,得到第一次煎煮滤液;
(2)第二次煎煮:将过滤出的八味中药加入其总质量7~12倍质量的水中,煎煮1~4h,过滤,得到第二次煎煮滤液;
(3)浓缩:将第一次煎煮滤液和第二次煎煮滤液合并,并将其浓缩得到浸膏;
(4)原料粉碎:将僵蚕(麸炒)、壁虎、土鳖虫、蜈蚣、水蛭、蜂房、地龙、乌稍蛇(酒制)和虻虫(去翅)九味药材进行粉碎至60~130目的细粉;
(5)混合:将上述步骤粉碎得到的细粉混入浸膏中,搅拌使其混合均匀;
(6)干燥:将混合后的软材进行干燥处理;
(7)粉碎制粒:将干燥后的干膏进行粉碎处理,得到药物颗粒;
(8)总混:将人工麝香和蟾酥(酒制)研细混匀,并将其混入粉碎后的药物颗粒中,混合均匀;
(9)装胶囊:将混合后的颗粒装入胶囊中,得到新型抗栓胶囊。
3.如权利要求2所述的一种新型抗栓胶囊的制备方法,其特征在于,所述步骤(3)中得到的浸膏的相对密度为1.05~1.4g/cm3。
4.如权利要求2所述的一种新型抗栓胶囊的制备方法,其特征在于,所述步骤(3)中的浓缩条件为40~90℃减压浓缩。
5.如权利要求2所述的一种新型抗栓胶囊的制备方法,其特征在于,所述步骤(6)中的干燥温度为30~100℃。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910590649.6A CN110193059A (zh) | 2019-07-02 | 2019-07-02 | 新型抗栓胶囊及其制备方法 |
CN202210077540.4A CN114344424A (zh) | 2019-07-02 | 2019-07-02 | 新抗栓胶囊及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910590649.6A CN110193059A (zh) | 2019-07-02 | 2019-07-02 | 新型抗栓胶囊及其制备方法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210077540.4A Division CN114344424A (zh) | 2019-07-02 | 2019-07-02 | 新抗栓胶囊及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110193059A true CN110193059A (zh) | 2019-09-03 |
Family
ID=67755607
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910590649.6A Pending CN110193059A (zh) | 2019-07-02 | 2019-07-02 | 新型抗栓胶囊及其制备方法 |
CN202210077540.4A Pending CN114344424A (zh) | 2019-07-02 | 2019-07-02 | 新抗栓胶囊及其制备方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210077540.4A Pending CN114344424A (zh) | 2019-07-02 | 2019-07-02 | 新抗栓胶囊及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (2) | CN110193059A (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1785383A (zh) * | 2005-11-10 | 2006-06-14 | 贵州益佰制药股份有限公司 | 一种治疗血栓的药物制剂及其制备方法 |
CN106421639A (zh) * | 2016-10-12 | 2017-02-22 | 徐琳 | 一种治疗心脑血管疾病的中药 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102973851B (zh) * | 2012-11-15 | 2015-01-28 | 上海景峰制药股份有限公司 | 一种提高抗栓胶囊中蟾酥和麝香均匀度的方法 |
CN105343454A (zh) * | 2015-11-20 | 2016-02-24 | 吴冲 | 一种治疗血栓的中药胶囊及其制备方法 |
-
2019
- 2019-07-02 CN CN201910590649.6A patent/CN110193059A/zh active Pending
- 2019-07-02 CN CN202210077540.4A patent/CN114344424A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1785383A (zh) * | 2005-11-10 | 2006-06-14 | 贵州益佰制药股份有限公司 | 一种治疗血栓的药物制剂及其制备方法 |
CN106421639A (zh) * | 2016-10-12 | 2017-02-22 | 徐琳 | 一种治疗心脑血管疾病的中药 |
Also Published As
Publication number | Publication date |
---|---|
CN114344424A (zh) | 2022-04-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1047946C (zh) | 老年病制剂 | |
CN101337061A (zh) | 一种活血止痛膏 | |
CN100457171C (zh) | 一种治疗中风偏瘫病药物的制备方法 | |
CN103656303A (zh) | 一种降血压中药胶囊及其制备方法 | |
CN101337025B (zh) | 一种抗衰美白、润肤除烦口服制剂及其制备方法 | |
CN101264154B (zh) | 一种中药口服制剂的制备方法 | |
CN1127967C (zh) | 一种治疗高血压的胶囊及其制备方法 | |
CN102631437B (zh) | 一种治疗风湿痹痛的药物及其制备方法 | |
CN110193059A (zh) | 新型抗栓胶囊及其制备方法 | |
CN102657736A (zh) | 一种治疗类风湿性关节炎的药物组合物及其制备方法 | |
CN109663037A (zh) | 一种治疗颈椎和腰椎增生的草药膏及其制作方法 | |
CN1422643A (zh) | 一种治疗红斑狼疮的口服药丸 | |
CN101642532A (zh) | 一种治疗中风的中药组合物及其制备方法 | |
CN103285278A (zh) | 一种预防和治疗缺血性脑中风的药物及其制备方法 | |
CN1180821C (zh) | 一种治疗脑血栓的药物及制备方法 | |
CN104257824B (zh) | 一种健儿清解颗粒及其制备方法 | |
CN100358552C (zh) | 一种治疗弱视的药物及其制备方法 | |
CN1048900C (zh) | 一种治疗子宫内膜异位症中药及制作工艺 | |
CN1051019C (zh) | 逐瘀通脉胶囊 | |
CN1977919A (zh) | 一种治疗冠心病心绞痛的中药制剂及其制备方法 | |
CN1183922C (zh) | 治疗手术后粘连症的药物及其制备工艺 | |
CN104800339A (zh) | 一种用于治疗骨折的中药组合物 | |
CN102488851A (zh) | 治疗反复发作生殖器疱疹的药物及其制备方法 | |
CN101780188B (zh) | 治疗前列腺疾病的胶囊 | |
CN106581214A (zh) | 一种治疗缺血性脑卒中的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190903 |