CN114344424A - 新抗栓胶囊及其制备方法 - Google Patents
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Abstract
本发明提供了一种新抗栓胶囊及其制备方法,包括以下重量份数的中药:当归尾170~210份、丹参170~210份、僵蚕60~130份、壁虎60~130份、土鳖虫170~210份、蜈蚣40~70份、水蛭170~210份、蜂房60~130份、地龙60~130份、马钱子30~60份、人工麝香1~5份、蟾酥1~3份、甘草60~130份、土茯苓170~210份、延胡索60~130份、骨碎补170~210份、乌稍蛇170~210份、虻虫40~70份、三棱60~130份;其制备方法包括:第一次煎煮;第二次煎煮;浓缩;原料粉碎;混合;干燥;粉碎制粒;总混;装胶囊。其工艺更加先进,可以更好的发挥疗效,便于服用。
Description
本申请是申请日为2019年07月02日、申请号为201910590649.6、发明名称为《新型抗栓胶囊及其制备方法》的分案申请。
技术领域
本发明涉及中医药的技术领域,特别是涉及新抗栓胶囊及其制备方法。
背景技术
抗栓胶囊是一种治疗血栓性疾病的纯中药制剂,具有活血化瘀,抗栓通脉的功能,用于血栓闭塞性脉管炎瘀血阻络症。对脑血栓、心肌梗塞,血栓性静脉炎等亦有较好的辅助治疗作用,经多年应用得到了较好的临床效果,但是随着社会的发展,为了更好的发挥疗效,便于服用,需要对其处方、工艺、功能主治、服用剂量等方面进行改进。
发明内容
为解决上述技术问题,本发明提供了新抗栓胶囊及其制备方法,工艺更加先进,可以更好的发挥疗效,且便于服用。
本发明的新抗栓胶囊,包括以下重量份数的中药:
当归尾170~210份、丹参170~210份、僵蚕(麸炒)60~130份、壁虎60~130份、土鳖虫170~210份、蜈蚣40~70份、水蛭170~210份、蜂房60~130份、地龙60~130份、马钱子(制)30~60份、人工麝香1~5份、蟾酥(酒制)1~3份、甘草60~130份、土茯苓170~210份、延胡索(醋制)60~130份、骨碎补(制)170~210份、乌稍蛇(酒制)170~210份、虻虫(去翅)40~70份、三棱60~130份。
本发明还提供了前述中药组合物在制备抗栓药物中的应用。
本发明还提供了前述中药组合物在制备治疗脑血栓药物中的应用。
本发明还提供了前述中药组合物在制备治疗心肌梗塞药物中的应用。
本发明的新抗栓胶囊的制备方法,包括以下步骤:
(1)第一次煎煮:分别称取当归尾、丹参、马钱子(制)、甘草、土茯苓、延胡索(醋制)、骨碎补(制)和三棱八味中药,加入其总质量7~12倍质量的水中,煎煮1~4h,过滤,得到第一次煎煮滤液;
(2)第二次煎煮:将过滤出的八味中药加入其总质量7~12倍质量的水中,煎煮1~4h,过滤,得到第二次煎煮滤液;
(3)浓缩:将第一次煎煮滤液和第二次煎煮滤液合并,并将其浓缩得到浸膏;
(4)原料粉碎:将僵蚕(麸炒)、壁虎、土鳖虫、蜈蚣、水蛭、蜂房、地龙、乌稍蛇(酒制)和虻虫(去翅)九味药材进行粉碎至60~130目的细粉;
(5)混合:将上述步骤粉碎得到的细粉混入浸膏中,搅拌使其混合均匀;
(6)干燥:将混合后的软材进行干燥处理;
(7)粉碎制粒:将干燥后的干膏进行粉碎处理,得到药物颗粒;
(8)总混:将人工麝香和蟾酥(酒制)研细混匀,并将其混入粉碎后的药物颗粒中,混合均匀;
(9)装胶囊:将混合后的颗粒装入胶囊中,得到新型抗栓胶囊。
优选的,所述步骤(3)中得到的浸膏的相对密度为1.05~1.4g/cm3。
优选的,所述步骤(3)中的浓缩条件为40~90℃减压浓缩。
优选的,所述步骤(6)中的干燥温度为30~100℃。
与现有技术相比本发明的有益效果为:
1、本发明采用纯中药处方进行制备,疗效好,服用方便,毒副作用小;
2、本发明从处方中去除国家二级濒危保护动物药材穿山甲,更利于保护野生资源;
3、本发明中煎煮液为40~90℃减压浓缩,相比传统100℃常压浓缩,浓缩温度低,耗能低,浓缩时间短,热敏性成分损失小,有效成分回收率高;服用量减少,疗效更佳,便于服用;
4、本发明的新抗栓胶囊扩大了疗效范围,对脑血栓、心肌梗塞,血栓性静脉炎等由有较好的辅助治疗作用变为治疗作用。本发明在制剂成型过程中不用辅料,产品更易吸收。
具体实施方式
下面结合实施例,对本发明的具体实施方式作进一步详细描述。以下实施例用于说明本发明,但不用来限制本发明的范围。
实施例1
分别称取以下重量份中药:当归尾200g、丹参200g、僵蚕(麸炒)100g、壁虎100g、土鳖虫200g、蜈蚣50g、水蛭200g、蜂房100g、地龙100g、马钱子(制)30g、人工麝香3g、蟾酥(酒制)1g、甘草100g、土茯苓200g、延胡索(醋制)100g、骨碎补(制)200g、乌稍蛇(酒制)200g、虻虫(去翅)50g、三棱80g。
分别称取当归尾、丹参、马钱子(制)、甘草、土茯苓、延胡索(醋制)、骨碎补(制)和三棱八味中药,加入其总质量8倍质量的水中,煎煮2h,过滤,得到第一次煎煮滤液,将过滤出的八味中药加入其总质量8倍质量的水中,煎煮1h,过滤,得到第二次煎煮滤液,将第一次煎煮滤液和第二次煎煮滤液合并,在65℃下进行减压浓缩,得到相对密度为1.2g/cm3的浸膏,将僵蚕(麸炒)、壁虎、土鳖虫、蜈蚣、水蛭、蜂房、地龙、乌稍蛇(酒制)和虻虫(去翅)九味药材进行粉碎至100目的细粉,将粉碎得到的细粉混入浸膏中,搅拌使其混合均匀,将混合后的软材在80℃下进行干燥处理,将干燥后的干膏进行粉碎处理,并过60目筛,得到药物颗粒,将人工麝香和蟾酥(酒制)研细混匀,并将其混入粉碎后的药物颗粒中,混合均匀,最后将混合后的颗粒装入胶囊中,得到新型抗栓胶囊。
实施例2
分别称取以下重量份中药:当归尾180g、丹参180g、僵蚕(麸炒)100g、壁虎100g、土鳖虫180g、蜈蚣50g、水蛭180g、蜂房100g、地龙100g、马钱子(制)60g、人工麝香1g、蟾酥(酒制)1g、甘草100g、土茯苓180g、延胡索(醋制)70g、骨碎补(制)200g、乌稍蛇(酒制)190g、虻虫(去翅)50g、三棱100g。
分别称取当归尾、丹参、马钱子(制)、甘草、土茯苓、延胡索(醋制)、骨碎补(制)和三棱八味中药,加入其总质量12倍质量的水中,煎煮3h,过滤,得到第一次煎煮滤液,将过滤出的八味中药加入其总质量12倍质量的水中,煎煮2.5h,过滤,得到第二次煎煮滤液,将第一次煎煮滤液和第二次煎煮滤液合并,在90℃下进行减压浓缩,得到相对密度为1.1g/cm3的浸膏,将僵蚕(麸炒)、壁虎、土鳖虫、蜈蚣、水蛭、蜂房、地龙、乌稍蛇(酒制)和虻虫(去翅)九味药材进行粉碎至120目的细粉,将粉碎得到的细粉混入浸膏中,搅拌使其混合均匀,将混合后的软材在100℃下进行干燥处理,将干燥后的干膏进行粉碎处理,并过100目筛,得到药物颗粒,将人工麝香和蟾酥(酒制)研细混匀,并将其混入粉碎后的药物颗粒中,混合均匀,最后将混合后的颗粒装入胶囊中,得到新型抗栓胶囊。
实施例3
分别称取以下重量份中药:当归尾170g、丹参170g、僵蚕(麸炒)100g、壁虎100g、土鳖虫170g、蜈蚣50g、水蛭170g、蜂房80g、地龙80g、马钱子(制)50g、人工麝香2g、蟾酥(酒制)3g、甘草80g、土茯苓200g、延胡索(醋制)90g、骨碎补(制)190g、乌稍蛇(酒制)190g、虻虫(去翅)40g、三棱90g。。
分别称取当归尾、丹参、马钱子(制)、甘草、土茯苓、延胡索(醋制)、骨碎补(制)和三棱八味中药,加入其总质量12倍质量的水中,煎煮12h,过滤,得到第一次煎煮滤液,将过滤出的八味中药加入其总质量12倍质量的水中,煎煮2h,过滤,得到第二次煎煮滤液,将第一次煎煮滤液和第二次煎煮滤液合并,在80℃下进行减压浓缩,得到相对密度为1.3g/cm3的浸膏,将僵蚕(麸炒)、壁虎、土鳖虫、蜈蚣、水蛭、蜂房、地龙、乌稍蛇(酒制)和虻虫(去翅)九味药材进行粉碎至80目的细粉,将粉碎得到的细粉混入浸膏中,搅拌使其混合均匀,将混合后的软材在90℃下进行干燥处理,将干燥后的干膏进行粉碎处理,并过80目筛,得到药物颗粒,将人工麝香和蟾酥(酒制)研细混匀,并将其混入粉碎后的药物颗粒中,混合均匀,最后将混合后的颗粒装入胶囊中,得到新型抗栓胶囊。
对所公开的实施例的上述说明,使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的,本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下,在其他实施例中实现。因此,本发明将不会被限制于本文所示的这些实施例,而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (10)
1.一种具有抗栓作用的中药组合物,其特征在于,包括以下重量份数的中药:
当归尾170~210份、丹参170~210份、僵蚕60~130份、壁虎60~130份、土鳖虫170~210份、蜈蚣40~70份、水蛭170~210份、蜂房60~130份、地龙60~130份、马钱子30~60份、人工麝香1~5份、蟾酥1~3份、甘草60~130份、土茯苓170~210份、延胡索60~130份、骨碎补170~210份、乌稍蛇170~210份、虻虫40~70份和三棱60~130份。
2.根据权利要求1所述的中药组合物,其特征在于,所述僵蚕的炮制方法为麸炒;所述蟾酥的炮制方法为酒制;所述延胡索的炮制方法为醋制;所述乌稍蛇的炮制方法为酒制;所述虻虫要去翅;所述马钱子和骨碎补经过炮制。
3.根据权利要求1或2所述的中药组合物,其特征在于,所述中药组合物的剂型为胶囊剂。
4.权利要求1或2所述的中药组合物在制备抗栓药物中的应用。
5.权利要求1或2所述的中药组合物在制备治疗脑血栓药物中的应用。
6.权利要求1或2所述的中药组合物在制备治疗心肌梗塞药物中的应用。
7.一种新抗栓胶囊的制备方法,其特征在于,包括以下步骤:
(1)第一次煎煮:分别称取当归尾、丹参、马钱子、甘草、土茯苓、延胡索、骨碎补和三棱八味中药,加入其总质量7~12倍质量的水中,煎煮1~4h,过滤,得到第一次煎煮滤液;
(2)第二次煎煮:将过滤出的八味中药加入其总质量7~12倍质量的水中,煎煮1~4h,过滤,得到第二次煎煮滤液;
(3)浓缩:将第一次煎煮滤液和第二次煎煮滤液合并,并将其浓缩得到浸膏;
(4)原料粉碎:将僵蚕、壁虎、土鳖虫、蜈蚣、水蛭、蜂房、地龙、乌稍蛇和虻虫九味药材进行粉碎至60~130目的细粉;
(5)混合:将上述步骤粉碎得到的细粉混入浸膏中,搅拌使其混合均匀;
(6)干燥:将混合后的软材进行干燥处理;
(7)粉碎制粒:将干燥后的干膏进行粉碎处理,得到药物颗粒;
(8)总混:将人工麝香和蟾酥研细混匀,并将其混入粉碎后的药物颗粒中,混合均匀;
(9)装胶囊:将混合后的颗粒装入胶囊中,得到新型抗栓胶囊。
8.如权利要求7所述的一种抗栓胶囊的制备方法,其特征在于,所述步骤(3)中得到的浸膏的相对密度为1.05~1.4g/cm3。
9.如权利要求7所述的一种抗栓胶囊的制备方法,其特征在于,所述步骤(3)中的浓缩条件为40~90℃减压浓缩。
10.如权利要求7所述的一种抗栓胶囊的制备方法,其特征在于,所述步骤(6)中的干燥温度为30~100℃。
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