CN110170016A - Liquid medicine and the preparation method and application thereof - Google Patents

Liquid medicine and the preparation method and application thereof Download PDF

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Publication number
CN110170016A
CN110170016A CN201910536767.9A CN201910536767A CN110170016A CN 110170016 A CN110170016 A CN 110170016A CN 201910536767 A CN201910536767 A CN 201910536767A CN 110170016 A CN110170016 A CN 110170016A
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liquid medicine
radix
davallia
rhizome
angelicae sinensis
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崔德年
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A61K36/126—Drynaria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The present invention relates to a kind of liquid medicine and the preparation method and application thereof, the liquid medicine is mixed using Radix Salviae Miltiorrhizae, radix cyathulae, west safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Artemisia anomala, peach kernel, the rhizome of davallia, Radix Notoginseng and rhizoma cyperi as raw material, treatment hypertension is had a good effect, overall clinical efficacy rate reaches 93.75%.Liquid medicine of the present invention, liquid medicine of the invention can be used for daily health caring, keeps fit and healthy, main prevention of arterial atherosis；Atherosclerotic dangerous diseases can be treated, hyperlipidemia, myocardial infarction, painstaking effort blockage, dizzy out of strength, insomnia forgetfulness, extremity numbness, chest distress and palpitation symptoms, cervical spondylosis, angina pectoris, coronary heart disease, cerebral hemorrhage, cerebral thrombosis apoplexy are cured mainly.

Description

Liquid medicine and the preparation method and application thereof
Technical field
The invention belongs to technical field of Chinese medicine, and in particular to a kind of liquid medicine and the preparation method and application thereof.
Background technique
The main reason for atherosclerosis is coronary heart disease, cerebral infarction, peripheral vascular disease.Lipidosis is artery congee The lesion basis of sample hardening, its main feature is that involvement arterial disease since inner membrance, generally first has lipid and the accumulation of compound carbohydrate, goes out Blood and thrombosis, and then proliferation of fibrous tissue and calcinosis, and have the gradually transformation and calcification of arterial media, lead to artery Wall thickening is hardened, lumen of vessels is narrow.Lesion often involves big-and-middle muscular artery, is enough to block lumen of artery once developing to, then this is dynamic The tissue or organ that arteries and veins is supplied are by ischemic or necrosis.Since the lipid appearance gathered in endarterium is athero- in yellow, Referred to as atherosclerosis.
It is known that artery throughout human body everywhere, so the artery of human body different parts can all have the possibility of morbidity.When So, also there is keypoint part among these, that is, be easier that the place of serious atherosclerosis occurs, such as: it is aorta, coronal dynamic Arteries and veins, arteria carotis, cerebral artery, arteria renalis etc..
There are some scholars to think, atherosclerosis is irreversible.Their the reasons why, is: once this hardening shape At substantially having the possibility of recovery from illness, be less likely to return to original state, it can only be delayed to more serious stage development；But More scholars then think: the early stage of atherosclerosis, if appropriate measures, mitigate the stenosis of symptom and blood vessel, It is promising.Therefore, prevention of arterial atherosis is just particularly important.
But China, currently, people does not pay attention to preventing mostly, treatment also only relies on western drug control, and side effect is larger, there is no Effective pure Chinese medicine can prevent and treat atherosclerosis.
In consideration of it, applying for this patent.
Summary of the invention
In order to solve the above problems existing in the present technology, the present invention provides a kind of good liquid medicine and preparation method thereof With application, the liquid medicine can long-term drinking, keep fit and healthy；Atherosclerosis can also be prevented and treated.
It is an object of the present invention to provide a kind of liquid medicine.
It is another object of the present invention to provide the preparation methods of two kinds of liquid medicine.
Another object of the present invention is to provide a kind of application of liquid medicine.
The liquid medicine of specific embodiment according to the present invention, the liquid medicine are made of following bulk pharmaceutical chemicals, and the bulk pharmaceutical chemicals include:
Radix Salviae Miltiorrhizae, radix cyathulae, west safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Artemisia anomala, peach kernel, the rhizome of davallia, Radix Notoginseng and rhizoma cyperi.
The liquid medicine of specific embodiment according to the present invention, wherein the liquid medicine is prepared from the following raw materials, and the raw material is by weight Measuring part includes:
Radix Salviae Miltiorrhizae 10-15g；Radix cyathulae 5-10g；West safflower 1-3g；Radix Angelicae Sinensis 6-12g；Rhizoma Chuanxiong 3-10g；Artemisia anomala 3-10g；Peach Benevolence 5-10g；Rhizome of davallia 3-9g；Radix Notoginseng 3-9g and rhizoma cyperi 6-10g.
The liquid medicine of specific embodiment according to the present invention, wherein the liquid medicine is prepared from the following raw materials, and the raw material is by weight Measuring part includes:
Radix Salviae Miltiorrhizae 12-13g；Radix cyathulae 7-8g；West safflower 1.5-2.5g；Radix Angelicae Sinensis 8-10g；Rhizoma Chuanxiong 5-8g；Artemisia anomala 5-8g；Peach Benevolence 7-8g；Rhizome of davallia 5-7g；Radix Notoginseng 5-7g and rhizoma cyperi 7-9g.
The liquid medicine of specific embodiment according to the present invention, wherein the liquid medicine is prepared from the following raw materials, and the raw material is by weight Measuring part includes:
Radix Salviae Miltiorrhizae 12.5g；Radix cyathulae 7.5g；West safflower 2g；Radix Angelicae Sinensis 9g；Rhizoma Chuanxiong 6.5g；Artemisia anomala 6.5g；Peach kernel 7.5g；Bone Broken benefit 6g；Radix Notoginseng 6g and rhizoma cyperi 8g.
The liquid medicine of specific embodiment according to the present invention, wherein the liquid medicine further includes white wine.White wine is used as and pushes simply Raw material of the pharmacological property in blood vessel interactive effect.
The liquid medicine of specific embodiment according to the present invention, wherein the white wine is the white wine of 35-40 degree.
The preparation method of the liquid medicine of specific embodiment according to the present invention, comprising the following steps:
(1) Radix Salviae Miltiorrhizae, radix cyathulae, west safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Artemisia anomala, peach kernel, the rhizome of davallia, Radix Notoginseng are weighed by weight ratio And rhizoma cyperi, it is uniformly mixed and forms mixture；
(2) white wine is added in the mixture obtained to step (1), is uniformly mixed, sealed soak 4-6 months, will soak Filtered solution is obtained by filtration in bubble liquid, the as described liquid medicine.
The preparation method of the liquid medicine of specific embodiment according to the present invention, wherein in step (1), the Radix Salviae Miltiorrhizae, river ox Powder is first broken into respectively before knee, west safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Artemisia anomala, peach kernel, the rhizome of davallia, Radix Notoginseng and rhizoma cyperi mixing, then is passed through respectively High-temperature short-time sterilization is crossed, the temperature of the high-temperature short-time sterilization is 121 DEG C, and the time of the high-temperature short-time sterilization is 5 seconds.
The preparation method of the liquid medicine of specific embodiment according to the present invention, wherein in step (2), the sealed soak Time is 5 months, and the temperature of immersion is 35-40 DEG C.The time that bulk pharmaceutical chemicals do not break into powder directly immersion is relatively longer, specifically Soaking time will see the pharmacological property in wine, generally manufactured liquid medicine after impregnating be poured into a little in cup, observation with disposable cup Liquid medicine, which is stained with cup, to be advisable.The room of special soaked liquor between being preferably formed with one, room temperature will reach 40 DEG C, and left and right makes liquid medicine cylinder in this way Interior liquid medicine pharmacological property is come more faster, shortens the wine time out.
The application of the liquid medicine of specific embodiment according to the present invention, wherein the liquid medicine is athero- in preparation prevention and treatment artery Harden the application in drug or health care product and food.
Details are as follows for the meridian distribution of property and flavor of various bulk pharmaceutical chemicals in the present invention:
Radix Salviae Miltiorrhizae, it is bitter, it is slightly cold；Converge to heart and liver channels；Effect, promoting blood circulation, promoting menstruation is antipruritic, relieving restlessness and restlessness, cool blood to disappear carbuncle.
Radix cyathulae, sweet in flavor, slight bitter are mild-natured；Return liver and kidney channel；Effect, dispelling stasis of blood and stimulating the menstrual flow is easing joint movement, inducing diuresis for treating strangurtia.
West safflower, it is sweet, it is slightly cold；Converge to heart and liver channels；Effect, activating microcirculation and removing stasis medicinal, removing pattogenic heat from the blood and toxic material from the body, resolving stagnation for tranquilization.
Radix Angelicae Sinensis, it is sweet, it is acrid in flavour and warm in nature；Return heart, liver, the spleen channel；Effect, replenishing and activating blood.Menstruation regulating is antipruritic, relax bowel and defecation.
Rhizoma Chuanxiong, it is acrid in flavour and warm in nature；Return liver, gallbladder, pericardium channel；Effect, blood-activating and qi-promoting, wind-expelling pain-stopping.
Artemisia anomala, bitter, temperature, return heart, liver, the spleen channel；Effect, removing blood stasis and acesodyne, hemostasis of curing the wound, blood-breaking dysmenorrhea, promoting digestion and removing indigestion.
Peach kernel, bitter, sweet and neutral, return heart, liver, large intestine channel；Effect, promoting blood circulation, relax bowel and defecation is relieving cough and asthma.
The rhizome of davallia, bitter, temperature；Return liver, kidney channel；Effect, analgesic of curing the wound of invigorating blood circulation, The strong bone of kidney tonifying.
Radix Notoginseng, sweet, slight bitter, temperature；Return liver, stomach meridian, effect, dissipating stasis and stanching bleeding, swelling and pain relieving.Rhizoma cyperi is pungent, slight bitter, micro- sweet and neutral； Return liver, spleen, three warps；Effect, soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.
The usage and dosage of liquid medicine of the invention: within patient is each taking 25g, once in the morning and once at night；Single is taken super It crosses 25g and will appear heartbeat and obviously slightly accelerate, the cerebrovascular has fluctuation.
The invention has the benefit that
1, in liquid medicine of the present invention, Herba Apii graveolentis extract plays the role of lowering blood pressure and blood fat, diuresis, Central nervous system There is Zhenan County's effect, the effect for the flatulence that can calm the nerves, alleviate.Radish seed extract help digestion and eliminate flatulence, lowering the adverse-rising QI to resolve phlegm, modern study: radish Sub- water extract has apparent antihypertensive effect.There is haw thorn extract lowering blood pressure and blood fat, heart tonifying, arrhythmia etc. to make With.Hyperlipidemia, hypertension are treated in cassia seed extract, heat-clearing improving eyesight, relax bowel and defecation.
2, liquid medicine of the invention can be used for daily health caring, keep fit and healthy, main prevention of arterial atherosis；
3, liquid medicine of the invention has preferable effect to treatment atherosclerotic dangerous diseases, cures mainly hyperlipidemia, the heart Muscle infarction, hypertension, painstaking effort blockage, dizzy out of strength, insomnia forgetfulness, extremity numbness, chest distress and palpitation symptoms, angina pectoris, coronary heart disease, brain Hemorrhage, cerebral thrombosis apoplexy, can also treat cervical spondylosis and prolapse of lumbar intervertebral disc.
4, the effective component of all pure natural plant extracts of the raw material of liquid medicine of the invention, has no toxic side effect, will not Dependence is generated, it is safer, it is more healthy.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below Detailed description.Obviously, described embodiment is only a part of the embodiments of the present invention, instead of all the embodiments. Based on the embodiments of the present invention, those of ordinary skill in the art obtained institute without making creative work There is other embodiment, belongs to the range that the present invention is protected.
1 part in following embodiment represents 1kg.
Embodiment 1
The present embodiment provides a kind of liquid medicine, raw material components are as follows:
Radix Salviae Miltiorrhizae 10g；Radix cyathulae 5g；West safflower 3g；Radix Angelicae Sinensis 6g；Rhizoma Chuanxiong 10g；Artemisia anomala 3g；Peach kernel 10g；Rhizome of davallia 3g；Three Seven 9g and rhizoma cyperi 6g.
Embodiment 2
The present embodiment provides a kind of liquid medicine, raw material components are as follows:
Radix Salviae Miltiorrhizae 13g；Radix cyathulae 7g；West safflower 2.5g；Radix Angelicae Sinensis 8g；Rhizoma Chuanxiong 8g；Artemisia anomala 5g；Peach kernel 8g；Rhizome of davallia 5g；Three Seven 7g and rhizoma cyperi 7g, further include white wine, the white wine that the white wine is 40 degree.
Embodiment 3
The present embodiment provides a kind of liquid medicine, raw material components are as follows:
Radix Salviae Miltiorrhizae 12g；Radix cyathulae 8g；West safflower 1.5g；Radix Angelicae Sinensis 10g；Rhizoma Chuanxiong 5g；Artemisia anomala 8g；Peach kernel 7g；Rhizome of davallia 7g； Radix Notoginseng 5g and rhizoma cyperi 9g.
The preparation method of the liquid medicine, comprising the following steps:
(1) Radix Salviae Miltiorrhizae, radix cyathulae, west safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Artemisia anomala, peach kernel, the rhizome of davallia, Radix Notoginseng are weighed by weight ratio And rhizoma cyperi, it is uniformly mixed and forms mixture；
(2) white wine is added in the mixture obtained to step (1), is uniformly mixed, sealed soak 6 months, will impregnates Filtered solution is obtained by filtration in liquid, the as described liquid medicine.
Embodiment 4
The present embodiment provides a kind of liquid medicine, raw material components are as follows:
Radix Salviae Miltiorrhizae 12.5g；Radix cyathulae 7.5g；West safflower 2g；Radix Angelicae Sinensis 9g；Rhizoma Chuanxiong 6.5g；Artemisia anomala 6.5g；Peach kernel 7.5g；Bone Broken benefit 6g；Radix Notoginseng 6g and rhizoma cyperi 8g, further includes white wine, the white wine that the white wine is 40 degree.
The preparation method of the liquid medicine, comprising the following steps:
(1) Radix Salviae Miltiorrhizae, radix cyathulae, west safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Artemisia anomala, peach kernel, the rhizome of davallia, Radix Notoginseng are weighed by weight ratio Powder is broken into respectively with rhizoma cyperi, then passes through high-temperature short-time sterilization respectively, and the temperature of the high-temperature short-time sterilization is 121 DEG C, the height The time of warm instantaneous sterilizing is 5 seconds, is uniformly mixed and forms mixture；
(2) white wine is added in the mixture obtained to step (1), be uniformly mixed, 35-40 DEG C sealed soak 4 months, Filtered solution is obtained by filtration in soak, the as described liquid medicine.
Comparative example 1
Unique difference of this comparative example and embodiment 4 is in raw material components without containing the rhizome of davallia.
Comparative example 2
Unique difference of this comparative example and embodiment 4 is in raw material components without containing peach kernel.
Influence of the liquid medicine that 1-4 of the embodiment of the present invention is obtained to rat blood pressure
Experimental animal: selection randomly selects 35 rats and weighs on platform balance, records weight, observes its activity situation.
Experimental method: 1. the foundation of hypertension animal model is grouped and index observing is administered: with rodent Wistar Rat is research object, establishes experimental endocrine type hypertension experimental animal model.After a week by rat adaptable fed, to After animal adapts to environment, be randomly divided into 7 big groups, every group 5: rat control group and rat model group, model group are embodiment 1 Group, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 1 group of comparative example and 2 groups of comparative example.Rat model group is subcutaneously injected daily Testosterone propionate, rat dosage are 5mg/kg, continuous 2 weeks, monitor blood pressure, establish experimental hypertension animal model.2. with injection Device pours into each 5ml/kg of glucose for control group daily every and continues 6 weeks, to make blank control；3. every to model group with syringe Day every pours into each 5ml/kg of liquid medicine of the present invention and continues 6 weeks.Two groups maintain in test normal raising.
The measurement of observation index blood pressure: it is indirect to carry out arteria caudalis under waking state using intelligent non-invasive blood pressure measuring for 6 weeks front and backs Survey pressure.Measure each group experiment front and back systolic pressure (systolicbloodpressure, SBP), respectively after taking 0min, 30min, 60min, each time point continuously measure three times, are averaged.SBP indicates (1mmHg ≈ 0.133kPa) with mmHg.Meter It calculates each group and itself forward and backward difference and the difference with control group is administered.
Experimental result: being analyzed using software, and measurement data is with mean ± standard deviationIt indicates, using pairing T is examined, and P < 0.05 is true statistical significance.The pretherapy and post-treatment systolic pressure comparing difference of control group is not statistically significant, control group clothes 2 months model group blood pressures of medicine are declined, and comparing difference is statistically significant (P < 0.05), are detailed in table l.
SBP variation is compared before and after 1 two groups of experiments of table
Group Before taking 0min 30min 60min
Control group 83.5±8.9 84.9±7.4 85.2±9.9 84.6±12.2
Example 1 group 150.5±13.2 139.2±14.1 131.3±11.0 91.3±9.4
2 groups of embodiment 149.6±10.5 138.6±12.8 129.9±10.3 90.8±10.8
3 groups of embodiment 150.9±9.2 138.9±11.5 129.3±9.7 90.1±6.8
4 groups of embodiment 150.5±15.2 138.2±13.2 129.5±12.3 89.2±10.9
Comparative example 1 149.9±11.6 145.7±10.9 139.8±12.1 130.5±11.1
Comparative example 2 150.1±12.4 142.9±11.5 135.2±11.8 123.4±12.3
2 months blood pressures from table 1 it follows that model group is taken medicine, drop to normal value substantially, and control group is taken medicine 2 months Blood pressure is declined without significant change, the blood pressure of comparative example group, but effect is not compared to being fine for liquid medicine of the invention.This hair Bright liquid medicine can not only play the role of effectively controlling hypertension, moreover it can be used to daily health caring, the heart and brain blood such as preventing hypertension The generation of pipe disease can prevent and treat vascular sclerosis.
Clinical case
The scheme of above-described embodiment 1-4 is that inventor passes through test of many times research as a result, can play preferably through on probation Treatment hyperlipidemia, painstaking effort blockage effect and health-care effect.It is hyperlipidemia 50, cardiovascular for clinical use 100 Block patient 50 of 50-70%.
Each one bag of the morning and evening that liquid medicine is made in the embodiment of the present invention 4, every bag be 20g, every bag Instant Drinks 1 time, even drink 3 Month, 46 patients with lipid have arrived normal value；2 blood lipids are decreased obviously, and 1 rate and blood-lipid decreased is unobvious；Do not adhere to 1 midway.Suffer from For person's total effective rate up to 96%, cure rate 92% is no to act on 4%.31 painstaking effort blockage patients decrease, averagely reduction 2- 6%, 13 painstaking effort blockage patients do not adhere to without significant change, 6 midways.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.

Claims (10)

1. a kind of liquid medicine, which is characterized in that the liquid medicine is made of following bulk pharmaceutical chemicals, and the bulk pharmaceutical chemicals include:
Radix Salviae Miltiorrhizae, radix cyathulae, west safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Artemisia anomala, peach kernel, the rhizome of davallia, Radix Notoginseng and rhizoma cyperi.
2. liquid medicine according to claim 1, which is characterized in that the liquid medicine is prepared from the following raw materials, and the raw material is by weight Measuring part includes:
Radix Salviae Miltiorrhizae 10-15g；Radix cyathulae 5-10g；West safflower 1-3g；Radix Angelicae Sinensis 6-12g；Rhizoma Chuanxiong 3-10g；Artemisia anomala 3-10g；Peach kernel 5- 10g；Rhizome of davallia 3-9g；Radix Notoginseng 3-9g and rhizoma cyperi 6-10g.
3. liquid medicine according to claim 2, which is characterized in that the liquid medicine is prepared from the following raw materials, and the raw material is by weight Measuring part includes:
Radix Salviae Miltiorrhizae 12-13g；Radix cyathulae 7-8g；West safflower 1.5-2.5g；Radix Angelicae Sinensis 8-10g；Rhizoma Chuanxiong 5-8g；Artemisia anomala 5-8g；Peach kernel 7- 8g；Rhizome of davallia 5-7g；Radix Notoginseng 5-7g and rhizoma cyperi 7-9g.
4. liquid medicine according to claim 3, which is characterized in that the liquid medicine is prepared from the following raw materials, and the raw material is by weight Measuring part includes:
Radix Salviae Miltiorrhizae 12.5g；Radix cyathulae 7.5g；West safflower 2g；Radix Angelicae Sinensis 9g；Rhizoma Chuanxiong 6.5g；Artemisia anomala 6.5g；Peach kernel 7.5g；The rhizome of davallia 6g；Radix Notoginseng 6g and rhizoma cyperi 8g.
5. liquid medicine according to claim 1 to 4, which is characterized in that the liquid medicine further includes white wine.
6. liquid medicine according to claim 5, which is characterized in that the white wine is the white wine of 35-40 degree.
7. the method for preparing any one of the claim 1-6 liquid medicine, which comprises the following steps:
(1) Radix Salviae Miltiorrhizae, radix cyathulae, west safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Artemisia anomala, peach kernel, the rhizome of davallia, Radix Notoginseng and perfume (or spice) are weighed by weight ratio It is attached, it is uniformly mixed and forms mixture；
(2) white wine is added in the mixture obtained to step (1), is uniformly mixed, sealed soak 4-6 months, by soak Filtered solution is obtained by filtration, the as described liquid medicine.
8. the preparation method of liquid medicine according to claim 7, which is characterized in that in step (1), the Radix Salviae Miltiorrhizae, radix cyathulae, Powder is first broken into respectively before west safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Artemisia anomala, peach kernel, the rhizome of davallia, Radix Notoginseng and rhizoma cyperi mixing, then respectively through excessively high Warm instantaneous sterilizing, the temperature of the high-temperature short-time sterilization are 121 DEG C, and the time of the high-temperature short-time sterilization is 5 seconds.
9. the preparation method of liquid medicine according to claim 7, which is characterized in that in step (2), the sealed soak when Between be 5 months, the temperature of immersion is 35-40 DEG C.
10. any liquid medicine of claim 1-6 is in preparation prevention and treatment atherosclerosis drug or health care product and food Using.
CN201910536767.9A 2019-06-20 2019-06-20 Liquid medicine and the preparation method and application thereof Pending CN110170016A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1476849A (en) * 2002-08-21 2004-02-25 韩海龙 Medicine composition for promoting blood circulation and removing stasis
CN107854664A (en) * 2017-12-25 2018-03-30 郑新龙 A kind of inrigorating qi and promoting blood circulation silt Wine for reducing blood-pressure and preparation method thereof
CN108992549A (en) * 2018-09-30 2018-12-14 珠海市厚生药业有限公司 A kind of pharmaceutical composition and preparation method thereof, application
CN109223926A (en) * 2018-12-05 2019-01-18 李天基 A kind of Chinese medicine composition and the preparation method and application thereof for treating hypertension

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1476849A (en) * 2002-08-21 2004-02-25 韩海龙 Medicine composition for promoting blood circulation and removing stasis
CN107854664A (en) * 2017-12-25 2018-03-30 郑新龙 A kind of inrigorating qi and promoting blood circulation silt Wine for reducing blood-pressure and preparation method thereof
CN108992549A (en) * 2018-09-30 2018-12-14 珠海市厚生药业有限公司 A kind of pharmaceutical composition and preparation method thereof, application
CN109223926A (en) * 2018-12-05 2019-01-18 李天基 A kind of Chinese medicine composition and the preparation method and application thereof for treating hypertension

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