CN110167966B - 程序性细胞死亡(pd-1)的单结构域抗体 - Google Patents

程序性细胞死亡(pd-1)的单结构域抗体 Download PDF

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CN110167966B
CN110167966B CN201880006096.9A CN201880006096A CN110167966B CN 110167966 B CN110167966 B CN 110167966B CN 201880006096 A CN201880006096 A CN 201880006096A CN 110167966 B CN110167966 B CN 110167966B
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single domain
cancer
binding
domain antibody
antibody
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CN110167966A (zh
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菲尔·海斯
詹姆斯·莱格
马蒂纳·莱万多夫斯卡
科莉特·约翰斯顿
布莱恩·麦吉尼斯
麦克·罗曼诺斯
克里斯蒂娜·罗桑
滕毓敏
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Crescendo Biologics Ltd
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/00—Immunoglobulins specific features
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CN201880006096.9A 2017-01-06 2018-01-08 程序性细胞死亡(pd-1)的单结构域抗体 Active CN110167966B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1700210.6 2017-01-06
GBGB1700207.2A GB201700207D0 (en) 2017-01-06 2017-01-06 Single domain antibodies to prgrammed cell death (PD-1)
GBGB1700210.6A GB201700210D0 (en) 2017-01-06 2017-01-06 Single domain antibodies to programmed cell death (PD-1)
GBGB1700208.0A GB201700208D0 (en) 2017-01-06 2017-01-06 Single domain antibodies to programmed cell death (PD-1)
GB1700208.0 2017-01-06
GB1700207.2 2017-01-06
PCT/GB2018/050036 WO2018127710A1 (en) 2017-01-06 2018-01-08 Single domain antibodies to programmed cell death (pd-1)

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CN110167966A CN110167966A (zh) 2019-08-23
CN110167966B true CN110167966B (zh) 2024-08-30

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US (5) US11814429B2 (enExample)
EP (3) EP3565841A1 (enExample)
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WO (3) WO2018127709A1 (enExample)

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